Morin mitigates acetaminophen-induced liver injury by potentiating Nrf2 regulated survival mechanism through molecular intervention in PHLPP2-Akt-Gsk3β axis

Apoptosis

Volumn 20, Issue 10, 2015, Pages 1296-1306

  Rizvi, Fatima ^a,b   Mathur, Alpana ^b   Kakkar, Poonam ^a,b  

^a ACADEMY OF SCIENTIFIC AND INNOVATIVE RESEARCH ACSIR   (India)

^b CSIR INDIAN INSTITUTE OF TOXICOLOGY RESEARCH   (India)

Author keywords

Acetaminophen; Flavonoid; Fyn kinase; Nrf2; Oxidative stress; PHLPP2

Indexed keywords

INTERLEUKIN 1BETA CONVERTING ENZYME; MORIN; PARACETAMOL; PROTEIN KINASE FYN; TRANSCRIPTION FACTOR NRF2; ANALGESIC AGENT; ANTIOXIDANT; FLAVONOID; GLYCOGEN SYNTHASE KINASE 3; GLYCOGEN SYNTHASE KINASE 3 BETA; NFE2L2 PROTEIN, RAT; PHLPP2 PROTEIN, RAT; PHOSPHOPROTEIN PHOSPHATASE; PLANT EXTRACT; PROTEIN KINASE B;

ACETAMINOPHEN INDUCED LIVER INJURY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; EARLY INTERVENTION; LIVER INJURY; LIVER TOXICITY; MALE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; UBIQUITINATION; ANIMAL; DRUG EFFECTS; DRUG-INDUCED LIVER INJURY; INFLAMMATION; LIVER; METABOLISM; MITOCHONDRION; PATHOLOGY; SIGNAL TRANSDUCTION; WISTAR RAT;

ACETAMINOPHEN; ANALGESICS, NON-NARCOTIC; ANIMALS; ANTIOXIDANTS; DRUG-INDUCED LIVER INJURY; FLAVONOIDS; GLYCOGEN SYNTHASE KINASE 3; INFLAMMATION; LIVER; MALE; MITOCHONDRIA; NF-E2-RELATED FACTOR 2; OXIDATIVE STRESS; PHOSPHOPROTEIN PHOSPHATASES; PLANT EXTRACTS; PROTO-ONCOGENE PROTEINS C-AKT; RATS, WISTAR; SIGNAL TRANSDUCTION;

EID: 84941258906     PISSN: 13608185     EISSN: 1573675X     Source Type: Journal    
DOI: 10.1007/s10495-015-1160-y     Document Type: Article

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