Anthocyanin-rich aronox extract from Aroniamelanocarpa E protects against 7β-hydroxycholesterol-induced apoptosis of endothelial cells

Annals of Nutrition and Metabolism

Volumn 53, Issue 3-4, 2009, Pages 283-294

  Zapolska Downar, Danuta ^a   Nowicka, Grazyna ^a   Sygitowicz, Grazyna ^a   Jarosz, Mirosław ^a  

^a MEDICAL UNIVERSITY OF WARSAW   (Poland)

Author keywords

Anthocyanins; Apoptosis; Atherosclerosis; Endothelial cells

Indexed keywords

7BETA HYDROXYCHOLESTEROL; ANTHOCYANIN; ARONIA MELANOCARPA E EXTRACT; ARONOX; CASPASE 3; CYTOCHROME C; DACTINOMYCIN; DICHLORODIHYDROFLUORESCEIN DIACETATE; FLUORESCENT DYE; LIPOCORTIN 5; PLANT EXTRACT; POLYPHENOL DERIVATIVE; PROPIDIUM IODIDE; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

ANTIOXIDANT ACTIVITY; APOPTOSIS; ARONIA MELANOCARPA E; ARTICLE; BERRY; CELL ASSAY; CELL PROTECTION; CONTROLLED STUDY; DOWN REGULATION; ENDOTHELIUM CELL; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME RELEASE; FOOD INTAKE; HUMAN; HUMAN CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; NICK END LABELING; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN CONTENT; PROTEIN EXPRESSION; PROTEIN SYNTHESIS INHIBITION; UMBILICAL VEIN; UPREGULATION;

ANNEXIN A5; ANTHOCYANINS; APOPTOSIS; CASPASE 3; CELL LINE; CYTOCHROMES C; ENDOTHELIAL CELLS; GENE EXPRESSION REGULATION; HUMANS; HYDROXYCHOLESTEROLS; IN SITU NICK-END LABELING; MEMBRANE POTENTIAL, MITOCHONDRIAL; PHOTINIA; PLANT EXTRACTS; PROTO-ONCOGENE PROTEINS C-BCL-2; REACTIVE OXYGEN SPECIES;

PHOTINIA MELANOCARPA;

EID: 58149386732     PISSN: 02506807     EISSN: None     Source Type: Journal    
DOI: 10.1159/000191290     Document Type: Article

References (48)

