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Volumn 21, Issue 1, 2014, Pages 15-25

Immune-based mechanisms of cytotoxic chemotherapy: Implications for the design of novel and rationale-based combined treatments against cancer

Author keywords

cancer; cellular immunity; chemotherapy; combined therapies; immune system

Indexed keywords

ALPHA INTERFERON; ANTHRACYCLINE; ANTINEOPLASTIC AGENT; CANCER VACCINE; CISPLATIN; CYCLOPHOSPHAMIDE; CYTOTOXIC AGENT; DACARBAZINE; DOCETAXEL; DOXORUBICIN; EPIRUBICIN; ETOPOSIDE; FLUDARABINE; FLUOROURACIL; FOLINIC ACID; GEMCITABINE; IRINOTECAN; METHOTREXATE; OXALIPLATIN; PACLITAXEL; PEPTIDE VACCINE; PHOSPHATE; PLATINUM; TEMOZOLOMIDE; VINBLASTINE; VINCRISTINE;

EID: 84890111958     PISSN: 13509047     EISSN: 14765403     Source Type: Journal    
DOI: 10.1038/cdd.2013.67     Document Type: Review
Times cited : (728)

References (140)
  • 1
    • 34948820602 scopus 로고    scopus 로고
    • Toll-like receptor 4-dependent contribution of the immune system to anticancer chemotherapy and radiotherapy
    • Apetoh L, Ghiringhelli F, Tesniere A, Obeid M, Ortiz C, Criollo A et al. Toll-like receptor 4-dependent contribution of the immune system to anticancer chemotherapy and radiotherapy. Nat Med 2007; 13: 1050-1059.
    • (2007) Nat Med , vol.13 , pp. 1050-1059
    • Apetoh, L.1    Ghiringhelli, F.2    Tesniere, A.3    Obeid, M.4    Ortiz, C.5    Criollo, A.6
  • 2
    • 0021058954 scopus 로고
    • Effect on natural killer and antibodydependent cellular cytotoxicity of adjuvant cytotoxic chemotherapy including melphalan in breast cancer
    • Mackay IR, Goodyear MD, Riglar C, Penschow J. Effect on natural killer and antibodydependent cellular cytotoxicity of adjuvant cytotoxic chemotherapy including melphalan in breast cancer. Cancer Immunol Immunother 1983; 16: 98-100.
    • (1983) Cancer Immunol Immunother , vol.16 , pp. 98-100
    • Mackay, I.R.1    Goodyear, M.D.2    Riglar, C.3    Penschow, J.4
  • 3
    • 0022625927 scopus 로고
    • Effect of chemotherapy on NK function in the peripheral blood of cancer patients
    • Braun DP, Harris JE. Effect of chemotherapy on NK function in the peripheral blood of cancer patients. Cancer Immunol Immunother 1986; 21: 240-245.
    • (1986) Cancer Immunol Immunother , vol.21 , pp. 240-245
    • Braun, D.P.1    Harris, J.E.2
  • 4
    • 0026015238 scopus 로고
    • The relationship of chemotherapeutic and endocrine intervention on natural killer cell activity in human breast cancer
    • Brenner BG, Margolese RG. The relationship of chemotherapeutic and endocrine intervention on natural killer cell activity in human breast cancer. Cancer 1991; 68: 482-488.
    • (1991) Cancer , vol.68 , pp. 482-488
    • Brenner, B.G.1    Margolese, R.G.2
  • 5
    • 0027482318 scopus 로고
    • Chemotherapyinduced differential changes in lymphocyte subsets and natural-killer-cell function in patients with advanced breast cancer
    • Sewell HF, Halbert CF, Robins RA, Galvin A, Chan S, Blamey RW. Chemotherapyinduced differential changes in lymphocyte subsets and natural-killer-cell function in patients with advanced breast cancer. Int J Cancer 1993; 55: 735-738.
    • (1993) Int J Cancer , vol.55 , pp. 735-738
    • Sewell, H.F.1    Halbert, C.F.2    Robins, R.A.3    Galvin, A.4    Chan, S.5    Blamey, R.W.6
  • 6
    • 33847368549 scopus 로고    scopus 로고
    • Metronomic cyclophosphamide regimen selectively depletes CD4+CD25+ regulatory T-cells and restores T and NK effector functions in end stage cancer patients
    • Ghiringhelli F, Menard C, Puig PE, Ladoire S, Roux S, Martin F et al. Metronomic cyclophosphamide regimen selectively depletes CD4+CD25+ regulatory T-cells and restores T and NK effector functions in end stage cancer patients. Cancer Immunol Immunother 2007; 56: 641-648.
    • (2007) Cancer Immunol Immunother , vol.56 , pp. 641-648
    • Ghiringhelli, F.1    Menard, C.2    Puig, P.E.3    Ladoire, S.4    Roux, S.5    Martin, F.6
  • 7
    • 74349102406 scopus 로고    scopus 로고
    • Administration of cyclophosphamide changes the immune profile of tumor-bearing mice
    • Liu P, Jaffar J, Hellstrom I, Hellstrom KE. Administration of cyclophosphamide changes the immune profile of tumor-bearing mice. J Immunother 2010; 33: 53-59.
    • (2010) J Immunother , vol.33 , pp. 53-59
    • Liu, P.1    Jaffar, J.2    Hellstrom, I.3    Hellstrom, K.E.4
  • 8
    • 84857723974 scopus 로고    scopus 로고
    • VEGF receptor inhibitors block the ability of metronomically dosed cyclophosphamide to activate innate immunity-induced tumor regression
    • Doloff JC, Waxman DJ. VEGF receptor inhibitors block the ability of metronomically dosed cyclophosphamide to activate innate immunity-induced tumor regression. Cancer Res 2012; 72: 1103-1115.
    • (2012) Cancer Res , vol.72 , pp. 1103-1115
    • Doloff, J.C.1    Waxman, D.J.2
  • 9
    • 84858755173 scopus 로고    scopus 로고
    • 5-Fluorouracil and interferon-Alpha immunochemotherapy enhances immunogenicity of murine pancreatic cancer through upregulation of NKG2D ligands and MHC class I
    • Khallouf H, Marten A, Serba S, Teichgraber V, Buchler MW, Jager D et al. 5-Fluorouracil and interferon-Alpha immunochemotherapy enhances immunogenicity of murine pancreatic cancer through upregulation of NKG2D ligands and MHC class I. J Immunother 2012; 35: 245-253.
    • (2012) J Immunother , vol.35 , pp. 245-253
    • Khallouf, H.1    Marten, A.2    Serba, S.3    Teichgraber, V.4    Buchler, M.W.5    Jager, D.6
  • 12
    • 83455203338 scopus 로고    scopus 로고
    • Identification and manipulation of tumor associated macrophages in human cancers
    • Heusinkveld M, van der Burg SH. Identification and manipulation of tumor associated macrophages in human cancers. J Transl Med 2011; 9: 216.
    • (2011) J Transl Med , vol.9 , pp. 216
    • Heusinkveld, M.1    Van Der Burg, S.H.2
  • 13
    • 67651165150 scopus 로고    scopus 로고
    • Influence of cyclophosphamide and its metabolic products on the activity of peritoneal macrophages in mice
    • Bryniarski K, Szczepanik M, Ptak M, Zemelka M, Ptak W. Influence of cyclophosphamide and its metabolic products on the activity of peritoneal macrophages in mice. Pharmacol Rep 2009; 61: 550-557.
    • (2009) Pharmacol Rep , vol.61 , pp. 550-557
    • Bryniarski, K.1    Szczepanik, M.2    Ptak, M.3    Zemelka, M.4    Ptak, W.5
  • 14
    • 78650956146 scopus 로고    scopus 로고
    • Anti-Tumour synergy of cytotoxic chemotherapy and anti-CD40 plus CpG-ODN immunotherapy through repolarization of tumour-Associated macrophages
    • Buhtoiarov IN, Sondel PM, Wigginton JM, Buhtoiarova TN, Yanke EM, Mahvi DA et al. Anti-Tumour synergy of cytotoxic chemotherapy and anti-CD40 plus CpG-ODN immunotherapy through repolarization of tumour-Associated macrophages. Immunology 2011; 132: 226-239.
    • (2011) Immunology , vol.132 , pp. 226-239
    • Buhtoiarov, I.N.1    Sondel, P.M.2    Wigginton, J.M.3    Buhtoiarova, T.N.4    Yanke, E.M.5    Mahvi, D.A.6
  • 16
    • 84868193089 scopus 로고    scopus 로고
    • Tumor suppression via paclitaxelloaded drug carriers that target inflammation marker upregulated in tumor vasculature and macrophages
    • Park S, Kang S, Chen X, Kim EJ, Kim J, Kim N et al. Tumor suppression via paclitaxelloaded drug carriers that target inflammation marker upregulated in tumor vasculature and macrophages. Biomaterials 2013; 34: 598-605.
    • (2013) Biomaterials , vol.34 , pp. 598-605
    • Park, S.1    Kang, S.2    Chen, X.3    Kim, E.J.4    Kim, J.5    Kim, N.6
  • 18
    • 84866784798 scopus 로고    scopus 로고
    • Leukocyte complexity predicts breast cancer survival and functionally regulates response to chemotherapy
    • DeNardo DG, Brennan DJ, Rexhepaj E, Ruffell B, Shiao SL, Madden SF et al. Leukocyte complexity predicts breast cancer survival and functionally regulates response to chemotherapy. Cancer Discov 2011; 1: 54-67.
    • (2011) Cancer Discov , vol.1 , pp. 54-67
    • DeNardo, D.G.1    Brennan, D.J.2    Rexhepaj, E.3    Ruffell, B.4    Shiao, S.L.5    Madden, S.F.6
  • 19
    • 82955189189 scopus 로고    scopus 로고
    • Macrophages and cathepsin proteases blunt chemotherapeutic response in breast cancer
    • Shree T, Olson OC, Elie BT, Kester JC, Garfall AL, Simpson K et al. Macrophages and cathepsin proteases blunt chemotherapeutic response in breast cancer. Genes Dev 2011; 25: 2465-2479.
