Lingonberries (Vaccinium vitis-idaea L) and blueberries (Vaccinium corymbosum) contain discrete epicatechin anthocyanin derivatives linked by ethyl bridges

Journal of Berry Research

Volumn 6, Issue 1, 2016, Pages 13-23

  Brown, Emma ^b   Gill, Chris ^b   Stewart, Derek ^a,c   McDougall, Gordon ^a  

^a SCOTTISH CROP RESEARCH INSTITUTE   (United Kingdom)

^b UNIVERSITY OF ULSTER   (United Kingdom)

^c HERIOT WATT UNIVERSITY   (United Kingdom)

Author keywords

Anthocyanins; berries; LCMSn; proanthocyanidins; Vaccinium

Indexed keywords

EID: 84960963779     PISSN: 18785093     EISSN: 18785123     Source Type: Journal    
DOI: 10.3233/JBR-150108     Document Type: Article

References (33)

1. Ek S, Kartimo H, Mattila S, Tolonen A. Characterization of phenolic compounds from lingonberry (Vaccinium vitis-idaea). J Agric Food Chem. 2006;54:9834-42.
2. Mane C, Loonis M, Juhel C, Dufour C, Malien-Aubert C. Food grade lingonberry extract: Polyphenolic composition and in vivo protective effect against oxidative stress. J Agric Food Chem. 2011;59:3330-9.
3. Zheng W, Wang SY. Oxygen radical absorbing capacity of phenolics in blueberries, cranberries, chokeberries, and lingonberries. J Agric Food Chem. 2003;51:502-9.
4. Seeram NP. Berry fruits for cancer prevention: Current status and future prospects. J Agric Food Chem. 2008;56:630-5.
5. Brown EM, McDougall GJ, Stewart D, Pereira-Caro G, Gonzalez-Barrio R, Allsopp P, Magee P, Crozier A, Rowland I, Gill CIR. Persistence of anticancer activity in berry extracts after simulated gastrointestinal digestion and colonic fermentation. PLoS One. 2012;7:1-10.
6. Brown EM, Latimer C, Allsopp P, Ternan NG, McMullan G, McDougall GJ, Stewart D, Crozier A, Rowland I, Gill CIR. In vitro and in vivo models of colorectal cancer: Antigenotoxic activity of berries. J Agric Food Chem. 2014;62:3852-66.
7. Olsson ME, Gustavsson KE, Andersson S, Nilsson A, Duan RD. Inhibition of cancer cell proliferation in vitro by fruit and berry extracts and correlations with antioxidant levels. J Agric Food Chem. 2004;52:7264-71.
8. Wu QK, Koponen JM, Mykkänen HM, Törrönen AR. Berry phenolic extracts modulate the expression of p21(WAF1) and Bax but not Bcl-2 in HT-29 colon cancer cells. J Agric Food Chem. 2007;55:1156-63.
9. McDougall GJ, Ross HA, Ikeji M, Stewart D. Berry extracts exert different antiproliferative effects against cervical and colon cancer cells grown in vitro. J Agric Food Chem. 2008;56:3016-23.
10. Misikangas M, Pajari AM, Päivärinta E, Oikarinen SI, Rajakangas J, Marttinen M, Tanayama H, Törrönen R, Mutanen M. Three Nordic berries inhibit intestinal tumorigenesis in multiple intestinal neoplasia/+ mice by modulating beta-catenin signaling in the tumor and transcription in the mucosa. J Nutr. 2007;137:2285-90.
11. Heyman L, Axling U, Blanco N, Sterner O, Holm C, Berger K. Evaluation of beneficial metabolic effects of berries in high-fat fed C57BL/6J mice. J Nutrition & Metab. 2014;17. article 403041.
12. Kivimaki AS, Siltari A, Ehlers P, Korpela R, Vapaatalo H. Lingonberry juice lowers blood pressure of spontaneously hypertensive rats (SHR). J Functional Foods. 2013;5:1432-40.
13. Torronen R, Kolehmainen M, Sarkkinen E, Mykkanen H, Niskanen L. Postprandial glucose, insulin, and free fatty acid responses to sucrose consumed with blackcurrants and lingonberries in healthy women. Amer J Clin Nutr. 2012;96:527-33.
14. McDougall GJ, Kulkarni NN, Stewart D. Berry polyphenols inhibit pancreatic lipase activity in vitro. Food Chem. 2009;115:193-9.
15. Toivanen M, Huttunen S, Lapinjoki S, Tikkanen-Kaukanen C. Inhibition of adhesion of Neisseria meningitidis to human epithelial cells by berry juice polyphenolic fractions. Phytother Res. 2011;25:828-32.
