Cardioprotective effects of aronia melanocarpa anthocyanins. From laboratory experiments to clinical practice

Current Pharmaceutical Design

Volumn 22, Issue 2, 2015, Pages 174-179

  Parzonko, Andrzej ^a   Naruszewicz, Marek ^a  

^a MEDICAL UNIVERSITY OF WARSAW   (Poland)

Author keywords

Anthocyanins; Aronia melanocarpa; Cardiovascular diseases; Chokeberry; Polyphenols; Prevention

Indexed keywords

ANTHOCYANIN;

CARDIOVASCULAR DISEASES; DIABETES MELLITUS, TYPE 2; DIETARY SUPPLEMENT; HUMAN; HYPERTENSION; PHOTINIA; PHYTOTHERAPY;

ANTHOCYANINS; CARDIOVASCULAR DISEASES; DIABETES MELLITUS, TYPE 2; DIETARY SUPPLEMENTS; HUMANS; HYPERTENSION; PHOTINIA; PHYTOTHERAPY;

EID: 84960950686     PISSN: 13816128     EISSN: 18734286     Source Type: Journal    
DOI: 10.2174/1381612822666151112152143     Document Type: Review

References (53)

1. Steinberg D. The LDL modification hypothesis of atherogenesis: an update. J Lipid Res 2009; 50 (Suppl): S376-81.
2. The ATBC Study Group. Incidence of cancer and mortality following alpha-tocopherol and beta-carotene supplementation: a postintervention follow-up. J Am Med Assoc 2003; 290: 476-85.
3. National Institutes of Health State-of-the-Science Conference Statement. Multivitamin/mineral supplements and chronic disease prevention. Ann Intern Med 2006; 145: 364-71.
4. Wedick NM, Pan A, Cassidy A, et al. Dietary flavonoid intakes and risk of type 2 diabetes in US men and women. Am J Clin Nutr 2012; 95: 925-33.
5. Cassidy A, O’Reilly EJ, Kay C, et al. Habitual intake of flavonoid subclasses and incident hypertension in adults. Am J Clin Nutr 2011; 93: 338-47.
6. Kokotkiewicz A, Jaremicz Z, Luczkiewicz M. Aronia plants: a review of traditional use, biological activities, and perspectives for modern medicine. J Med Food 2010; 13: 255-69.
7. Oszmiański J, Wojdyło A. Aronia melanocarpa phenolics and their antioxidant activity. Eur Food Res Technol 2005; 221: 809-13.
8. Wu XL, Gu LW, Prior RL, McKay S. Characterization of anthocyanins and proanthocyanidins in some cultivars of Ribes, Aronia, and Sambucus and their antioxidant capacity. J Agric Food Chem 2004; 52: 7846-56.
9. Aura AM, Martin-Lopez P, O'Leary KA, et al. In vitro metabolism of anthocyanins by human gut microflora. Eur J Nutr 2005; 44: 133-42.
10. Vitaglione P, Donnarumma G, Napolitano A, et al. Protocatechuic acid is the major human metabolite of cyanidin-glucosides. J Nutr 2007; 137: 2043-8.
11. Kay CD, Mazza G, Holub BJ, Wang J. Anthocyanin metabolites in human urine and serum. Br J Nutr 2004; 91: 933-42.
12. Kay CD, Mazza G, Holub BJ. Anthocyanin exist in the circulation primarly as metabolites in adult men. J Nutr 2005; 135: 2582-8.
13. Wiczkowski W, Romaszko E, Piskula MK. Bioavailibility of cyanidin glycosides from natural chokeberry (Aronia melanocarpa) juice with dietary-relevant dose of anthocyanins in humans. J Agric Food Chem 2010; 58: 12130-6.
14. Deprez S, Brezillou C, Rabot S, et al. Polymeric proanthocyanidins are catabolized by human colonic microflora into low-molecularweight phenolic acids. J Nutr 2000; 130: 2733-8.
15. Appeldorn MM, Vincken JP, Aura AM, Hollman PCH, Gruppen H. Procyanidin dimers are metabolized by human microbiota with 2-(3,4-dihydroxyphenyl)acetic acid and 5-(3,4-dihydroxyphenyl)-γ-valerolactone as the major metabolites. J Agric Food Chem 2009; 57: 1084-92.
16. Deprez S, Mila I, Huneau J-F, Tom D, Scalbert A. Transport of proanthocyanidin dimer, trimer and polymer across monolayer of human intestinal epithelial Caco-2 cells. Antioxid Redox Sign 2001; 3: 957-67.
17. Gonthier MP, Verny MA, Besson C, Remsey C, Scalbert A. Chlorogenic acid bioavailability largely depends on its metabolism by the gut microflora in rats. J Nutr 2003; 133: 1853-9.