    • (2011) Genes Dev , vol.25 , pp. 2465-2479
    • Shree, T.1    Olson, O.C.2    Elie, B.T.3    Kester, J.C.4    Garfall, A.L.5    Simpson, K.6
  • 20
    • 77953945438 scopus 로고    scopus 로고
    • Cyclophosphamide enhances immunity by modulating the balance of dendritic cell subsets in lymphoid organs
    • Nakahara T, Uchi H, Lesokhin AM, Avogadri F, Rizzuto GA, Hirschhorn-Cymerman D et al. Cyclophosphamide enhances immunity by modulating the balance of dendritic cell subsets in lymphoid organs. Blood 2010; 115: 4384-4392.
    • (2010) Blood , vol.115 , pp. 4384-4392
    • Nakahara, T.1    Uchi, H.2    Lesokhin, A.M.3    Avogadri, F.4    Rizzuto, G.A.5    Hirschhorn-Cymerman, D.6
  • 21
    • 79551523389 scopus 로고    scopus 로고
    • Cyclophosphamide synergizes with type I interferons through systemic dendritic cell reactivation and induction of immunogenic tumor apoptosis
    • Schiavoni G, Sistigu A, Valentini M, Mattei F, Sestili P, Spadaro F et al. Cyclophosphamide synergizes with type I interferons through systemic dendritic cell reactivation and induction of immunogenic tumor apoptosis. Cancer Res 2011; 71: 768-778.
    • (2011) Cancer Res , vol.71 , pp. 768-778
    • Schiavoni, G.1    Sistigu, A.2    Valentini, M.3    Mattei, F.4    Sestili, P.5    Spadaro, F.6
  • 22
    • 84859597239 scopus 로고    scopus 로고
    • Preconditioning chemotherapy with cisplatin enhances the antitumor activity of cytokine-induced killer cells in a murine melanoma model
    • Chen J, Huang X, Huang G, Chen Y, Chen L, Song H. Preconditioning chemotherapy with cisplatin enhances the antitumor activity of cytokine-induced killer cells in a murine melanoma model. Cancer Biother Radiopharm 2012; 27: 210-220.
    • (2012) Cancer Biother Radiopharm , vol.27 , pp. 210-220
    • Chen, J.1    Huang, X.2    Huang, G.3    Chen, Y.4    Chen, L.5    Song, H.6
  • 23
    • 70849115361 scopus 로고    scopus 로고
    • Regular dose of gemcitabine induces an increase in CD14+ monocytes and CD11c+ dendritic cells in patients with advanced pancreatic cancer
    • Soeda A, Morita-Hoshi Y, Makiyama H, Morizane C, Ueno H, Ikeda M et al. Regular dose of gemcitabine induces an increase in CD14+ monocytes and CD11c+ dendritic cells in patients with advanced pancreatic cancer. Jpn J Clin Oncol 2009; 39: 797-806.
    • (2009) Jpn J Clin Oncol , vol.39 , pp. 797-806
    • Soeda, A.1    Morita-Hoshi, Y.2    Makiyama, H.3    Morizane, C.4    Ueno, H.5    Ikeda, M.6
  • 24
    • 70149089227 scopus 로고    scopus 로고
    • Classification of chemotherapeutic agents based on their differential in vitro effects on dendritic cells
    • Tanaka H, Matsushima H, Mizumoto N, Takashima A. Classification of chemotherapeutic agents based on their differential in vitro effects on dendritic cells. Cancer Res 2009; 69: 6978-6986.
    • (2009) Cancer Res , vol.69 , pp. 6978-6986
    • Tanaka, H.1    Matsushima, H.2    Mizumoto, N.3    Takashima, A.4
  • 25
    • 68349123372 scopus 로고    scopus 로고
    • Chemotherapeutic agents in noncytotoxic concentrations increase antigen presentation by dendritic cells via an IL-12-dependent mechanism
    • Shurin GV, Tourkova IL, Kaneno R, Shurin MR. Chemotherapeutic agents in noncytotoxic concentrations increase antigen presentation by dendritic cells via an IL-12-dependent mechanism. J Immunol 2009; 183: 137-144.
    • (2009) J Immunol , vol.183 , pp. 137-144
    • Shurin, G.V.1    Tourkova, I.L.2    Kaneno, R.3    Shurin, M.R.4
  • 26
    • 68349083269 scopus 로고    scopus 로고
    • Chemomodulation of human dendritic cell function by antineoplastic agents in low noncytotoxic concentrations
    • Kaneno R, Shurin GV, Tourkova IL, Shurin MR. Chemomodulation of human dendritic cell function by antineoplastic agents in low noncytotoxic concentrations. J Transl Med 2009; 7: 58.
    • (2009) J Transl Med , vol.7 , pp. 58
    • Kaneno, R.1    Shurin, G.V.2    Tourkova, I.L.3    Shurin, M.R.4
  • 27
    • 70149097098 scopus 로고    scopus 로고
    • Dual therapeutic efficacy of vinblastine as a unique chemotherapeutic agent capable of inducing dendritic cell maturation
    • Tanaka H, Matsushima H, Nishibu A, Clausen BE, Takashima A. Dual therapeutic efficacy of vinblastine as a unique chemotherapeutic agent capable of inducing dendritic cell maturation. Cancer Res 2009; 69: 6987-6994.
    • (2009) Cancer Res , vol.69 , pp. 6987-6994
    • Tanaka, H.1    Matsushima, H.2    Nishibu, A.3    Clausen, B.E.4    Takashima, A.5
  • 28
    • 84872966087 scopus 로고    scopus 로고
    • Impact of chemotherapeutic agents on the immunostimulatory properties of human 6-sulfo LacNAc+ (slan) dendritic cells
    • Wehner R, Bitterlich A, Meyer N, Kloss A, Schakel K, Bachmann M et al. Impact of chemotherapeutic agents on the immunostimulatory properties of human 6-sulfo LacNAc+ (slan) dendritic cells. Int J Cancer 2013; 132: 1351-1359.
    • (2013) Int J Cancer , vol.132 , pp. 1351-1359
    • Wehner, R.1    Bitterlich, A.2    Meyer, N.3    Kloss, A.4    Schakel, K.5    Bachmann, M.6
  • 29
    • 0041592513 scopus 로고    scopus 로고
    • Influence of drug-induced apoptotic death on processing and presentation of tumor antigens by dendritic cells
    • Buttiglieri S, Galetto A, Forno S, De Andrea M, Matera L. Influence of drug-induced apoptotic death on processing and presentation of tumor antigens by dendritic cells. Int J Cancer 2003; 106: 516-520.
    • (2003) Int J Cancer , vol.106 , pp. 516-520
    • Buttiglieri, S.1    Galetto, A.2    Forno, S.3    De Andrea, M.4    Matera, L.5
  • 30
    • 1542719818 scopus 로고    scopus 로고
    • Drug- And cell-mediated antitumor cytotoxicities modulate cross-presentation of tumor antigens by myeloid dendritic cells
    • Galetto A, Buttiglieri S, Forno S, Moro F, Mussa A, Matera L. Drug- And cell-mediated antitumor cytotoxicities modulate cross-presentation of tumor antigens by myeloid dendritic cells. Anticancer Drugs 2003; 14: 833-843.
    • (2003) Anticancer Drugs , vol.14 , pp. 833-843
    • Galetto, A.1    Buttiglieri, S.2    Forno, S.3    Moro, F.4    Mussa, A.5    Matera, L.6
  • 33
    • 84856301759 scopus 로고    scopus 로고
    • Exploitation of the propulsive force of chemotherapy for improving the response to cancer immunotherapy
    • Proietti E, Moschella F, Capone I, Belardelli F. Exploitation of the propulsive force of chemotherapy for improving the response to cancer immunotherapy. Mol Oncol 2012; 6: 1-14.
    • (2012) Mol Oncol , vol.6 , pp. 1-14
    • Proietti, E.1    Moschella, F.2    Capone, I.3    Belardelli, F.4
  • 34
    • 38949216307 scopus 로고    scopus 로고
    • Changes in cellular immunity during chemotherapy for primary breast cancer with anthracycline regimens
    • Wijayahadi N, Haron MR, Stanslas J, Yusuf Z. Changes in cellular immunity during chemotherapy for primary breast cancer with anthracycline regimens. J Chemother 2007; 19: 716-723.
    • (2007) J Chemother , vol.19 , pp. 716-723
    • Wijayahadi, N.1    Haron, M.R.2    Stanslas, J.3    Yusuf, Z.4
  • 35
    • 0037089545 scopus 로고    scopus 로고
    • Gemcitabine exerts a selective effect on the humoral immune response: Implications for combination chemo-immunotherapy
    • Nowak AK, Robinson BW, Lake RA. Gemcitabine exerts a selective effect on the humoral immune response: Implications for combination chemo-immunotherapy. Cancer Res 2002; 62: 2353-2358.
    • (2002) Cancer Res , vol.62 , pp. 2353-2358
    • Nowak, A.K.1    Robinson, B.W.2    Lake, R.A.3
  • 36
    • 25144466458 scopus 로고    scopus 로고
    • Gemcitabine selectively eliminates splenic Gr-1+/CD11b+ myeloid suppressor cells in tumor-bearing animals and enhances antitumor immune activity
    • Suzuki E, Kapoor V, Jassar AS, Kaiser LR, Albelda SM. Gemcitabine selectively eliminates splenic Gr-1+/CD11b+ myeloid suppressor cells in tumor-bearing animals and enhances antitumor immune activity. Clin Cancer Res 2005; 11: 6713-6721.
