Virgin Olive Oil Enriched with Its Own Phenols or Complemented with Thyme Phenols Improves DNA Protection against Oxidation and Antioxidant Enzyme Activity in Hyperlipidemic Subjects

Journal of Agricultural and Food Chemistry

Volumn 64, Issue 9, 2016, Pages 1879-1888

  Romeu, Marta ^a   Rubió, Laura ^a,b   Sánchez Martos, Vanessa ^a   Castañer, Olga ^c   De La Torre, Rafael ^c   Valls, Rosa M ^a   Ras, Rosa ^d   Pedret, Anna ^a   Catalán, Úrsula ^a   López De Las Hazas, María Del Carmen ^b   Motilva, María J ^b   Fitó, Montserrat ^c   Solà, Rosa ^a   Giralt, Montserrat ^a  

^a UNIVERSITAT ROVIRA I VIRGILI   (Spain)

^b UNIVERSITY OF LLEIDA   (Spain)

^c HOSPITAL DEL MAR   (Spain)

^d Center for Omics Sciences   (Spain)

Author keywords

enzymatic antioxidants; hyperlipidemia; oxidative stress; phenol enrichment; thyme phenols; virgin olive oil

Indexed keywords

ANTIOXIDANTS; BIOCHEMISTRY; DNA; ENZYME ACTIVITY; ENZYMES; METABOLITES; OXIDATIVE STRESS; OXYGEN; PHENOLS;

ANTIOXIDANT ENZYME ACTIVITY; ENZYMATIC SYSTEM; HYPERLIPIDEMIA; OXIDATIVE DNA DAMAGE; PHENOLIC COMPOUNDS; PHENOLIC METABOLITES; SUPER OXIDE DISMUTASE; VIRGIN OLIVE OIL;

OLIVE OIL;

ANTIOXIDANT; BIOLOGICAL MARKER; DNA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; OLIVE OIL; PHENOL DERIVATIVE; SUPEROXIDE DISMUTASE;

ADULT; AGED; ANALYSIS; ANIMAL; BLOOD; CHEMISTRY; CONTROLLED STUDY; CROSSOVER PROCEDURE; DNA DAMAGE; DOUBLE BLIND PROCEDURE; DRUG EFFECTS; ERYTHROCYTE; FEMALE; FORTIFIED FOOD; HUMAN; HYPERLIPIDEMIAS; MALE; METABOLISM; MIDDLE AGED; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; RANDOMIZED CONTROLLED TRIAL; RAT; THYMUS (PLANT); URINE; VERY ELDERLY; WISTAR RAT;

ADULT; AGED; AGED, 80 AND OVER; ANIMALS; ANTIOXIDANTS; BIOMARKERS; CROSS-OVER STUDIES; DNA; DNA DAMAGE; DOUBLE-BLIND METHOD; ERYTHROCYTES; FEMALE; FOOD, FORTIFIED; HUMANS; HYPERLIPIDEMIAS; MALE; MIDDLE AGED; NF-KAPPA B; OLIVE OIL; OXIDATION-REDUCTION; OXIDATIVE STRESS; PHENOLS; RATS; RATS, WISTAR; SUPEROXIDE DISMUTASE; THYMUS PLANT;

EID: 84960441358     PISSN: 00218561     EISSN: 15205118     Source Type: Journal    
DOI: 10.1021/acs.jafc.5b04915     Document Type: Article

References (32)

