Development of a topical treatment for psoriasis targeting RORγ: From bench to skin

PLoS ONE

Volumn 11, Issue 2, 2016, Pages

  Smith, Susan H ^a   Peredo, Carlos E ^a   Takeda, Yukimasa ^b   Bui, Thi ^a   Neil, Jessica ^a   Rickard, David ^d   Millerman, Elizabeth ^a   Therrien, Jean Philippe ^a   Nicodeme, Edwige ^c   Brusq, Jean Marie ^c   Birault, Veronique ^e   Viviani, Fabrice ^c   Hofland, Hans ^a,f   Jetten, Anton M ^b   Cote Sierra, Javier ^a,g  

^a Stiefel Laboratories Inc   (United States)

^b NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^c GLAXOSMITHKLINE   (France)

^d GLAXOSMITHKLINE   (United States)

^e GLAXOSMITHKLINE   (United Kingdom)

^f Dermira Inc   (United States)

^g PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIPSORIASIS AGENT; CLOBETASOL; GSK 2981278; GSK 3038548; GSK 3038549; IMIQUIMOD; INTERLEUKIN 17; INTERLEUKIN 19; INTERLEUKIN 22; PLACEBO; RETINOID RELATED ORPHAN RECEPTOR GAMMA; UNCLASSIFIED DRUG; AMINOQUINOLINE DERIVATIVE; IMMUNOLOGIC FACTOR; LUCIFERASE; MOLECULAR LIBRARY; RORC PROTEIN, HUMAN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFECT; DRUG EFFICACY; DRUG POTENCY; DRUG SCREENING; DRUG SELECTIVITY; DRUG SPECIFICITY; EX VIVO STUDY; FEMALE; GENE INACTIVATION; HUMAN; HUMAN CELL; HUMAN TISSUE; IL17A GENE; IN VIVO STUDY; MOUSE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN SYNTHESIS INHIBITION; PSORIASIS; SKIN BIOPSY; TH17 CELL; TOPICAL TREATMENT; ANIMAL; ANTAGONISTS AND INHIBITORS; BAGG ALBINO MOUSE; CHEMICALLY INDUCED; CUTANEOUS DRUG ADMINISTRATION; DRUG EFFECTS; GENE EXPRESSION; GENETICS; IMMUNOLOGY; JURKAT CELL LINE; METABOLISM; MOLECULAR LIBRARY; PATHOLOGY; PERMEABILITY; PHARMACOLOGY; PRECLINICAL STUDY; PRIMARY CELL CULTURE; REPORTER GENE; SKIN; SYNTHESIS; TRANSLATIONAL RESEARCH;

ADMINISTRATION, CUTANEOUS; AMINOQUINOLINES; ANIMALS; DRUG EVALUATION, PRECLINICAL; FEMALE; GENE EXPRESSION; GENES, REPORTER; HUMANS; IMMUNOLOGIC FACTORS; INTERLEUKIN-17; JURKAT CELLS; LUCIFERASES; MICE; MICE, INBRED BALB C; NUCLEAR RECEPTOR SUBFAMILY 1, GROUP F, MEMBER 3; PERMEABILITY; PRIMARY CELL CULTURE; PSORIASIS; SKIN; SMALL MOLECULE LIBRARIES; TH17 CELLS; TRANSLATIONAL MEDICAL RESEARCH;

EID: 84960538989     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0147979     Document Type: Article

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