    • (2005) Clin Cancer Res , vol.11 , pp. 6713-6721
    • Suzuki, E.1    Kapoor, V.2    Jassar, A.S.3    Kaiser, L.R.4    Albelda, S.M.5
  • 38
    • 0017147275 scopus 로고
    • Comparative study of cyclophosphamide, 6-mercaptopurine, azathiopurine and methotrexate. Relative effects on the humoral and the cellular immune response in the mouse
    • Otterness IG, Chang YH. Comparative study of cyclophosphamide, 6-mercaptopurine, azathiopurine and methotrexate. Relative effects on the humoral and the cellular immune response in the mouse. Clin Exp Immunol 1976; 26: 346-354.
    • (1976) Clin Exp Immunol , vol.26 , pp. 346-354
    • Otterness, I.G.1    Chang, Y.H.2
  • 39
    • 84907113444 scopus 로고
    • Comparative effects of azathioprine, cyclophosphamide and frentizole on cellular immunity in mice
    • Smith SR, Terminelli C, Kipilman CT, Smith Y. Comparative effects of azathioprine, cyclophosphamide and frentizole on cellular immunity in mice. J Immunopharmacol 1981; 3: 133-170.
    • (1981) J Immunopharmacol , vol.3 , pp. 133-170
    • Smith, S.R.1    Terminelli, C.2    Kipilman, C.T.3    Smith, Y.4
  • 40
    • 0021719261 scopus 로고
    • Potentiation of human cell-mediated and humoral immunity by low-dose cyclophosphamide
    • Berd D, Maguire HC Jr, Mastrangelo MJ. Potentiation of human cell-mediated and humoral immunity by low-dose cyclophosphamide. Cancer Res 1984; 44: 5439-5443.
    • (1984) Cancer Res , vol.44 , pp. 5439-5443
    • Berd, D.1    Maguire Jr., H.C.2    Mastrangelo, M.J.3
  • 41
    • 33846878993 scopus 로고    scopus 로고
    • Cyclophosphamide enhances the antitumor efficacy of adoptively transferred immune cells through the induction of cytokine expression, B-cell and T-cell homeostatic proliferation, and specific tumor infiltration
    • Bracci L, Moschella F, Sestili P, La Sorsa V, Valentini M, Canini I et al. Cyclophosphamide enhances the antitumor efficacy of adoptively transferred immune cells through the induction of cytokine expression, B-cell and T-cell homeostatic proliferation, and specific tumor infiltration. Clin Cancer Res 2007; 13: 644-653.
    • (2007) Clin Cancer Res , vol.13 , pp. 644-653
    • Bracci, L.1    Moschella, F.2    Sestili, P.3    La Sorsa, V.4    Valentini, M.5    Canini, I.6
  • 42
    • 0032518412 scopus 로고    scopus 로고
    • Importance of cyclophosphamide-induced bystander effect on T-cells for a successful tumor eradication in response to adoptive immunotherapy in mice
    • Proietti E, Greco G, Garrone B, Baccarini S, Mauri C, Venditti M et al. Importance of cyclophosphamide-induced bystander effect on T-cells for a successful tumor eradication in response to adoptive immunotherapy in mice. J Clin Invest 1998; 101: 429-441.
    • (1998) J Clin Invest , vol.101 , pp. 429-441
    • Proietti, E.1    Greco, G.2    Garrone, B.3    Baccarini, S.4    Mauri, C.5    Venditti, M.6
  • 43
    • 79956085853 scopus 로고    scopus 로고
    • Unraveling cancer chemoimmunotherapy mechanisms by gene and protein expression profiling of responses to cyclophosphamide
    • Moschella F, Valentini M, Arico E, Macchia I, Sestili P, D'Urso MT et al. Unraveling cancer chemoimmunotherapy mechanisms by gene and protein expression profiling of responses to cyclophosphamide. Cancer Res 2011; 71: 3528-3539.
    • (2011) Cancer Res , vol.71 , pp. 3528-3539
    • Moschella, F.1    Valentini, M.2    Arico, E.3    Macchia, I.4    Sestili, P.5    D'Urso, M.T.6
  • 45
    • 70349240438 scopus 로고    scopus 로고
    • Vivo sensitized and in vitro activated B cells mediate tumor regression in cancer adoptive immunotherapy
    • Li Q, Teitz-Tennenbaum S, Donald EJ, Li M, Chang AE. In vivo sensitized and in vitro activated B cells mediate tumor regression in cancer adoptive immunotherapy. J Immunol 2009; 183: 3195-3203.
    • (2009) J Immunol , vol.183 , pp. 3195-3203
    • Li, Q.1    Teitz-Tennenbaum, S.2    Donald, E.J.3    Li, M.4    Chang, A.E.5
  • 46
    • 61849137236 scopus 로고    scopus 로고
    • Chemotherapy induced transient B-cell depletion boosts antibody-forming cells expansion driven by an epidermal growth factor-based cancer vaccine
    • Montero E, Valdes M, Avellanet J, Lopez A, Perez R, Lage A. Chemotherapy induced transient B-cell depletion boosts antibody-forming cells expansion driven by an epidermal growth factor-based cancer vaccine. Vaccine 2009; 27: 2230-2239.
    • (2009) Vaccine , vol.27 , pp. 2230-2239
    • Montero, E.1    Valdes, M.2    Avellanet, J.3    Lopez, A.4    Perez, R.5    Lage, A.6
  • 47
    • 84155163020 scopus 로고    scopus 로고
    • Cancer cells containing nanoscale chemotherapeutic drugs generate antiovarian cancer-specific CD4+ T-cells in peritoneal space
    • Kim JE, Jang MJ, Lee JI, Chung YH, Jeong JH, Hung CF et al. Cancer cells containing nanoscale chemotherapeutic drugs generate antiovarian cancer-specific CD4+ T-cells in peritoneal space. J Immunother 2012; 35: 1-13.
    • (2012) J Immunother , vol.35 , pp. 1-13
    • Kim, J.E.1    Jang, M.J.2    Lee, J.I.3    Chung, Y.H.4    Jeong, J.H.5    Hung, C.F.6
  • 48
    • 84872000581 scopus 로고    scopus 로고
    • Dose-dense chemotherapy improves mechanisms of antitumor immune response
    • Chang CL, Hsu YT, Wu CC, Lai YZ, Wang C, Yang YC et al. Dose-dense chemotherapy improves mechanisms of antitumor immune response. Cancer Res 2013; 73: 119-127.
    • (2013) Cancer Res , vol.73 , pp. 119-127
    • Chang, C.L.1    Hsu, Y.T.2    Wu, C.C.3    Lai, Y.Z.4    Wang, C.5    Yang, Y.C.6
  • 49
    • 77951086882 scopus 로고    scopus 로고
    • 5-Fluorouracil selectively kills tumor-Associated myeloid-derived suppressor cells resulting in enhanced T-cell-dependent antitumor immunity
    • Vincent J, Mignot G, Chalmin F, Ladoire S, Bruchard M, Chevriaux A et al. 5-Fluorouracil selectively kills tumor-Associated myeloid-derived suppressor cells resulting in enhanced T-cell-dependent antitumor immunity. Cancer Res 2010; 70: 3052-3061.
    • (2010) Cancer Res , vol.70 , pp. 3052-3061
    • Vincent, J.1    Mignot, G.2    Chalmin, F.3    Ladoire, S.4    Bruchard, M.5    Chevriaux, A.6
  • 50
    • 81155150019 scopus 로고    scopus 로고
    • Neoadjuvant in situ gene-mediated cytotoxic immunotherapy improves postoperative outcomes in novel syngeneic esophageal carcinoma models
    • Predina JD, Judy B, Aliperti LA, Fridlender ZG, Blouin A, Kapoor V et al. Neoadjuvant in situ gene-mediated cytotoxic immunotherapy improves postoperative outcomes in novel syngeneic esophageal carcinoma models. Cancer Gene Ther 2011; 18: 871-883.
    • (2011) Cancer Gene Ther , vol.18 , pp. 871-883
    • Predina, J.D.1    Judy, B.2    Aliperti, L.A.3    Fridlender, Z.G.4    Blouin, A.5    Kapoor, V.6
  • 51
    • 84862572405 scopus 로고    scopus 로고
    • The immunological impact of neoadjuvant chemotherapy on the tumor microenvironment of esophageal squamous cell carcinoma
    • Tsuchikawa T, Md MM, Yamamura Y, Shichinohe T, Hirano S, Kondo S. The immunological impact of neoadjuvant chemotherapy on the tumor microenvironment of esophageal squamous cell carcinoma. Ann Surg Oncol 2012; 19: 1713-1719.
    • (2012) Ann Surg Oncol , vol.19 , pp. 1713-1719
    • Tsuchikawa, T.1    Md, M.M.2    Yamamura, Y.3    Shichinohe, T.4    Hirano, S.5    Kondo, S.6
  • 52
    • 79960426821 scopus 로고    scopus 로고
    • Pivotal role of innate and adaptive immunity in anthracycline chemotherapy of established tumors
    • Mattarollo SR, Loi S, Duret H, Ma Y, Zitvogel L, Smyth MJ. Pivotal role of innate and adaptive immunity in anthracycline chemotherapy of established tumors. Cancer Res 2011; 71: 4809-4820.
    • (2011) Cancer Res , vol.71 , pp. 4809-4820
    • Mattarollo, S.R.1    Loi, S.2    Duret, H.3    Ma, Y.4    Zitvogel, L.5    Smyth, M.J.6
  • 53
    • 0022473607 scopus 로고
    • A new approach to the adoptive immunotherapy of cancer with tumor-infiltrating lymphocytes
    • Rosenberg SA, Spiess P, Lafreniere R. A new approach to the adoptive immunotherapy of cancer with tumor-infiltrating lymphocytes. Science 1986; 233: 1318-1321.
