Direct observation of R-loop formation by single RNA-guided Cas9 and Cascade effector complexes

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 27, 2014, Pages 9798-9803

  Szczelkun, Mark D ^a   Tikhomirova, Maria S ^b,c   Sinkunas, Tomas ^d   Gasiunas, Giedrius ^d   Karvelis, Tautvydas ^d   Pschera, Patrizia ^c   Siksnys, Virginijus ^d   Seidel, Ralf ^b,c  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

^b UNIVERSITY OF MÜNSTER   (Germany)

^c DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

^d VILNIUS UNIVERSITY   (Lithuania)

Author keywords

crRNA; Genome engineering; Magnetic tweezers

Indexed keywords

CASCADE PROTEIN; CRISPR ASSOCIATED PROTEIN; CRISPR ASSOCIATED PROTEIN 9; DNA; RNA; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL PHENOMENA; CONTROLLED STUDY; CRISPR CAS SYSTEM; DISSOCIATION; DNA SUPERCOILING; MOLECULAR RECOGNITION; MOLECULAR STABILITY; PRIORITY JOURNAL; PROTEIN MOTIF; PROTOSPACER ADJACENT MOTIF; R LOOP DISSOCIATION; R LOOP FORMATION;

CRRNA; GENOME ENGINEERING; MAGNETIC TWEEZERS;

CRISPR-ASSOCIATED PROTEINS; DNA, SUPERHELICAL; MUTATION; PROTEIN CONFORMATION; RNA, GUIDE;

EID: 84903975702     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1402597111     Document Type: Article

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