메뉴 건너뛰기




Volumn 32, Issue , 2016, Pages 66-76

The "fate" of polymeric and lipid nanoparticles for brain delivery and targeting: Strategies and mechanism of blood-brain barrier crossing and trafficking into the central nervous system

Author keywords

Blood brain barrier; Brain; Brain tumors; Central nervous system; Nanomedicine; Polymeric nanoparticles; Solid lipid nanoparticles

Indexed keywords

ANTINEOPLASTIC AGENT; LIPOSOME; NANOCARRIER; POLYMER; SOLID LIPID NANOPARTICLE;

EID: 84961618744     PISSN: 17732247     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jddst.2015.07.007     Document Type: Article
Times cited : (59)

References (119)
  • 1
    • 0033401924 scopus 로고    scopus 로고
    • Novel targets for CNS gene therapy
    • H.J. Federoff Novel targets for CNS gene therapy Gene Ther. 6 1999 1907 1908
    • (1999) Gene Ther. , vol.6 , pp. 1907-1908
    • Federoff, H.J.1
  • 2
    • 0036007257 scopus 로고    scopus 로고
    • Why is the global CNS pharmaceutical market so under-penetrated?
    • W.M. Pardridge Why is the global CNS pharmaceutical market so under-penetrated? Drug Discov. Today 7 2002 5 7
    • (2002) Drug Discov. Today , vol.7 , pp. 5-7
    • Pardridge, W.M.1
  • 3
    • 63249115678 scopus 로고    scopus 로고
    • The blood-brain barrier in brain homeostasis and neurological diseases
    • N. Weiss, F. Miller, S. Cazaubon, and P.O. Couraud The blood-brain barrier in brain homeostasis and neurological diseases Biochim. Biophys. Acta 1788 2009 842 857
    • (2009) Biochim. Biophys. Acta , vol.1788 , pp. 842-857
    • Weiss, N.1    Miller, F.2    Cazaubon, S.3    Couraud, P.O.4
  • 5
    • 66149102898 scopus 로고    scopus 로고
    • Challenges and opportunities in CNS delivery of therapeutics for neurodegenerative diseases
    • T.M. Barchet, and M.M. Amiji Challenges and opportunities in CNS delivery of therapeutics for neurodegenerative diseases Expert Opin. Drug Deliv. 6 2009 211 225
    • (2009) Expert Opin. Drug Deliv. , vol.6 , pp. 211-225
    • Barchet, T.M.1    Amiji, M.M.2
  • 8
    • 79957510027 scopus 로고    scopus 로고
    • Effects of external phase on D-cycloserine loaded W/O nanocapsules prepared by the interfacial polymerization method
    • T. Musumeci, C.A. Ventura, C. Carbone, R. Pignatello, and G. Puglisi Effects of external phase on D-cycloserine loaded W/O nanocapsules prepared by the interfacial polymerization method Eur. J. Med. Chem. 46 2011 2828 2834
    • (2011) Eur. J. Med. Chem. , vol.46 , pp. 2828-2834
    • Musumeci, T.1    Ventura, C.A.2    Carbone, C.3    Pignatello, R.4    Puglisi, G.5
  • 9
  • 10
    • 84857239428 scopus 로고    scopus 로고
    • Preparation and optimization of PIT solid lipid nanoparticles via statistical factorial design
    • C. Carbone, B. Tomasello, B. Ruozi, M. Renis, and G. Puglisi Preparation and optimization of PIT solid lipid nanoparticles via statistical factorial design Eur. J. Med. Chem. 49 2012 110 117
    • (2012) Eur. J. Med. Chem. , vol.49 , pp. 110-117
    • Carbone, C.1    Tomasello, B.2    Ruozi, B.3    Renis, M.4    Puglisi, G.5
  • 11
    • 84861142135 scopus 로고    scopus 로고
    • In vitro evaluation on a model of blood brain barrier of idebenone-loaded solid lipid nanoparticles
    • L. Montenegro, A. Trapani, A. Latrofa, and G. Puglisi In vitro evaluation on a model of blood brain barrier of idebenone-loaded solid lipid nanoparticles J. Nanosci. Nanotechnol. 12 2012 330 337
    • (2012) J. Nanosci. Nanotechnol. , vol.12 , pp. 330-337
    • Montenegro, L.1    Trapani, A.2    Latrofa, A.3    Puglisi, G.4
  • 13
    • 84871968690 scopus 로고    scopus 로고
    • New amphiphilic conjugates of Amino-Poly(ethylene glycols) with lipoamino acids as surface modifiers of colloidal drug carriers
    • R. Pignatello, V. Pantò, G. Impallomeni, G.M. Carnemolla, C. Carbone, and G. Puglisi New amphiphilic conjugates of Amino-Poly(ethylene glycols) with lipoamino acids as surface modifiers of colloidal drug carriers Macromol. Chem. Phys. 214 2013 46 55