    • (1986) Science , vol.233 , pp. 1318-1321
    • Rosenberg, S.A.1    Spiess, P.2    Lafreniere, R.3
  • 54
    • 0034662114 scopus 로고    scopus 로고
    • Cyclophosphamide enhances anti-Tumor effect of wild-Type p53-specific CTL
    • Vierboom MP, Bos GM, Ooms M, Offringa R, Melief CJ. Cyclophosphamide enhances anti-Tumor effect of wild-Type p53-specific CTL. Int J Cancer 2000; 87: 253-260.
    • (2000) Int J Cancer , vol.87 , pp. 253-260
    • Vierboom, M.P.1    Bos, G.M.2    Ooms, M.3    Offringa, R.4    Melief, C.J.5
  • 55
    • 0034653477 scopus 로고    scopus 로고
    • Cyclophosphamide induces type I interferon and augments the number of CD44(hi) T lymphocytes in mice: Implications for strategies of chemoimmunotherapy of cancer
    • Schiavoni G, Mattei F, Di Pucchio T, Santini SM, Bracci L, Belardelli F et al. Cyclophosphamide induces type I interferon and augments the number of CD44(hi) T lymphocytes in mice: Implications for strategies of chemoimmunotherapy of cancer. Blood 2000; 95: 2024-2030.
    • (2000) Blood , vol.95 , pp. 2024-2030
    • Schiavoni, G.1    Mattei, F.2    Di Pucchio, T.3    Santini, S.M.4    Bracci, L.5    Belardelli, F.6
  • 56
    • 77950600201 scopus 로고    scopus 로고
    • Chemotherapy rescues tumor-driven aberrant CD4+ T-cell differentiation and restores an activated polyfunctional helper phenotype
    • Ding ZC, Blazar BR, Mellor AL, Munn DH, Zhou G. Chemotherapy rescues tumor-driven aberrant CD4+ T-cell differentiation and restores an activated polyfunctional helper phenotype. Blood 2010; 115: 2397-2406.
    • (2010) Blood , vol.115 , pp. 2397-2406
    • Ding, Z.C.1    Blazar, B.R.2    Mellor, A.L.3    Munn, D.H.4    Zhou, G.5
  • 58
    • 60849125398 scopus 로고    scopus 로고
    • Mechanisms involved in synergistic anticancer effects of anti-4-1BB and cyclophosphamide therapy
    • Kim YH, Choi BK, Oh HS, Kang WJ, Mittler RS, Kwon BS. Mechanisms involved in synergistic anticancer effects of anti-4-1BB and cyclophosphamide therapy. Mol Cancer Ther 2009; 8: 469-478.
    • (2009) Mol Cancer Ther , vol.8 , pp. 469-478
    • Kim, Y.H.1    Choi, B.K.2    Oh, H.S.3    Kang, W.J.4    Mittler, R.S.5    Kwon, B.S.6
  • 60
    • 77956920709 scopus 로고    scopus 로고
    • Dacarbazine treatment before peptide vaccination enlarges T-cell repertoire diversity of melan-Aspecific, tumor-reactive CTL in melanoma patients
    • Palermo B, Del Bello D, Sottini A, Serana F, Ghidini C, Gualtieri N et al. Dacarbazine treatment before peptide vaccination enlarges T-cell repertoire diversity of melan-Aspecific, tumor-reactive CTL in melanoma patients. Cancer Res 2010; 70: 7084-7092.
    • (2010) Cancer Res , vol.70 , pp. 7084-7092
    • Palermo, B.1    Del Bello, D.2    Sottini, A.3    Serana, F.4    Ghidini, C.5    Gualtieri, N.6
  • 61
    • 54049093133 scopus 로고    scopus 로고
    • Differential impairment of regulatory T-cells rather than effector T-cells by paclitaxel-based chemotherapy
    • Zhang L, Dermawan K, Jin M, Liu R, Zheng H, Xu L et al. Differential impairment of regulatory T-cells rather than effector T-cells by paclitaxel-based chemotherapy. Clin Immunol 2008; 129: 219-229.
    • (2008) Clin Immunol , vol.129 , pp. 219-229
    • Zhang, L.1    Dermawan, K.2    Jin, M.3    Liu, R.4    Zheng, H.5    Xu, L.6
  • 62
    • 0035674305 scopus 로고    scopus 로고
    • Th2/Th1 switch induced by a single low dose of cyclophosphamide in a rat metastatic lymphoma model
    • Matar P, Rozados VR, Gervasoni SI, Scharovsky GO. Th2/Th1 switch induced by a single low dose of cyclophosphamide in a rat metastatic lymphoma model. Cancer Immunol Immunother 2002; 50: 588-596.
    • (2002) Cancer Immunol Immunother , vol.50 , pp. 588-596
    • Matar, P.1    Rozados, V.R.2    Gervasoni, S.I.3    Scharovsky, G.O.4
  • 64
    • 79951743212 scopus 로고    scopus 로고
    • Functional specialization of interleukin-1& family members
    • Iwakura Y, Ishigame H, Saijo S, Nakae S. Functional specialization of interleukin-1& family members. Immunity 2011; 34: 149-162.
    • (2011) Immunity , vol.34 , pp. 149-162
    • Iwakura, Y.1    Ishigame, H.2    Saijo, S.3    Nakae, S.4
  • 65
    • 67651094058 scopus 로고    scopus 로고
    • Endogenous IL-17 contributes to reduced tumor growth and metastasis
    • Kryczek I, Wei S, Szeliga W, Vatan L, Zou W. Endogenous IL-17 contributes to reduced tumor growth and metastasis. Blood 2009; 114: 357-359.
    • (2009) Blood , vol.114 , pp. 357-359
    • Kryczek, I.1    Wei, S.2    Szeliga, W.3    Vatan, L.4    Zou, W.5
  • 66
    • 84872086179 scopus 로고    scopus 로고
    • Chemotherapy-Triggered cathepsin B release in myeloid-derived suppressor cells activates the Nlrp3 inflammasome and promotes tumor growth
    • Bruchard M, Mignot G, Derangere V, Chalmin F, Chevriaux A, Vegran F et al. Chemotherapy-Triggered cathepsin B release in myeloid-derived suppressor cells activates the Nlrp3 inflammasome and promotes tumor growth. Nat Med 2013; 19: 57-64.
    • (2013) Nat Med , vol.19 , pp. 57-64
    • Bruchard, M.1    Mignot, G.2    Derangere, V.3    Chalmin, F.4    Chevriaux, A.5    Vegran, F.6
  • 67
    • 79551514818 scopus 로고    scopus 로고
    • Cyclophosphamide induces differentiation of Th17 cells in cancer patients
    • Viaud S, Flament C, Zoubir M, Pautier P, LeCesne A, Ribrag V et al. Cyclophosphamide induces differentiation of Th17 cells in cancer patients. Cancer Res 2011; 71: 661-665.
    • (2011) Cancer Res , vol.71 , pp. 661-665
    • Viaud, S.1    Flament, C.2    Zoubir, M.3    Pautier, P.4    LeCesne, A.5    Ribrag, V.6
  • 69
    • 65049084189 scopus 로고    scopus 로고
    • Tumor-Associated macrophages and the related myeloid-derived suppressor cells as a paradigm of the diversity of macrophage activation
    • Mantovani A, Sica A, Allavena P, Garlanda C, Locati M. Tumor-Associated macrophages and the related myeloid-derived suppressor cells as a paradigm of the diversity of macrophage activation. Hum Immunol 2009; 70: 325-330.
    • (2009) Hum Immunol , vol.70 , pp. 325-330
    • Mantovani, A.1    Sica, A.2    Allavena, P.3    Garlanda, C.4    Locati, M.5
  • 70
    • 0033168037 scopus 로고    scopus 로고
    • Tumor rejection by in vivo administration of anti-CD25 (interleukin-2 receptor alpha) monoclonal antibody
    • Onizuka S, Tawara I, Shimizu J, Sakaguchi S, Fujita T, Nakayama E. Tumor rejection by in vivo administration of anti-CD25 (interleukin-2 receptor alpha) monoclonal antibody. Cancer Res 1999; 59: 3128-3133.
    • (1999) Cancer Res , vol.59 , pp. 3128-3133
    • Onizuka, S.1    Tawara, I.2    Shimizu, J.3    Sakaguchi, S.4    Fujita, T.5    Nakayama, E.6
  • 71
    • 0035903324 scopus 로고    scopus 로고
    • Synergism of cytotoxic T lymphocyte-Associated antigen 4 blockade and depletion of CD25(+) regulatory T-cells in antitumor therapy reveals alternative pathways for suppression of autoreactive cytotoxic T lymphocyte responses
    • Sutmuller RP, van Duivenvoorde LM, van Elsas A, Schumacher TN, Wildenberg ME, Allison JP et al. Synergism of cytotoxic T lymphocyte-Associated antigen 4 blockade and depletion of CD25(+) regulatory T-cells in antitumor therapy reveals alternative pathways for suppression of autoreactive cytotoxic T lymphocyte responses. J Exp Med 2001; 194: 823-832.
    • (2001) J Exp Med , vol.194 , pp. 823-832
    • Sutmuller, R.P.1    Van Duivenvoorde, L.M.2    Van Elsas, A.3    Schumacher, T.N.4    Wildenberg, M.E.5    Allison, J.P.6
  • 72
    • 84880948301 scopus 로고    scopus 로고
    • Clinical perspectives on targeting of myeloid derived suppressor cells in the treatment of cancer
    • Najjar YG, Finke JH. Clinical perspectives on targeting of myeloid derived suppressor cells in the treatment of cancer. Front Oncol 2013; 3: 49.
    • (2013) Front Oncol , vol.3 , pp. 49
    • Najjar, Y.G.1    Finke, J.H.2
  • 74
    • 79961016549 scopus 로고    scopus 로고
    • Platinum-based drugs disrupt STAT6-mediated suppression of immune responses against cancer in humans and mice
    • Lesterhuis WJ, Punt CJ, Hato SV, Eleveld-Trancikova D, Jansen BJ, Nierkens S et al. Platinum-based drugs disrupt STAT6-mediated suppression of immune responses against cancer in humans and mice. J Clin Invest 2011; 121: 3100-3108.
