Antimicrobial action of compounds from marine seaweed

Marine Drugs

Volumn 14, Issue 3, 2016, Pages

  Pérez, María José ^a   Falqué, Elena ^a   Domínguez, Herminia ^a  

^a UNIVERSITY OF VIGO   (Spain)

Author keywords

Antimicrobial; Extraction techniques; In vitro and in vivo assays; Seaweed

Indexed keywords

AGAR; ALGAL EXTRACT; ALGINIC ACID; ALKALOID; CARRAGEENAN; FATTY ACID; FUCOIDIN; GALACTAN; LAMINARAN; LECTIN; LIPID; OLIGOSACCHARIDE; PHENOL; PIGMENT; POLYSACCHARIDE; ANTIINFECTIVE AGENT;

ACNE VULGARIS; ANTIBACTERIAL ACTIVITY; ANTIFUNGAL ACTIVITY; ANTIMICROBIAL ACTIVITY; ANTIPROTOZOAL ACTIVITY; ANTIVIRAL ACTIVITY; AQUACULTURE; BIOFOULING; CONCENTRATION RESPONSE; CYTOTOXICITY ASSAY; DRUG EFFICACY; DRUG MECHANISM; DRUG PURIFICATION; DRUG RESPONSE; DRUG STRUCTURE; DRUG SYNTHESIS; FOOD QUALITY; FOOD SAFETY; GROWTH INHIBITORY CONCENTRATION; HUMAN; IN VITRO STUDY; IN VIVO STUDY; MICROBIAL GROWTH; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PERIODONTITIS; REVIEW; SEASONAL VARIATION; ANIMAL; ANTIBIOTIC RESISTANCE; BROWN ALGA; CHEMISTRY; DRUG DEVELOPMENT; GREEN ALGA; ISOLATION AND PURIFICATION; METABOLISM; MULTIDRUG RESISTANCE; PROCEDURES; RED ALGA; SEAWEED;

ANIMALS; ANTI-INFECTIVE AGENTS; CHLOROPHYTA; DRUG DISCOVERY; DRUG RESISTANCE, MICROBIAL; DRUG RESISTANCE, MULTIPLE; HUMANS; PHAEOPHYTA; RHODOPHYTA; SEAWEED;

EID: 84960427390     PISSN: None     EISSN: 16603397     Source Type: Journal    
DOI: 10.3390/md14030052     Document Type: Review

References (168)