    • (2013) Macromol. Chem. Phys. , vol.214 , pp. 46-55
    • Pignatello, R.1    Pantò, V.2    Impallomeni, G.3    Carnemolla, G.M.4    Carbone, C.5    Puglisi, G.6
  • 14
    • 84877806241 scopus 로고    scopus 로고
    • Trans-ferulic acid-based solid lipid nanoparticles and their antioxidant effect in rat brain microsomes
    • S. Trombino, R. Cassano, T. Ferrarelli, E. Barone, N. Picci, and C. Mancuso Trans-ferulic acid-based solid lipid nanoparticles and their antioxidant effect in rat brain microsomes Coll. Surf. B Biointerfaces 109 2013 273 279
    • (2013) Coll. Surf. B Biointerfaces , vol.109 , pp. 273-279
    • Trombino, S.1    Cassano, R.2    Ferrarelli, T.3    Barone, E.4    Picci, N.5    Mancuso, C.6
  • 18
    • 84895921035 scopus 로고    scopus 로고
    • Nose-to-brain delivery: Evaluation of polymeric nanoparticles on olfactory ensheathing cells uptake
    • T. Musumeci, R. Pellitteri, M. Spatuzza, and G. Puglisi Nose-to-brain delivery: evaluation of polymeric nanoparticles on olfactory ensheathing cells uptake J. Pharm. Sci. 103 2014 628 635
    • (2014) J. Pharm. Sci. , vol.103 , pp. 628-635
    • Musumeci, T.1    Pellitteri, R.2    Spatuzza, M.3    Puglisi, G.4
  • 20
    • 0028928571 scopus 로고
    • Analgesic activity of the hexapeptide dalagrin adsorbed on the surface of polysorbate-80 coated polybutylcyanoacrylate nanoparticles
    • R.N. Alyautidin, D. Gother, and V. Petrov Analgesic activity of the hexapeptide dalagrin adsorbed on the surface of polysorbate-80 coated polybutylcyanoacrylate nanoparticles Eur. J. Pharm. Biopharm. 41 1995 44 48
    • (1995) Eur. J. Pharm. Biopharm. , vol.41 , pp. 44-48
    • Alyautidin, R.N.1    Gother, D.2    Petrov, V.3
  • 22
    • 84868127411 scopus 로고    scopus 로고
    • Nanomedicine: The future for advancing medicine and neuroscience
    • G. Tosi, B. Ruozi, and D. Belletti Nanomedicine: the future for advancing medicine and neuroscience Nanomedicine 7 2012 1113 1116
    • (2012) Nanomedicine , vol.7 , pp. 1113-1116
    • Tosi, G.1    Ruozi, B.2    Belletti, D.3
  • 23
    • 3042613166 scopus 로고    scopus 로고
    • Sustained cytoplasmic delivery of drugs with intracellular receptors using biodegradable nanoparticles
    • J. Panyam, and V. Labhasetwar Sustained cytoplasmic delivery of drugs with intracellular receptors using biodegradable nanoparticles Mol. Pharm. 1 2004 77 84
    • (2004) Mol. Pharm. , vol.1 , pp. 77-84
    • Panyam, J.1    Labhasetwar, V.2
  • 24
    • 0033180164 scopus 로고    scopus 로고
    • Receptor-mediated and enzyme- dependent targeting of cytotoxic anticancer drugs
    • G.M. Dubowchik, and M.A. Walker Receptor-mediated and enzyme- dependent targeting of cytotoxic anticancer drugs Pharm. Ther. 83 1999 67 123
    • (1999) Pharm. Ther. , vol.83 , pp. 67-123
    • Dubowchik, G.M.1    Walker, M.A.2
  • 25
    • 0242584817 scopus 로고    scopus 로고
    • Micellar nanocontainers distribute to defined cytoplasmic organelles
    • R. Savic, L. Luo, A. Eisenberg, and D. Maysinger Micellar nanocontainers distribute to defined cytoplasmic organelles Science 300 2003 615 618
    • (2003) Science , vol.300 , pp. 615-618
    • Savic, R.1    Luo, L.2    Eisenberg, A.3    Maysinger, D.4
  • 28
    • 0036205158 scopus 로고    scopus 로고
    • D.D. Allen Nanoparticle technology for drug delivery across the blood-brain barrier
    • P.R. Lockman, R.J. Mumper, and M.A. Khan D.D. Allen Nanoparticle technology for drug delivery across the blood-brain barrier Drug Dev. Ind. Pharm. 28 2002 1 13
    • (2002) Drug Dev. Ind. Pharm. , vol.28 , pp. 1-13
    • Lockman, P.R.1    Mumper, R.J.2    Khan, M.A.3
  • 29
    • 6344294066 scopus 로고    scopus 로고
    • Influence of the surface properties on nanoparticle-mediated transport of drugs to the brain
    • J. Kreuter Influence of the surface properties on nanoparticle-mediated transport of drugs to the brain J. Nanosci. Nanotechnol. 4 2004 484 488
    • (2004) J. Nanosci. Nanotechnol. , vol.4 , pp. 484-488
