Determination of free and glucuronidated kaempferol in rat plasma by LC-MS/MS: Application to pharmacokinetic study

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 878, Issue 23, 2010, Pages 2137-2140

  Zhang, Wei Dong ^a   Wang, Xiao Juan ^a   Zhou, Si Yuan ^a   Gu, Yi ^a   Wang, Rong ^a   Zhang, Tao Li ^a   Gan, Hong Quan ^a  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Genistenin; Kaempferol; LC MS MS; Pharmacokinetic; Quantitative analysis

Indexed keywords

AGLYCONES; ANALYTES; BIOANALYTICAL METHODS; ELECTROSPRAY IONIZATION TANDEM MASS SPECTROMETRY; FLAVANOIDS; GLUCURONIDES; HPLC-MS/MS; INTERNAL STANDARDS; ISOCRATIC ELUTION; KAEMPFEROL; LC-MS/MS; LIQUID-LIQUID EXTRACTION; MOBILE PHASE; MONITORING MODE; ORAL ADMINISTRATION; PHARMACOKINETIC STUDIES; QUANTITATIVE ANALYSIS; RAT PLASMA; VALIDATED METHODS;

ACETONITRILE; DRUG PRODUCTS; ETHERS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IONIZATION; LIQUIDS; MASS SPECTROMETRY; ORGANIC ACIDS; PARTICLE DETECTORS; PHARMACOKINETICS; PLASMA (HUMAN); SOLVENT EXTRACTION;

ELECTROSPRAY IONIZATION;

ACETONITRILE; FORMIC ACID; KAEMPFEROL; GLUCURONIDE; KAEMPFEROL DERIVATIVE;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG DETERMINATION; ELECTROSPRAY MASS SPECTROMETRY; FLOW RATE; FOOD AND DRUG ADMINISTRATION; LIQUID CHROMATOGRAPHY; LIQUID LIQUID EXTRACTION; MASS SPECTROMETRY; NONHUMAN; PRIORITY JOURNAL; RAT; SENSITIVITY AND SPECIFICITY; STANDARD; ANIMAL; BLOOD; CHEMISTRY; DRUG ADMINISTRATION ROUTE; PROCEDURES; TIME;

ANIMALS; CHROMATOGRAPHY, LIQUID; DRUG ADMINISTRATION ROUTES; GLUCURONIDES; KAEMPFEROLS; MASS SPECTROMETRY; RATS; REFERENCE STANDARDS; TIME FACTORS;

RATTUS;

EID: 77955058292     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2010.06.002     Document Type: Article

References (13)

1. Rice-Evans C.A., Miller N.J., Paganga G. Free Radic. Biol. Med 1996, 20:933.
2. Hollman P.C.H., Katan M. Biomed. Pharmacother. 1997, 51:305.
3. Tu Y.C., Lian T.W., Yen J.H., Chen Z.T., Wu M.J. J. Agric. Food Chem. 2007, 55:9969.
4. Trivedi R., Kumar S., Kumar A., Siddiqui J.A., Swarnkar G., Gupta V., Kendurker A., Dwivedi A.K., Romero J.R., Chattopadhyay N. Mol. Cell. Endocrinol. 2008, 289:85.
5. Zhang Y., Chen A.Y., Li M., Chen C., Yao Q. J. Surg. Res. 2008, 148:17.
6. Sharma V., Joseph C., Ghosh S., Agarwal A., Mishra M.K., Sen E. Mol. Cancer Ther. 2007, 6:2544.
7. Lopez-Sanchez C., Martin-Romero F.J., Sun F., Luis L., Samhan-Arias A.K., Garcia-Martinez V., Gutierrez-Merino C. Brain Res. 2007, 1182:123.
8. Hamalainen M., Nieminen R., Vuorela P., Heinonen M., Moilanen E. Mediators Inflamm. 2007, 2007:1.
9. Tian Y., Jiang X.H., Lan K., Yang P. Huaxi Yaoxue Zazhi 2008, 23:357. (in Chinese).
10. Bolarinwa A., Linseisen J. J. Chromatogr. B 2005, 823:143.
11. Ader P., Wessmann A., Wolffram S. Free Radic. Biol. Med. 2000, 28:1056.
12. Qunlin Zhang, Yunjing Zhang, Zhongtang Zhang, Zidong Lu J. Chromatogr. B 2009, 877:3595-3600.
13. U.S. Department of Health and Human Services, Food and Drug Administration, Center for Drug Evaluation and Research, Guidance for Industry, Bioanalytical Method Validation, 2001.