Cannabinoids Decrease Corticostriatal Synaptic Transmission via an Effect on Glutamate Uptake

Journal of Neuroscience

Volumn 23, Issue 35, 2003, Pages 11073-11077

  Brown, Timothy M ^a   Brotchie, Jonathan M ^a,b   Fitzjohn, Stephen M ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b UNIVERSITY HEALTH NETWORK   (Canada)

Author keywords

Basal ganglia; Cannabinoid; Glutamate; MGluR; Release; Striatum; Tetrahydrocannabinol; Uptake

Indexed keywords

CANNABINOID; CANNABINOID 1 RECEPTOR; GLUTAMATE TRANSPORTER; GLUTAMIC ACID; METABOTROPIC RECEPTOR; TETRAHYDROCANNABINOL;

ANIMAL CELL; ARTICLE; BASAL GANGLION; BRAIN CORTEX; CONTROLLED STUDY; MALE; MOTOR PERFORMANCE; NEUROTRANSMITTER RELEASE; NONHUMAN; PRESYNAPTIC NERVE; PRIORITY JOURNAL; PROTEIN LOCALIZATION; RAT; STRIATE CORTEX; SYNAPTIC MEMBRANE; SYNAPTIC TRANSMISSION;

EID: 0347379832     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.23-35-11073.2003     Document Type: Article

References (24)

1. Anderson WW, Collingridge GL (2001) The LTP Program: a data acquisition program for on-line analysis of long-term potentiation and other synaptic events. J Neurosci Methods 108:71-83.
2. Anwyl R (1999) Metabotropic glutamate receptors: electrophysiological properties and role in plasticity. Brain Res Brain Res Rev 29:83-120.
3. Benjamin AM, Quastel JH (1976) Cerebral uptakes and exchange diffusion in vitro of L- and D-glutamates. J Neurochem 26:431-441.
4. Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248-254.
5. Brasnjo G, Otis TS (2001) Neuronal glutamate transporters control activation of postsynaptic metabotropic glutamate receptors and influence cerebellar long-term depression. Neuron 31:607-616.
6. Chen W, Aoki C, Mahadomrongkul V, Gruber CE, Wang GJ, Blitzblau R, Irwin N, Rosenberg PA (2002) Expression of a variant form of the glutamate transporter GLT1 in neuronal cultures and in neurons and astrocytes in the rat brain. J Neurosci 22:2142-2152.
7. Danbolt NC (2001) Glutamate uptake. Prog Neurobiol 65:1-105.
8. Gerdeman G, Lovinger DM (2001) CB1 cannabinoid receptor inhibits synaptic release of glutamate in rat dorsolateral striatum. J Neurophysiol 85:468-471.
9. Gerdeman GL, Ronesi J, Lovinger DM (2002) Postsynaptic endocannabinoid release is critical to long-term depression in the striatum. Nat Neurosci 5:446-451.
10. Gubellini P, Saulle E, Centonze D, Bonsi P, Pisani A, Bernardi G, Conquet F, Calabresi P (2001) Selective involvement of mGlu1 receptors in corticostriatal LTD. Neuropharmacology 40:839-846.
11. Huang CC, Lo SW, Hsu KS (2001) Presynaptic mechanisms underlying cannabinoid inhibition of excitatory synaptic transmission in rat striatal neurons. J Physiol (Lond) 532:731-748.
12. Kingston AE, Ornstein PL, Wright RA, Johnson BG, Mayne NG, Burnett JP, Belagaje R, Wu S, Schoepp DD (1998) LY341495 is a nanomolar potent and selective antagonist of group II metabotropic glutamate receptors. Neuropharmacology 37:1-12.
13. Kreitzer AC, Regehr WG (2001) Cerebellar depolarization-induced suppression of inhibition is mediated by endogenous cannabinoids. J Neurosci 21:RC174(1-5).
14. Maneuf YP, Nash JE, Crossman AR, Brotchie JM (1996) Activation of the cannabinoid receptor by delta 9-tetrahydrocannabinol reduces gamma-aminobutyric acid uptake in the globus pallidus. Eur J Pharmacol 308:161-164.
15. 3H]-glutamic acid release by dopaminergic drugs. Life Sci 26:2073-2081.
16. Pertwee RG (1997) Pharmacology of cannabinoid CB1 and CB2 receptors. Pharmacol Ther 74:129-180.
17. Pisano P, Samuel D, Nieoullon A, Kerkerian-Le Goff L (1996) Activation of the adenylate cyclase-dependent protein kinase pathway increases high affinity glutamate uptake into rat striatal synaptosomes. Neuropharmacology 35:541-547.
18. Rodriguez de Fonseca F, Del Arco I, Martin-Calderon JL, Gorriti MA, Navarro M (1998) Role of the endogenous cannabinoid system in the regulation of motor activity, Neurobiol Dis 5:483-501.
19. Rodriguez JJ, Mackie K, Pickel VM (2001) Ultrastructural localization of the CB1 cannabinoid receptor in mu-opioid receptor patches of the rat caudate putamen nucleus. J Neurosci 21:823-833.
20. Rouse ST, Marino MJ, Bradley SR, Awad H, Wittmann M, Conn PJ (2000) Distribution and roles of metabotropic glutamate receptors in the basal ganglia motor circuit: implications for treatment of Parkinson's disease and related disorders. Pharmacol Ther 88:427-435.
21. Sjöström PJ, Turrigiano GG, Nelson SB (2003) Neocortical LTD via coincident activation of presynaptic NMDA and cannabinoid receptors. Neuron 39:641-654.
22. Suchak SK, Baloyianni NV, Perkinton MS, Williams RJ, Meldrum BS, Rattray M (2003) The "glial" glutamate transporter, EAAT2 (Glt-1) accounts for high affinity glutamate uptake into adult rodent nerve endings. J Neurochem 84:522-532.
23. Sung KW, Choi S, Lovinger DM (2001) Activation of group I mGluRs is necessary for induction of long-term depression at striatal synapses. J Neurophysiol 86:2405-2412.
24. Wang SJ (2003) Cannabinoid CB(1) receptor-mediated inhibition of glutamate release from rat hippocampal synaptosomes. Eur J Pharmacol 469: 47-55.