Translating the genomic revolution - Targeted genome editing in primates

New England Journal of Medicine

Volumn 370, Issue 24, 2014, Pages 2342-2345

  Cathomen, Toni ^a   Ehl, Stephan ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR CCR5; CRISPR ASSOCIATED PROTEIN; ENDONUCLEASE; MEGANUCLEASE; METHYL CPG BINDING PROTEIN 2; NUCLEASE; RAG1 PROTEIN; RNA GUIDED NUCLEASE; STAT1 PROTEIN; TRANSCRIPTION ACTIVATOR LIKE EFFECTOR NUCLEASE; UNCLASSIFIED DRUG; ZINC FINGER NUCLEASE;

ARTICLE; CD4+ T LYMPHOCYTE; DNA BINDING; DNA MODIFICATION; DNA REPAIR; DNA SEQUENCE; DOUBLE STRANDED DNA BREAK; EMBRYO DEVELOPMENT; GENE DISRUPTION; GENE INACTIVATION; GENE MUTATION; GENE TARGETING; GENETIC EDITING; GENOMICS; GENOTYPE; HEART DISEASE; HEMATOPOIETIC STEM CELL; HETEROZYGOTE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNE DEFICIENCY; MALIGNANT NEOPLASTIC DISEASE; MECP2 GENE; MOLECULAR GENETICS; NONHUMAN; PLURIPOTENT STEM CELL; PPARY GENE; PREGNANCY; PRIMATE MODEL; PRIORITY JOURNAL; RAG1 GENE; STAT1 GENE; TOTIPOTENT STEM CELL;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEATS; EMBRYO, MAMMALIAN; ENDONUCLEASES; GENE TARGETING; GENOME; GENOMICS; MACACA; MODELS, ANIMAL; PRIMATES; RNA, GUIDE;

EID: 84902187031     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJMcibr1403629     Document Type: Article

References (6)

1. Niu Y, Shen B, Cui Y, et al. Generation of gene-modified cynomolgus monkey via Cas9/RNA-mediated gene targeting in one-cell embryos. Cell 2014;156:836-43.
2. Liu H, Chen Y, Niu Y, et al. TALEN-mediated gene mutagenesis in rhesus and cynomolgus monkeys. Cell Stem Cell 2014;14:323-8.
3. de Souza N. Primer: genome editing with engineered nucleases. Nat Methods 2012;9:27.
4. Genetic microsurgery for the masses. Science 2013;342:1434-5.
5. Tebas P, Stein D, Tang WW, et al. Gene editing of CCR5 in autologous CD4 T cells of persons infected with HIV. N Engl J Med 2014;370:901-10.
6. Garate Z, Davis BR, Quintana-Bustamante O, Segovia JC. New frontier in regenerative medicine: site-specific gene correction in patient-specific induced pluripotent stem cells. Hum Gene Ther 2013;24:571-83.