18. Couteau D, McCartney AL, Gibson GR, Williamson G, Faulds CB. Isolation and characterization of human colonic bacteria able to hydrolyze chlorogenic acid. J Appl Microbiol 2001; 90: 873-81.
19. Rechner AR, Spencer JP, Kuhnle G, Hahn U, Rice-Evans CA. Novel biomarkers of the metabolism of caffeic acid derivatives in vivo. Free Radical Biol Med 2001; 30: 1213-22.
20. Rop O, Mlcek J, Jurikova T, et al. Phenolic content, antioxidant capacity, radical oxygen species scavenging and lipid peroxidation inhibiting activities of extracts of five black chokeberry (Aronia melanocarpa (Michx.) Elliot) cultivars. J Med Plants Res 2010; 4: 2431-7.
21. Dietrich-Muszalska A, Kopka J, Kontek B. Polyphenols from berries of Aronia melanocarpa reduce the plasma lipid peroxidation induced by ziprasidone. Schizophrenia Res Treatment 2014, article ID 602390, doi: 10.1155/2014/602390
22. Francik R, Kroniak M, Sanocka I, Barto H, Hebda T, Francik S. Aronia melanocarpa treatment and antioxidant status in selected tissues in wistar rats. BioMed Res Intl 2014; Article ID 457085, doi: 10.1155/2014/457085
23. Ryszawa N, Kawczyska-Drózdz A, Pryjma J, et al. Effects of novel plant antioxidants on platelet superoxide production and aggregation in atherosclerosis. J Physiol Pharmacol 2006; 57: 611-26.
24. Olas B, Wachowicz B, Nowak P, et al. Studies on antioxidant properties of polyphenol-rich extract from berries of Aronia melanocarpa in blood platelets. J Physiol Pharmacol 2008; 59: 823-35.
25. Malinowska J, Oleszek W, Stochmal A, Olas B. The polyphenolrich extracts from black chokeberry and grape seeds impair changes in the platelet adhesion and aggregation induced by a model of hyperhomocysteinemia. Eur J Nutr 2013; 52: 1049-57.
26. Kędzierska M, Olas B, Wachowicz B, et al. An extract from berries of Aronia melanocarpa modulates the generation of superoxide anion radicals in blood platelets from breast cancer patients. Planta Med 2009; 75: 1405-9.
27. Effects of the commercial extract of aronia on oxidative stress in blood platelets isolated from breast cancer patients after surgery and various phases of the chemotherapy. Fitoterapia 2012; 83: 310-7.
28. Kędzierska M, Olas B, Wachowicz B, et al. Changes of platelet antioxidative enzymes during oxidative stress: The protective effect of polyphenol-rich extract from berries of Aronia melanocarpa and grape seeds. Platelets 2011; 22: 385-9.
29. Libby P. Inflammation in atherosclerosis. Arterioscler Thromb Vasc Biol 2012; 32: 2045-51.
30. Zapolska-Downar D, Bryk D, Małecki M, Hajdukiewicz K, Sitkiewicz D. Aronia melanocarpa fruit extract exhibits antiinflammatory activity in human aortic endothelial cells. Eur J Nutr 2012; 51: 563-72.
31. Zapolska-Downar D, Nowicka G, Sygitowicz G, Jarosz M. Anthocyanin-rich Aronox extract from Aronia melanocarpa E protects against 7β-hydroxycholesterol-induced apoptosis of endothelial cells. Ann Nutr Metab 2008; 53: 283-94.
32. Ohgami K, Ilieva I, Shiratori K, et al. Anti-inflammatory effects of aronia extract on rat endotoxin-induced uveitis. Invest Ophthalmol Vis Sci 2005; 46: 275-81.
33. Yang H, Oh KH, Yoo YC. Anti-inflammatory effect of hot water extract of aronia fruits in LPS-stimulated RAW 264.7 macrophages. J Korean Soc Food Sci Nutr 2015; 44: 7-13.
34. Olas B, Wachowicz B, Tomczak A, et al. Comparative anti-platelet and antioxidant properties of polyphenol-rich extracts from: berries of Aronia melanocarpa, seeds of grape and bark of Yucca schidigera in vitro. Platelets 2008; 19: 70-7.
35. Sikora J, Markowicz-Piasecka M, Broncel M, Mikiciuk-Olasik E. Extract of Aronia melanocarpa-modified hemostasis: in vitro studies. Eur J Nutr 2014; 53: 653.
