Bcl-2-modifying factor induces renal proximal tubular cell apoptosis in diabetic mice

Diabetes

Volumn 61, Issue 2, 2012, Pages 474-484

  Lau, Garnet J ^a   Godin, Nicolas ^a   Maachi, Hasna ^a   Lo, Chao Sheng ^a   Wu, Shyh Jong ^a   Zhu, Jian Xin ^a   Brezniceanu, Marie Luise ^a   Chénier, Isabelle ^a   Fragasso Marquis, Joelle ^a   Lattouf, Jean Baptiste ^a   Ethier, Jean ^a   Filep, Janos G ^b   Ingelfinger, Julie R ^c   Nair, Viji ^d   Kretzler, Matthias ^d   Cohen, Clemens D ^e   Zhang, Shao Ling ^a   Chan, John S D ^a  

^a CENTRE HOSPITALIER DE L UNIVERSITÉ DE MONTRÉAL   (Canada)

^b MAISONNEUVE ROSEMONT HOSPITAL   (Canada)

^c MASSACHUSETTS GENERAL HOSPITAL   (United States)

^d UNIVERSITY OF MICHIGAN   (United States)

^e UNIVERSITY HOSPITAL ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE; RNA; TRANSFORMING GROWTH FACTOR BETA1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; DIABETIC NEPHROPATHY; DNA MICROARRAY; GENE EXPRESSION; IMMUNOHISTOCHEMISTRY; KIDNEY PROXIMAL TUBULE; KIDNEY TUBULE CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; TRANSGENIC MOUSE;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; APOPTOSIS; CASPASE 3; CELLS, CULTURED; DIABETES MELLITUS, EXPERIMENTAL; HUMANS; IMMUNOHISTOCHEMISTRY; KIDNEY TUBULES, PROXIMAL; MICE; MICE, INBRED C57BL; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PROTO-ONCOGENE PROTEINS C-BCL-2; RATS; REACTIVE OXYGEN SPECIES; REAL-TIME POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 84863082340     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db11-0141     Document Type: Article

References (42)