    • Kreuter, J.1
  • 31
    • 33646452047 scopus 로고    scopus 로고
    • The use of Pep: Trans vectors for the delivery of drugs into the central nervous system
    • J.M. Scherrmann, and J. Temsamani The use of Pep: trans vectors for the delivery of drugs into the central nervous system Int. Congr. Ser. 1277 2005 199 211
    • (2005) Int. Congr. Ser. , vol.1277 , pp. 199-211
    • Scherrmann, J.M.1    Temsamani, J.2
  • 34
    • 0024300189 scopus 로고
    • Liposomes targeting to mouse brain: Mannose as a recognition marker
    • F. Umezawa, and Y. Eto Liposomes targeting to mouse brain: mannose as a recognition marker Biochem. Biophys. Res. Comm. 153 1988 1038 1044
    • (1988) Biochem. Biophys. Res. Comm. , vol.153 , pp. 1038-1044
    • Umezawa, F.1    Eto, Y.2
  • 35
    • 0036463371 scopus 로고    scopus 로고
    • Drug and gene targeting to the brain with molecular Trojan horses
    • W.M. Pardridge Drug and gene targeting to the brain with molecular Trojan horses Nat. Rev. Drug. Discov. 1 2002 131 139
    • (2002) Nat. Rev. Drug. Discov. , vol.1 , pp. 131-139
    • Pardridge, W.M.1
  • 36
    • 70449529637 scopus 로고    scopus 로고
    • Approaches to transport therapeutic drugs across the blood-brain barrier to treat brain diseases
    • R. Gabathuler Approaches to transport therapeutic drugs across the blood-brain barrier to treat brain diseases Neurobiol. Dis. 37 2010 48 57
    • (2010) Neurobiol. Dis. , vol.37 , pp. 48-57
    • Gabathuler, R.1
  • 37
    • 0033961913 scopus 로고    scopus 로고
    • Transferrin and transferring receptor function in brain barrier systems
    • T. Moos, and E.H. Morgan Transferrin and transferring receptor function in brain barrier systems Cell. Mol. Neurobiol. 20 2001 77 95
    • (2001) Cell. Mol. Neurobiol. , vol.20 , pp. 77-95
    • Moos, T.1    Morgan, E.H.2
  • 38
    • 8344282653 scopus 로고    scopus 로고
    • Targeting anti-transferrin receptor antibody (OX26) and OX26-conjugated liposomes to brain capillary endothelial cells using in situ perfusion
    • S. Gosk, C. Vermehren, G. Storm, and T. Moos Targeting anti-transferrin receptor antibody (OX26) and OX26-conjugated liposomes to brain capillary endothelial cells using in situ perfusion J. Cer. Blood Flow. Met. 24 2004 1193 1204
    • (2004) J. Cer. Blood Flow. Met. , vol.24 , pp. 1193-1204
    • Gosk, S.1    Vermehren, C.2    Storm, G.3    Moos, T.4
  • 43
    • 79952933732 scopus 로고    scopus 로고
    • Development of novel Zn2+ loaded nanoparticles designed for cell-type targeted drug release in CNS neurons: In vitro evidences
    • A.M. Grabrucker, C.C. Garner, T.M. Boeckers, L. Bondioli, B. Ruozi, F. Forni, M.A. Vandelli, and G. Tosi Development of novel Zn2+ loaded nanoparticles designed for cell-type targeted drug release in CNS neurons: in vitro evidences PLoS One 6 2011 e17851
    • (2011) PLoS One , vol.6
    • Grabrucker, A.M.1    Garner, C.C.2    Boeckers, T.M.3    Bondioli, L.4    Ruozi, B.5    Forni, F.6    Vandelli, M.A.7    Tosi, G.8
  • 49
    • 84912150441 scopus 로고    scopus 로고
    • Liposomes bi-functionalized with phosphatidic acid and an ApoE-derived peptide affect Aβ aggregation features and cross the blood-brain-barrier: Implications for therapy of Alzheimer disease
    • L. Bana, S. Minniti, E. Salvati, S. Sesana, V. Zambelli, A. Cagnotto, A. Orlando, E. Cazzaniga, R. Zwart, W. Scheper, M. Masserini, and F. Re Liposomes bi-functionalized with phosphatidic acid and an ApoE-derived peptide affect Aβ aggregation features and cross the blood-brain-barrier: implications for therapy of Alzheimer disease Nanomedicine 10 2013 1583 1590
    • (2013) Nanomedicine , vol.10 , pp. 1583-1590
    • Bana, L.1    Minniti, S.2    Salvati, E.3    Sesana, S.4    Zambelli, V.5    Cagnotto, A.6    Orlando, A.7    Cazzaniga, E.8    Zwart, R.9    Scheper, W.10    Masserini, M.11    Re, F.12
  • 50
    • 84877288426 scopus 로고    scopus 로고
