Berry phenolic extracts modulate the expression of p21WAF1 and Bax but Not Bcl-2 in HT-29 colon cancer cells

Journal of Agricultural and Food Chemistry

Volumn 55, Issue 4, 2007, Pages 1156-1163

  Wu, Quoc K ^a   Koponen, Jani M ^a   Mykkänen, Hannu M ^a   Törrönen, A Ritta ^a  

^a UNIVERSITY OF EASTERN FINLAND   (Finland)

Author keywords

Anthocyanins; Antiproliferation; Bax; Bcl 2; Bilberry; Black currant; Cell cycle arrest; Cell growth; Cloudberry; Colon cancer; HT 29; Lingonberry; p21WAF1; Phenolic compounds; Raspberry; Strawberry

Indexed keywords

FRAGARIA X ANANASSA; RIBES HUDSONIANUM; RUBUS CHAMAEMORUS; RUBUS GLAUCUS; VACCINIUM MYRTILLUS; VACCINIUM VITIS-IDAEA;

BAX PROTEIN, HUMAN; CDKN1A PROTEIN, HUMAN; CYCLIN DEPENDENT KINASE INHIBITOR 1A; DNA FRAGMENT; MESSENGER RNA; PHENOL DERIVATIVE; PROTEIN BAX; UNCLASSIFIED DRUG;

ARTICLE; CELL DIVISION; CELL STRAIN HT29; CHEMISTRY; COLON TUMOR; DRUG EFFECT; FRUIT; GENE EXPRESSION; GENETICS; HUMAN; METABOLISM; PATHOLOGY; PROTO ONCOGENE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

BCL-2-ASSOCIATED X PROTEIN; CELL DIVISION; COLONIC NEOPLASMS; CYCLIN-DEPENDENT KINASE INHIBITOR P21; DNA FRAGMENTATION; FRUIT; GENE EXPRESSION; GENES, BCL-2; HT29 CELLS; HUMANS; PHENOLS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 34249863077     PISSN: 00218561     EISSN: None     Source Type: Journal    
DOI: 10.1021/jf062320t     Document Type: Article

References (39)