1. Bhadury, P.; Wright, P. C. Exploitation of marine algae: Biogenic compounds for potential antifouling applications. Planta 2004, 219, 561-578.
2. Hellio, C.; Marechal, J. P.; Veron, B.; Bremer, G.; Clare, A. S.; Le Gal, Y. Seasonal variation of antifouling activities of marine algae from the Brittany coast (France). Mar. Biotechnol. 2004, 6, 67-82.
3. Águila-Ramírez, R. N.; Arenas-González, A.; Hernández-Guerrero, C. J.; González-Acosta, B.; Borges-Souza, J. M.; Veron, B.; Pope, J.; Hellio, C. Antimicrobial and antifouling activities achieved by extracts of seaweeds from Gulf of California, Mexico. Hidrobiologica 2012, 22, 8-15.
4. Wijesinghe, W. A. J. P.; Athukorala, Y.; Jeon, Y. J. Effect of anticoagulative sulfated polysaccharide purified from enzyme-assistant extract of a brown seaweed Ecklonia cava on Wistar rats. Carbohydr. Polym. 2011, 86, 917-921.
5. Damonte, E. B.; Matulewicz, M. C.; Cerezo, A. S. Sulfated seaweed polysaccharides as antiviral agents. Curr. Med. Chem. 2004, 11, 2399-2419.
6. Cox, S.; Abu-Ghannam, N.; Gupta, S. An assessment of the antioxidant and antimicrobial activity of six species of edible Irish seaweeds. Int. Food Res. J. 2010, 17, 205-220.
7. Namvar, F.; Tahir, P. M.; Mohamad, R.; Mahdavi, M.; Abedi, P.; Najafi, T. F.; Rahman, H. S.; Jawaid, M. Biomedical Properties of Edible Seaweed in Cancer Therapy and Chemoprevention Trials: A Review. Nat. Prod. Commun. 2013, 8, 1811-1820. [PubMed]
8. Kazlowska, K.; Hsu, T.; Hou, C. C.; Yang, W. C.; Tsai, G. J. Anti-inflammatory properties of phenolic compounds and crude extract from Porphyra dentate. J. Ethnopharmacol. 2010, 128, 123-130.
9. Thanigaivel, S.; Hindu Vidhya, S.; Vijayakumar, S.; Mukherjee, A.; Chandrasekaran, N.; Thomas, J. Differential solvent extraction of two seaweeds and their efficacy in controlling Aeromonas salmonicida infection in Oreochromis mossambicus a novel therapeutic approach. Aquaculture 2015, 433, 56-64.
10. Cheung, R. C. F.; Wong, J. H.; Pan, W. L.; Chan, Y. S.; Yin, C. M.; Dan, X. L.; Wang, H. X.; Fang, E. F.; Lam, S. K.; Ngai, P. H. K.; et al. Antifungal and antiviral products of marine organisms. Appl. Microbiol. Biotechnol. 2014, 98, 3475-3494.
11. Yasuhara-Bell, J.; Lu, Y. Marine compounds and their antiviral activities. Antivir. Res. 2010, 86, 231-240.
12. Singh, R. P.; Kumari, P.; Reddy, C. R. K. Antimicrobial compounds from seaweed-associated bacteria and fungi. Appl. Microbiol. Biotechnol. 2015, 99, 1571-1586.
13. Valliappan, K.; Sun, W.; Li, Z. Marine actinobacteria associated with marine organisms and their potentials in producing pharmaceutical natural products. Appl. Microbiol. Biotechnol. 2014, 98, 7365-7377.
14. Vatsos, I. N.; Rebours, C. Seaweed extracts as antimicrobial agents in aquaculture. J. Appl. Phycol. 2015, 27, 2017-2035.
15. Eom, S. H.; Kim, Y. M.; Kim, S. K. Antimicrobial effect of phlorotannins from marine brown algae. Food Chem. Toxicol. 2012, 50, 3251-3255.
16. Abu-Ghannam, N.; Rajauria, G. Antimicrobial activity of compounds isolated from algae. In Functional Ingredients from Algae for Foods and Nutraceuticals; Domínguez, H., Ed.; Woodhead Publishing: Cambridge, UK, 2013; pp. 287-306.
17. Fernandes, D. R. P.; de Oliveira, V. P.; Valentin, Y. Y. Seaweed biotechnology in Brazil: Six decades of studies on natural products and their antibiotic and other biological activities. J. Appl. Phycol. 2014, 26, 1923-1937.
18. Gouveia, V.; Seca, A. M. L.; Barreto, M. C.; Pinto, D. C. G. A. Di- and sesquiterpenoids from Cystoseira genus: Structure, intra-molecular transformations and biological activity. Mini Rev. Med. Chem. 2013, 13, 1150-1159.
19. Suleria, H. A. R.; Osborne, S.; Masci, P.; Gobe, G. Marine-based nutraceuticals: An innovative trend in the food and supplement industries. Mar. Drugs 2015, 13, 6336-6351.
20. Balboa, E. M.; Conde, E.; Moure, A.; Falqué, E.; Dominguez, H. In vitro antioxidant properties of crude extracts and compounds from brown algae. Food Chem. 2013, 138, 1764-1785.