1. Martín-Peláez, S.; Covas, M. I.; Fitó, M.; Kušar, A.; Pravst, I. Health effects of olive oil polyphenols: recent advances and possibilities for the use of health claims Mol. Nutr. Food Res. 2013, 57, 760-771 10.1002/mnfr.201200421
2. Rabovsky, A.; Cuomo, J.; Eich, N. Measurement of plasma antioxidant reserve after supplementation with various antioxidants in healthy subjects Clin. Chim. Acta 2006, 371, 55-60 10.1016/j.cca.2006.02.020
3. Rubió, L.; Motilva, M. J.; MacIà, A.; Ramo, T.; Romero, M. P. Development of a phenol-enriched olive oil with both its own phenolic compounds and complementary phenols from thyme J. Agric. Food Chem. 2012, 60, 3105-3112 10.1021/jf204902w
4. Rubió, L.; Serra, A.; Chen, C. Y.; Macià, A.; Romero, M. P.; Covas, M. I.; Solà, R.; Motilva, M. Effect of the co-occurring components from olive oil and thyme extracts on the antioxidant status and its bioavailability in an acute ingestion in rats Food Funct. 2014, 5 (4) 740 10.1039/c3fo60446b
5. Rubió, L.; Farrà, M.; de La Torre, R.; Macià, A.; Romero, M. P.; Valls, R. M.; Solà, R.; Farré, M.; Fitó, M.; Motilva, M. J. Metabolite profiling of olive oil and thyme phenols after a sustained intake of two phenol-enriched olive oils by humans: identification of compliance markers Food Res. Int. 2014, 65, 59 10.1016/j.foodres.2014.05.009
6. Plestina-Borjan, I.; Katusic, D.; Medvidovic-Grubisic, M.; Supe-Domic, D.; Bucan, K.; Tandara, L.; R, V. Association of age-related macular degeneration with erythrocyte antioxidant enzymes activity and serum total antioxidant status Oxid. Med. Cell. Longevity 2015, 2105, 804054 10.1155/2015/804054
7. EFSA Panel on Dietetic Products Nutrition and Allergies (NDA)s. Guidance on the scientific requirements for health claims related to antioxidants, oxidative damage and cardiovascular health EFSA J. 2011, 9, 1-13
8. Cooke, M. S.; Lunec, J.; Evans, M. D. Progress in the analysis of urinary oxidative DNA damage Free Radical Biol. Med. 2002, 33 (12) 1601-1614 10.1016/S0891-5849(02)01146-2
9. Davies, S. S.; Roberts, L. J. F2-isoprostanes as an indicator and risk factor for coronary heart disease Free Radical Biol. Med. 2011, 50, 559-566 10.1016/j.freeradbiomed.2010.11.023
10. Edrey, Y. H.; Salmon, A. B. Revisiting an age-old question regarding oxidative stress Free Radical Biol. Med. 2014, 71, 368-378 10.1016/j.freeradbiomed.2014.03.038
11. Rubió, L.; MacIà, A.; Valls, R. M.; Pedret, A.; Romero, M. P.; Solà, R.; Motilva, M. J. A new hydroxytyrosol metabolite identified in human plasma: hydroxytyrosol acetate sulphate Food Chem. 2012, 134 (2) 1132-1136 10.1016/j.foodchem.2012.02.192
12. Vázquez Roncero, A.; Janer Del Valle, C.; Janer Del Valle, M. L. Determinación de los polifenoles totales del aceite de oliva Grasas Aceites 1973, 24 (6) 350
13. Rubió, L.; Serra, A.; Macià, A.; Borrà, X.; Romero, M. P.; Motilva, M. J. Validation of determination of plasma metabolites derived from thyme bioactive compounds by improved liquid chromatography coupled to tandem mass spectrometry J. Chromatogr. B: Anal. Technol. Biomed. Life Sci. 2012, 905, 75-84 10.1016/j.jchromb.2012.07.040
14. Morelló, J. R.; Romero, M. P.; Motilva, M. J. Effect of the maturation of the olive fruit on the phenolic fraction of drupes and oils from Arbequina, Farga, and Morrut cultivars J. Agric. Food Chem. 2004, 52 (19) 6002-6009 10.1021/jf035300p
15. Criado, M. N.; Romero, M. P.; Casanovas, M.; Motilva, M. J. Pigment profile and colour of monovarietal virgin olive oils from Arbequina cultivar obtained during two consecutive crop seasons Food Chem. 2008, 110 (4) 873-880 10.1016/j.foodchem.2008.02.075
16. McCord, J. M.; Fridovich, I. Superoxide dismutase. An enzymic function for erythrocuprein (hemocuprein) J. Biol. Chem. 1969, 244 (22) 6049-6055