1. Nangaku M. Mechanisms of tubulointerstitial injury in the kidney: final common pathways to end-stage renal failure. Intern Med 2004;43:9-17 (Pubitemid 38208370)
2. Gilbert RE, Cooper ME. The tubulointerstitium in progressive diabetic kidney disease: more than an aftermath of glomerular injury? Kidney Int 1999;56:1627-1637 (Pubitemid 29518163)
3. Marcussen N. Tubulointerstitial damage leads to atubular glomeruli: significance and possible role in progression. Nephrol Dial Transplant 2000;15(Suppl. 6):74-75
4. Drummond K, Mauer M; International Diabetic Nephropathy Study Group. The early natural history of nephropathy in type 1 diabetes: II. Early renal structural changes in type 1 diabetes. Diabetes 2002;51:1580-1587 (Pubitemid 34826628)
5. Beyenbach KW. Kidneys sans glomeruli. Am J Physiol Renal Physiol 2004;286:F811-F827 (Pubitemid 38508982)
6. Najafian B, Kim Y, Crosson JT, Mauer M. Atubular glomeruli and glomerulotubular junction abnormalities in diabetic nephropathy. J Am Soc Nephrol 2003;14:908-917 (Pubitemid 36359273)
7. Najafian B, Crosson JT, Kim Y, Mauer M. Glomerulotubular junction abnormalities are associated with proteinuria in type 1 diabetes. J Am Soc Nephrol 2006;17(Suppl. 2):S53-S60
8. Han HJ, Lee YJ, Park SH, Lee JH, Taub M. High glucose-induced oxidative stress inhibits Na+/glucose cotransporter activity in renal proximal tubule cells. Am J Physiol Renal Physiol 2005;288:F988-F996 (Pubitemid 40569765)
9. Thevenod F. Nephrotoxicity and the proximal tubule. Insights from cadmium. Nephron Physiol 2003;93:p87-p93
10. Rogers LK, Bates CM, Welty SE, Smith CV. Diquat induces renal proximal tubule injury in glutathione reductase-deficient mice. Toxicol Appl Pharmacol 2006;217:289-298 (Pubitemid 44855814)
11. de Haan JB, Stefanovic N, Nikolic-Paterson D, et al. Kidney expression of glutathione peroxidase-1 is not protective against streptozotocin-induced diabetic nephropathy. Am J Physiol Renal Physiol 2005;289:F544-F551 (Pubitemid 41208469)
12. Zhang Y, Wada J, Hashimoto I, et al. Therapeutic approach for diabetic nephropathy using gene delivery of translocase of inner mitochondrial membrane 44 by reducing mitochondrial superoxide production. J Am Soc Nephrol 2006;17:1090-1101
13. Kumar D, Zimpelmann J, Robertson S, Burns KD. Tubular and interstitial cell apoptosis in the streptozotocin-diabetic rat kidney. Nephron Exp Nephrol 2004;96:e77-e88
14. Kelly DJ, Stein-Oakley A, Zhang Y, et al. Fas-induced apoptosis is a feature of progressive diabetic nephropathy in transgenic (mRen-2)27 rats: attenuation with renin-angiotensin blockade. Nephrology (Carlton) 2004;9:7-13 (Pubitemid 38230524)
15. Susztak K, Ciccone E, McCue P, Sharma K, Böttinger EP. Multiple metabolic hits converge on CD36 as novel mediator of tubular epithelial apoptosis in diabetic nephropathy. PLoS Med 2005;2:e45
16. Kumar D, Robertson S, Burns KD. Evidence of apoptosis in human diabetic kidney. Mol Cell Biochem 2004;259:67-70 (Pubitemid 38519217)
17. Verzola D, Gandolfo MT, Ferrario F, et al. Apoptosis in the kidneys of patients with type II diabetic nephropathy. Kidney Int 2007;72:1262-1272 (Pubitemid 350059668)
18. Hsieh TJ, Zhang SL, Filep JG, Tang SS, Ingelfinger JR, Chan JSD. High glucose stimulates angiotensinogen gene expression via reactive oxygen species generation in rat kidney proximal tubular cells. Endocrinology 2002;143:2975-2985 (Pubitemid 34809870)
19. Hsieh TJ, Fustier P, Zhang S-L, et al. High glucose stimulates angiotensinogen gene expression and cell hypertrophy via activation of the hexosamine biosynthesis pathway in rat kidney proximal tubular cells. Endocrinology 2003;144:4338-4349 (Pubitemid 37204833)
20. Liu F, Brezniceanu M-L, Wei C-C, et al. Overexpression of angiotensinogen increases tubular apoptosis in diabetes. J Am Soc Nephrol 2008;19:269-280 (Pubitemid 351240649)
21. Brezniceanu ML, Liu F, Wei C-C, et al. Catalase overexpression attenuates angiotensinogen expression and apoptosis in diabetic mice. Kidney Int 2007;71:912-923 (Pubitemid 46663797)