    • (2011) J Clin Invest , vol.121 , pp. 3100-3108
    • Lesterhuis, W.J.1    Punt, C.J.2    Hato, S.V.3    Eleveld-Trancikova, D.4    Jansen, B.J.5    Nierkens, S.6
  • 75
    • 26844464792 scopus 로고    scopus 로고
    • CD4+CD25+ regulatory T-cells inhibit natural killer cell functions in a transforming growth factor-betadependent manner
    • Ghiringhelli F, Menard C, Terme M, Flament C, Taieb J, Chaput N et al. CD4+CD25+ regulatory T-cells inhibit natural killer cell functions in a transforming growth factor-betadependent manner. J Exp Med 2005; 202: 1075-1085.
    • (2005) J Exp Med , vol.202 , pp. 1075-1085
    • Ghiringhelli, F.1    Menard, C.2    Terme, M.3    Flament, C.4    Taieb, J.5    Chaput, N.6
  • 76
    • 15944410592 scopus 로고    scopus 로고
    • Inhibition of CD4(+)25+ T regulatory cell function implicated in enhanced immune response by low-dose cyclophosphamide
    • Lutsiak ME, Semnani RT, De Pascalis R, Kashmiri SV, Schlom J, Sabzevari H. Inhibition of CD4(+)25+ T regulatory cell function implicated in enhanced immune response by low-dose cyclophosphamide. Blood 2005; 105: 2862-2868.
    • (2005) Blood , vol.105 , pp. 2862-2868
    • Lutsiak, M.E.1    Semnani, R.T.2    De Pascalis, R.3    Kashmiri, S.V.4    Schlom, J.5    Sabzevari, H.6
  • 77
    • 79953188695 scopus 로고    scopus 로고
    • DNA alkylating therapy induces tumor regression through an HMGB1-mediated activation of innate immunity
    • Guerriero JL, Ditsworth D, Catanzaro JM, Sabino G, Furie MB, Kew RR et al. DNA alkylating therapy induces tumor regression through an HMGB1-mediated activation of innate immunity. J Immunol 2011; 186: 3517-3526.
    • (2011) J Immunol , vol.186 , pp. 3517-3526
    • Guerriero, J.L.1    Ditsworth, D.2    Catanzaro, J.M.3    Sabino, G.4    Furie, M.B.5    Kew, R.R.6
  • 78
    • 84860815596 scopus 로고    scopus 로고
    • Metronomic cyclophosphamide treatment in metastasized breast cancer patients: Immunological effects and clinical outcome
    • Ge Y, Domschke C, Stoiber N, Schott S, Heil J, Rom J et al. Metronomic cyclophosphamide treatment in metastasized breast cancer patients: Immunological effects and clinical outcome. Cancer Immunol Immunother 2012; 61: 353-362.
    • (2012) Cancer Immunol Immunother , vol.61 , pp. 353-362
    • Ge, Y.1    Domschke, C.2    Stoiber, N.3    Schott, S.4    Heil, J.5    Rom, J.6
  • 79
    • 68549112974 scopus 로고    scopus 로고
    • Treg depletion with a low-dose metronomic temozolomide regimen in a rat glioma model
    • Banissi C, Ghiringhelli F, Chen L, Carpentier AF. Treg depletion with a low-dose metronomic temozolomide regimen in a rat glioma model. Cancer Immunol Immunother 2009; 58: 1627-1634.
    • (2009) Cancer Immunol Immunother , vol.58 , pp. 1627-1634
    • Banissi, C.1    Ghiringhelli, F.2    Chen, L.3    Carpentier, A.F.4
  • 80
    • 0027499281 scopus 로고
    • Heterogeneity of splenic natural suppressor cells induced in mice by treatment with cyclophosphamide
    • Brooks-Kaiser JC, Bourque LA, Hoskin DW. Heterogeneity of splenic natural suppressor cells induced in mice by treatment with cyclophosphamide. Immunopharmacology 1993; 25: 117-129.
    • (1993) Immunopharmacology , vol.25 , pp. 117-129
    • Brooks-Kaiser, J.C.1    Bourque, L.A.2    Hoskin, D.W.3
  • 81
    • 0023639559 scopus 로고
    • Stimulation of suppressor cells in the bone marrow and spleens of high dose cyclophosphamide-Treated C57Bl/6 mice
    • Nikcevich DA, Duffie GP, Young MR, Ellis NK, Kaufman GE, Wepsic HT. Stimulation of suppressor cells in the bone marrow and spleens of high dose cyclophosphamide-Treated C57Bl/6 mice. Cell Immunol 1987; 109: 349-359.
    • (1987) Cell Immunol , vol.109 , pp. 349-359
    • Nikcevich, D.A.1    Duffie, G.P.2    Young, M.R.3    Ellis, N.K.4    Kaufman, G.E.5    Wepsic, H.T.6
  • 82
    • 0021997551 scopus 로고
    • Cyclophosphamide-induced suppressor cells in mice: Suppression of the antibody response in vitro and characterization of the effector cells
    • Segre M, Tomei E, Segre D. Cyclophosphamide-induced suppressor cells in mice: Suppression of the antibody response in vitro and characterization of the effector cells. Cell Immunol 1985; 91: 443-454.
    • (1985) Cell Immunol , vol.91 , pp. 443-454
    • Segre, M.1    Tomei, E.2    Segre, D.3
  • 83
    • 54849440346 scopus 로고    scopus 로고
    • Increased circulating myeloid-derived suppressor cells correlate with clinical cancer stage, metastatic tumor burden, and doxorubicin-cyclophosphamide chemotherapy
    • Diaz-Montero CM, Salem ML, Nishimura MI, Garrett-Mayer E, Cole DJ, Montero AJ. Increased circulating myeloid-derived suppressor cells correlate with clinical cancer stage, metastatic tumor burden, and doxorubicin- cyclophosphamide chemotherapy. Cancer Immunol Immunother 2009; 58: 49-59.
    • (2009) Cancer Immunol Immunother , vol.58 , pp. 49-59
    • Diaz-Montero, C.M.1    Salem, M.L.2    Nishimura, M.I.3    Garrett-Mayer, E.4    Cole, D.J.5    Montero, A.J.6
  • 84
    • 77949889975 scopus 로고    scopus 로고
    • Cyclophosphamide induces dynamic alterations in the host microenvironments resulting in a Flt3 ligand-dependent expansion of dendritic cells
    • Salem ML, Al-Khami AA, El-Naggar SA, Diaz-Montero CM, Chen Y, Cole DJ. Cyclophosphamide induces dynamic alterations in the host microenvironments resulting in a Flt3 ligand-dependent expansion of dendritic cells. J Immunol 2010; 184: 1737-1747.
    • (2010) J Immunol , vol.184 , pp. 1737-1747
    • Salem, M.L.1    Al-Khami, A.A.2    El-Naggar, S.A.3    Diaz-Montero, C.M.4    Chen, Y.5    Cole, D.J.6
  • 85
    • 84878589185 scopus 로고    scopus 로고
    • Cyclophosphamide Promotes chronic inflammation-dependent immunosuppression and prevents antitumor response in melanoma
    • Sevko A, Sade-Feldman M, Kanterman J, Michels T, Falk CS, Umansky L et al. Cyclophosphamide Promotes chronic inflammation-dependent immunosuppression and prevents antitumor response in melanoma. J Invest Dermatol 2012; 133: 1610-1619.
    • (2012) J Invest Dermatol , vol.133 , pp. 1610-1619
    • Sevko, A.1    Sade-Feldman, M.2    Kanterman, J.3    Michels, T.4    Falk, C.S.5    Umansky, L.6
  • 86
    • 17544401819 scopus 로고    scopus 로고
    • Cyclophosphamide induces the development of early myeloid cells suppressing tumor cell growth by a nitric oxidedependent mechanism
    • Pelaez B, Campillo JA, Lopez-Asenjo JA, Subiza JL. Cyclophosphamide induces the development of early myeloid cells suppressing tumor cell growth by a nitric oxidedependent mechanism. J Immunol 2001; 166: 6608-6615.
    • (2001) J Immunol , vol.166 , pp. 6608-6615
    • Pelaez, B.1    Campillo, J.A.2    Lopez-Asenjo, J.A.3    Subiza, J.L.4
  • 87
    • 84874116665 scopus 로고    scopus 로고
    • Metronomic chemotherapy with low-dose cyclophosphamide plus gemcitabine can induce anti-Tumor T-cell immunity in vivo
    • Tongu M, Harashima N, Monma H, Inao T, Yamada T, Kawauchi H et al. Metronomic chemotherapy with low-dose cyclophosphamide plus gemcitabine can induce anti-Tumor T-cell immunity in vivo. Cancer Immunol Immunother 2012; 62: 383-391.
    • (2012) Cancer Immunol Immunother , vol.62 , pp. 383-391
    • Tongu, M.1    Harashima, N.2    Monma, H.3    Inao, T.4    Yamada, T.5    Kawauchi, H.6
  • 88
    • 79952056158 scopus 로고    scopus 로고
    • CD4+Foxp3+ regulatory T-cell impairment by paclitaxel is independent of toll-like receptor 4
    • Zhu Y, Liu N, Xiong SD, Zheng YJ, Chu YW. CD4+Foxp3+ regulatory T-cell impairment by paclitaxel is independent of toll-like receptor 4. Scand J Immunol 2011; 73: 301-308.