17. Paglia DE, V. W. Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase J. Lab. Clin. Med. 1967, 70 (1) 158
18. Aebi, H. [13] Catalase in vitro Methods Enzymol. 1984, 105 (C) 121-126 10.1016/S0076-6879(84)05016-3
19. Halliwell, B. Why and how should we measure oxidative DNA damage in nutritional studies? How far have we come? Am. J. Clin. Nutr. 2000, 72 (5) 1082-1087
20. Sharma, H.; Kanwal, R.; Bhaskaran, N.; Gupta, S. Plant flavone apigenin binds to nucleic acid bases and reduces oxidative DNA damage in prostate epithelial cells PLoS One 2014, 9 (3) e91588 10.1371/journal.pone.0091588
21. Jena, N. R.; Mishra, P. C. Formation of ring-opened and rearranged products of guanine: Mechanisms and biological significance Free Radical Biol. Med. 2012, 53, 81-94 10.1016/j.freeradbiomed.2012.04.008
22. Machowetz, A.; Poulsen, H. E.; Gruendel, S.; Weimann, A.; Fitó, M.; Marrugat, J.; de la Torre, R.; Salonen, J. T.; Nyyssönen, K.; Mursu, J.; Nascetti, S.; Gaddi, A.; Kiesewetter, H.; Bäumler, H.; Selmi, H.; Kaikkonen, J.; Zunft, H. J.; Covas, M. I.; Koebnick CMachowetz, A.; Poulsen, H. E.; Gruendel, S.; We, K. C. Effect of olive oils on biomarkers of oxidative DNA stress in Northern and Southern Europeans FASEB J. 2007, 21 (1) 45 10.1096/fj.06-6328com
23. Hillestrom, P. R.; Covas, M. I.; Poulsen, H. E. Effect of dietary virgin olive oil on urinary excretion of etheno-DNA adducts Free Radical Biol. Med. 2006, 41 (7) 1133-1138 10.1016/j.freeradbiomed.2006.06.013
24. Weinbrenner, T.; Fitó, M.; de la Torre, R.; Saez, G. T.; Rijken, P.; Tormos, C.; Coolen, S.; Albaladejo, M. F.; Abanades, S.; Schroder, H. Olive oils high in phenolic compounds modulate oxidative/antioxidative status in men J. Nutr. 2004, 134, 2314-2321
25. Salvini, S.; Sera, F.; Caruso, D.; Giovannelli, L.; Visioli, F.; Saieva, C.; Masala, G.; Ceroti, M.; Giovacchini, V.; Pitozzi, V. et al. Daily consumption of a high-phenol extra-virgin olive oil reduces oxidative DNA damage in postmenopausal women Br. J. Nutr. 2006, 95 (4) 742-751 10.1079/BJN20051674
26. Johnson, F.; Giulivi, C. Superoxide dismutases and their impact upon human health Mol. Aspects Med. 2005, 26, 340-352 10.1016/j.mam.2005.07.006
27. Vandenberg, J. J. M.; Denkamp, J. A. F.; Lubin, B. H.; Roelofsen, B.; Kuypers, F. A. Kinetics and site specificity of hydroperoxide-induced oxidative damage in red-blood-cells Free Radical Biol. Med. 1992, 12 (6) 487-498 10.1016/0891-5849(92)90102-M
28. Silva, D. G. H.; Belini Junior, E.; De Almeida, E. A.; Bonini-Domingos, C. R. Oxidative stress in sickle cell disease: an overview of erythrocyte redox metabolism and current antioxidant therapeutic strategies Free Radical Biol. Med. 2013, 65, 1101-1109 10.1016/j.freeradbiomed.2013.08.181
29. Zhao, B.; Ma, Y.; Xu, Z.; Wang, J.; Wang, F.; Wang, D.; Pan, S.; Wu, Y.; Pan, H.; Xu, D. et al. Hydroxytyrosol, a natural molecule from olive oil, suppresses the growth of human hepatocellular carcinoma cells via inactivating AKT and nuclear factor-kappa B pathways Cancer Lett. 2014, 347 (1) 79-87 10.1016/j.canlet.2014.01.028
30. Tilstra, J. S.; Robinson, A. R.; Wang, J.; Gregg, S. Q.; Clauson, C. L.; Reay, D. P.; Nasto, L. A., St; Croix, C. M.; Usas, A.; Vo, N. et al. NF-κB inhibition delays DNA damage-induced senescence and aging in mice J. Clin. Invest. 2012, 122 (7) 2601-2612 10.1172/JCI45785
31. Bouayed, J.; Bohn, T. Exogenous antioxidants-double-edged swords in cellular redox state: health beneficial effects at physiologic doses versus deleterious effects at high doses Oxid. Med. Cell. Longevity 2010, 3, 228-237 10.4161/oxim.3.4.12858
32. Valko, M.; Leibfritz, D.; Moncol, J.; Cronin, M. T. D.; Mazur, M.; Telser, J. Free radicals and antioxidants in normal physiological functions and human disease Int. J. Biochem. Cell Biol. 2007, 39 (1) 44-84 10.1016/j.biocel.2006.07.001