1. Mallat Z, Tedgui A: Apoptosis in the vasculature: mechanisms and functional importance. Br J Pharmacol 2000;130:947-962.
2. Li P, Nijhawan D, Budihardjo I, Srinivasula SM, Ahmad M, Alnemri ES, Wang X: Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade. Cell 1997;91:479-489.
3. Susin SA, Zamzami N, Kroemer G: Mitochondria as regulators of apoptosis: doubt no more. Biochim Biophys Acta 1998;1366:151-165.
4. Cory S, Adams JM: The Bcl2 family: regulators of the cellular life-or-death switch. Nat Rev Cancer 2002;2:647-656.
5. Stoneman VE, Bennett MR: Role of apoptosis in atherosclerosis and its therapeutic implications. Clin Sci (Lond) 2004;107:343-354.
6. Choy JC, Granville DJ, Hunt DW, McManus BM: Endothelial cell apoptosis: biochemical characteristics and potential implications for atherosclerosis. J Mol Cell Cardiol 2001;33:1673-1690.
7. Dimmeler S, Hermann C, Zeiher AM: Apoptosis of endothelial cells. Contribution to the pathophysiology of atherosclerosis? Eur Cytokine Netw 1998;9:697-698.
8. Hughes H, Mathews B, Lenz ML, Guyton JR: Cytotoxicity of oxidized LDL to porcine aortic smooth muscle cells is associated with the oxysterols 7-ketocholesterol and 7-hydroxycholesterol. Arterioscler Thromb 1994;14:1177-1185.
9. Brown AJ, Leong SL, Dean RT, Jessup W: 7-Hydroperoxycholesterol and its products in oxidized low density lipoprotein and human atherosclerotic plaque. J Lipid Res 1997;38:1730-1745.
10. Brown AJ, Jessup W: Oxysterols and atherosclerosis. Atherosclerosis 1999;142:1-28.
11. Lizard G, Miguet C, Besséde G, Monier S, Gueldry S, Neel D, Gambert P: Impairment with various antioxidants of the loss of mitochondrial transmembrane potential and of the cytosolic release of cytochrome c occuring during 7-ketocholesterol-induced apoptosis. Free Radic Biol Med 2000;28:743-753.
12. Miguet-Alfonsi C, Prunet C, Monier S, Bessède G, Lemaire-Ewing S, Berthier A, Ménétrier F, Néel D, Gambert P, Lizard G: Analysis of oxidative processes and of myelin figures formation before and after the loss of mitochondrial transmembrane potential during 7beta- hydroxycholesterol and 7-ketocholesterol-induced apoptosis: comparison with various pro-apoptotic chemicals. Biochem Pharmacol 2002;64:527-541.
13. Ryan L, O'Callaghan YC, O'Brien NM: Generation of an oxidative stress precedes caspase activation during 7beta-hydroxycholesterol-induced apoptosis in U937 cells. J Biochem Mol Toxicol 2004;18:50-59.
14. Panini SR, Sinensky MS: Mechanisms of oxysterol-induced apoptosis. Curr Opin Lipidol 2001;12:529-533.
15. Nishio E, Watanabe Y: Oxysterols induced apoptosis in cultured smooth muscle cells through CPP32 protease activation and bcl-2 protein downregulation. Biochem Biophys Res Commun 1996;226:928-934.
16. Lizard G, Gueldry S, Sordet O, Monier S, Athias A, Miguet C, Bessede G, Lemaire S, Solary E, Gambert P: Glutathione is implied in the control of 7-ketocholesterol-induced apoptosis, which is associated with radical oxygen species production. FASEB J 1998;12:1651-1663.
17. Curin Y, Andriantsitohaina R: Polyphenols as potential therapeutical agents against cardiovascular diseases. Pharmacol Rep 2005;57(suppl):97-107.
18. Wawer I: Aronia melanocarpa : Nature Combined with Health. Nature's Print, 2006.
19. Cao G, Muccitelli HU, Sánchez-Moreno C, Prior RL: Anthocyanins are absorbed in glycated forms in elderly women: a pharmacokinetic study. Am J Clin Nutr 2001;73:920-926.
20. Youdim KA, Martin A, Joseph JA: Incorporation of the elderberry anthocyanins by endothelial cells increases protection against oxidative stress. Free Radic Biol Med 2000;29:51-60.
21. Jaffe EA: Culture and identification of large vessel cells; in Jaffe EA (ed): Biology of Endothelial Cells. Boston, Martinus Nijhoff Publ, 1984, pp 1-9.
22. Martin S, Giannone G, Andriantsitohaina R, Martinez MC: Delphinidin, an active compound of red wine, inhibits endothelial cell apoptosis via nitric oxide pathway and regulation of calcium homeostasis. Br J Pharmacol 2003;139:1095-1102.
23. Aoyama T, Takemura G, Maruyama R, Kosai K, Takahashi T, Koda M, Hayakawa K, Kawase Y, Minatoguchi S, Fujiwara H: Molecular mechanisms of non-apoptosis by Fas stimulation alone versus apoptosis with an additional actinomycin D in cultured cardiomyocytes. Cardiovasc Res 2002;55:787-798.
