Characterization of lysosome-destabilizing DOPE/PLGA nanoparticles designed for cytoplasmic drug release

International Journal of Pharmaceutics

Volumn 471, Issue 1-2, 2014, Pages 349-357

  Chhabra, Resham ^a   Grabrucker, Andreas M ^a   Veratti, Patrizia ^b   Belletti, Daniela ^b   Boeckers, Tobias M ^a   Vandelli, Maria Angela ^b   Forni, Flavio ^b   Tosi, Giovanni ^b   Ruozi, Barbara ^b  

^a UNIVERSITY OF ULM   (Germany)

^b UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

Author keywords

DOPE; Drug delivery; Endo lysosomes; Nanoparticles (NPs); PLGA; Stability

Indexed keywords

1,2 DIOLEOYL SN GLYCERO 3 PHOSPHOETHANOLAMINE; GLYCEROPHOSPHOETHANOLAMINE; LIPID; NANOPARTICLE; POLYGLACTIN; UNCLASSIFIED DRUG; 1,2-DIOLEOYL-GLYCERO-3-PHOSPHATIDYL ETHANOLAMINE; BOVINE SERUM ALBUMIN; DRUG CARRIER; LACTIC ACID; PHOSPHATIDYLETHANOLAMINE; POLYGLYCOLIC ACID; POLYLACTIC ACID-POLYGLYCOLIC ACID COPOLYMER;

ANIMAL CELL; ARTICLE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOPLASMIC DRUG RELEASE; CYTOSOL; DEGRADATION; DRUG DESIGN; DRUG FORMULATION; DRUG RELEASE; DRUG SAFETY; HYBRID; INTERNALIZATION; LIPOSOMAL DELIVERY; LYSOSOME; MOUSE; NERVE CELL CULTURE; NONHUMAN; PH; PRIORITY JOURNAL; RAT; ANIMAL; APOPTOSIS; CELL SURVIVAL; CHEMISTRY; CYTOPLASM; DRUG EFFECTS; DRUG STABILITY; DRUG STORAGE; FIBROBLAST; INBRED MOUSE STRAIN; METABOLISM; NERVE CELL; PRIMARY CELL CULTURE; SURFACE PROPERTY; TOXICITY;

ANIMALS; APOPTOSIS; CELL SURVIVAL; CYTOPLASM; DRUG CARRIERS; DRUG LIBERATION; DRUG STABILITY; DRUG STORAGE; FIBROBLASTS; LACTIC ACID; LYSOSOMES; MICE, INBRED STRAINS; NANOPARTICLES; NEURONS; PHOSPHATIDYLETHANOLAMINES; POLYGLYCOLIC ACID; PRIMARY CELL CULTURE; RATS; SERUM ALBUMIN, BOVINE; SURFACE PROPERTIES;

EID: 84902160464     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2014.05.054     Document Type: Article

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