Comparison of in vivo and in vitro digestion on polyphenol composition in lingonberries: Potential impact on colonic health

BioFactors

Volumn 40, Issue 6, 2014, Pages 611-623

  Brown, Emma M ^a   Nitecki, Sonja ^a   Pereira Caro, Gema ^b   Mcdougall, Gordon J ^c   Stewart, Derek ^c   Rowland, Ian ^d   Crozier, Alan ^b   Gill, Chris I R ^a  

^a UNIVERSITY OF ULSTER   (United Kingdom)

^b UNIVERSITY OF GLASGOW   (United Kingdom)

^c SCOTTISH CROP RESEARCH INSTITUTE   (United Kingdom)

^d UNIVERSITY OF READING   (United Kingdom)

Author keywords

(poly)phenol; Anti genotoxic; Colorectal cancer; Digestion; Ileostomy; Lingonberry

Indexed keywords

3 (PHENYL)PROPIONIC ACID; 4 HYDROXYBENZOIC ACID; 4' HYDROXYPHENYLACETIC ACID; ANTHOCYANIN; ANTIMUTAGENIC AGENT; ANTITOXIN; COUMARIC ACID; CYANIDIN 3 ARABINOSIDE; CYANIDIN 3 GLUCOSIDE; CYANIDIN 3 O (6'' O ACETYL)GLUCOSIDE; CYANIDIN 3 O GALACTOSIDE; CYANIDIN 3 O GLUCOSIDE; CYANIDIN 3 O SAMBUBIOSIDE; CYANIDIN 3 O XYLOSIDE; DELPHINIDIN 3 O GALACTOSIDE; FERULIC ACID; GALLIC ACID; LINGONBERRY EXTRACT; PELARGONIDIN 3 O GLUCOSIDE; PEONIDIN 3 O GALACTOSIDE; PEONIDIN 3 O GLUCOSIDE; PHENYLACETIC ACID; PLANT EXTRACT; PLANT MEDICINAL PRODUCT; POLYPHENOL DERIVATIVE; PROANTHOCYANIDIN DERIVATIVE; PROTOCATECHUIC ACID; QUERCETIN DERIVATIVE; TYROSOL; UNCLASSIFIED DRUG; POLYPHENOL;

ADULT; ARTICLE; BIOLOGICAL ACTIVITY; CELL INVASION; CELL MIGRATION; CELL MOTILITY; CHEMICAL COMPOSITION; COLORECTAL CANCER; COMET ASSAY; COMPARATIVE STUDY; CONTROLLED STUDY; DIGESTION; FRAMESHIFT MUTATION; GENOTOXICITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN TISSUE; ILEOSTOMY; IN VITRO DIGESTION; IN VITRO STUDY; IN VIVO STUDY; LINGONBERRY; MALE; MUTAGENIC ACTIVITY; NONHUMAN; PRIORITY JOURNAL; TANDEM MASS SPECTROMETRY; BODY FLUID; CELL MOTION; CHEMISTRY; DRUG EFFECTS; FERMENTATION; ILEUM; ISOLATION AND PURIFICATION; METABOLISM; PHYSIOLOGY; TUMOR CELL LINE;

VACCINIUM VITIS-IDAEA;

ADULT; ANTHOCYANINS; ANTIMUTAGENIC AGENTS; BODY FLUIDS; CELL LINE, TUMOR; CELL MOVEMENT; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DIGESTION; FERMENTATION; HUMANS; ILEOSTOMY; ILEUM; MALE; PLANT EXTRACTS; POLYPHENOLS; TANDEM MASS SPECTROMETRY; VACCINIUM VITIS-IDAEA;

EID: 84921048721     PISSN: 09516433     EISSN: 18728081     Source Type: Journal    
DOI: 10.1002/biof.1173     Document Type: Article

References (34)