36. Malinowska J, Oleszek W, Stochmal A, Olas B. Aronia melanocarpa extract suppresses the biotoxicity of homocysteine and its metabolite on the hemostatic activity of fibrinogen and plasma. Nutrition 2012; 28: 793-8.
37. Luzak B, Golanski J, Rozalski M, Krajewska U, Olas B, Watala C. Extract of Aronia melanocarpa fruits potentiates the inhibition of platelets aggregation in the presence of endothelial cells. Arch Med Sci 2010; 6: 141-4.
38. Bell DR, Gochenaur K. Direct vasoactive and vasoprotective properties of anthocyanin-rich extracts. J Appl Physiol 2006; 100: 1164-70.
39. Kim JH, Auger C, Kurita I, et al. Aronia melanocarpa juice, a rich source of polyphenols, induces endothelium-dependent relaxations in porcine coronary arteries via the redox-sensitive activation of endothelial nitric oxide synthase. Nitric Oxide 2013; 35: 54-64.
40. Ciocoiu M, Badescu L, Miron A, Badescu M. The involvement of a polyphenol-rich extract of black chokeberry in oxidative stress on experimental arterial hypertension. Evidence-Based Complementary and Alternative Medicine 2013; Article ID 912769, doi: 10.1155/2013/912769.
41. Hellstrom JK, Shikov AN, Makarova MN, et al. Blood pressurelowering properties of chokeberry (Aronia mitchurinii, var. Viking). J Funct Food 2010; 2: 163-9.
42. Sikora J, Broncel M, Mikiciuk-Olasik E. Aronia melanocarpa Elliot reduces the activity of angiotensin I-converting enzyme-in vitro and ex vivo studies. Oxidative Med Cell Longevity 2014, Article ID 739721, doi: 10.1155/2014/739721.
43. Endtmann C, Ebrahimian T, Czech T, et al. Angiotensin II impairs endothelial progenitor cell number and function in vitro and in vivo: Implications for vascular regeneration Hypertension 2011; 58: 394-403.
44. Imanishi T, Hano T, Nishio I. Angiotensin II accelerates endothelial progenitor cell senescence through induction of oxidative stress. J Hypertens 2005; 23: 97-104.
45. Parzonko A, Oświt A, Bazylko A, Naruszewicz M. Anthocyansrich Aronia melanocarpa extract possesses ability to protect endothelial progenitor cells against angiotensin II induced dysfunction Phytomedicine 2015; 22: 1238-46.
46. Sorrenti V, Mazza F, Campisi A, et al. Heme oxygenase induction by cyanidin-3-O-β-glucoside in cultured human endothelial cells. Mol Nutr Food Res 2007; 51; 580-6.
47. Milbury PE, Graf B, Curran-Celentano JM, Blumberg JB. Bilberry (Vaccinium myrtillus) anthocyanins modulate heme oxygenase-1 and glutathione S-transferase-pi expression in ARPE-19 cells. Invest Ophthalmol Vis Sci 2007; 48: 2343-9.
48. Valcheva-Kuzmanova S, Kuzmanov K, Mihova V, Krasnaliev I, Borisova P, Belcheva A. Antihyperlipidemic effect of Aronia melanocarpa fruit juice in rats fed a high-cholesterol diet. Plant Foods Hum Nutr 2007; 62: 19-24.
49. Valcheva-Kuzmanova S, Kuzmanov K, Tancheva S, Belcheva A. Hypoglycemic and hypolipidemic effects of Aronia melanocarpa fruit juice in streptozotocin-induced diabetic rats. Methods Find Exp Clin Pharmacol 2007; 29: 1-5.
50. Jurgoński A, Juśkiewicz J, Zduńczyk Z. Ingestion of black chokeberry fruit extract leads to intestinal and systemic changes in a rat model of prediabetes and hyperlipidemia. Plant Foods Hum Nutr 2008; 63: 176-82.
51. Chrubasik C, Li G, Chrubasik S. The clinical effectiveness of chokeberry: a systematic review. Phytother Res 2010; 24: 1107-14.
52. Naruszewicz M, Laniewska I, Millo B, Dłuzniewski M Combination therapy of statin with flavonoids rich extract from chokeberry fruits enhanced reduction in cardiovascular risk markers in patients after myocardial infraction (MI). Atherosclerosis 2007; 194: e179-84.
53. Sikora J, Broncel M, Markowicz M, Chałubiński M, Wojdan K, Mikiciuk-Olasik E. Short-term supplementation with Aronia melanocarpa extract improves platelet aggregation, clotting, and fibrinolysis in patients with metabolic syndrome. Eur J Nutr 2012; 51: 549-56.