21. Usov, A. I. Chemical structures of algal polysaccharides. In Functional Ingredients from Algae for Foods and Nutraceuticals; Domínguez, H., Ed.; Woodhead Publishing: Cambridge, UK, 2013; pp. 23-86.
22. Vera, J.; Castro, J.; González, A.; Moenne, A. Review: Seaweed polysaccharides and derived oligosaccharides stimulate defense responses and protection against pathogens in plants. Mar. Drugs 2011, 9, 2514-2525.
23. Kraan, S. Algal polysaccharides, novel applications and outlook. In Carbohydrates-Comprehensive Studies on Glycobiology and Glycotechnology; Chang, C.-F., Ed.; InTech: Rijeka, Croatia, 2012.
24. Ahmadi, A.; Moghadamtousi, S. Z.; Abubakar, S.; Zandi, K. Antiviral potential of algae polysaccharides isolated from marine sources: A review. BioMed Res. Int. 2015, 2015.
25. Rioux, L. E.; Turgeon, S. L.; Beaulieu, M. Characterization of polysaccharides extracted from brown seaweeds. Carbohydr. Polym. 2007, 69, 530-537.
26. Cardoso, M. S.; Carvalho, G. L.; Silva, J. P.; Rodrigues, S. M.; Pereira, R. O.; Pereira, L. Bioproducts from seaweeds: A review with special focus on the Iberian Peninsula. Curr. Org. Chem. 2014, 18, 896-917.
27. Tutor, M. A.; Meyer, A. S. Fucoidans from brown seaweeds: An update on structures, extraction techniques and use of enzymes as tools for structural elucidation. RSC Adv. 2013, 3, 8131-8141.
28. Alves, A.; Sousa, R. A.; Reis, R. L. A practical perspective on ulvan extracted from green algae. J. Appl. Phycol. 2013, 25, 407-424.
29. Jiao, G.; Yu, G.; Zhang, J.; Ewart, H. S. Chemical structures and bioactivities of sulfated polysaccharides from marine algae. Mar. Drugs 2011, 9, 196-223.
30. Kumari, P.; Kumar, M.; Reddy, C. R. K.; Jha, B. Algal lipids, fatty acids and sterols. In Functional Ingredients from Algae for Foods and Nutraceuticals; Domínguez, H., Ed.; Woodhead Publishing: Cambridge, UK, 2013; pp. 87-134.
31. Plouguerné, E.; da Gama, B. A. P.; Pereira, R. C.; Barreto-Bergter, E. Glycolipids from seaweeds and their potential biotechnological applications. Front. Cell. Infect. Microbiol. 2014, 4, 1-5.
32. Singh, I. P.; Sidana, J. Phlorotannins. In Functional Ingredients from Algae for Foods and Nutraceuticals; Domínguez, H., Ed.; Woodhead Publishing: Cambridge, UK, 2013; pp. 181-204.
33. Gupta, S.; Abu-Ghannam, N. Recent developments in the application of seaweeds or seaweed extracts as a means for enhancing the safety and quality attributes of foods. Innov. Food Sci. Emerg. Technol. 2011, 12, 600-609.
34. Kraan, S. Pigments and minor compounds in algae. In Functional Ingredients from Algae for Foods and Nutraceuticals; Domínguez, H., Ed.; Woodhead Publishing: Cambridge, UK, 2013; pp. 205-251.
35. Christaki, E.; Bonos, E.; Giannenas, I.; Florou-Paneri, P. Functional properties of carotenoids originating from algae. J. Sci. Food Agric. 2013, 93, 5-11.
36. Singh, R. S.; Thakur, S. R.; Bansal, P. Algal lectins as promising biomolecules for biomedical research. Crit. Rev. Microbiol. 2015, 41, 77-88.
37. Cheung, R. C. F.; Wong, J. H.; Pan, W.; Chan, Y. S.; Yin, C.; Dan, X.; Ng, T. B. Marine lectins and their medicinal applications. Appl. Microbiol. Biotechnol. 2015, 99, 3755-3773.
38. Güven, K. S.; Percot, A.; Sezik, E. Alkaloids in Marine Algae. Mar. Drugs 2010, 8, 269-284.
39. Barbosa, M.; Valentão, P.; Andrade, P. B. Bioactive compounds from macroalgae in the new millennium: Implications for neurodegenerative diseases. Mar. Drugs 2014, 12, 4934-4972.
40. Bedoux, G.; Hardouin, K.; Burlot, A. S.; Bourgougnon, N. Bioactive compounds from seaweeds: Cosmetic applications and future development. Adv. Bot. Res. 2014, 71, 345-379.
41. El Gamal, A. A. Biological importance of marine algae. Saudi Pharm. J. 2010, 18, 1-25.
42. Ely, R.; Supriya, T.; Naik, C. G. Antimicrobial activity of marine organisms collected off the coast of South East India. J. Exp. Mar. Biol. Ecol. 2004, 309, 121-127.
