Insight on the fate of CNS-targeted nanoparticles. Part I: Rab5-dependent cell-specific uptake and distribution

Journal of Controlled Release

Volumn 174, Issue 1, 2014, Pages 195-201

  Vilella, Antonietta ^a   Tosi, Giovanni ^a   Grabrucker, Andreas M ^b   Ruozi, Barbara ^a   Belletti, Daniela ^a   Vandelli, Maria Angela ^a   Boeckers, Tobias M ^b   Forni, Flavio ^a   Zoli, Michele ^a  

^a UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

^b UNIVERSITY OF ULM   (Germany)

Author keywords

CNS targeting; Distribution; Nanoparticles; Neuronal uptake

Indexed keywords

CELL CULTURE; CELL PROLIFERATION; CELLS; NANOPARTICLES; NEURODEGENERATIVE DISEASES; NEURONS;

BLOOD-BRAIN BARRIER; CENTRAL NERVOUS SYSTEMS; CNS TARGETING; DISTRIBUTION; NANOPARTICLE (NPS); NEURONAL UPTAKE; POLY LACTIDE-CO-GLYCOLIDE; TARGETED NANOPARTICLE;

TARGETED DRUG DELIVERY;

CLATHRIN; GLYCOPEPTIDE; NANOPARTICLE; POLYGLACTIN; RAB PROTEIN; RAB5 PROTEIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; BRAIN CELL; CELL INTERACTION; CELL POPULATION; CELL TYPE; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; ENDOCYTOSIS; ENDOSOME; GLIA CELL; HIPPOCAMPAL NEURONAL CULTURE; IMMUNOREACTIVITY; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION;

CNS TARGETING; DISTRIBUTION; NANOPARTICLES; NEURONAL UPTAKE;

ANIMALS; BIOLOGICAL TRANSPORT; BRAIN; CELLS, CULTURED; ENDOCYTOSIS; GLYCOPEPTIDES; LACTIC ACID; MICE; MICE, INBRED C57BL; NANOPARTICLES; NEUROGLIA; NEURONS; POLYGLYCOLIC ACID; RAB5 GTP-BINDING PROTEINS;

EID: 84890289935     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2013.11.023     Document Type: Article

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