The tuberin/mTOR pathway promotes apoptosis of tubular epithelial cells in diabetes

Journal of the American Society of Nephrology

Volumn 22, Issue 2, 2011, Pages 262-273

  Velagapudi, Chakradhar ^a   Bhandari, Basant S ^a   Abboud Werner, Sherry ^a   Simone, Simona ^a,b   Abboud, Hanna E ^a   Habib, Samy L ^a,c  

^a Mays Cancer Center at UT Health San Antonio   (United States)

^b UNIVERSITY OF BARI   (Italy)

^c SOUTH TEXAS VETERANS HEALTH CARE SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; CYTOCHROME C; GLUCOSE; INSULIN; MAMMALIAN TARGET OF RAPAMYCIN; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN BCL 2; TRANSCRIPTION FACTOR YY1; TUBERIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL NUCLEUS; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOPLASM; CYTOSOL; ENZYME ACTIVATION; ENZYME ACTIVITY; HYPERGLYCEMIA; IN VITRO STUDY; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN TREATMENT; KIDNEY CORTEX; KIDNEY TUBULE EPITHELIUM; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; RAT;

EID: 79551670515     PISSN: 10466673     EISSN: 15333450     Source Type: Journal    
DOI: 10.1681/ASN.2010040352     Document Type: Article

References (33)