    • Liposomes functionalized to overcome the blood-brain barrier and to target amyloid-β peptide: The chemical design affects the permeability across an in vitro model
    • E. Salvati, F. Re, S. Sesana, I. Cambianica, G. Sancini, M. Masserini, and M. Gregori Liposomes functionalized to overcome the blood-brain barrier and to target amyloid-β peptide: the chemical design affects the permeability across an in vitro model Int. J. Nanomed. 8 2013 1749 1758
    • (2013) Int. J. Nanomed. , vol.8 , pp. 1749-1758
    • Salvati, E.1    Re, F.2    Sesana, S.3    Cambianica, I.4    Sancini, G.5    Masserini, M.6    Gregori, M.7
  • 52
    • 0000545811 scopus 로고
    • An in situ brain perfusion technique to study cerebrovascular transport in the rat
    • Y. Takasato, S.I. Rapoport, and Q.R. Smith An in situ brain perfusion technique to study cerebrovascular transport in the rat Am. J. Physiol. 247 1984 H484 H493
    • (1984) Am. J. Physiol. , vol.247 , pp. H484-H493
    • Takasato, Y.1    Rapoport, S.I.2    Smith, Q.R.3
  • 53
    • 0344185347 scopus 로고    scopus 로고
    • In situ blood-brain barrier transport of nanoparticles
    • J.M. Koziara, P.R. Lockman, D.D. Allen, and R.J. Mumper In situ blood-brain barrier transport of nanoparticles Pharm. Res. 20 2003 1772 1778
    • (2003) Pharm. Res. , vol.20 , pp. 1772-1778
    • Koziara, J.M.1    Lockman, P.R.2    Allen, D.D.3    Mumper, R.J.4
  • 54
    • 0242500461 scopus 로고    scopus 로고
    • In vivo and in vitro assessment of baseline blood-brain barrier parameters in the presence of novel nanoparticles
    • P.R. Lockman, J. Koziara, K.E. Roder, J. Paulson, T.J. Abbruscato, R.J. Mumper, and D.D. Allen In vivo and in vitro assessment of baseline blood-brain barrier parameters in the presence of novel nanoparticles Pharm. Res. 20 2003 705 713
    • (2003) Pharm. Res. , vol.20 , pp. 705-713
    • Lockman, P.R.1    Koziara, J.2    Roder, K.E.3    Paulson, J.4    Abbruscato, T.J.5    Mumper, R.J.6    Allen, D.D.7
  • 56
    • 0000792079 scopus 로고    scopus 로고
    • An update on the in situ brain perfusion technique: Simple, faster, better
    • D.D. Allen, J. Oki, and Q.R. Smith An update on the in situ brain perfusion technique: simple, faster, better Pharm. Res. 14 1997 337
    • (1997) Pharm. Res. , vol.14 , pp. 337
    • Allen, D.D.1    Oki, J.2    Smith, Q.R.3
  • 57
    • 4544240398 scopus 로고    scopus 로고
    • Paclitaxel nanoparticles for the potential treatment of brain tumors
    • J.M. Koziara, P.R. Lockman, D.D. Allen, and R.J. Mumper Paclitaxel nanoparticles for the potential treatment of brain tumors J. Control. Release 30 2004 259 269
    • (2004) J. Control. Release , vol.30 , pp. 259-269
    • Koziara, J.M.1    Lockman, P.R.2    Allen, D.D.3    Mumper, R.J.4
  • 60
    • 33749025543 scopus 로고    scopus 로고
    • Influence of surfactants, polymer and doxorubicin loading on the anti-tumour effect of poly(butyl cyanoacrylate) nanoparticles in a rat glioma model
    • A. Ambruosi, S. Gelperina, A. Khalansky, S. Tanski, A. Theisen, and J. Kreuter Influence of surfactants, polymer and doxorubicin loading on the anti-tumour effect of poly(butyl cyanoacrylate) nanoparticles in a rat glioma model J. Microencapsul. 23 2006 582 592
    • (2006) J. Microencapsul. , vol.23 , pp. 582-592
    • Ambruosi, A.1    Gelperina, S.2    Khalansky, A.3    Tanski, S.4    Theisen, A.5    Kreuter, J.6
  • 61
    • 0033649767 scopus 로고    scopus 로고
    • Body distribution of 3H-labelled dalargin bound to poly(butylcyanoacrylate) nanoparticles after their i.v. injection in mice
    • U. Schroeder, H. Schroeder, and B.A. Sabel Body distribution of 3H-labelled dalargin bound to poly(butylcyanoacrylate) nanoparticles after their i.v. injection in mice Life Sci. 66 2000 495 502
    • (2000) Life Sci. , vol.66 , pp. 495-502
    • Schroeder, U.1    Schroeder, H.2    Sabel, B.A.3
  • 63
    • 53849097674 scopus 로고    scopus 로고
    • Development of a smart nano-vehicle to target cerebrovascular amyloid deposits and brain parenchymal plaques observed in Alzheimer's disease and cerebral amyloid angiopathy
