Inhibitors of hepatitis C virus polymerase: Synthesis and characterization of novel 2-oxy-6-fluoro-N-((S)-1-hydroxy-3-phenylpropan-2-yl)-benzamides

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 7, 2010, Pages 2119-2124

  Cheng, Cliff C ^a   Shipps Jr , Gerald W ^a   Yang, Zhiwei ^a   Kawahata, Noriyuki ^a   Lesburg, Charles A ^a   Duca, José S ^a   Bandouveres, Jamie ^a   Bracken, Jack D ^a   Jiang, Chuan kui ^a   Agrawal, Sony ^a   Ferrari, Eric ^a   Huang, H C ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

ALIS: automated ligand identification system; Antiviral; HCV NS5B polymerase; Hepatitis C virus; Palm site inhibitors; Replicon; Structure based drug design (SBDD)

Indexed keywords

BENZAMIDE DERIVATIVE; ENZYME INHIBITOR; LIGAND; NS5B POLYMERASE; UNCLASSIFIED DRUG; VIRUS ENZYME;

ARTICLE; CHEMICAL ANALYSIS; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG POTENCY; DRUG SYNTHESIS; HEPATITIS C VIRUS; IC 50; IN VITRO STUDY; MUTANT; NONHUMAN; PROTEIN DOMAIN; STRUCTURE ACTIVITY RELATION;

ANTIVIRAL AGENTS; BENZAMIDES; CRYSTALLOGRAPHY; DRUG DESIGN; ENZYME INHIBITORS; HEPACIVIRUS; HEPATITIS C; HUMANS; MODELS, MOLECULAR; RNA REPLICASE; STRUCTURE-ACTIVITY RELATIONSHIP; VIRAL NONSTRUCTURAL PROTEINS;

HEPATITIS C VIRUS;

EID: 77949487755     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.02.054     Document Type: Article

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