1. Stewart, B.W. and Kleihues, P., eds. (2003) World Cancer Report. IARC Press, Lyon.
2. Aune, D., Chan, D. S., Lau, R., Vieira, R., Greenwood, D. C., et al. (2011) Dietary fibre, whole grains, and risk of colorectal cancer: systematic review and dose-response meta-analysis of prospective studies. Br. Med. J. 343, d6617.
3. Johnson, C. M., Wei, C., Ensor, J. E., Smolenski, D. J., Amos, C. I., et al. (2013) Meta-analyses of colorectal cancer risk factors. Cancer Causes Control 24, 1207-1222.
4. Ek S., Kartimo H., Mattila S., and Tolonen A. (2006) Characterization of phenolic compounds from lingonberry (Vaccinium vitis-idaea). J. Agric. Food Chem. 54, 9834-9842.
5. Mane, C., Loonis, M., Juhel, C., Dufour, C., and Malien-Aubert C. (2011) Food grade lingonberry extract: polyphenolic composition and in vivo protective effect against oxidative stress. J. Agric. Food Chem. 59, 3330-3339.
6. Zheng, W. and Wang, S. Y. (2003) Oxygen radical absorbing capacity of phenolics in blueberries, cranberries, chokeberries, and lingonberries. J. Agric. Food Chem. 51, 502-509.
7. Seeram, N. P. (2008) Berry fruits for cancer prevention: current status and future prospects. J. Agric. Food Chem. 56, 630-635.
8. Brown, E. M., Latimer, C., Allsopp, P., Ternan, N. G., McMullan, G., et al. In vitro and in vivo models of colorectal cancer: antigenotoxic activity of berries. J. Agric. Food Chem. 2014 Jan 21. [Epub ahead of print]
9. Olsson, M. E., Gustavsson, K. E., Andersson, S., Nilsson, A., and Duan, R. D. (2004) Inhibition of cancer cell proliferation in vitro by fruit and berry extracts and correlations with antioxidant levels. J. Agric. Food Chem. 52, 7264-7271.
10. Wu, Q. K., Koponen, J. M., Mykkänen, H. M., and Törrönen, A. R. (2007) Berry phenolic extracts modulate the expression of p21(WAF1) and Bax but not Bcl-2 in HT-29 colon cancer cells. J. Agric. Food Chem. 55, 1156-1163.
11. McDougall, G. J., Ross, H. A., Ikeji, M., and Stewart, D. (2008) Berry extracts exert different antiproliferative effects against cervical and colon cancer cells grown in vitro. J. Agric. Food Chem. 56, 3016-3023.
12. Misikangas, M., Pajari, A. M., Päivärinta, E., Oikarinen, S. I., Rajakangas, J., et al. (2007) Three Nordic berries inhibit intestinal tumorigenesis in multiple intestinal neoplasia/+ mice by modulating beta-catenin signaling in the tumor and transcription in the mucosa. J. Nutr. 137, 2285-2290.
13. Brown, E. M., Gill, C. I., McDougall, G. J., and Stewart D. (2012) Mechanisms underlying the anti-proliferative effects of berry components in in vitro models of colon cancer. Curr. Pharm. Biotechnol. 13, 200-209.
14. Crozier, A., Jaganath, I. B., and Clifford, M. N. (2009) Dietary phenolics: chemistry, bioavailability and effects on health. Nat. Prod. Rep. 26, 1001-1043.
15. Del Rio, D., Borges, G., and Crozier, A. (2010) Berry flavonoids and phenolics: bioavailability and evidence of protective effects. Br. J. Nutr. 104, S67-S90.
16. Gonzalez-Barrio, R., Borges, G., Mullen, W., and Crozier, A. (2010) Bioavailability of raspberry anthocyanins and ellagitannins following consumption of raspberries by healthy humans and subjects with an ileostomy. J. Agric. Food Chem. 58, 3933-3939.
17. Gill, C.I.R., McDougall, G.J., Glidewell, S., Steward, D., Tuohy, K., et al. (2010) Profiling of phenols in human fecal water after raspberry supplementation. J. Agric. Food Chem. 58, 10389-10395.
