One-step encapsulation of siRNA between lipid-layers of multi-layer polycation liposomes by lipoplex freeze-thawing

Journal of Controlled Release

Volumn 228, Issue , 2016, Pages 1-8

  Koide, Hiroyuki ^a   Okamoto, Ayaka ^a   Tsuchida, Hiroki ^a   Ando, Hidenori ^a   Ariizumi, Saki ^a   Kiyokawa, Chiaki ^a   Hashimoto, Masahiro ^a   Asai, Tomohiro ^a   Dewa, Takehisa ^b   Oku, Naoto ^a  

^a UNIVERSITY OF SHIZUOKA   (Japan)

^b NAGOYA INSTITUTE OF TECHNOLOGY   (Japan)

Author keywords

Freeze thaw; Polycation liposomes; siRNA encapsulation; Small interfering RNA

Indexed keywords

ENZYME INHIBITION; FREEZING; RNA; THAWING;

ATTRACTIVE STRATEGIES; FETAL BOVINE SERUM; FREEZE-THAW; ONE-STEP ENCAPSULATIONS; POLYCATIONS; SMALL INTERFERING RNA; SMALL INTERFERING RNA (SIRNA); TRANSFECTION EFFICIENCY;

LIPOSOMES;

LIPID; LIPOPLEX; LIPOSOME; MACROGOL; NANOCARRIER; POLYCATION; POLYCATION LIPOSOME; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; MACROGOL DERIVATIVE; POLYAMINE; POLYCATIONS;

ANIMAL CELL; ANIMAL MODEL; ARTICLE; CHEMICAL STRUCTURE; CONTROLLED STUDY; CYTOTOXICITY; DRUG ACCUMULATION; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; DRUG STABILITY; FETAL BOVINE SERUM; FREEZE THAWING; IN VITRO STUDY; IN VIVO STUDY; INCUBATION TIME; LIPID BILAYER; MALE; MELANOMA; MELANOMA CELL; MOUSE; NANOENCAPSULATION; NONHUMAN; PRIORITY JOURNAL; SERUM; ANIMAL; BAGG ALBINO MOUSE; CHEMISTRY; FREEZING; GENETIC TRANSFECTION; GENETICS; RNA INTERFERENCE; TUMOR CELL LINE;

ANIMALS; CELL LINE, TUMOR; FREEZING; LIPIDS; LIPOSOMES; MALE; MICE; MICE, INBRED BALB C; POLYAMINES; POLYETHYLENE GLYCOLS; RNA INTERFERENCE; RNA, SMALL INTERFERING; TRANSFECTION;

EID: 84961674959     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2016.01.032     Document Type: Article

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