    • E.K. Agyare, G.L. Curran, M. Ramakrishnan, C.C. Yu, J.F. Poduslo, and K.K. Kandimalla Development of a smart nano-vehicle to target cerebrovascular amyloid deposits and brain parenchymal plaques observed in Alzheimer's disease and cerebral amyloid angiopathy Pharm. Res. 25 2008 2674 2684
    • (2008) Pharm. Res. , vol.25 , pp. 2674-2684
    • Agyare, E.K.1    Curran, G.L.2    Ramakrishnan, M.3    Yu, C.C.4    Poduslo, J.F.5    Kandimalla, K.K.6
  • 66
    • 1142309721 scopus 로고    scopus 로고
    • Specific role of polysorbate 80 coating on the targeting of nanoparticles to the brain
    • W. Sun, C. Xie, H. Wang, and Y. Hu Specific role of polysorbate 80 coating on the targeting of nanoparticles to the brain Biomaterials 25 2004 3065 3071
    • (2004) Biomaterials , vol.25 , pp. 3065-3071
    • Sun, W.1    Xie, C.2    Wang, H.3    Hu, Y.4
  • 67
  • 68
    • 40849097322 scopus 로고    scopus 로고
    • Poly(n-butylcyanoacrylate) nanoparticles coated with polysorbate 80 for the targeted delivery of rivastigmine into the brain to treat Alzheimer's disease
    • B. Wilson, M.K. Samanta, K. Santhi, K.P.S. Kumar, N. Paramakrishnan, and B. Suresh Poly(n-butylcyanoacrylate) nanoparticles coated with polysorbate 80 for the targeted delivery of rivastigmine into the brain to treat Alzheimer's disease Brain Res. 1200 2008 159 168
    • (2008) Brain Res. , vol.1200 , pp. 159-168
    • Wilson, B.1    Samanta, M.K.2    Santhi, K.3    Kumar, K.P.S.4    Paramakrishnan, N.5    Suresh, B.6
  • 69
  • 70
  • 71
    • 0030447660 scopus 로고    scopus 로고
    • Brain drug delivery of small molecules using immunoliposomes
    • J. Huwyler, D. Wu, and W.M. Pardridge Brain drug delivery of small molecules using immunoliposomes Proc. Natl. Acad. Sci. U. S. A. 93 1996 14164 14169
    • (1996) Proc. Natl. Acad. Sci. U. S. A. , vol.93 , pp. 14164-14169
    • Huwyler, J.1    Wu, D.2    Pardridge, W.M.3
  • 72
    • 0030987679 scopus 로고    scopus 로고
    • Receptor mediated delivery of daunomycin using immunoliposomes: Pharmacokinetics and tissue distribution in the rat
    • J. Huwyler, J. Yan, and W.M. Pardridge Receptor mediated delivery of daunomycin using immunoliposomes: pharmacokinetics and tissue distribution in the rat J. Pharm. Exp. Ther. 282 1997 1541 1546
    • (1997) J. Pharm. Exp. Ther. , vol.282 , pp. 1541-1546
    • Huwyler, J.1    Yan, J.2    Pardridge, W.M.3
  • 73
    • 24644485229 scopus 로고    scopus 로고
    • Targeting of daunomycin using biotinylated immunoliposomes: Pharmacokinetics, tissue distribution and in vitro pharmacological effects
    • A. Schnyder, S. Krähenbühl, J. Drewe, and J. Huwyler Targeting of daunomycin using biotinylated immunoliposomes: pharmacokinetics, tissue distribution and in vitro pharmacological effects J. Drug Targ. 13 2005 325 335
    • (2005) J. Drug Targ. , vol.13 , pp. 325-335
    • Schnyder, A.1    Krähenbühl, S.2    Drewe, J.3    Huwyler, J.4
  • 74
    • 75949119718 scopus 로고    scopus 로고
    • Brain-targeted solid lipid nanoparticles containing riluzole: Preparation, characterization and biodistribution
    • M.L. Bondì, E.F. Craparo, G. Giammona, and F. Drago Brain-targeted solid lipid nanoparticles containing riluzole: preparation, characterization and biodistribution Nanomedicine 5 2010 25 32
    • (2010) Nanomedicine , vol.5 , pp. 25-32
    • Bondì, M.L.1    Craparo, E.F.2    Giammona, G.3    Drago, F.4
  • 75
    • 0030853702 scopus 로고    scopus 로고
    • Influence of the type of surfactant on the analgesic effects induced by the peptide dalargin after its delivery across the blood-brain barrier using surfactant-coated nanoparticles
    • J. Kreuter, V.E. Petrov, D.A. Kharkevich, and R.N. Alyautdin Influence of the type of surfactant on the analgesic effects induced by the peptide dalargin after its delivery across the blood-brain barrier using surfactant-coated nanoparticles J. Control. Rel 49 1997 81 87