1. Giovannucci, E.; Willett, W. C. Dietary factors and risk of colon cancer. Ann. Med. 1994, 26, 443-452.
2. World Cancer Research Fund. Food, Nutrition and the Prevention of Cancer: a Global Perspective; World Cancer Research Fund and American Institute for Cancer Research: Washington, DC, 1997.
3. Surh, Y. J. Cancer chemoprevention with dietary phytochemicals. Nat. Rev. Cancer 2003, 3, 768-780.
4. Kang, S. Y.; Seeram, N. P.; Nair, M. G.; Bourquin, L. D. Tart cherry anthocyanins inhibit tumor development in Apc(Min) mice and reduce proliferation of human colon cancer cells. Cancer Lett. 2003, 194, 13-19.
5. Katsube, N.; Iwashita. K.; Tsushida. T.; Yamaki, K.; Kobori, M. Induction of apoptosis in cancer cells by bilberry (Vaccinium myrtillus) and the anthocyanins. J. Agric. Food Chem. 2003, 51, 68-75.
6. Weyant, M. J.; Carothers, A. M.; Dannenberg, A. J.; Bertagnolli, M. M. (+)-Catechin inhibits intestinal tumor formation and suppresses focal adhesion kinase activation in the min/+ mouse. Cancer Res. 2001, 61, 118-125.
7. Häkkinen, S.; Heinonen, M.; Kärenlampi, S.; Mykkänen, H.; Ruuskanen, J.; Törrönen, R. Screening of selected flavonoids and phenolic acids in 19 berries. Food Res. Int. 1999, 32, 345-353.
8. Häkkinen, S. H.; Kärenlampi, S. O.; Heinonen, I. M.; Mykkänen, H. M.; Törrönen, A. R. Content of the flavonols quercetin, myricetin, and kaempferol in 25 edible berries. J. Agric. Food Chem. 1999, 47, 2274-2279.
9. Häkkinen, S. H.; Kärenlampi, S. O.; Mykkänen, H. M.; Heinonen, I. M.; Törrönen, A. R. Ellagic acid content in berries: Influence of domestic processing and storage. Eur. Food Res. Technol. 2000, 212, 75-80.
10. Määttä-Riihinen, K. R.; Kamal-Eldin, A.; Mattila, P. H.; Gonzáles-Paramás, A. M.; Törrönen, A. R. Distribution and contents of phenolic compounds in 18 Scandinavian berry species. J. Agric. Food Chem. 2004, 52, 4477-4486.
11. Määttä-Riihinen, K. R.; Kamal-Eldin, A.; Törrönen, A. R. Identification and quantification of phenolic compounds in berries of Fragaria and Rubus species (family Rosaceae). J. Agric. Food Chem. 2004, 52, 6178-6187.
12. Malik, M.; Zhao, C.; Schoene, N.; Guisti, M. M.; Moyer, M. P.; Magnuson, B. A. Anthocyanin-rich extract from Aronia meloncarpa E induces a cell cycle block in colon cancer but not normal colonic cells. Nutr. Cancer 2003, 46, 186-196.
13. Zhao, C.; Giusti, M. M.; Malik, M.: Moyer, M. P.; Magnuson, B. A. Effects of commercial anthocyanin-rich extracts on colonic cancer and nontumorigenic colonic cell growth. J. Agric. Food Chem. 2004, 52, 6122-6128.
14. Seeram, N. P.; Adams, L. S.; Hardy, M. L.; Heber, D. Total cranberry extract versus its phytochemical constituents: antiproliferative and synergistic effects against human tumor cell lines. J. Agric. Food Chem. 2004, 52, 2512-2517.
15. Ferguson, P. J.; Kurowska, E.; Freeman, D. J.; Chambers, A. F.; Koropatnick, D. J. A flavonoid fraction from cranberry extract inhibits proliferation of human tumor cell lines. J. Nutr. 2004, 134, 1529-1535.
16. Lazze, M. C.; Savio, M.; Pizzala, R.; Cazzalini, O.; Perucca, P.; Scovassi, A. I.; Stivala, L. A.; Bianchi, L. Anthocyanins induce cell cycle perturbations and apoptosis in different human cell lines. Carcinogenesis 2004, 25, 1427-1433.
17. Cory, S.; Adams, J. M. The Bcl2 family: regulators of the cellular life-or-death switch. Nat. Rev. Cancer 2002, 2, 647-656.
18. Weinberg, W. C.; Denning, M. F. P21Wafl control of epithelial cell cycle and cell fate. Crit. Rev. Oral Biol. Med. 2002, 13, 453-464.
19. Cabrera, C.; Giménez, R.; López, M. C. Determination of tea components with antioxidant activity. J. Agric. Food Chem. 2003, 51, 4427-4435.
20. Kähkönen, M. P.; Hopia, A. I.: Heinonen, M. Berry phenolics and their antioxidant activity. J. Agric. Food Chem. 2001, 49, 4076-4082.