    • (2011) Scand J Immunol , vol.73 , pp. 301-308
    • Zhu, Y.1    Liu, N.2    Xiong, S.D.3    Zheng, Y.J.4    Chu, Y.W.5
  • 89
    • 77956680680 scopus 로고    scopus 로고
    • A novel chemoimmunomodulating property of docetaxel: Suppression of myeloid-derived suppressor cells in tumor bearers
    • Kodumudi KN, Woan K, Gilvary DL, Sahakian E, Wei S, Djeu JY. A novel chemoimmunomodulating property of docetaxel: Suppression of myeloid-derived suppressor cells in tumor bearers. Clin Cancer Res 2010; 16: 4583-4594.
    • (2010) Clin Cancer Res , vol.16 , pp. 4583-4594
    • Kodumudi, K.N.1    Woan, K.2    Gilvary, D.L.3    Sahakian, E.4    Wei, S.5    Djeu, J.Y.6
  • 90
    • 79959308025 scopus 로고    scopus 로고
    • Restoration of antitumor immunity through selective inhibition of myeloid derived suppressor cells by anticancer therapies
    • Apetoh L, Vegran F, Ladoire S, Ghiringhelli F. Restoration of antitumor immunity through selective inhibition of myeloid derived suppressor cells by anticancer therapies. Curr Mol Med 2011; 11: 365-372.
    • (2011) Curr Mol Med , vol.11 , pp. 365-372
    • Apetoh, L.1    Vegran, F.2    Ladoire, S.3    Ghiringhelli, F.4
  • 92
    • 84856482299 scopus 로고    scopus 로고
    • Influence of chemotherapy on nitric oxide synthase, indole-Amine-2,3- dioxygenase and CD124 expression in granulocytes and monocytes of non-small cell lung cancer
    • Sim SH, Ahn YO, Yoon J, Kim TM, Lee SH, Kim DW et al. Influence of chemotherapy on nitric oxide synthase, indole-Amine-2,3-dioxygenase and CD124 expression in granulocytes and monocytes of non-small cell lung cancer. Cancer Sci 2012; 103: 155-160.
    • (2012) Cancer Sci , vol.103 , pp. 155-160
    • Sim, S.H.1    Ahn, Y.O.2    Yoon, J.3    Kim, T.M.4    Lee, S.H.5    Kim, D.W.6
  • 94
    • 18344375283 scopus 로고    scopus 로고
    • Immunotherapy and chemotherapy-A practical partnership
    • Lake RA, Robinson BW. Immunotherapy and chemotherapy-A practical partnership. Nat Rev Cancer 2005; 5: 397-405.
    • (2005) Nat Rev Cancer , vol.5 , pp. 397-405
    • Lake, R.A.1    Robinson, B.W.2
  • 95
    • 0035371646 scopus 로고    scopus 로고
    • A role for loss of p53 function in sensitivity of ovarian carcinoma cells to taxanes
    • Cassinelli G, Supino R, Perego P, Polizzi D, Lanzi C, Pratesi G et al. A role for loss of p53 function in sensitivity of ovarian carcinoma cells to taxanes. Int J Cancer 2001; 92: 738-747.
    • (2001) Int J Cancer , vol.92 , pp. 738-747
    • Cassinelli, G.1    Supino, R.2    Perego, P.3    Polizzi, D.4    Lanzi, C.5    Pratesi, G.6
  • 96
    • 0032847005 scopus 로고    scopus 로고
    • Bcl-2 family members in childhood acute lymphoblastic leukemia: Relationships with features at presentation, in vitro and in vivo drug response and long-Term clinical outcome
    • Salomons GS, Smets LA, Verwijs-Janssen M, Hart AA, Haarman EG, Kaspers GJ et al. Bcl-2 family members in childhood acute lymphoblastic leukemia: Relationships with features at presentation, in vitro and in vivo drug response and long-Term clinical outcome. Leukemia 1999; 13: 1574-1580.
    • (1999) Leukemia , vol.13 , pp. 1574-1580
    • Salomons, G.S.1    Smets, L.A.2    Verwijs-Janssen, M.3    Hart, A.A.4    Haarman, E.G.5    Kaspers, G.J.6
  • 99
    • 84876753532 scopus 로고    scopus 로고
    • Anticancer chemotherapy-induced intratumoral recruitment and differentiation of antigen-presenting cells
    • Ma Y, Adjemian S, Mattarollo SR, Yamazaki T, Aymeric L, Yang H et al. Anticancer chemotherapy-induced intratumoral recruitment and differentiation of antigen-presenting cells. Immunity 2013; 38: 729-741.
    • (2013) Immunity , vol.38 , pp. 729-741
    • Ma, Y.1    Adjemian, S.2    Mattarollo, S.R.3    Yamazaki, T.4    Aymeric, L.5    Yang, H.6
  • 100
    • 23244464772 scopus 로고    scopus 로고
    • Dendritic cellmediated cross-presentation of antigens derived from colon carcinoma cells exposed to a highly cytotoxic multidrug regimen with gemcitabine, oxaliplatin, 5-fluorouracil, and leucovorin, elicits a powerful human antigen-specific CTL response with antitumor activity in vitro
    • Correale P, Cusi MG, Del Vecchio MT, Aquino A, Prete SP, Tsang KY et al. Dendritic cellmediated cross-presentation of antigens derived from colon carcinoma cells exposed to a highly cytotoxic multidrug regimen with gemcitabine, oxaliplatin, 5-fluorouracil, and leucovorin, elicits a powerful human antigen-specific CTL response with antitumor activity in vitro. J Immunol 2005; 175: 820-828.
    • (2005) J Immunol , vol.175 , pp. 820-828
    • Correale, P.1    Cusi, M.G.2    Del Vecchio, M.T.3    Aquino, A.4    Prete, S.P.5    Tsang, K.Y.6
  • 101
    • 74549126817 scopus 로고    scopus 로고
    • Immunological factors relating to the antitumor effect of temozolomide chemoimmunotherapy in a murine glioma model
    • Kim TG, Kim CH, Park JS, Park SD, Kim CK, Chung DS et al. Immunological factors relating to the antitumor effect of temozolomide chemoimmunotherapy in a murine glioma model. Clin Vaccine Immunol 2010; 17: 143-153.
    • (2010) Clin Vaccine Immunol , vol.17 , pp. 143-153
    • Kim, T.G.1    Kim, C.H.2    Park, J.S.3    Park, S.D.4    Kim, C.K.5    Chung, D.S.6
  • 103
    • 79960957085 scopus 로고    scopus 로고
    • Mitotic catastrophe: A mechanism for avoiding genomic instability
    • Vitale I, Galluzzi L, Castedo M, Kroemer G. Mitotic catastrophe: A mechanism for avoiding genomic instability. Nat Rev Mol Cell Biol 2011; 12: 385-392.
    • (2011) Nat Rev Mol Cell Biol , vol.12 , pp. 385-392
    • Vitale, I.1    Galluzzi, L.2    Castedo, M.3    Kroemer, G.4
  • 105
    • 2642553881 scopus 로고    scopus 로고
    • Regulation of an ATG7-beclin 1 program of autophagic cell death by caspase-8
    • Yu L, Alva A, Su H, Dutt P, Freundt E, Welsh S et al. Regulation of an ATG7-beclin 1 program of autophagic cell death by caspase-8. Science 2004; 304: 1500-1502.
    • (2004) Science , vol.304 , pp. 1500-1502
    • Yu, L.1    Alva, A.2    Su, H.3    Dutt, P.4    Freundt, E.5    Welsh, S.6
  • 106
    • 77950541904 scopus 로고    scopus 로고
    • Everolimus (RAD001) in the treatment of advanced renal cell carcinoma: A review
    • Agarwala SS, Case S. Everolimus (RAD001) in the treatment of advanced renal cell carcinoma: A review. Oncologist 2010; 15: 236-245.
    • (2010) Oncologist , vol.15 , pp. 236-245
    • Agarwala, S.S.1    Case, S.2
  • 107
    • 33846794896 scopus 로고    scopus 로고
    • Autophagy inhibition enhances therapy-induced apoptosis in a Myc-induced model of lymphoma
    • Amaravadi RK, Yu D, Lum JJ, Bui T, Christophorou MA, Evan GI et al. Autophagy inhibition enhances therapy-induced apoptosis in a Myc-induced model of lymphoma. J Clin Invest 2007; 117: 326-336.
    • (2007) J Clin Invest , vol.117 , pp. 326-336
    • Amaravadi, R.K.1    Yu, D.2    Lum, J.J.3    Bui, T.4    Christophorou, M.A.5    Evan, G.I.6
  • 108
    • 83755181759 scopus 로고    scopus 로고
    • Autophagydependent anticancer immune responses induced by chemotherapeutic agents in mice
    • Michaud M, Martins I, Sukkurwala AQ, Adjemian S, Ma Y, Pellegatti P et al. Autophagydependent anticancer immune responses induced by chemotherapeutic agents in mice. Science 2011; 334: 1573-1577.
    • (2011) Science , vol.334 , pp. 1573-1577
    • Michaud, M.1    Martins, I.2    Sukkurwala, A.Q.3    Adjemian, S.4    Ma, Y.5    Pellegatti, P.6
  • 109
    • 0035171866 scopus 로고    scopus 로고
    • Treatment of human colon carcinoma cell lines with anti-neoplastic agents enhances their lytic sensitivity to antigen-specific CD8+ cytotoxic T lymphocytes
    • Bergmann-Leitner ES, Abrams SI. Treatment of human colon carcinoma cell lines with anti-neoplastic agents enhances their lytic sensitivity to antigen-specific CD8+ cytotoxic T lymphocytes. Cancer Immunol Immunother 2001; 50: 445-455.
    • (2001) Cancer Immunol Immunother , vol.50 , pp. 445-455
    • Bergmann-Leitner, E.S.1    Abrams, S.I.2
  • 110
    • 77951178310 scopus 로고    scopus 로고
    • Chemotherapy enhances tumor cell susceptibility to CTL-mediated killing during cancer immunotherapy in mice
    • Ramakrishnan R, Assudani D, Nagaraj S, Hunter T, Cho HI, Antonia S et al. Chemotherapy enhances tumor cell susceptibility to CTL-mediated killing during cancer immunotherapy in mice. J Clin Invest 2010; 120: 1111-1124.