1. Verzola D, Bertolotto MB, Villaggio B, Ottonello L, Dallegri F, Berruti V, Gandolfo MT, Frumento G, Garibotto G, Defferrari G: Taurine prevents apoptosis induced by high ambient glucose in human tubule renal cells. J Investig Med 50: 443-451, 2002 (Pubitemid 35278685)
2. Allen AD, Harwood SM, Varagunam M, Raftery MJ, Yaqoob MM: High glucose-induced oxidative stress causes apoptosis in proximal tubular epithelial cells and is mediated by multiple caspases. FASEB J 17: 908-921, 2003
3. Liu F, Brezniceanu ML, Wei CC, Chénier I, Sachetelli S, Zhang SL, Filep JG, Ingelfinger JR, Chan JS: Overexpression of angiotensinogen increases tubular apoptosis in diabetes. J Am Soc Nephrol 19: 269-280, 2007
4. Verzola D, Bertolotto MB, Villaggio B, Ottonello L, Dallegri F, Salvatore F, Berruti V, Gandolfo MT, Garibotto G, Defferrari G: Oxidative stress mediates apoptotic changes induced by hyperglycemia in human tubular kidney cells. J Am Soc Nephrol 15: S85-S87, 2004 (Pubitemid 38018463)
5. 1. Kidney Int 59: 1695-1705, 2001
6. Simone S, Gorin Y, Velagapudi C, Abboud HE, Habib SL: Mechanism of oxidative DNA damage in diabetes. Diabetes 57: 2626-2636, 2008
7. Garami A, Zwartkruis FJ, Nobukuni T, Joaquin M, Roccio M, Stocker H, Kozma SC, Hafen E, Bos JL, Thomas G: Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling is inhibited by TSC1 and TSC2. Mol Cell 11: 1457-1466, 2003 (Pubitemid 36776533)
8. Saucedo LJ, Gao X, Chiarelli DA, Li L, Pan D, Edgar BA: Rheb promotes cell growth as a component of the insulin/TOR signaling network. Nat Cell Biol 5: 566-571, 2003
9. Tee AR, Manning BD, Roux PP, Cantley LC, Blenis J: Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb. Curr Biol 13: 1259-1268, 2003
10. Zhang Y, Gao X, Saucedo LJ, Ru B, Edgar BA, Pan D: Rheb is a direct target of the tuberous sclerosis tumor suppressor proteins. Nat Cell Biol 5: 578-581, 2003
11. Kolb TD, Duan L, Davis MA: Tsc2 expression increases the susceptibility of renal tumor cells to apoptosis. Toxicol Sci 88: 331-339, 2005
12. Freilinger A, Rosner M, Krupitza G, Nishino M, Lubec G, Korsmeyer SJ, Hengstschlager M: Tuberin activates the proapoptotic molecule BAD. Oncogene 25: 6467-6479, 2006 (Pubitemid 44607079)
13. Dufner A, Thomas G: Ribosomal S6 kinase signaling and the control of translation. Exp Cell Res 253: 100-109, 1999
14. Calastretti A, Bevilacqua A, Ceriani C, Vigano S, Zancai P, Capaccioli S, Nicolin A: Damaged microtubules can inactivate BCL-2 by means of the mTOR kinase. Oncogene 20: 6172-6180, 2001
15. Cory S, Adams JM: The BCL2 family: Regulators of the cellular life-ordeath switch. Nat Rev Cancer 2: 647-656, 2002
16. Jeong BC, Kwak C, Cho KS, Kim BS, Hong SK, Kim JI, Lee C, Kim HH: Apoptosis induced by oxalate in human renal tubular epithelial HK2 cells. Urol Res 33: 87-92, 2005
17. Nicholson DW, Ali A, Thornberry NA, Vaillancourt JP, Ding CK, Gallant M, Gareau Y, Griffin PR, Labelle M, Lazebnik YA, Munday NA, Raju SM, Smulson ME, Amin TT, Yu Vl, Miller DK: Identification and inhibition of the CED-3 protease necessary for mammalian apoptosis. Nature 376: 37-43, 1995
18. Tewari M, Quan LT, O'Rourke K, Desnoyers S, Zeng Z, Beidler DR, Poirier GG, Salvesen GS, Dixit VM: Yama/CPP32β, a mammalian homolog of CED-3 is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-Ribose) polymerase. Cell 81: 801-809, 1995
19. Rhun YL, Kirklan JB, Shah GM: Cellular responses to DNA damage in the absence of poly(ADP-ribose) polymerase. Biochem Biophys Res Commun 245: 1-10, 1998
20. Soriano FG, Virag L, Jagtap P, Szabo E, Mabley JG, Liaudet L, Marton A, Hoyt DG, Murthy KGK, Salzman A, Southan GJ, Szabo C: Diabetic endothelial dysfunction: The role of poly(ADP-ribose) polymerase activation. Nat Med 7: 108-113, 2001
21. Du X, Matsumura T, Edelstein D, Rossetti L, Zsengeller Z, Szabo C, Brownlee M: Inhibition of GAPDH activity by poly(ADP-ribose) polymerase activates three major pathways of hyperglycemic damage in endothelial cells. J Clin Invest 112: 1049-1057, 2003 (Pubitemid 38056320)
22. Brownlee M: The pathobiology of diabetic complications. Diabetes 54: 1615-1625, 2005
23. Krippner-Heidenreich A, Walsemann G, Beyrouthy MJ, Speckgens S, Kraft R, Thole H, Talanian RV, Hurt MM, Luscher B: Caspase-dependent regulation and subcellular redistribution of the transcriptional modulator YY1 during apoptosis. Molec Cell Biol 25: 3704-3714, 2005 (Pubitemid 40559576)
24. Sekulic A, Hudson CC, Homme JL, Yin P, Otterness DM, Karnitz LM, Abraham RT: A direct linkage between the phosphoinositide 3-kinase-AKT signaling pathway and the mammalian target of rapamycin in mitogen-stimulated and transformed cells. Cancer Res 60: 3504-3513, 2000
25. Chen J, Fang Y: A novel pathway regulating the mammalian target of rapamycin (mTOR) signaling. Biochem Pharmacol 64: 1071-1077, 2002
26. Anita Öst, Kristoffer Svensson, Iida Ruishalme, Cecilia Brännmark, Niclas Franck. Attenuated mTOR signaling and enhanced autophagy in adipocytes from obese patients with type 2 diabetes. Mol Med 16: 235-246, 2010
27. Zhou Z, Wu S, Li X, Xue Z, Tong J: Rapamycin induces autophagy and exacerbates metabolism associated complications in a mouse model of type 1 diabetes. Indian J Exp Biol 48: 31-38, 2010
28. Earnshaw WC, Martins LM, Kaufmann SH: Mammmalian caspases: structure, activation, substrates, and functions during apoptosis. Annu Rev Biochem 68: 383-424, 1999
29. Berger NA: Poly(ADP-ribose) in the cellular response to DNA damage. Radiation Res 101: 4-15, 1985
30. Habib SL, Phan MN, Patel Sk LID, Monks TJ, Lau SS: Reduced constitutive 8-oxoguanine-DNA glycosylase expression and impaired induction following oxidative DNA damage in the tuberin deficient Eker rat. Carcinogenesis 24: 573-582, 2003
31. Bradford MM: A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72: 248-254, 1976
32. Habib SL, Simone S, Barnes JJ, Abboud HE: Tuberin haploinsufficiency is associated with the loss of OGG1 in rat kidney tumors. Molec Cancer 7: 10-14, 2008
33. Habib SL, Riley DJ, Bhandari B, Mahimainathan L, Abboud HE: Tuberin regulates the DNA repair enzyme OGG1. Am J Physiol Renal Physiol 294: F281-F290, 2008