    • (1997) J. Control. Rel , vol.49 , pp. 81-87
    • Kreuter, J.1    Petrov, V.E.2    Kharkevich, D.A.3    Alyautdin, R.N.4
  • 76
    • 0037335187 scopus 로고    scopus 로고
    • Direct evidence that polysorbate-80-coated poly(butylcyanoacrylate) nanoparticles deliver drugs to the CNS via specific mechanisms requiring prior binding of drug to the nanoparticles
    • J. Kreuter, P. Ramge, V. Petrov, S. Hamm, S.E. Gelperina, B. Engelhardt, R. Alyautdin, H. von Briesen, and D.J. Begley Direct evidence that polysorbate-80-coated poly(butylcyanoacrylate) nanoparticles deliver drugs to the CNS via specific mechanisms requiring prior binding of drug to the nanoparticles Pharm. Res. 20 2003 409 416
    • (2003) Pharm. Res. , vol.20 , pp. 409-416
    • Kreuter, J.1    Ramge, P.2    Petrov, V.3    Hamm, S.4    Gelperina, S.E.5    Engelhardt, B.6    Alyautdin, R.7    Von Briesen, H.8    Begley, D.J.9
  • 78
    • 0030993566 scopus 로고    scopus 로고
    • Delivery of loperamide across the blood-brain barrier with polysorbate 80-coated polybutylcyanoacrylate nanoparticles
    • R.N. Alyautdin, V.E. Petrov, K. Langer, A. Berthold, D.A. Kharkevich, and J. Kreuter Delivery of loperamide across the blood-brain barrier with polysorbate 80-coated polybutylcyanoacrylate nanoparticles Pharm. Res. 14 1997 325 328
    • (1997) Pharm. Res. , vol.14 , pp. 325-328
    • Alyautdin, R.N.1    Petrov, V.E.2    Langer, K.3    Berthold, A.4    Kharkevich, D.A.5    Kreuter, J.6
  • 79
    • 25844484030 scopus 로고    scopus 로고
    • Cationic albumin-conjugated pegylated nanoparticles as novel drug carrier for brain delivery
    • W. Lu, Y. Zhang, Y.Z. Tan, K.L. Hu, X.G. Jiang, and S.K. Fu Cationic albumin-conjugated pegylated nanoparticles as novel drug carrier for brain delivery J. Control. Release 107 2005 428 448
    • (2005) J. Control. Release , vol.107 , pp. 428-448
    • Lu, W.1    Zhang, Y.2    Tan, Y.Z.3    Hu, K.L.4    Jiang, X.G.5    Fu, S.K.6
  • 80
    • 33846188096 scopus 로고    scopus 로고
    • Cationic albumin-conjugated pegylated nanoparticles allow gene delivery into brain tumors via intravenous administration
    • W. Lu, Q. Sun, J. Wan, Z. She, and X.G. Jiang Cationic albumin-conjugated pegylated nanoparticles allow gene delivery into brain tumors via intravenous administration Cancer Res. 66 2006 11878 11887
    • (2006) Cancer Res. , vol.66 , pp. 11878-11887
    • Lu, W.1    Sun, Q.2    Wan, J.3    She, Z.4    Jiang, X.G.5
  • 81
    • 33847148515 scopus 로고    scopus 로고
    • Brain delivery property and accelerated blood clearance of cationic albumin conjugated pegylated nanoparticle
    • W. Lu, J. Wan, Z. She, and X. Jiang Brain delivery property and accelerated blood clearance of cationic albumin conjugated pegylated nanoparticle J. Control. Release 118 2007 38 53
    • (2007) J. Control. Release , vol.118 , pp. 38-53
    • Lu, W.1    Wan, J.2    She, Z.3    Jiang, X.4
  • 84
    • 84890859871 scopus 로고    scopus 로고
    • Brain-targeted polymeric nanoparticles: In vivo evidence of different routes of administration in rodents
    • G. Tosi, B. Ruozi, D. Belletti, A. Vilella, M. Zoli, M.A. Vandelli, and F. Forni Brain-targeted polymeric nanoparticles: in vivo evidence of different routes of administration in rodents Nanomedicine 8 2013 1373 1383
    • (2013) Nanomedicine , vol.8 , pp. 1373-1383
    • Tosi, G.1    Ruozi, B.2    Belletti, D.3    Vilella, A.4    Zoli, M.5    Vandelli, M.A.6    Forni, F.7
  • 86
    • 0034815482 scopus 로고    scopus 로고
    • Receptor-mediated gene targeting to tissues in vivo following intravenous administration of pegylated immunoliposomes
    • N. Shi, R.J. Boado, and W.M. Pardridge Receptor-mediated gene targeting to tissues in vivo following intravenous administration of pegylated immunoliposomes Pharm. Res. 18 2001 1091 1095
    • (2001) Pharm. Res. , vol.18 , pp. 1091-1095
    • Shi, N.1    Boado, R.J.2    Pardridge, W.M.3
  • 87
    • 0035940380 scopus 로고    scopus 로고