21. Baj, A.; Bombardelli, E.; Gabetta, B.; Martinelli, E. Qualitative and quantitative evaluation of Vaccinium myrtillus anthocyanins by high-resolution gas chromatography and high-performance liquid chromatography. J. Chromatogr. 1983, 279, 365-372.
22. Kalt, W.; McDonald, J.; Ricker, R.; Lu, X. Anthocyanin content and profile within and among blueberry species. Can. J. Plant Sci. 1999, 79, 617-623.
23. Slimestad, R.; Solheim, H. Anthocyanins from black currants (Ribes nigrum L.). J. Agric. Food Chem. 2002, 50, 3228-3231.
24. Ichiyanagi, T.; Hatano, Y.; Matsugo, S.; Konishi, T. Structural dependence of HPLC separation pattern of anthocyanins from bilberry (Vaccinium myrtillus L.). Chem. Pharm. Bull. (Tokyo) 2004, 52, 628-630.
25. Määttä, K.; Kamal-Eldin, A.; Törrönen, R. Phenolic compounds in berries of black, red, green, and white currants (Ribes sp.). Antioxid. Redox. Signal. 2001, 3, 981-993.
26. Määttä, K. R.; Kamal-Eldin, A.; Törrönen, A. R. High-performance liquid chromatography (HPLC) analysis of phenolic compounds in berries with diode array and electrospray ionization mass spectrometric (MS) detection: Ribes species. J. Agric. Food Chem. 2003, 51, 6736-6744.
27. Yi. W.; Fischer, J.; Akoh, C. C. Study of anticancer activities of muscadine grape phenolics in vitro. J. Agric. Food Chem. 2005, 53, 8804-8812.
28. Zhang, Y.; Vareed, S. K.; Nair, M. G. Human tumor cell growth inhibition by nontoxic anthocyanidins, the pigments in fruits and vegetables. Life Sci. 2005, 76, 1465-1472.
29. Olsson, M. E.; Gustavsson, K. E.; Andersson, S.; Nilsson, A.; Duan, R. D. Inhibition of cancer cell proliferation in vitro by fruit and berry extracts and correlations with antioxidant levels. J. Agric. Food Chem. 2004, 52, 7264-7271.
30. Seeram, N. P.; Adams, L. S.: Henning. S. M.; Niu. Y.: Zhang, Y.; Nah, M. G.; Heber, D. In vitro antiproliferative, apoptotic and antioxidant activities of punicalagin, ellagic acid and a total pomegranate tannin extract are enhanced in combination with other polyphenols as found in pomegranate juice. J. Nutr. Biochem. 2005, 16, 360-367.
31. Liu, M.; Li, X. Q.; Weber, C.; Lee, C. Y.; Brown, J.; Liu, R. H. Antioxidant and antiproliferative activities of raspberries. J. Agric. Food Chem. 2002, 50, 2926-2930.
32. Manthey, J. A.; Guthrie, N. Antiproliferative activities of citrus flavonoids against six human cancer cell lines. J. Agric. Food Chem. 2002, 50, 5837-5843.
33. Kim, W. K; Bang, M. H.; Kim, E. S.; Kang, N. E.; Jung, K. C.; Cho, H. J.; Park, J. H. Quercetin decreases the expression of ErbB2 and ErbB3 proteins in HT-29 human colon cancer cells. J. Nutr. Biochem. 2005, 16, 155-162.
34. Alia, M.; Mateos, R.; Ramos, S.; Lecumberri, E.; Bravo, L.; Goya, L. Influence of quercetin and rutin on growth and antioxidant defense system of a human hepatoma cell line (HepG2). Eur. J. Nutr. 2006, 45, 19-28.
35. Han, C.; Ding, H.; Casto, B.; Stoner, G. D.; D'Ambrosio, S. M. Inhibition of the growth of premalignant and malignant human oral cell lines by extracts and components of black raspberries. Nutr. Cancer 2005, 51, 207-217.
36. Ramos, S.; Alia, M.; Bravo, L.; Goya, L. Comparative effects of food-derived polyphenols on the viability and apoptosis of a human hepatoma cell line (HepG2). J. Agric. Food Chem. 2005, 53, 1271-1280.
37. Narayanan, B. A.; Geoffroy. O.; Willingham, M. C.; Re. G. G.; Nixon, D. W. p53/p21(WAFl/C!Pl) expression and its possible role in Gl arrest and apoptosis in ellagic acid treated cancer cells. Cancer Lett. 1999, 136, 215-221.
38. Li, T. M.; Chen, G. W.: Su, C. C.; Lin, J. G.; Yeh, C. C.; Cheng, K. C.; Chung, J. G. Ellagic acid induced p53/p21 expression, Gl arrest and apoptosis in human bladder cancer T24 cells. Anticancer Res. 2005, 25, 971-979.
39. Yu. Z.; Li, W.; Liu. F. Inhibition of proliferation and induction of apoptosis by genistein in colon cancer HT-29 cells. Cancer Lett. 2004, 215, 159-166.