Phosphocreatine protects endothelial cells from oxidized low-density lipoprotein-induced apoptosis by modulating the PI3K/Akt/eNOS pathway

Apoptosis

Volumn 20, Issue 12, 2015, Pages 1563-1576

  Ahsan, Anil ^a   Han, Guozhu ^a   Pan, Junfang ^b   Liu, Shumin ^a   Padhiar, Arshad Ahmed ^a   Chu, Peng ^a   Sun, Zhengwu ^a   Zhang, Zonghui ^a   Sun, Bin ^a   Wu, Jingjun ^a   Irshad, Aisha ^c   Lin, Yuan ^a   Peng, Jinyong ^a   Tang, Zeyao ^a  

^a DALIAN MEDICAL UNIVERSITY   (China)

^b Shanghai Huatuo Pharmaceutical Technology Development Limited Company   (China)

^c DALIAN UNIVERSITY   (China)

Author keywords

Akt; Apoptosis; Endothelium; oxLDL; PCR; ROS

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; CASPASE 3; CASPASE 9; CREATINE PHOSPHATE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; FLUORESCENT DYE; LACTATE DEHYDROGENASE; MALONALDEHYDE; NITRIC OXIDE; OXIDIZED LOW DENSITY LIPOPROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; SUPEROXIDE DISMUTASE; 2-(4-MORPHOLINYL)-8-PHENYL-4H-1-BENZOPYRAN-4-ONE; ANTIOXIDANT; CHROMONE DERIVATIVE; LOW DENSITY LIPOPROTEIN; MORPHOLINE DERIVATIVE; NOS3 PROTEIN, HUMAN; PROTECTIVE AGENT;

APOPTOSIS; ARTICLE; ASSAY; CCK ASSAY; CELL DAMAGE; CELL DEATH; CELL GROWTH; CELL PROLIFERATION; CELL PROTECTION; CELL STRUCTURE; CELL SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; ENZYME ACTIVATION; ENZYME ACTIVITY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; MEMBRANE PERMEABILITY; MICROSCOPY; MITOCHONDRIAL MEMBRANE POTENTIAL; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; SPECTROPHOTOMETRY; UMBILICAL VEIN ENDOTHELIAL CELL; WESTERN BLOTTING; CELL LINE; DRUG EFFECTS; METABOLISM;

ANTIOXIDANTS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CASPASE 3; CASPASE 9; CELL LINE; CHROMONES; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; LIPOPROTEINS, LDL; MEMBRANE POTENTIAL, MITOCHONDRIAL; MORPHOLINES; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE III; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHOCREATINE; PROTECTIVE AGENTS; PROTO-ONCOGENE PROTEINS C-AKT; PROTO-ONCOGENE PROTEINS C-BCL-2; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; SUPEROXIDE DISMUTASE;

EID: 84943750753     PISSN: 13608185     EISSN: 1573675X     Source Type: Journal    
DOI: 10.1007/s10495-015-1175-4     Document Type: Article

References (50)

