ALIS: An affinity selection-mass spectrometry system for the discovery and characterization of protein-ligand interactions

Mass Spectrometry in Medicinal Chemistry

Volumn 36, Issue , 2007, Pages 121-156

  Annis, Allen ^a   Chuang, Cheng Chi ^a   Nazef, Naim ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Affinity selection mass spectrometry system for the discovery and characterization of protein ligand interactions; ALIS; ALIS system design; Competition based binding site determination and affinity ranking in mixtures; Discovery of ligands from combinatorial libraries; Protein ligand dissociation rate measurement; Quantitative binding affinity measurement; Spectroscopic and biophysical methods

Indexed keywords

BINDING ENERGY; DISSOCIATION; DRUG PRODUCTS; MASS SPECTROMETRY; PROTEINS; SITE SELECTION;

ALIS; BIOPHYSICAL METHODS; COMBINATORIAL LIBRARY; PROTEIN LIGANDS; QUANTITATIVE BINDING; SPECTROMETRY SYSTEMS;

LIGANDS;

EID: 84884611511     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/9783527610907.ch3     Document Type: Chapter

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