Berberine activates Nrf2 nuclear translocation and protects against oxidative damage via a phosphatidylinositol 3-kinase/Akt-dependent mechanism in NSC34 motor neuron-like cells

European Journal of Pharmaceutical Sciences

Volumn 46, Issue 5, 2012, Pages 415-425

  Hsu, Ya Yun ^a   Chen, Cheng Sheng ^b,c   Wu, Sheng Nan ^d   Jong, Yuh Jyh ^a,b   Lo, Yi Ching ^a,e  

^a KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

^b KAOHSIUNG MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^c KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

^d NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

^e KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

Author keywords

Antioxidant defense; Berberine; Neuroprotection; Nrf2 HO 1; PI3K Akt

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; BERBERINE; HEME OXYGENASE 1; INSULIN RECEPTOR; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN BCL 2; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; SURVIVAL MOTOR NEURON PROTEIN; TRANSCRIPTION FACTOR NRF2;

ANIMAL CELL; ARTICLE; CELL SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; EMBRYO; GENE TRANSLOCATION; MITOCHONDRIAL MEMBRANE; MOTONEURON; MOUSE; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION;

ACTIVE TRANSPORT, CELL NUCLEUS; ANIMALS; ANTIOXIDANTS; APOPTOSIS; BERBERINE; CELL LINE, TUMOR; CHROMONES; CYTOPROTECTION; DOSE-RESPONSE RELATIONSHIP, DRUG; GLUTATHIONE; HEME OXYGENASE-1; HYDROGEN PEROXIDE; MEMBRANE PROTEINS; MICE; MITOCHONDRIA; MORPHOLINES; MOTOR NEURONS; NEUROPROTECTIVE AGENTS; NF-E2-RELATED FACTOR 2; OXIDANTS; OXIDATIVE STRESS; PHOSPHATIDYLINOSITOL 3-KINASE; PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTOR, IGF TYPE 1; RECEPTOR, INSULIN; SIGNAL TRANSDUCTION; SUPEROXIDE DISMUTASE;

EID: 84861189612     PISSN: 09280987     EISSN: 18790720     Source Type: Journal    
DOI: 10.1016/j.ejps.2012.03.004     Document Type: Article

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