Cannabidiol induces rapid-acting antidepressant-like effects and enhances cortical 5-HT/glutamate neurotransmission: Role of 5-HT1A receptors

Neuropharmacology

Volumn 103, Issue , 2016, Pages 16-26

  Linge, Raquel ^a,b   Jiménez Sánchez, Laura ^b,c,d   Campa, Leticia ^b,c   Pilar Cuéllar, Fuencisla ^a,b   Vidal, Rebeca ^a,b,e   Pazos, Angel ^a,b   Adell, Albert ^a,c   Díaz, Álvaro ^a,b  

^a UNIVERSITY OF CANTABRIA   (Spain)

^b CENTRO DE INVESTIGACIÓN BIOMÉDICA EN RED DE SALUD MENTAL CIBERSAM   (Spain)

^c INSTITUT D INVESTIGACIONS BIOMÈDIQUES AUGUST PI I SUNYER IDIBAPS   (Spain)

^d FIB   (Spain)

^e UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

Author keywords

5 HT1A receptor; Antidepressant; Cannabidiol; Glutamate; Olfactory bulbectomy; Serotonin

Indexed keywords

CANNABIDIOL; GLUTAMIC ACID; SEROTONIN; SEROTONIN 1A RECEPTOR; ANTIDEPRESSANT AGENT; ANXIOLYTIC AGENT;

ANHEDONIA; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIDEPRESSANT ACTIVITY; ARTICLE; AUTORADIOGRAPHY; BRAIN REGION; CONTROLLED STUDY; DEPRESSION; DRUG EFFECT; DRUG MECHANISM; EMOTIONALITY; GLUTAMATERGIC NEUROTRANSMISSION; HYPERACTIVITY; IN VIVO STUDY; MALE; MICRODIALYSIS; MOUSE; NEUROCHEMISTRY; NEUROTRANSMISSION; NONHUMAN; OLFACTORY BULBECTOMY; OPEN FIELD TEST; POSTSYNAPTIC INHIBITION; PRESYNAPTIC INHIBITION; PRIORITY JOURNAL; RECEPTOR BLOCKING; SIGNAL TRANSDUCTION; SUCROSE PREFERENCE TEST; TREATMENT DURATION; TREATMENT OUTCOME; VENTROMEDIAL PREFRONTAL CORTEX; ANIMAL; C57BL MOUSE; DISEASE MODEL; DRUG EFFECTS; METABOLISM; OLFACTORY BULB; PREFRONTAL CORTEX; SURGERY; SYNAPTIC TRANSMISSION;

ANIMALS; ANTI-ANXIETY AGENTS; ANTIDEPRESSIVE AGENTS; BEHAVIOR, ANIMAL; CANNABIDIOL; DEPRESSIVE DISORDER; DISEASE MODELS, ANIMAL; GLUTAMIC ACID; MALE; MICE; MICE, INBRED C57BL; OLFACTORY BULB; PREFRONTAL CORTEX; RECEPTOR, SEROTONIN, 5-HT1A; SEROTONIN; SYNAPTIC TRANSMISSION;

EID: 84961344765     PISSN: 00283908     EISSN: 18737064     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2015.12.017     Document Type: Article

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