Intracerebral injection of preformed synthetic tau fibrils initiates widespread tauopathy and neuronal loss in the brains of tau transgenic mice

Neurobiology of Disease

Volumn 73, Issue , 2015, Pages 83-95

  Peeraer, Eve ^a   Bottelbergs, Astrid ^a   Van Kolen, Kristof ^a   Stancu, Ilie Cosmin ^b   Vasconcelos, Bruno ^b   Mahieu, Michel ^a   Duytschaever, Hilde ^a   Ver Donck, Luc ^a   Torremans, An ^c   Sluydts, Ellen ^c   Van Acker, Nathalie ^c   Kemp, John A ^a   Mercken, Marc ^a   Brunden, Kurt R ^d   Trojanowski, John Q ^d   Dewachter, Ilse ^b   Lee, Virginia M Y ^d   Moechars, Diederik ^a  

^a JANSSEN RESEARCH AND DEVELOPMENT   (Belgium)

^b UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

^c HistoGeneX NV   (Belgium)

^d UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Cell death; Seeding; Spreading; Tau pathology

Indexed keywords

TAU PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN NERVE CELL; BRAIN REGION; CELL LOSS; CONTROLLED STUDY; FRONTAL CORTEX; HIPPOCAMPAL CA1 REGION; IN VIVO STUDY; MOUSE; NEUROPATHOLOGY; NONHUMAN; PROTEIN AGGREGATION; PROTEIN PHOSPHORYLATION; TAUOPATHY; TRANSGENIC MOUSE; AGE; ANALYSIS OF VARIANCE; ANIMAL; CHEMICALLY INDUCED; CHEMISTRY; DISEASE COURSE; DISEASE MODEL; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; HEMISPHERIC DOMINANCE; HIPPOCAMPUS; HUMAN; METABOLISM; MUTATION; NEUROFIBRILLARY TANGLE; PATHOLOGY;

AGE FACTORS; ANALYSIS OF VARIANCE; ANIMALS; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; FUNCTIONAL LATERALITY; GENE EXPRESSION REGULATION; HIPPOCAMPUS; HUMANS; MICE; MICE, TRANSGENIC; MUTATION; NEUROFIBRILLARY TANGLES; TAU PROTEINS; TAUOPATHIES;

EID: 84908430607     PISSN: 09699961     EISSN: 1095953X     Source Type: Journal    
DOI: 10.1016/j.nbd.2014.08.032     Document Type: Article

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