Templated misfolding of Tau by prion-like seeding along neuronal connections impairs neuronal network function and associated behavioral outcomes in Tau transgenic mice

Acta Neuropathologica

Volumn 129, Issue 6, 2015, Pages 875-894

  Stancu, Ilie Cosmin ^a   Vasconcelos, Bruno ^a   Ris, Laurence ^b   Wang, Peng ^a   Villers, Agnès ^b   Peeraer, Eve ^c   Buist, Arjan ^c   Terwel, Dick ^d   Baatsen, Peter ^e   Oyelami, Tutu ^c   Pierrot, Nathalie ^a   Casteels, Cindy ^f   Bormans, Guy ^f   Kienlen Campard, Pascal ^a   Octave, Jean Nöel ^a   Moechars, Diederik ^c   Dewachter, Ilse ^a  

^a UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

^b UNIVERSITY OF MONS   (Belgium)

^c JANSSEN RESEARCH AND DEVELOPMENT   (Belgium)

^d reMYND   (Belgium)

^e UNIVERSITY OF LEUVEN   (Belgium)

^f KU Leuven   (Belgium)

Author keywords

AD; Cognition; Motoric deficits; Neuronal network; Prion like propagation; Synaptic; Tau; Tau pathology; Tauopathies; TauP301 heterogeneity

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR STIMULATING AGENT; PRION PROTEIN; TAU PROTEIN; CALCIUM; FURA 2; FURA-2-AM; PRION;

AMYGDALOID NUCLEUS; ANIMAL BEHAVIOR; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BASAL GANGLION; BRAIN REGION; CALCIUM SIGNALING; COGNITION; CONNECTOME; CONTROLLED STUDY; DISEASE COURSE; ELECTROPHYSIOLOGY; ENTORHINAL CORTEX; EX VIVO STUDY; FRONTAL CORTEX; GLUCOSE METABOLISM; GRIP STRENGTH; HEK293 CELL LINE; HIPPOCAMPAL CA1 REGION; HIPPOCAMPUS; IMMUNOGOLD ELECTRON MICROSCOPY; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; LIMIT OF DETECTION; LONG TERM POTENTIATION; MOTOR CONTROL; MOTOR COORDINATION; MOTOR CORTEX; MOUSE; NERVE CELL NETWORK; NERVE CELL PLASTICITY; NEUROFIBRILLARY TANGLE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN FOLDING; SUBICULUM; SYNAPTIC TRANSMISSION; TASK PERFORMANCE; TAUOPATHY; THALAMUS; TRANSGENIC MOUSE; ANALOGS AND DERIVATIVES; ANIMAL; C57BL MOUSE; COGNITION DISORDERS; CYTOLOGY; DISEASE MODEL; EXPLORATORY BEHAVIOR; GENETICS; MEMBRANE POTENTIAL; METABOLISM; MUTATION; NEWBORN; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; PRION; PROTEOSTASIS DEFICIENCY; ULTRASTRUCTURE;

ANIMALS; ANIMALS, NEWBORN; CALCIUM; COGNITION DISORDERS; DISEASE MODELS, ANIMAL; EXPLORATORY BEHAVIOR; FURA-2; HIPPOCAMPUS; IN VITRO TECHNIQUES; MEMBRANE POTENTIALS; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MUTATION; NERVE NET; NEUROFIBRILLARY TANGLES; PRIONS; PROTEOSTASIS DEFICIENCIES; TAU PROTEINS; TAUOPATHIES;

EID: 84929707383     PISSN: 00016322     EISSN: 14320533     Source Type: Journal    
DOI: 10.1007/s00401-015-1413-4     Document Type: Article

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