Extreme obesity induces massive beta cell expansion in mice through self-renewal and does not alter the beta cell lineage

Diabetologia

Volumn 59, Issue 6, 2016, Pages 1231-1241

  Cox, Aaron R ^a,b   Lam, Carol J ^a,b   Rankin, Matthew M ^c   King, Kourtney A ^c   Chen, Pan ^c   Martinez, Ramon ^a,b   Li, Changhong ^c   Kushner, Jake A ^a,b  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b TEXAS CHILDREN S HOSPITAL   (United States)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Beta cell expansion; Cell fate; Lineage tracing; Obesity

Indexed keywords

GLUCOSE; INSULIN; TAMOXIFEN; LEPTIN RECEPTOR; LEPTIN RECEPTOR, MOUSE;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY MASS; CELL DIVISION; CELL EXPANSION; CELL FATE; CELL GROWTH; CELL LINEAGE; CELL PROLIFERATION; CELL SELF-RENEWAL; CONTROLLED STUDY; FEMALE; GENE DELETION; GLUCOSE BLOOD LEVEL; GLUCOSE HOMEOSTASIS; GLUCOSE INTOLERANCE; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; MALE; MOUSE; NONHUMAN; OBESITY; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; STEM CELL; WEIGHT GAIN; ANIMAL; DEFICIENCY; DISEASE MODEL; GENETICS; KNOCKOUT MOUSE; PATHOLOGY; PHYSIOLOGY;

ANIMALS; CELL PROLIFERATION; DISEASE MODELS, ANIMAL; FEMALE; IMMUNOHISTOCHEMISTRY; INSULIN-SECRETING CELLS; MALE; MICE; MICE, KNOCKOUT; OBESITY; RECEPTORS, LEPTIN;

EID: 84961773525     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-016-3922-7     Document Type: Article

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