    • Brain specific expression of an exogenous gene after i.v. administration
    • N. Shi, Y. Zhang, C. Zhu, R.J. Boado, and W.M. Pardridge Brain specific expression of an exogenous gene after i.v. administration Proc. Natl. Acad. Sci. 98 2001 12754 12759
    • (2001) Proc. Natl. Acad. Sci. , vol.98 , pp. 12754-12759
    • Shi, N.1    Zhang, Y.2    Zhu, C.3    Boado, R.J.4    Pardridge, W.M.5
  • 88
    • 0033938847 scopus 로고    scopus 로고
    • Claudin-1 and claudin-5 expression and tight junction morphology are altered in blood vessels of human glioblastoma multiforme
    • S. Liebner, A. Fischmann, G. Rascher, F. Duffner, E.H. Grote, H. Kalbacher, and H. Wolburg Claudin-1 and claudin-5 expression and tight junction morphology are altered in blood vessels of human glioblastoma multiforme Acta Neuropathol. 100 2000 323 331
    • (2000) Acta Neuropathol. , vol.100 , pp. 323-331
    • Liebner, S.1    Fischmann, A.2    Rascher, G.3    Duffner, F.4    Grote, E.H.5    Kalbacher, H.6    Wolburg, H.7
  • 89
    • 0347555450 scopus 로고    scopus 로고
    • Organ-specific gene expression in the rhesus monkey eye following intravenous non-viral gene transfer
    • Y. Zhang, F. Schlachetzki, J.Y. Li, R.J. Boado, and W.M. Pardridge Organ-specific gene expression in the rhesus monkey eye following intravenous non-viral gene transfer Mol. Vis. 9 2003 465 472
    • (2003) Mol. Vis. , vol.9 , pp. 465-472
    • Zhang, Y.1    Schlachetzki, F.2    Li, J.Y.3    Boado, R.J.4    Pardridge, W.M.5
  • 90
    • 72749112539 scopus 로고    scopus 로고
    • A novel animal model to evaluate the ability of a drug delivery system to promote the passage through the BBB
    • M. Iannone, D. Cosco, F. Cilurzo, C. Celia, D. Paolino, V. Mollace, D. Rotiroti, and M. Fresta A novel animal model to evaluate the ability of a drug delivery system to promote the passage through the BBB Neurosci. Lett. 469 2010 93 96
    • (2010) Neurosci. Lett. , vol.469 , pp. 93-96
    • Iannone, M.1    Cosco, D.2    Cilurzo, F.3    Celia, C.4    Paolino, D.5    Mollace, V.6    Rotiroti, D.7    Fresta, M.8
  • 96
    • 0015291143 scopus 로고
    • Tumor angiogenesis: A quantitative method for histologic grading
    • S. Brem, R. Cotran, and J. Folkman Tumor angiogenesis: a quantitative method for histologic grading J. Int. Cancer Inst. 48 1972 347 356
    • (1972) J. Int. Cancer Inst. , vol.48 , pp. 347-356
    • Brem, S.1    Cotran, R.2    Folkman, J.3
  • 100
    • 0034470379 scopus 로고    scopus 로고
    • Vascular microenvironment in gliomas
    • P. Vajkoczy, and M.D. Menger Vascular microenvironment in gliomas J. Neurooncol. 50 2001 99 108
    • (2001) J. Neurooncol. , vol.50 , pp. 99-108
    • Vajkoczy, P.1    Menger, M.D.2
  • 102
    • 33845382806 scopus 로고
    • Nonparametric estimation from incomplete observations
    • E.L. Kaplan, and P. Meier Nonparametric estimation from incomplete observations J. Am. Stat. Ass 53 1958 457 481
    • (1958) J. Am. Stat. Ass , vol.53 , pp. 457-481
    • Kaplan, E.L.1    Meier, P.2
  • 103
    • 2342471420 scopus 로고    scopus 로고
    • The blood-brain barrier: An overview, structure, regulation, and clinical implications
    • P. Ballabh, A. Braun, and M. Nedergaard The blood-brain barrier: an overview, structure, regulation, and clinical implications Neurobiol. Dis. 16 2004 1 13
    • (2004) Neurobiol. Dis. , vol.16 , pp. 1-13
    • Ballabh, P.1    Braun, A.2    Nedergaard, M.3
  • 104
    • 0029585915 scopus 로고
    • Doxorubicin encapsulated in sterically stabilized liposomes for the treatment of a brain tumor model: Biodistribution and therapeutic efficacy
    • T. Siegal, A. Horowitz, and A. Gabizon Doxorubicin encapsulated in sterically stabilized liposomes for the treatment of a brain tumor model: biodistribution and therapeutic efficacy J. Neurosurg. 83 1995 1029 1037
    • (1995) J. Neurosurg. , vol.83 , pp. 1029-1037
    • Siegal, T.1    Horowitz, A.2    Gabizon, A.3
  • 105
    • 0030770632 scopus 로고    scopus 로고