22. Brezniceanu M-L, Liu F, Wei CC, et al. Attenuation of interstitial fibrosis and tubular apoptosis in db/db transgenic mice overexpressing catalase in renal proximal tubular cells. Diabetes 2008;57:1-9
23. Ding Y, Davisson RL, Hardy DO, et al. The kidney androgen-regulated protein promoter confers renal proximal tubule cell-specific and highly androgen-responsive expression on the human angiotensinogen gene in transgenic mice. J Biol Chem 1997;272:28142-28148 (Pubitemid 27473625)
24. Ingelfinger JR, Jung F, Diamant D, et al. Rat proximal tubule cell line transformed with origin-defective SV40 DNA: autocrine ANG II feedback. Am J Physiol 1999;276:F218-F227 (Pubitemid 29102286)
25. Vinay P, Gougoux A, Lemieux G. Isolation of a pure suspension of rat proximal tubules. Am J Physiol 1981;241:F403-F411
26. Brezniceanu ML, Wei C-C, Zhang S-L, et al. Transforming growth factor-beta 1 stimulates angiotensinogen gene expression in kidney proximal tubular cells. Kidney Int 2006;69:1977-1985 (Pubitemid 43924261)
27. Smyth GK. Linear models and empirical bayes methods for assessing differential expression in microarray experiments. Stat Appl Genet Mol Biol 2004;3:Article3
28. Smyth GK, Michaud J, Scott HS. Use of within-array replicate spots for assessing differential expression in microarray experiments. Bioinformatics 2005;21:2067-2075 (Pubitemid 40668046)
29. Wettenhall JM, Simpson KM, Satterley K, Smyth GK. affylmGUI: a graphical user interface for linear modeling of single channel microarray data. Bioinformatics 2006;22:897-899
30. Gentleman RC, Carey VJ, Bates DM, et al. Bioconductor: open software development for computational biology and bioinformatics. Genome Biol 2004;5:R80.1-R80.16
31. Wu Z, Irizarry R, Gentleman R, Martinez-Murillo F, Spencer F. A model-based background adjustment for oligonucleotide expression arrays. J Am Stat Assoc 2004;99:909-917 (Pubitemid 39665934)
32. Ashburner M, Ball CA, Blake JA, et al.; The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat Genet 2000;25:25-29 (Pubitemid 30257031)
33. Liu F, Wei CC, Wu SJ, et al. Apocynin attenuates tubular apoptosis and tubulointerstitial fibrosis in transgenic mice independent of hypertension. Kidney Int 2009;75:156-166
34. Cohen CD, Frach K, Schlöndorff D, Kretzler M. Quantitative gene expression analysis in renal biopsies: a novel protocol for a high-throughput multicenter application. Kidney Int 2002;61:133-140 (Pubitemid 34075139)
35. Lindenmeyer MT, Kretzler M, Boucherot A, et al. Interstitial vascular rarefaction and reduced VEGF-A expression in human diabetic nephropathy. J Am Soc Nephrol 2007;18:1765-1776 (Pubitemid 46870313)
36. Schmid H, Boucherot A, Yasuda Y, et al.; European Renal cDNA Bank (ERCB) Consortium. Modular activation of nuclear factor-kappaB transcriptional programs in human diabetic nephropathy. Diabetes 2006;55:2993-3003 (Pubitemid 44923635)
37. Susztak K, Böttinger EP. Diabetic nephropathy: a frontier for personalized medicine. J Am Soc Nephrol 2006;17:361-367
38. Allen DA, Harwood S, Varagunam M, Raftery MJ, Yaqoob MM. High glucose-induced oxidative stress causes apoptosis in proximal tubular epithelial cells and is mediated by multiple caspases. FASEB J 2003;17:908-910
39. Morales AA, Olsson A, Celsing F, Osterborg A, Jondal M, Osorio LM. Expression and transcriptional regulation of functionally distinct Bmf isoforms in B-chronic lymphocytic leukemia cells. Leukemia 2004;18:41-47 (Pubitemid 38159437)
40. Schmelzle T, Mailleux AA, Overholtzer M, et al. Functional role and oncogene-regulated expression of the BH3-only factor Bmf in mammary epithelial anoikis and morphogenesis. Proc Natl Acad Sci USA 2007;104:3787-3792 (Pubitemid 47181532)
41. Ramjaun AR, Tomlinson S, Eddaoudi A, Downward J. Upregulation of two BH3-only proteins, Bmf and Bim, during TGF beta-induced apoptosis. Oncogene 2007;26:970-981
42. Lei K, Davis RJ. JNK phosphorylation of Bim-related members of the Bcl2 family induces Bax-dependent apoptosis. Proc Natl Acad Sci USA 2003;100:2432-2437 (Pubitemid 36297516)