16. Howell AB. Cranberry proanthocyanidins and the maintenance of urinary tract health. Crit Rev Food Sci Nutr. 2002;42:273-8.
17. Kontiokari T, Sundqvist K, Nuutinen M, Pokka T, Koskela M, Uhari M. Randomised trial of cranberry-lingonberry juice and Lactobacillus GG drink for the prevention of urinary tract infections in women. Brit Med J. 2001;322:1571-3.
18. Jepson RG, Williams G, Craig JC. Cranberries for preventing urinary tract infections. Cochrane Database Syst Rev. 2012;17:10:CD001321. doi: 10.1002/14651858.CD001321.pub5
19. Davidson E, Zimmermann BF, Jungfer E, Chrubasik-Hausmann S. Prevention of urinary tract infections with Vaccinium products. Phytother Res. 2014;28:465-70.
20. Howell AB, Reed JD, Krueger CG, Winterbottom R, Cunningham DG, Leahy M. A-type cranberry proanthocyanidins and uropathogenic bacterial anti-adhesion activity. Phytochemistry. 2005;66:2281-91.
21. Brown EM, Nitecki S, Pereira-Caro G, McDougall GJ, Stewart D, Rowland I, Crozier A, Gill CIR. Comparison of in vivo and in vitro digestion on polyphenol composition in lingonberries: Potential impact on colonic health. Biofactors. 2014;40:611-23.
22. Deighton N, Brennan R, Finn C, Davies HV. Antioxidant properties of domesticated and wild Rubus species. J Sci Food Agric. 2000;80:1307-13.
23. Hellström JK, Mattila PH. HPLC determination of extractable and unextractable proanthocyanidins in plant materials. J Agric Food Chem. 2008;56:7617-24.
24. Andersen, ØM. Chromatographic separation of anthocyanins in cowberry (Lingonberry, Vaccinium vitis-idaea L). J Food Sci. 1985;50:1230-2.
25. Cho MJ, Howard LR, Prior RL, Clark JR. Flavonoid glycosides and antioxidant capacity of various blackberry, blueberry and red grape genotypes determined by high-performance liquid chromatography/mass spectrometry. J Sci Food Agric. 2004;84:1771-82.
26. Tarascou I, Mazauric JP, Meudec E, Souquet JM, Cunningham D, Nojeim S, Cheynier V, Fulcrand H. Characterisation of genuine and derived cranberry proanthocyanidins by LC-ESI-MS. Food Chemistry. 2011;128:802-10.
27. Krueger CG, Vestling MM, Reed JD. Matrix-assisted laser desorption-ionization time-of-flight mass spectrometry of anthocyaninpoly-flavan-3-ol oligomers in cranberry fruit (Vaccinium macrocarpon, Ait.) and spray-dried cranberry juice. In: Red Wine Colour, ACS Symposium Series 886. American Chemical Society, 2004, pp. 232-46.
28. Reed JD, Krueger CG,VestlingMM.MALDI-TOFmass spectrometry of oligomeric food polyphenols. Phytochemistry. 2005;66:2248-63.
29. McDougall GJ, Shpiro F, Dobson P, Smith P, Blake A, Stewart D. Different polyphenolic components of soft fruits inhibit β-amylase and β-glucosidase. J Agric Food Chem. 2005;53:2760-66.
30. Yousef GG, Brown AF, Funakoshi Y, Mbeunkui F, Grace MH, Ballington JR, Loraine A, Lila MA. Efficient quantification of the health-relevant anthocyanin and phenolic acid profiles in commercial cultivars and breeding selections of blueberries (Vaccinium spp.). J Agric Food Chem. 2013;61:4806-15.
31. Timberlake CF, Bridle P. Interactions between anthocyanins, phenolic compounds, and acetaldehyde and their significance in red wines. Amer J Enol Vitic. 1976;27:97-105.
32. Shoji T, Goda Y, Toyoda M, Yanagida A, Kanda T. Characterization and structures of anthocyanin pigments generated in rosé cider during vinification. Phytochemistry. 2002;59:183-9.
33. Mateus N, Silva AM, Santos-Buelga C, Rivas-Gonzalo JC, de Freitas V. Identification of anthocyanin-flavanol pigments in red wines by NMR and mass spectrometry. J Agric Food Chem. 2002;50:2110-6.