A novel animal model to evaluate the ability of a drug delivery system to promote the passage through the BBB

Neuroscience Letters

Volumn 469, Issue 1, 2010, Pages 93-96

  Iannone, Michelangelo ^a   Cosco, Donato ^b   Cilurzo, Felisa ^b   Celia, Christian ^b   Paolino, Donatella ^b   Mollace, Vincenzo ^b   Rotiroti, Domenicantonio ^b   Fresta, Massimo ^b  

^a CNR   (Italy)

^b UNIVERSITY MAGNA GRAECIA OF CATANZARO   (Italy)

Author keywords

Animal model; BBB drug passage; Colloidal carrier; Drug delivery systems; Electrocorticogram; Lithium tacrine model; Nanoparticles; Poly l lactid acid

Indexed keywords

ANIMALS; BIOLOGICAL TRANSPORT; BLOOD-BRAIN BARRIER; CA1 REGION, HIPPOCAMPAL; CAPILLARY PERMEABILITY; CENTRAL NERVOUS SYSTEM AGENTS; CHOLINESTERASE INHIBITORS; DISEASE MODELS, ANIMAL; DRUG DELIVERY SYSTEMS; EPILEPSY; LITHIUM CHLORIDE; NANOPARTICLES; POLYESTERS; RATS; TACRINE;

EID: 72749112539     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2009.11.051     Document Type: Article

References (23)

1. Abbott N.J. Astrocyte-endothelial interactions and blood-brain barrier permeability. J. Anat. 200 (2002) 629-638
2. Alyautdin R., Gothier D., Petrov V., Kharkevich D., and Kreuter J. Analgesic activity of the hexapeptide dalargin adsorbed on the surface of polysorbate 80-coated poly(butyl cyanoacrylate) nanoparticles. Eur. J. Pharm. Biopharm. 41 (1995) 44-48
3. Bagetta G., Iannone M., Scorsa A.M., and Nisticò G. Tacrine-induced seizures and brain damage in LiCl-treated rats can be prevented by N omega-nitro-l-arginine methyl ester. Eur. J. Pharmacol. 213 (1992) 301-314
4. Bagetta G., Massoud R., Rodinò P., Federici G., and Nisticò G. Systemic administration of lithium chloride and tacrine increases nitric oxide synthase activity in the hippocampus of rats. Eur. J. Pharmacol. 237 (1993) 61-64
5. Bagetta G., Paoletti A.M., Leta A., Del Duca C., Nisticò R., Rotiroti D., and Corasaniti M.T. Abnormal expression of neuronal nitric oxide synthase triggers limbic seizures and hippocampal damage in rat. Biochem. Biophys. Res. Commun. 291 (2002) 255-260
6. Banks W.A. Characteristics of compounds that cross the blood-brain barrier. BMC Neurol. 9 Suppl. 1 (2009) S3
7. Bernacki J., Dobrowolska A., Nierwińska K., and Małecki A. Physiology and pharmacological role of the blood-brain barrier. Pharmacol. Rep. 60 (2008) 600-622
8. de Lange E.C. Potential role of ABC transporters as a detoxification system at the blood-CSF barrier. Adv. Drug Deliv. Rev. 56 (2004) 1793-1809
9. Denora N., Trapani A., Laquintana V., Lopedota A., and Trapani G. Recent advances in medicinal chemistry and pharmaceutical technology - strategies for drug delivery to the brain. Curr. Top. Med. Chem. 9 (2009) 182-196
10. Fattal E., and Vauthier C. Nanoparticles as drug delivery systems. Encyclopedia of Pharmaceutical Technology (2002), Marcel Dekker, New York pp. 1864-1882
11. Iannone M., Ciriolo M.R., Rotilio G., and Nisticò G. Intra-nigral infusion of Cu-free superoxide dismutase prevents paraquat-induced behavioural stimulation and EcoG epileptogenic discharges in rats. Neuropharmacology 30 (1991) 893-898
12. Kim H.R., Andrieux K., Gil S., Taverna M., Chacun H., Desmaele D., Taran F., Georgin D., and Couvreur P. Translocation of poly(ethylene glycol-co-hexadecyl)cyanoacrylate nanoparticles into rat brain endothelial cells: role of apolipoproteins in receptor-mediated endocytosis. Biomacromolecules 8 (2007) 793-799
13. Kreuter J. Nanoparticulate systems for brain delivery of drugs. Adv. Drug Deliv. Rev. 47 (2001) 65-81
14. Kreuter J., Petrov V.E., Kharkevich D.A., and Alyautdin R. Influence of the type of surfactant on the analgesic effects induced by the peptide dalargin after its delivery across the blood-brain barrier using surfactant-coated nanoparticles. J. Control. Release 49 (1997) 81-87
15. Kreuter J., Ramge P., Petrov V., Hamm S., Gelperina S.E., Engelhardt B., Alyautdin R., von Briesen H., and Begley D.J. Direct evidence that polysorbate-80-coated poly(butylcyanoacrylate) nanoparticles deliver drugs to the CNS via specific mechanisms requiring prior binding of drug to the nanoparticles. Pharm. Res. 20 (2003) 409-416
16. Levin V.A. Relationship of octanol/water partition coefficient and molecular weight to rat brain capillary permeability. J. Med. Chem. 23 (1980) 682-684
17. Ohtsuki S., and Terasaki T. Contribution of carrier-mediated transport systems to the blood-brain barrier as a supporting and protecting interface for the brain; importance for CNS drug discovery and development. Pharm. Res. 24 (2007) 1745-1758
18. Paolino D., Cosco D., Cilurzo F., and Fresta M. Innovative drug delivery systems for the administration of natural compounds. Curr. Bioact. Compd. 3 (2007) 262-277
19. Paxinos G., and Watson C. The Rat Brain in Stereotaxic Coordinates (1982), Academic Press, New York
20. Quintanar-Guerrero D., Allémann E., Doelker E., and Fessi H. Preparation and characterization of nanocapsules from preformed polymers by a new process based on emulsification-diffusion technique. Pharm. Res. 15 (1998) 1056-1062
21. Saarinen-Savolainen P., Jarvinen T., Taipale H., and Urtti A. Method for evaluating drug release from liposomes in sink conditions. Int. J. Pharm. 159 (1997) 27-33
22. Tosi G., Costantino L., Ruozi B., Forni F., and Vandelli M.A. Polymeric nanoparticles for the drug delivery to the central nervous system. Expert Opin. Drug Deliv. 5 (2008) 155-174
23. Weiss N., Miller F., Cazaubon S., and Couraud P.O. The blood-brain barrier in brain homeostasis and neurological diseases. Biochim. Biophys. Acta 1788 (2009) 842-857