Freeze-anneal-thaw cycling of unilamellar liposomes: Effect on encapsulation efficiency

Pharmaceutical Research

Volumn 31, Issue 1, 2014, Pages 97-103

  Costa, Antonio P ^a   Xu, Xiaoming ^b   Burgess, Diane J ^a  

^a UNIVERSITY OF CONNECTICUT   (United States)

^b CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

Author keywords

annealing; cryo concentration; freeze drying; freeze thaw cycling; Tenofovir

Indexed keywords

LIPOSOME; TENOFOVIR;

ARTICLE; DRUG FORMULATION; ELECTRIC POTENTIAL; ENCAPSULATION; FREEZE ANNEAL THAW CYCLING; FREEZING; LOW TEMPERATURE PROCEDURES; PARTICLE SIZE; PRIORITY JOURNAL; TEMPERATURE;

CHEMISTRY, PHARMACEUTICAL; DRUG COMPOUNDING; DRUG STABILITY; FREEZING; PARTICLE SIZE; TEMPERATURE; UNILAMELLAR LIPOSOMES;

EID: 84891605658     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-013-1135-z     Document Type: Article

References (17)

1. Pick U. Liposomes with a large trapping capacity prepared by freezing and thawing of sonicated phospholipid mixtures. Arch Biochem Biophys. 1981;212(1):186-94.
2. Mayer LD, Hope MJ, Cullis PR, Janoff AS. Solute distributions and trapping efficiencies observed in freeze-thawed multilamellar vesicles. Biochim Biophys Acta - Biomembr. 1985;817(1):193-6.
3. Castile JD, Taylor KMG. Factors affecting the size distribution of liposomes produced by freeze-thaw extrusion. Int J Pharm. 1999;188(1):87-95. (Pubitemid 29472463)
4. Xu X, Khan MA, Burgess DJ. Predicting hydrophilic drug encapsulation inside unilamellar liposomes. Int J Pharm. 2012;423:410-8.
5. Aliño SF, García M, Lejarreta M, Bobadilla M, Pérez-Yarza G, Unda FJ. Trapping drug efficiency in liposomes produced by extrusion of freeze-thaw multilamellar vesicles. Biochem Soc Trans. 1989;17(6):1000-1. (Pubitemid 20028019)
6. Traïkia M, Warschawski DE, Recouvreur M, Cartaud J, Devaux PF. Formation of unilamellar vesicles by repetitive freeze-thaw cycles: characterization by electron microscopy and 31P-nuclear magnetic resonance. Eur Biophys J. 2000;29(3):184-95.
7. MacDonald RC, Jones FD, Qui R. Fragmentation into small vesicles of dioleoylphosphatidylcholine bilayers during freezing and thawing. Biochim Biophys Acta - Biomembr. 1994;1191(2):362-70. (Pubitemid 24183559)
8. Hope MJ, Bally MB, Mayer LD, Janoff AS, Cullis PR. Generation of multilamellar and unilamellar phospholipid vesicles. Chem Phys Lipids. 1986;40(2-4):89-107.
9. Xu X, Costa A, Burgess D. Protein encapsulation in unilamellar liposomes: high encapsulation efficiency and a novel technique to assess lipid-protein interaction. Pharm Res. 2012, Netherlands: Springer, 1-13.
10. Hwang SY, Kim HK, Choo J, Seong GH, Hien TBD, Lee EK. Effects of operating parameters on the efficiency of liposomal encapsulation of enzymes. Colloids Surf B. 2012;94(1):296-303.
11. Colletier J-P, Chaize B, Winterhalter M, Fournier D. Protein encapsulation in liposomes: efficiency depends on interactions between protein and phospholipid bilayer. BMC Biotechnol. 2002;2(1):9. (Pubitemid 38846445)
12. Anzai K, Yoshida M, Kirino Y. Change in intravesicular volume of liposomes by freeze-thaw treatment as studied by the ESR stopped-flow technique. Biochim Biophys Acta - Biomembr. 1990;1021(1):21-6. (Pubitemid 20047000)
13. Tetko IV, Gasteiger J, Todeschini R, Mauri A, Livingstone D, Ertl P, et al. Virtual computational chemistry laboratory - design and description. J Comput Aid Mol Des. 2005;19:453-63. (Pubitemid 41613292)
14. Xu X, Khan MA, Burgess DJ. A quality by design (QbD) case study on liposomes containing hydrophilic API: I. Formulation, processing design and risk assessment. Int J Pharm. 2011;419(1-2):52-9.
15. Talsma H, Van Steenbergen MJ, Crommelin DJA. The cryopreservation of liposomes: 3. Almost complete retention of a water-soluble marker in small liposomes in a cryoprotectant containing dispersion after a freezing/thawing cycle. Int J Pharm. 1991;77(2-3):119-26.
16. Sabín J, Prieto G, Ruso JM, Hidalgo-Alvarez R, Sarmiento F. Size and stability of liposomes: a possible role of hydration and osmotic forces. Eur Phys J E. 2006;20(4):401-8. (Pubitemid 44386800)
17. Siow LF, Rades T, Lim MH. Characterizing the freezing behavior of liposomes as a tool to understand the cryopreservation procedures. Cryobiology. 2007;55(3):210-21. (Pubitemid 350137307)