    • Liposome-mediated therapy of intracranial brain tumors in a rat model
    • U.S. Sharma, A. Sharma, R.I. Chau, and M. Straubinger Liposome-mediated therapy of intracranial brain tumors in a rat model Pharm. Res. 8 1997 992 998
    • (1997) Pharm. Res. , vol.8 , pp. 992-998
    • Sharma, U.S.1    Sharma, A.2    Chau, R.I.3    Straubinger, M.4
  • 108
    • 0036365052 scopus 로고    scopus 로고
    • In vivo targeting of SF/HGF and c-met expression via U1snRNA/ribozymes inhibits glioma growth and angiogenesis and promotes apoptosis
    • R. Abounader, B. Lal, C. Luddy, G. Koe, B. Davidson, E.M. Rosen, and J. Laterra In vivo targeting of SF/HGF and c-met expression via U1snRNA/ribozymes inhibits glioma growth and angiogenesis and promotes apoptosis FASEB J. 16 2002 108 110
    • (2002) FASEB J. , vol.16 , pp. 108-110
    • Abounader, R.1    Lal, B.2    Luddy, C.3    Koe, G.4    Davidson, B.5    Rosen, E.M.6    Laterra, J.7
  • 110
    • 33846499122 scopus 로고    scopus 로고
    • Chemotherapy of brain tumour using doxorubicin bound to surfactant-coated poly(butyl cyanoacrylate) nanoparticles: Revisiting the role of surfactants
    • B. Petri, A. Bootz, A. Khalansky, T. Hekmatara, R. Müller, R. Uhl, R.,J. Kreuter, and S.E. Gelperina Chemotherapy of brain tumour using doxorubicin bound to surfactant-coated poly(butyl cyanoacrylate) nanoparticles: revisiting the role of surfactants J. Control. Release 117 2007 51 58
    • (2007) J. Control. Release , vol.117 , pp. 51-58
    • Petri, B.1    Bootz, A.2    Khalansky, A.3    Hekmatara, T.4    Müller, R.5    Uhl, R.6    Kreuter, R.J.7    Gelperina, S.E.8
  • 111
    • 61549106604 scopus 로고    scopus 로고
    • Antitumor effects of polysorbate-80 coated gemcitabine polybutylcyanoacrylate nanoparticles in vitro and its pharmacodynamics in vivo on C6 glioma cells of a brain tumor model
    • C.X. Wang, L.S. Huang, L.B. Hou, L. Jiang, Z.T. Yan, Y.L. Wang, and Z.-L. Chen Antitumor effects of polysorbate-80 coated gemcitabine polybutylcyanoacrylate nanoparticles in vitro and its pharmacodynamics in vivo on C6 glioma cells of a brain tumor model Brain Res. 1261 2009 91 99
    • (2009) Brain Res. , vol.1261 , pp. 91-99
    • Wang, C.X.1    Huang, L.S.2    Hou, L.B.3    Jiang, L.4    Yan, Z.T.5    Wang, Y.L.6    Chen, Z.-L.7
  • 115
    • 84871569985 scopus 로고    scopus 로고
    • Nanoparticles for imaging and treating brain cancer
    • J.D. Meyers, T. Doane, C. Burda, and J.P. Basilion Nanoparticles for imaging and treating brain cancer Nanomedicine 8 2013 123 143
    • (2013) Nanomedicine , vol.8 , pp. 123-143
    • Meyers, J.D.1    Doane, T.2    Burda, C.3    Basilion, J.P.4
  • 116
    • 0036665418 scopus 로고    scopus 로고
    • Antisense gene therapy of brain cancer with an artificial virus gene delivery system
    • Y. Zhang, C. Zhu, and W.M. Pardridge Antisense gene therapy of brain cancer with an artificial virus gene delivery system Mol. Ther. 6 2002 67 72
    • (2002) Mol. Ther. , vol.6 , pp. 67-72
    • Zhang, Y.1    Zhu, C.2    Pardridge, W.M.3
  • 117
    • 67249130759 scopus 로고    scopus 로고
    • Dual-targeting topotecan liposomes modified with Tamoxifen and Wheat Germ Agglutinin significantly improve drug transport across the blood-brain barrier and survival of brain tumor-bearing animals
    • J. Du, W.L. Lu, X. Ying, Y. Liu, P. Du, W. Tian, Y. Men, J. Guo, Y. Zhang, R.J. Li, J. Zhou, J.-N. Lou, J.-C. Wang, X. Zhang, and Q. Zhang Dual-targeting topotecan liposomes modified with Tamoxifen and Wheat Germ Agglutinin significantly improve drug transport across the blood-brain barrier and survival of brain tumor-bearing animals Mol. Pharm. 3 2009 905 917
    • (2009) Mol. Pharm. , vol.3 , pp. 905-917
    • Du, J.1    Lu, W.L.2    Ying, X.3    Liu, Y.4    Du, P.5    Tian, W.6    Men, Y.7    Guo, J.8    Zhang, Y.9    Li, R.J.10    Zhou, J.11    Lou, J.-N.12    Wang, J.-C.13    Zhang, X.14    Zhang, Q.15


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.