Reduced Insulin Production Relieves Endoplasmic Reticulum Stress and Induces β Cell Proliferation

Cell Metabolism

Volumn 23, Issue 1, 2016, Pages 179-193

  Szabat, Marta ^a   Page, Melissa M ^a   Panzhinskiy, Evgeniy ^a   Skovsø, Søs ^a   Mojibian, Majid ^a   Fernandez Tajes, Juan ^b   Bruin, Jennifer E ^a   Bround, Michael J ^a   Lee, Jason T C ^a   Xu, Eric E ^c   Taghizadeh, Farnaz ^a   O'Dwyer, Shannon ^a   Van De Bunt, Martijn ^b   Moon, Kyung Mee ^a   Sinha, Sunita ^a   Han, Jun ^d   Fan, Yong ^e   Lynn, Francis C ^c   Trucco, Massimo ^e   Borchers, Christoph H ^d   Foster, Leonard J ^a   Nislow, Corey ^a   Kieffer, Timothy J ^a   Johnson, James D ^a   more..

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^d UNIVERSITY OF VICTORIA   (Canada)

^e ALLEGHENY HEALTH NETWORK   (United States)

Author keywords

beta cells; dedifferentiation; diabetes; ER stress; insulin; islets; metabolomic; proliferation; protein synthesis; proteomic; transcriptomic

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 4; CYCLIN D1; GLUCAGON; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; INSULIN; PROTEIN; PROTEIN KINASE B; PROTEOME; TRANSCRIPTOME; TRIB3 PROTEIN; UNCLASSIFIED DRUG; X BOX BINDING PROTEIN 1;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; ENDOPLASMIC RETICULUM STRESS; GENE EXPRESSION; HYPERGLYCEMIA; INSULIN SYNTHESIS; METABOLOMICS; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN PROCESSING; PROTEOMICS; SIGNAL TRANSDUCTION; TRANSCRIPTOMICS; UPREGULATION; ANIMAL; BIOSYNTHESIS; CELL CULTURE; KNOCKOUT MOUSE; METABOLISM; METABOLOME; NONOBESE DIABETIC MOUSE; PHYSIOLOGY; PROTEIN PROTEIN INTERACTION; SCID MOUSE;

ANIMALS; CELL PROLIFERATION; CELLS, CULTURED; ENDOPLASMIC RETICULUM STRESS; INSULIN; INSULIN-SECRETING CELLS; METABOLOME; MICE, INBRED NOD; MICE, KNOCKOUT; MICE, SCID; PROTEIN INTERACTION MAPS; PROTEOME; SIGNAL TRANSDUCTION; TRANSCRIPTOME;

EID: 84955356391     PISSN: 15504131     EISSN: 19327420     Source Type: Journal    
DOI: 10.1016/j.cmet.2015.10.016     Document Type: Article

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