Inhibition of Akt (ser473) phosphorylation and rapamycin-resistant cell growth by knockdown of mammalian target of rapamycin with small interfering RNA in vascular endothelial growth factor receptor-1-targeting vector

Biological and Pharmaceutical Bulletin

Volumn 34, Issue 5, 2011, Pages 602-608

  Koide, Hiroyuki ^a   Asai, Tomohiro ^a   Furuya, Keiichi ^a   Tsuzuku, Takuma ^a   Kato, Hiroki ^a   Dewa, Takehisa ^b   Nango, Mamoru ^b   Maeda, Noriyuki ^c   Oku, Naoto ^a  

^a UNIVERSITY OF SHIZUOKA   (Japan)

^b NAGOYA INSTITUTE OF TECHNOLOGY   (Japan)

^c Nippon Fine Chemical Co Ltd   (Japan)

Author keywords

Akt; Mammalian target of rapamycin; Phosphatase and tensin homolog deleted from chromosome 10; Polycation liposome; Small interfering RNA

Indexed keywords

ALANYLPROLYLARGINYLPROLYLGLYCINE; DICETYL PHOSPHATE TETRAETHYLENEPENTAMINE BASED POLYCATION LIPOSOME; DRUG VEHICLE; LIPOSOME; MAMMALIAN TARGET OF RAPAMYCIN; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 2; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B; RAPAMYCIN; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; VASCULOTROPIN RECEPTOR 1;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL; CANCER INHIBITION; CELL GROWTH; CHROMOSOME 10; CONTROLLED STUDY; DOSE RESPONSE; DRUG DELIVERY SYSTEM; DRUG DOSAGE FORM COMPARISON; DRUG EFFECT; DRUG EFFICACY; DRUG PROTEIN BINDING; DRUG SENSITIVITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; GENE SILENCING; HUMAN; HUMAN CELL; MALE; NEGATIVE FEEDBACK; PROTEIN EXPRESSION; PROTEIN MODIFICATION; PROTEIN SYNTHESIS INHIBITION; PROTEIN TARGETING; SIGNAL TRANSDUCTION;

BASE SEQUENCE; BLOTTING, WESTERN; CELL DIVISION; CELL LINE, TUMOR; GENE KNOCKDOWN TECHNIQUES; HUMANS; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; PTEN PHOSPHOHYDROLASE; RNA, SMALL INTERFERING; SERINE; TOR SERINE-THREONINE KINASES; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-1;

EID: 79955654426     PISSN: 09186158     EISSN: 13475215     Source Type: Journal    
DOI: 10.1248/bpb.34.602     Document Type: Article

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