18. González-Barrio, R., Edwards, C.A., and Crozier, A. (2011) Colonic catabolism of ellagitannins, ellagic acid and raspberry anthocyanins: in vivo and in vitro studies. Drug Metab. Dispos. 39, 1680-1688.
19. Brown, E. M., McDougall, G. J., Stewart, D., Pereira-Caro, G., Gonzalez-Barrio, R., et al. (2012) Persistence of anticancer activity in berry extracts after simulated gastrointestinal digestion and colonic fermentation. PLoS One 7, 1-10.
20. Gil-Izquierdo, A., Zafrilla, P., and Tomas-Barberan, F. A. (2002) An in vitro method to simulate phenolic compound release from the food matrix in the gastrointestinal tract. Eur. Food Res. Technol. 214, 155-159.
21. McDougall, G. J., Dobson, P., Smith, P., Blake, A., and Stewart, D. (2005) Assessing potential bioavailability of raspberry anthocyanins using an in vitro digestion system. J. Agric. Food Chem. 53, 5896-5904.
22. Stalmach, A., Mullen, W., Steiling, H., Williamson, G., Lean, M.E., et al. (2010) Absorption, metabolism, and excretion of green tea flavan-3-ols in humans with an ileostomy. Mol. Nutr. Food Res. 54, 323-334.
23. Robbins, R. J., Leonczak, J., Johnson, J.C., Li, J., Kwik-Uribe, C., et al. (2009) Method performance and multi-laboratory assessment of a normal phase high pressure liquid chromatography-fluorescence detection method for the quantitation of flavanols and procyanidins in cocoa and chocolate containing samples. J. Chromatogr. A 1216, 4831-4840.
24. Pearson, J.R., Gill, C.I., and Rowland, I.R. (2009) Diet, fecal water, and colon cancer-development of a biomarker. Nutr. Rev. 67, 509-526.
25. Gratz, S.W., Wallace, R.J., and El-Nezami, H.S. (2011) Recent Perspectives on the Relations between Fecal Mutagenicity, Genotoxicity, and Diet. Front Pharmacol. 2, 1-9.
26. van Duynhoven, J., Vaughan, E. E., Jacobs, D. M., Kemperman, R., van Velzen, E. J., et al. (2011) Metabolic fate of polyphenols in the human superorganism. Proc. Natl. Acad. Sci. USA 108, 4531-4538.
27. Aura, A. M. (2008) Microbial metabolism of dietary phenolic compounds in the colon. Phytochem. Rev. 7, 407-429.
28. Holst, B. and Williamson, G. (2008) Nutrients and phytochemicals: from bioavailability to bioefficacy beyond antioxidants. Curr. Opin. Biotechnol. 19, 73-82.
29. Coates, E. M., Popa, G., Gill, C. I., McCann, M. J., McDougall, G. J., et al. (2007) Colon-available raspberry polyphenols exhibit anti-cancer effects on in vitro models of colon cancer. J. Carcinog. 6:4.
30. Bermudez-Soto, M. J., Tomas-Barberan, F. A., and Garcia-Conesa, M. T. (2007) Stability of polyphenols in chokeberry (Aronia melanocarpa) subjected to in vitro gastric and pancreatic digestion. Food Chem. 102, 865-874.
31. Dixon, R.A., Xie, D. Y., and Sharma, S. B. (2005) Proanthocyanidins-a final frontier in flavonoid research? New Phytol. 165, 9-28.
32. Makena, P. S. and Chung, K. T. (2007) Effects of various plant polyphenols on bladder carcinogen benzidine-induced mutagenicity. Food Chem Toxicol 45, 1899-1909.
33. Singh, B. N., Singh, B. R., Singh, R. L., Prakash, D., Singh, D, et al. (2009) Polyphenolics from various extracts/fractions of red onion (Allium cepa) peel with potent antioxidant and antimutagenic activities. Food Chem. Toxicol. 47, 1161-1167.
34. Spada, P. D. S., de Souza, G. G. N., Bortolini, G. V., Henriques, J. A. P., and Salvador, M. (2008) Antioxidant, mutagenic, and antimutagenic activity of frozen fruits. J. Med. Food, 11, 144-151.