Plant flavone apigenin binds to nucleic acid bases and reduces oxidative DNA damage in prostate epithelial cells

PLoS ONE

Volumn 9, Issue 3, 2014, Pages

  Sharma, Haripaul ^a,b   Kanwal, Rajnee ^a,b   Bhaskaran, Natarajan ^a,b   Gupta, Sanjay ^a,b,c  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY HOSPITALS OF CLEVELAND   (United States)

^c CASE WESTERN RESERVE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

8 HYDROXYDEOXYGUANOSINE; APIGENIN; HYDROGEN PEROXIDE; REACTIVE OXYGEN METABOLITE; 8-OXO-7-HYDRODEOXYGUANOSINE; CALF THYMUS DNA; DEOXYGUANOSINE; DNA; NUCLEIC ACID;

ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; BIOACCUMULATION; CANCER CELL; CELL NUCLEUS MATRIX; CELL NUCLEUS MEMBRANE; CELL PROTECTION; CELL TRANSPORT; CELLULAR DISTRIBUTION; COMPARATIVE STUDY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOSOL; DNA DAMAGE; DRUG DNA BINDING; DRUG EFFECT; DRUG EXPOSURE; DRUG STABILITY; DRUG STRUCTURE; DRUG UPTAKE; GENOPROTECTIVE EFFECT; HUMAN; HUMAN CELL; IN VITRO STUDY; INTERCALATION COMPLEX; MICHAELIS MENTEN KINETICS; MICROSOME; OXIDATIVE STRESS; PROSTATE CANCER; PROSTATE EPITHELIUM; ULTRAVIOLET SPECTROPHOTOMETRY; ANALOGS AND DERIVATIVES; CELL DEATH; CELL FRACTIONATION; CHEMISTRY; CYTOLOGY; DRUG EFFECTS; ENDOCYTOSIS; EPITHELIUM CELL; KINETICS; MALE; METABOLISM; OXIDATION REDUCTION REACTION; PATHOLOGY; PROSTATE; PROSTATE TUMOR; TUMOR CELL LINE;

APIGENIN; CELL DEATH; CELL LINE, TUMOR; CYTOPROTECTION; DEOXYGUANOSINE; DNA; DNA DAMAGE; ENDOCYTOSIS; EPITHELIAL CELLS; HUMANS; HYDROGEN PEROXIDE; KINETICS; MALE; NUCLEIC ACIDS; OXIDATION-REDUCTION; PROSTATE; PROSTATIC NEOPLASMS; REACTIVE OXYGEN SPECIES; SPECTROPHOTOMETRY, ULTRAVIOLET; SUBCELLULAR FRACTIONS;

EID: 84897541026     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0091588     Document Type: Article

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