24. Shim D, Kang HY, Jeon BW, Kang SS, Chang SI, Kim HY: Protein kinase B inhibits apoptosis induced by actinomycin D in ECV304 cells through phosphorylation of caspase 8. Arch Biochem Biophys 2004;425:214-220.
25. Dimmeler S, Brinkmann S, Neugebauer E: Endotoxin-induced changes of endothelial cell viability and permability: protective effect of a 21-aminosteroid. Eur J Pharmacol 1995;287:257-261.
26. 2 in cultured endothelial cells. Arch Biochem Biophys 1993;302:348-355.
27. Slater AF, Nobel CS, Orrenius S: The role of intracellular oxidants in apoptosis. Biochim Biophys Acta 1995;1271:59-62.
28. Ryan L, O'Callaghan YC, O'Brien NM: The role of the mitochondria in apoptosis induced by 7beta-hydroxycholesterol and cholesterol-5beta,6beta- epoxide. Br J Nutr 2005;94:519-525.
29. Grütter MG: Caspases: key players in programmed cell death. Curr Opin Struct Biol 2000;10:649-655.
30. Colles SM, Maxson JM, Carlson SG, Chisolm GM: Oxidized LDL-induced injury and apoptosis in atherosclerosis: potential roles for oxysterols. Trends Cardiovasc Med 2001;11:131-138.
31. Uemura M, Manabe H, Yoshida N, Fujita N, Ochiai J, Matsumoto N, Takagi T, Naito Y, Yoshikawa T: Alpha-tocopherol prevents apoptosis of vascular endothelial cells via a mechanism exceeding that of mere antioxidation. Eur J Pharmacol 2002;456:29-37.
32. Vermes I, Haanen C, Steffens-Nakken H, Reutelingsperger C: A novel assay for apoptosis: flow cytometric detection of phosphatidylserine expression on early apoptotic cells cells using fluorescein labelled Annexin V. J Immunol Methods 1995;184:39-51.
33. Basnakian AG, James SJ: A rapid and sensitive assay for the detection of DNA fragmentation during early phases of apoptosis. Nucleic Acids Res 1994;22:2714-2715.
34. Green DR, Reed JC: Mitochondria and apoptosis. Science 1998;281:1309-1312.
35. Morel Y, Barouki R: Repression of gene expression by oxidative stress. Biochem J 1999;342:481-496.
36. McGowan AJ, Fernandes RS, Samali A, Cotter TG: Anti-oxidants and apoptosis. Biochem Soc Trans 1996;24:229-233.
37. Ou HC, Chou FP, Sheen HM, Lin TM, Yang CH, Huey-Herng Sheu W: Resveratrol, a polyphenolic compound in red wine, protects against oxidized LDL-induced cytotoxicity in endothelial cells. Clin Chim Acta 2006;364:196-204.
38. Ashe PC, Berry MD: Apoptotic signaling cascades. Prog Neuropsychopharmacol Biol Psychiatry 2003;27:199-214.
39. Bernardi P, Scorrano L, Colonna R, Petronilli V, Di Lisa F: Mitochondria and cell death: mechanistic aspects and methodological issues. Eur J Biochem 1999;264:687-701.
40. Tatton WG, Olanow CW: Apoptosis in neurodegenerative diseases: the role of mitochondria. Biochim Biophys Acta 1999;1410:195-213.
41. Napoli C, Quehenberger O, De Nigris F, Abete P, Glass CK, Palinski W: Mildly oxidized low density lipoprotein activates multiple apoptotic signaling pathways in human coronary cells. FASEB J 2000;14:1996-2007.
42. Wintergerst ES, Jelk J, Rahner C, Asmis R: Apoptosis induced by oxidized low density lipoprotein in human monocyte-derived macrophages involves CD36 and activation of caspase-3. Eur J Biochem 2000;267:6050-6059.
43. Salvayre R, Auge N, Benoist H, Negre-Salvayre A: Oxidized low-density lipoprotein-induced apoptosis. Biochim Biophys Acta 2002;1585:213-221.
44. Jeong YJ, Choi YJ, Kwon HM, Kang SW, Park HS, Lee M, Kang YH: Differential inhibition of oxidized LDL-induced apoptosis in human endothelial cells treated with different flavonoids. Br J Nutr 2005;93:581-591.
45. Choi YJ, Kang JS, Park JH, Lee YJ, Choi JS, Kang YH: Polyphenolic flavonoids differ in their antiapoptotic efficacy in hydrogen peroxide-treated human vascular endothelial cells. J Nutr 2003;133:985-991.
46. Bagchi D, Bagchi M, Stohs SJ, Das DK, Ray SD, Kuszynski CA, Joshi SS, Pruess HG: Free radicals and grape seed proanthocyanidin extract: importance in human health and disease prevention. Toxicology 2000;148:187-197.
47. Bagchi D, Bagchi M, Stohs S, Ray SD, Sen CK, Preuss HG: Cellular protection with proanthocyanidins derived from grape seeds. Ann NY Acad Sci 2002;957:260-270.
48. Matsumoto H, Inaba H, Kishi M, Tominaga S, Hirayama M, Tsuda T: Orally administered delphinidin 3-rutinoside and cyanidin 3-rutinoside are directly absorbed in rats and humans and appear in the blood as the intact forms. J Agric Food Chem 2001;49:1546-1551.