1. Weinberg PD (2004) Rate-limiting steps in the development of atherosclerosis: the response-to-influx theory. J Vasc Res 41(1):1-17
2. Ross R (1999) Atherosclerosis - an inflammatory disease. N Engl J Med 340(2):115-126
3. Hansson GK (2005) Inflammation, atherosclerosis, and coronary artery disease. N Engl J Med 352(16):1685-1695
4. Steinberg D et al (1989) Beyond cholesterol. Modifications of low-density lipoprotein that increase its atherogenicity. N Engl J Med 320(14):915-924
5. Napoli C (2003) Oxidation of LDL, atherogenesis, and apoptosis. Ann N Y Acad Sci 1010:698-709
6. Romano M et al (1998) Ultrastructural localization of secretory type II phospholipase A2 in atherosclerotic and nonatherosclerotic regions of human arteries. Arterioscler Thromb Vasc Biol 18(4):519-525
7. Auge N et al (1999) Role of sphingosine 1-phosphate in the mitogenesis induced by oxidized low density lipoprotein in smooth muscle cells via activation of sphingomyelinase, ceramidase, and sphingosine kinase. J Biol Chem 274(31):21533-21538
8. Salvayre R et al (2002) Oxidized low-density lipoprotein-induced apoptosis. Biochim Biophys Acta 1585(2-3):213-221
9. Cho BB, Toledo-Pereyra LH (2008) Caspase-independent programmed cell death following ischemic stroke. J Invest Surg 21(3):141-147
10. Fulton D et al (1999) Regulation of endothelium-derived nitric oxide production by the protein kinase Akt. Nature 399(6736):597-601
11. Datta SR, Brunet A, Greenberg ME (1999) Cellular survival: a play in three Akts. Genes Dev 13(22):2905-2927
12. Chavakis E et al (2001) Oxidized LDL inhibits vascular endothelial growth factor-induced endothelial cell migration by an inhibitory effect on the Akt/endothelial nitric oxide synthase pathway. Circulation 103(16):2102-2107
13. Huie RE, Padmaja S (1993) The reaction of no with superoxide. Free Radic Res Commun 18(4):195-199
14. Jaffe EA et al (1973) Culture of human endothelial cells derived from umbilical veins. Identification by morphologic and immunologic criteria. J Clin Invest 52(11):2745-2756
15. Spaet TH, Stemerman MB (1972) Platelet adhesion. Ann N Y Acad Sci 201:13-21
16. Stemerman MB, Spaet TH (1972) The subendothelium and thrombogenesis. Bull N Y Acad Med 48(2):289-301
17. Ohta MY et al (2000) Inhibitory effect of troglitazone on TNF-alpha-induced expression of monocyte chemoattractant protein-1 (MCP-1) in human endothelial cells. Diabetes Res Clin Pract 48(3):171-176
18. Fitch CD et al (1968) Creatine metabolism in skeletal muscle. 3. Specificity of the creatine entry process. J Biol Chem 243(8):2024-2027
19. Chambers DJ et al (1996) St. Thomas' Hospital cardioplegia: enhanced protection with exogenous creatine phosphate. Ann Thorac Surg 61(1):67-75
20. Balestrino M et al (2002) Role of creatine and phosphocreatine in neuronal protection from anoxic and ischemic damage. Amino Acids 23(1-3):221-229
21. Wang CB et al (1995) Rapid isolation of large amount of plasma VLDL and LDL by a two step ultracentrifugation. J Tongji Med Univ 15(4):198-200
22. Aviram M, Vaya J (2001) Markers for low-density lipoprotein oxidation. Methods Enzymol 335:244-256
23. Amaravadi R, Thompson CB (2005) The survival kinases Akt and Pim as potential pharmacological targets. J Clin Invest 115(10):2618-2624
24. Mannarino E, Pirro M (2008) Molecular biology of atherosclerosis. Clin Cases Miner Bone Metab 5(1):57-62
25. Resch U et al (2006) Reduction of oxidative stress and modulation of autoantibodies against modified low-density lipoprotein after rosuvastatin therapy. Br J Clin Pharmacol 61(3):262-274
26. Chen CH et al (2000) Oxidized low-density lipoproteins inhibit endothelial cell proliferation by suppressing basic fibroblast growth factor expression. Circulation 101(2):171-177
27. Inoue M et al (2001) Oxidized LDL regulates vascular endothelial growth factor expression in human macrophages and endothelial cells through activation of peroxisome proliferator-activated receptor-gamma. Arterioscler Thromb Vasc Biol 21(4):560-566
28. Kuzuya M et al (2001) VEGF protects against oxidized LDL toxicity to endothelial cells by an intracellular glutathione-dependent mechanism through the KDR receptor. Arterioscler Thromb Vasc Biol 21(5):765-770
29. Jovinge S et al (1996) Human monocytes/macrophages release TNF-alpha in response to Ox-LDL. Arterioscler Thromb Vasc Biol 16(12):1573-1579
30. Erl W, Weber PC, Weber C (1998) Monocytic cell adhesion to endothelial cells stimulated by oxidized low density lipoprotein is mediated by distinct endothelial ligands. Atherosclerosis 136(2):297-303
31. Davignon J, Ganz P (2004) Role of endothelial dysfunction in atherosclerosis. Circulation 109(23 Suppl 1):iii27-iii32
32. Thorin-Trescases N et al (2005) Pathological aging of the vascular endothelium: are endothelial progenitor cells the sentinels of the cardiovascular system? Can J Cardiol 21(12):1019-1024
33. Sun J et al (2007) Mast cells promote atherosclerosis by releasing proinflammatory cytokines. Nat Med 13(6):719-724
34. Chen YH et al (2006) Anti-inflammatory effects of different drugs/agents with antioxidant property on endothelial expression of adhesion molecules. Cardiovasc Hematol Disord Drug Targets 6(4):279-304
35. Lander HM (1997) An essential role for free radicals and derived species in signal transduction. Faseb J 11(2):118-124
36. Chandel NS et al (2000) Role of oxidants in NF-kappa B activation and TNF-alpha gene transcription induced by hypoxia and endotoxin. J Immunol 165(2):1013-1021
37. Roebuck KA (1999) Oxidant stress regulation of IL-8 and ICAM-1 gene expression: differential activation and binding of the transcription factors AP-1 and NF-kappaB (review). Int J Mol Med 4(3):223-230
38. Droge W (2002) Free radicals in the physiological control of cell function. Physiol Rev 82(1):47-95
39. Gauthaman K et al (2001) Effect of chronic treatment with bark of Terminalia arjuna: a study on the isolated ischemic-reperfused rat heart. J Ethnopharmacol 75(2-3):197-201
40. Luo X et al (1998) Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors. Cell 94(4):481-490
41. Sugawara T et al (2004) Neuronal death/survival signaling pathways in cerebral ischemia. NeuroRx 1(1):17-25
42. Hockenbery D et al (1990) Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death. Nature 348(6299):334-336
43. Choy JC et al (2001) Endothelial cell apoptosis: biochemical characteristics and potential implications for atherosclerosis. J Mol Cell Cardiol 33(9):1673-1690
44. Ly JD, Grubb DR, Lawen A (2003) The mitochondrial membrane potential (deltapsi(m)) in apoptosis; an update. Apoptosis 8(2):115-128
45. Dimmeler S et al (1999) Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation. Nature 399(6736):601-605
46. Achan V et al (2003) Asymmetric dimethylarginine causes hypertension and cardiac dysfunction in humans and is actively metabolized by dimethylarginine dimethylaminohydrolase. Arterioscler Thromb Vasc Biol 23(8):1455-1459
47. Ignarro LJ et al (1999) Nitric oxide as a signaling molecule in the vascular system: an overview. J Cardiovasc Pharmacol 34(6):879-886
48. Napoli C et al (2006) Nitric oxide and atherosclerosis: an update. Nitric Oxide 15(4):265-279
49. Mannick JB et al (1999) Fas-induced caspase denitrosylation. Science 284(5414):651-654
50. Hoffmann J et al (2001) Aging enhances the sensitivity of endothelial cells toward apoptotic stimuli: important role of nitric oxide. Circ Res 89(8):709-715