The novel NOX inhibitor 2-acetylphenothiazine impairs collagen-dependent thrombus formation in a GPVI-dependent manner

British Journal of Pharmacology

Volumn 168, Issue 1, 2013, Pages 212-224

  Vara, D ^a   Campanella, M ^b,c   Pula, G ^a  

^a University of Bath   (United Kingdom)

^b ROYAL VETERINARY COLLEGE   (United Kingdom)

^c UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

2 acetylphenothiazine; adhesion; aggregation; dihydroethidium; GPVI; NADPH oxidase; platelet; reactive oxygen species; thrombus formation

Indexed keywords

2 ACETYLPHENOTHIAZINE; 5 CARBOXY 2'7' DICHLORODIHYDROFLUORESCEIN DIACETATE; 6 CARBOXY 2'7' DICHLORODIHYDROFLUORESCEIN DIACETATE; COLLAGEN; COLLAGEN RELATED PEPTIDE; FIBRINOGEN; FLUORESCEIN DERIVATIVE; GLYCOPROTEIN VI; HYDROETHIDINE; INTEGRIN; INTEGRIN ALPHA2BBETA3; PEPTIDE DERIVATIVE; PHENOTHIAZINE DERIVATIVE; PROTEIN KINASE C; PROTEIN KINASE SYK; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; SUPEROXIDE; UNCLASSIFIED DRUG;

ARTICLE; BLOOD CLOTTING; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INHIBITION; HUMAN; HUMAN CELL; IMAGING; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; SINGLE CELL IMAGING; THROMBOCYTE; THROMBOCYTE ADHESION; THROMBOCYTE AGGREGATION;

COLLAGEN; FIBRINOLYTIC AGENTS; HUMANS; MEMBRANE GLYCOPROTEINS; NADPH OXIDASE; PHENOTHIAZINES; PLATELET ACTIVATION; PLATELET ADHESIVENESS; PLATELET AGGREGATION; PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX; PLATELET MEMBRANE GLYCOPROTEINS; SIGNAL TRANSDUCTION; THROMBOSIS;

EID: 84872869398     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2012.02130.x     Document Type: Article

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