Heterotypic seeding of Tau fibrillization by pre-aggregated Abeta provides potent seeds for prion-like seeding and propagation of Tau-pathology in vivo

Acta Neuropathologica

Volumn 131, Issue 4, 2016, Pages 549-569

  Vasconcelos, Bruno ^a   Stancu, Ilie Cosmin ^a   Buist, Arjan ^b   Bird, Matthew ^a   Wang, Peng ^a   Vanoosthuyse, Alexandre ^a   Van Kolen, Kristof ^b   Verheyen, An ^b   Kienlen Campard, Pascal ^a   Octave, Jean Noël ^a   Baatsen, Peter ^c   Moechars, Diederik ^b   Dewachter, Ilse ^a  

^a UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

^b JANSSEN RESEARCH AND DEVELOPMENT   (Belgium)

^c UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

Alzheimer s disease; Amyloid beta; Heterotypic seeding; Prion like; Tau

Indexed keywords

ALPHA SYNUCLEIN; AMYLOID BETA PROTEIN; TAU PROTEIN; GREEN FLUORESCENT PROTEIN; PRESENILIN 1; PRION PROTEIN; PSEN1 PROTEIN, HUMAN;

ALZHEIMER DISEASE; ARTICLE; CONTROLLED STUDY; ENTORHINAL CORTEX; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LOCUS CERULEUS; MOUSE; NONHUMAN; PATHOGENESIS; PRION; PRIORITY JOURNAL; PROTEIN AGGREGATION; WESTERN BLOTTING; ANALYSIS OF VARIANCE; ANIMAL; CHEMICALLY INDUCED; DISEASE MODEL; GENETIC TRANSFECTION; GENETICS; HEK293 CELL LINE; IMMUNOHISTOCHEMISTRY; METABOLISM; MUTATION; PATHOLOGY; PROTEINOSIS; TAUOPATHY; TRANSGENIC MOUSE; ULTRASTRUCTURE;

AMYLOID BETA-PEPTIDES; ANALYSIS OF VARIANCE; ANIMALS; DISEASE MODELS, ANIMAL; GREEN FLUORESCENT PROTEINS; HEK293 CELLS; HUMANS; IMMUNOHISTOCHEMISTRY; MICE, TRANSGENIC; MUTATION; PRESENILIN-1; PRION PROTEINS; PROTEIN AGGREGATION, PATHOLOGICAL; TAU PROTEINS; TAUOPATHIES; TRANSFECTION;

EID: 84961120503     PISSN: 00016322     EISSN: 14320533     Source Type: Journal    
DOI: 10.1007/s00401-015-1525-x     Document Type: Article

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