    • (2010) J Clin Invest , vol.120 , pp. 1111-1124
    • Ramakrishnan, R.1    Assudani, D.2    Nagaraj, S.3    Hunter, T.4    Cho, H.I.5    Antonia, S.6
  • 111
    • 70349170354 scopus 로고    scopus 로고
    • Cyclophosphamide chemotherapy sensitizes tumor cells to TRAIL-dependent CD8 T-cellmediated immune attack resulting in suppression of tumor growth
    • van der Most RG, Currie AJ, Cleaver AL, Salmons J, Nowak AK, Mahendran S et al. Cyclophosphamide chemotherapy sensitizes tumor cells to TRAIL-dependent CD8 T-cellmediated immune attack resulting in suppression of tumor growth. PLoS One 2009; 4: E6982.
    • (2009) PLoS One , vol.4
    • Van Der Most, R.G.1    Currie, A.J.2    Cleaver, A.L.3    Salmons, J.4    Nowak, A.K.5    Mahendran, S.6
  • 112
    • 50849131938 scopus 로고    scopus 로고
    • Trans-presentation of IL-15 dictates IFN-producing killer dendritic cells effector functions
    • Ullrich E, Bonmort M, Mignot G, Jacobs B, Bosisio D, Sozzani S et al. Trans-presentation of IL-15 dictates IFN-producing killer dendritic cells effector functions. J Immunol 2008; 180: 7887-7897.
    • (2008) J Immunol , vol.180 , pp. 7887-7897
    • Ullrich, E.1    Bonmort, M.2    Mignot, G.3    Jacobs, B.4    Bosisio, D.5    Sozzani, S.6
  • 113
    • 24144443517 scopus 로고    scopus 로고
    • The DNA damage pathway regulates innate immune system ligands of the NKG2D receptor
    • Gasser S, Orsulic S, Brown EJ, Raulet DH. The DNA damage pathway regulates innate immune system ligands of the NKG2D receptor. Nature 2005; 436: 1186-1190.
    • (2005) Nature , vol.436 , pp. 1186-1190
    • Gasser, S.1    Orsulic, S.2    Brown, E.J.3    Raulet, D.H.4
  • 114
    • 77956911325 scopus 로고    scopus 로고
    • Chemotherapy-induced genotoxic stress promotes sensitivity to natural killer cell cytotoxicity by enabling missingself recognition
    • Fine JH, Chen P, Mesci A, Allan DS, Gasser S, Raulet DH et al. Chemotherapy-induced genotoxic stress promotes sensitivity to natural killer cell cytotoxicity by enabling missingself recognition. Cancer Res 2010; 70: 7102-7113.
    • (2010) Cancer Res , vol.70 , pp. 7102-7113
    • Fine, J.H.1    Chen, P.2    Mesci, A.3    Allan, D.S.4    Gasser, S.5    Raulet, D.H.6
  • 115
    • 74249120625 scopus 로고    scopus 로고
    • Pre-Treatment with chemotherapy can enhance the antigenicity and immunogenicity of tumours by promoting adaptive immune responses
    • Liu WM, Fowler DW, Smith P, Dalgleish AG. Pre-Treatment with chemotherapy can enhance the antigenicity and immunogenicity of tumours by promoting adaptive immune responses. Br J Cancer 2010; 102: 115-123.
    • (2010) Br J Cancer , vol.102 , pp. 115-123
    • Liu, W.M.1    Fowler, D.W.2    Smith, P.3    Dalgleish, A.G.4
  • 116
    • 0038326676 scopus 로고    scopus 로고
    • Induction of tumor cell apoptosis in vivo increases tumor antigen cross-presentation, cross-priming rather than cross-Tolerizing host tumor-specific CD8 T-cells
    • Nowak AK, Lake RA, Marzo AL, Scott B, Heath WR, Collins EJ et al. Induction of tumor cell apoptosis in vivo increases tumor antigen cross-presentation, cross-priming rather than cross-Tolerizing host tumor-specific CD8 T-cells. J Immunol 2003; 170: 4905-4913.
    • (2003) J Immunol , vol.170 , pp. 4905-4913
    • Nowak, A.K.1    Lake, R.A.2    Marzo, A.L.3    Scott, B.4    Heath, W.R.5    Collins, E.J.6
  • 117
    • 65349131915 scopus 로고    scopus 로고
    • ATMATR-dependent up-regulation of DNAM-1 and NKG2D ligands on multiple myeloma cells by therapeutic agents results in enhanced NK-cell susceptibility and is associated with a senescent phenotype
    • Soriani A, Zingoni A, Cerboni C, Iannitto ML, Ricciardi MR, Di Gialleonardo V et al. ATMATR-dependent up-regulation of DNAM-1 and NKG2D ligands on multiple myeloma cells by therapeutic agents results in enhanced NK-cell susceptibility and is associated with a senescent phenotype. Blood 2009; 113: 3503-3511.
    • (2009) Blood , vol.113 , pp. 3503-3511
    • Soriani, A.1    Zingoni, A.2    Cerboni, C.3    Iannitto, M.L.4    Ricciardi, M.R.5    Di Gialleonardo, V.6
  • 118
    • 0019411617 scopus 로고
    • Differential effects of cytotoxic agents on hematopoietic progenitors
    • Botnick LE, Hannon EC, Vigneulle R, Hellman S. Differential effects of cytotoxic agents on hematopoietic progenitors. Cancer Res 1981; 41: 2338-2342.
    • (1981) Cancer Res , vol.41 , pp. 2338-2342
    • Botnick, L.E.1    Hannon, E.C.2    Vigneulle, R.3    Hellman, S.4
  • 119
    • 0037943965 scopus 로고    scopus 로고
    • Lack of dendritic cell mobilization into the peripheral blood of cancer patients following standard- or highdose chemotherapy plus granulocyte-colony stimulating factor
    • Ferrari S, Rovati B, Porta C, Alessandrino PE, Bertolini A, Collova E et al. Lack of dendritic cell mobilization into the peripheral blood of cancer patients following standard- or highdose chemotherapy plus granulocyte-colony stimulating factor. Cancer Immunol Immunother 2003; 52: 359-366.
    • (2003) Cancer Immunol Immunother , vol.52 , pp. 359-366
    • Ferrari, S.1    Rovati, B.2    Porta, C.3    Alessandrino, P.E.4    Bertolini, A.5    Collova, E.6
  • 120
    • 70350108862 scopus 로고    scopus 로고
    • Cyclophosphamide resets dendritic cell homeostasis and enhances antitumor immunity through effects that extend beyond regulatory T-cell elimination
    • Radojcic V, Bezak KB, Skarica M, Pletneva MA, Yoshimura K, Schulick RD et al. Cyclophosphamide resets dendritic cell homeostasis and enhances antitumor immunity through effects that extend beyond regulatory T-cell elimination. Cancer Immunol Immunother 2010; 59: 137-148.
    • (2010) Cancer Immunol Immunother , vol.59 , pp. 137-148
    • Radojcic, V.1    Bezak, K.B.2    Skarica, M.3    Pletneva, M.A.4    Yoshimura, K.5    Schulick, R.D.6
  • 121
    • 77649191014 scopus 로고    scopus 로고
    • Cyclophosphamide induces bone marrow to yield higher numbers of precursor dendritic cells in vitro capable of functional antigen presentation to T-cells in vivo
    • Salem ML, El-Naggar SA, Cole DJ. Cyclophosphamide induces bone marrow to yield higher numbers of precursor dendritic cells in vitro capable of functional antigen presentation to T-cells in vivo. Cell Immunol 2010; 261: 134-143.
    • (2010) Cell Immunol , vol.261 , pp. 134-143
    • Salem, M.L.1    El-Naggar, S.A.2    Cole, D.J.3
  • 122
    • 0037293242 scopus 로고    scopus 로고
    • Response of hematopoiesis to cyclophosphamide follows highly specific patterns in bone marrow and spleen
    • Sefc L, Psenak O, Sykora V, Sulc K, Necas E. Response of hematopoiesis to cyclophosphamide follows highly specific patterns in bone marrow and spleen. J Hematother Stem Cell Res 2003; 12: 47-61.
    • (2003) J Hematother Stem Cell Res , vol.12 , pp. 47-61
    • Sefc, L.1    Psenak, O.2    Sykora, V.3    Sulc, K.4    Necas, E.5
  • 123
    • 33846004208 scopus 로고    scopus 로고
    • Defining the ability of cyclophosphamide preconditioning to enhance the antigen-specific CD8+ T-cell response to peptide vaccination: Creation of a beneficial host microenvironment involving type I IFNs and myeloid cells
    • Salem ML, Kadima AN, El-Naggar SA, Rubinstein MP, Chen Y, Gillanders WE et al. Defining the ability of cyclophosphamide preconditioning to enhance the antigen-specific CD8+ T-cell response to peptide vaccination: Creation of a beneficial host microenvironment involving type I IFNs and myeloid cells. J Immunother 2007; 30: 40-53.
    • (2007) J Immunother , vol.30 , pp. 40-53
    • Salem, M.L.1    Kadima, A.N.2    El-Naggar, S.A.3    Rubinstein, M.P.4    Chen, Y.5    Gillanders, W.E.6
  • 124
    • 0034161989 scopus 로고    scopus 로고
    • Heterogeneity of angiogenesis and blood vessel maturation in human tumors: Implications for antiangiogenic tumor therapies
    • Eberhard A, Kahlert S, Goede V, Hemmerlein B, Plate KH, Augustin HG. Heterogeneity of angiogenesis and blood vessel maturation in human tumors: Implications for antiangiogenic tumor therapies. Cancer Res 2000; 60: 1388-1393.
