Extract from Aronia melanocarpa fruits potentiates the inhibition of platelet aggregation in the presence of endothelial cells

Archives of Medical Science

Volumn 6, Issue 2, 2010, Pages 141-144

  Luzak, Boguslawa ^a   Golanski, Jacek ^a   Rozalski, Marek ^a   Krajewska, Urszula ^a   Olas, Beata ^b   Watala, Cezary ^a  

^a MEDICAL UNIVERSITY OF LODZ   (Poland)

^b UNIVERSITY OF LODZ   (Poland)

Author keywords

Aronia melanocarpa (chokeberry); Endothelial cells; Platelet aggregation; Platelet reactivity; Polyphenols

Indexed keywords

ADENOSINE DIPHOSPHATE; ANTITHROMBOCYTIC AGENT; ARONIA MELANOCARPA EXTRACT; PADGEM PROTEIN; UNCLASSIFIED DRUG;

ADULT; ARONIA MELANOCARPA; ARTICLE; BERRY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFICACY; DRUG MECHANISM; ENDOTHELIUM CELL; FEMALE; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; IN VITRO STUDY; MALE; NORMAL HUMAN; PROTEIN EXPRESSION; THROMBOCYTE AGGREGATION INHIBITION;

EID: 77951958985     PISSN: 17341922     EISSN: None     Source Type: Journal    
DOI: 10.5114/aoms.2010.13884     Document Type: Article

References (13)

1. Vita JA. Polyphenols and cardiovascular disease: effects on endothelial and platelet function. Am J Clin Nutr 2005; 81: 292S-7S.
2. Janaszewska A, Golanski J, Watala C. Natural compounds as modulators of platelet function. In: The activity of natural compounds in diseases prevention and therapy. Durackova Z. (ed); Rozum a Zdravie, o.z; Slovak Academic Press, 2007; 1: 199-225.
3. Kulling SE, Rawel HM. Chokeberry (Aronia melanocarpa): A review on the characteristic components and potential health effects. Planta Med 2008; 74: 1625-1634
4. Kowalczyk E, Krzesinski P, Fijalkowski P, Blaszczyk J, Kowalski J. The use of anthocyanins in the treatment of cardiovascular diseases [Polish]. Pol Merkur Lekarski 2005; 19: 108-110 (Pubitemid 41001353)
5. Broncel M, Kozirog-Kolacinska M, Andryskowski G, et al. Effect of anthocyanins from Aronia melanocarpa on blood pressure, concentration of endothelin-1 and lipids in patients with metabolic syndrome [Polish]. Pol Merkur Lekarski 2007; 23: 116-119
6. Valcheva-Kuzmanova S, Kuzmanov K, Mihova V, Krasnaliev I, Borisova P, Belcheva A. Antihyperlipidemic effect of Aronia melanocarpa fruit juice in rats fed a high-cholesterol diet. Plant Foods Hum Nutr 2007; 62: 19-24. (Pubitemid 46327408)
7. Golanski J, Golanski R, Iwaszkiewicz A, Chlopicki S, Gresner P, Watala C. Resistance to aspirin in patients after coronary artery bypass grafting is transient. Impact on the monitoring of aspirin antiplatelet therapy. Therap Drug Monit 2005; 27: 484-490
8. Broekman MJ, Eiroa AM, Marcus AJ. Inhibition of human platelet reactivity by endothelium-derived relaxing factor from human umbilical vein endothelial cells in suspension: blockade of aggregation and secretion by an aspirin-insensitive mechanism. Blood 1991; 78: 1033-1040
9. Nosaka S, Nakayama K, Hashimoto M, et al. Inhibition of platelet aggregation by endocardial endothelial cells. Life Sci 1996; 59: 559-564 (Pubitemid 26274417)
10. Andre P, Delaney SM, LaRocca T, et al. P2Y12 regulates platelet adhesion/activation, thrombus growth, and thrombus stability in injured arteries. J Clin Invest 2003; 112: 398-406. (Pubitemid 38063768)
11. Wihlborg AK, Malmsjo M, Eyjolfsson A, Gustafsson R, Jacobson K, Erlinge D. Extracellular nucleotides induce vasodilatation in human arteries via prostaglandins, nitric oxide and endothelium-derived hyperpolarising factor. Br J Pharmacol 2003; 138: 1451-1458 (Pubitemid 36609640)
12. Mendes A, Desgranges C, Cheze C, Vercauteren J, Freslon JL. Vasorelaxant effects of grape polyphenols in rat isolated aorta. Possible involvement of a purinergic pathway. Fundam Clin Pharmacol 2003; 17: 673-681
13. Nardini M, Natella F, Scaccini C. Role of dietary polyphenols in platelet aggregation. A review of the supplementation studies. Platelets 2007; 18: 224-243