    • (2000) Cancer Res , vol.60 , pp. 1388-1393
    • Eberhard, A.1    Kahlert, S.2    Goede, V.3    Hemmerlein, B.4    Plate, K.H.5    Augustin, H.G.6
  • 125
    • 0035865363 scopus 로고    scopus 로고
    • Redefining the target: Chemotherapeutics as antiangiogenics
    • Miller KD, Sweeney CJ, Sledge GW Jr. Redefining the target: Chemotherapeutics as antiangiogenics. J Clin Oncol 2001; 19: 1195-1206.
    • (2001) J Clin Oncol , vol.19 , pp. 1195-1206
    • Miller, K.D.1    Sweeney, C.J.2    Sledge Jr., G.W.3
  • 126
    • 0041589524 scopus 로고    scopus 로고
    • Maximum tolerable dose and low-dose metronomic chemotherapy have opposite effects on the mobilization and viability of circulating endothelial progenitor cells
    • Bertolini F, Paul S, Mancuso P, Monestiroli S, Gobbi A, Shaked Y et al. Maximum tolerable dose and low-dose metronomic chemotherapy have opposite effects on the mobilization and viability of circulating endothelial progenitor cells. Cancer Res 2003; 63: 4342-4346.
    • (2003) Cancer Res , vol.63 , pp. 4342-4346
    • Bertolini, F.1    Paul, S.2    Mancuso, P.3    Monestiroli, S.4    Gobbi, A.5    Shaked, Y.6
  • 127
    • 20444467321 scopus 로고    scopus 로고
    • Immunostimulatory effects of low-dose cyclophosphamide are controlled by inducible nitric oxide synthase
    • Loeffler M, Kruger JA, Reisfeld RA. Immunostimulatory effects of low-dose cyclophosphamide are controlled by inducible nitric oxide synthase. Cancer Res 2005; 65: 5027-5030.
    • (2005) Cancer Res , vol.65 , pp. 5027-5030
    • Loeffler, M.1    Kruger, J.A.2    Reisfeld, R.A.3
  • 129
    • 79959772576 scopus 로고    scopus 로고
    • Ipilimumab plus dacarbazine for previously untreated metastatic melanoma
    • Robert C, Thomas L, Bondarenko I, O'Day S, DJM, Garbe C et al. Ipilimumab plus dacarbazine for previously untreated metastatic melanoma. N Engl J Med 2011; 364: 2517-2526.
    • (2011) N Engl J Med , vol.364 , pp. 2517-2526
    • Robert, C.1    Thomas, L.2    Bondarenko, I.3    O'Day, S.D.J.M.4    Garbe, C.5
  • 130
    • 84877149232 scopus 로고    scopus 로고
    • Rationale for targeting the immune system through checkpoint molecule blockade in the treatment of non-small-cell lung cancer
    • Zielinski C, Knapp S, Mascaux C, Hirsch F. Rationale for targeting the immune system through checkpoint molecule blockade in the treatment of non-small-cell lung cancer. Ann Oncol 2013; 24: 1170-1179.
    • (2013) Ann Oncol , vol.24 , pp. 1170-1179
    • Zielinski, C.1    Knapp, S.2    Mascaux, C.3    Hirsch, F.4
  • 131
    • 79955533004 scopus 로고    scopus 로고
    • Type I IFNs control antigen retention and survival of CD8{alpha}+ dendritic cells after uptake of tumor apoptotic cells leading to cross-priming
    • Lorenzi S, Mattei F, Sistigu A, Bracci L, Spadaro F, Sanchez M et al. Type I IFNs control antigen retention and survival of CD8{alpha}+ dendritic cells after uptake of tumor apoptotic cells leading to cross-priming. J Immunol 2011; 186: 5142-5150.
    • (2011) J Immunol , vol.186 , pp. 5142-5150
    • Lorenzi, S.1    Mattei, F.2    Sistigu, A.3    Bracci, L.4    Spadaro, F.5    Sanchez, M.6
  • 132
    • 84858760109 scopus 로고    scopus 로고
    • Combining immunotherapy and targeted therapies in cancer treatment
    • Vanneman M, Dranoff G. Combining immunotherapy and targeted therapies in cancer treatment. Nat Rev Cancer 2012; 12: 237-251.
    • (2012) Nat Rev Cancer , vol.12 , pp. 237-251
    • Vanneman, M.1    Dranoff, G.2
  • 133
    • 84857506147 scopus 로고    scopus 로고
    • Consequence of dose scheduling of sunitinib on host immune response elements and vaccine combination therapy
    • Farsaci B, Higgins JP, Hodge JW. Consequence of dose scheduling of sunitinib on host immune response elements and vaccine combination therapy. Int J Cancer 2012; 130: 1948-1959.
    • (2012) Int J Cancer , vol.130 , pp. 1948-1959
    • Farsaci, B.1    Higgins, J.P.2    Hodge, J.W.3
  • 134
    • 63549105681 scopus 로고    scopus 로고
    • Sunitinib mediates reversal of myeloid-derived suppressor cell accumulation in renal cell carcinoma patients
    • Ko JS, Zea AH, Rini BI, Ireland JL, Elson P, Cohen P et al. Sunitinib mediates reversal of myeloid-derived suppressor cell accumulation in renal cell carcinoma patients. Clin Cancer Res 2009; 15: 2148-2157.
    • (2009) Clin Cancer Res , vol.15 , pp. 2148-2157
    • Ko, J.S.1    Zea, A.H.2    Rini, B.I.3    Ireland, J.L.4    Elson, P.5    Cohen, P.6
  • 135
    • 80052493233 scopus 로고    scopus 로고
    • Imatinib potentiates antitumor T-cell responses in gastrointestinal stromal tumor through the inhibition of Ido
    • Balachandran VP, Cavnar MJ, Zeng S, Bamboat ZM, Ocuin LM, Obaid H et al. Imatinib potentiates antitumor T-cell responses in gastrointestinal stromal tumor through the inhibition of Ido. Nat Med 2011; 17: 1094-1100.
    • (2011) Nat Med , vol.17 , pp. 1094-1100
    • Balachandran, V.P.1    Cavnar, M.J.2    Zeng, S.3    Bamboat, Z.M.4    Ocuin, L.M.5    Obaid, H.6
  • 136
    • 27144538568 scopus 로고    scopus 로고
    • Regulation of dendritic cell differentiation and antitumor immune response in cancer by pharmacologic-selective inhibition of the janus-Activated kinase 2/signal transducers and activators of transcription 3 pathway
    • Nefedova Y, Nagaraj S, Rosenbauer A, Muro-Cacho C, Sebti SM, Gabrilovich DI. Regulation of dendritic cell differentiation and antitumor immune response in cancer by pharmacologic-selective inhibition of the janus-Activated kinase 2/signal transducers and activators of transcription 3 pathway. Cancer Res 2005; 65: 9525-9535.
    • (2005) Cancer Res , vol.65 , pp. 9525-9535
    • Nefedova, Y.1    Nagaraj, S.2    Rosenbauer, A.3    Muro-Cacho, C.4    Sebti, S.M.5    Gabrilovich, D.I.6
  • 137
    • 77950205394 scopus 로고    scopus 로고
    • The proteasome inhibitor bortezomib sensitizes melanoma cells toward adoptive CTL attack
    • Seeger JM, Schmidt P, Brinkmann K, Hombach AA, Coutelle O, Zigrino P et al. The proteasome inhibitor bortezomib sensitizes melanoma cells toward adoptive CTL attack. Cancer Res 2010; 70: 1825-1834.
    • (2010) Cancer Res , vol.70 , pp. 1825-1834
    • Seeger, J.M.1    Schmidt, P.2    Brinkmann, K.3    Hombach, A.A.4    Coutelle, O.5    Zigrino, P.6
  • 138
    • 77954373338 scopus 로고    scopus 로고
    • Selective BRAFV600E inhibition enhances T-cell recognition of melanoma without affecting lymphocyte function
    • Boni A, Cogdill AP, Dang P, Udayakumar D, Njauw CN, Sloss CM et al. Selective BRAFV600E inhibition enhances T-cell recognition of melanoma without affecting lymphocyte function. Cancer Res 2010; 70: 5213-5219.
    • (2010) Cancer Res , vol.70 , pp. 5213-5219
    • Boni, A.1    Cogdill, A.P.2    Dang, P.3    Udayakumar, D.4    Njauw, C.N.5    Sloss, C.M.6
  • 139
    • 84856332921 scopus 로고    scopus 로고
    • Cetuximab +/- chemotherapy enhances dendritic cell-mediated phagocytosis of colon cancer cells and ignites a highly efficient colon cancer antigen-specific cytotoxic T-cell response in vitro
    • Correale P, Botta C, Cusi MG, Del Vecchio MT, De Santi MM, Gori Savellini G et al. Cetuximab +/- chemotherapy enhances dendritic cell-mediated phagocytosis of colon cancer cells and ignites a highly efficient colon cancer antigen-specific cytotoxic T-cell response in vitro. Int J Cancer 2012; 130: 1577-1589.
    • (2012) Int J Cancer , vol.130 , pp. 1577-1589
    • Correale, P.1    Botta, C.2    Cusi, M.G.3    Del Vecchio, M.T.4    De Santi, M.M.5    Gori Savellini, G.6
  • 140
    • 43049144967 scopus 로고    scopus 로고
    • Antibody association with HER-2/neu-Targeted vaccine enhances CD8 T-cell responses in mice through Fc-mediated activation of DCs
    • Kim PS, Armstrong TD, Song H, Wolpoe ME, Weiss V, Manning EA et al. Antibody association with HER-2/neu-Targeted vaccine enhances CD8 T-cell responses in mice through Fc-mediated activation of DCs. J Clin Invest 2008; 118: 1700-1711.
    • (2008) J Clin Invest , vol.118 , pp. 1700-1711
    • Kim, P.S.1    Armstrong, T.D.2    Song, H.3    Wolpoe, M.E.4    Weiss, V.5    Manning, E.A.6


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