43. Pinteus, S.; Alves, C.; Monteiro, H.; Araújo, E.; Horta, A.; Pedrosa, R. Asparagopsis armata and Sphaerococcus coronopifolius as a natural source of antimicrobial compounds. World J. Microbiol. Biotechnol. 2015, 31, 445-451.
44. Kolsi, R. B. A.; Frikha, D.; Jribi, I.; Hamza, A.; Feki, L.; Belghith, K. Screening of antibacterial and antifongical activity in marine macroalgae and Magnoliophytea from coast of Tunisia. Int. J. Pharm. Pharm. Sci. 2015, 7, 47-51.
45. Cavallo, R. A.; Acquaviva, M. I.; Stabili, L.; Cecere, E.; Petrocelli, A.; Narracci, M. Antibacterial activity of marine macroalgae against fish pathogenic Vibrio species. Cent. Eur. J. Biol. 2013, 8, 646-653.
46. Mhadhebi, L.; Chaiebb, K.; Bouraoui, A. Evaluation of antimicrobial activity of organic fractions of six marine algae from tunisian Mediterranean coasts. Int. J. Pharm. Pharm. Sci. 2012, 4, 534-537.
47. Bansemir, A.; Blume, M.; Schröder, S.; Lindequist, U. Screening of cultivated seaweeds for antibacterial activity against fish pathogenic bacteria. Aquaculture 2006, 252, 79-84.
48. Beaulieu, L.; Thibodeau, J.; Desbiens, M.; Saint-Louis, R.; Zatylny-Gaudin, C.; Thibault, S. Evidence of antibacterial activities in peptide fractions originating from snow crab (Chionoecetes opilio) by-products. Probiotics Antimicrob. Proteins 2010, 2, 197-209.
49. Bouhlal, R.; Riadi, H.; Martínez, J.; Bourgougnon, N. The antibacterial potential of the seaweeds (Rhodophyceae) of the Strait of Gibraltar and the Mediterranean coast of Morocco. Afr. J. Biotechnol. 2010, 9, 6365-6372.
50. Thanigaivel, S.; Vijayakumar, S.; Mukherjee, A.; Chandrasekaran, N.; Thomas, J. Antioxidant and antibacterial activity of Chaetomorpha antennina against shrimp pathogen Vibrio parahaemolyticus. Aquaculture 2014, 433, 467-475.
51. Thanigaivel, S.; Vijayakumar, S.; Gopinath, S.; Mukherjee, A.; Chandrasekaran, N.; Thomas, J. In vivo and in vitro antimicrobial activity of Azadirachta indica (Lin) against Citrobacter freundii isolated from naturally infected Tilapia (Oreochromis mossambicus). Aquaculture 2015, 437, 252-255.
52. Shanmughapriya, S.; Manilal, A.; Sujith, S.; Selvin, J. Seghal Kiran, G.; Natarajaseenivasan, K. Antimicrobial activity of seaweeds extracts against multiresistant pathogens. Ann. Microbiol. 2008, 58, 535-541.
53. García-Bueno, N.; Decottignies, P.; Turpin, V.; Dumay, J.; Paillard, C.; Stiger-Pouvreau, V.; Kervarec, N.; Pouchus, Y. F.; Marín-Atucha, A. A.; Fleurence, J. Seasonal antibacterial activity of two red seaweeds, Palmaria palmata and Grateloupia turuturu, on European abalone pathogen Vibrio harveyi. Aquat. Living Resour. 2014, 27, 83-89.
54. Cox, S.; Turley, G. H.; Rajauria, G.; Abu-Ghannam, N.; Jaiswal, A. K. Antioxidant potential and antimicrobial efficacy of seaweed (Himanthalia elongata) extract in model food systems. J. Appl. Phycol. 2014, 26, 1823-1831.
55. Dubber, D.; Harder, T. Extracts of Ceramium rubrum, Mastocarpus stellatus and Laminaria digitata inhibit growth of marine and fish pathogenic bacteria at ecologically realistic concentrations. Aquaculture 2008, 274, 196-200.
56. Boisvert, C.; Beaulieu, L.; Bonnet, C.; Pelletier, E. Assessment of the antioxidant and antibacterial activities of three species of edible seaweeds. J. Food Biochem. 2015, 39, 377-387.
57. Bazes, S.; Silkina, A.; Defer, D.; Bernède-Bauduin, C.; Quéméner, E.; Braud, J. P.; Bourgougnon, N. Active substances from Ceramium botryocarpum used as antifouling products in aquaculture. Aquaculture 2006, 258, 664-674.
58. Hellio, C.; De La Broise, D.; Dufossé, L.; Le Gal, Y.; Bourgougnon, N. Inhibition of marine bacteria by extract of macroalgae: Potential use for environmentally friendly paints. Mar. Environ. Res. 2001, 52, 231-247.
59. Spavieri, J.; Allmendinger, A.; Kaiser, M.; Casey, R.; Hingley-Wilson, S.; Lalvani, A.; Guiry, M. D.; Blunden, G.; Tasdemir, D. Antimycobacterial, antiprotozoal and cytotoxic potential of twenty-one brown algae (Phaeophyceae) from British and Irish waters. Phytother. Res. 2010, 24, 1724-1729.
60. Bouhlal, R.; Riadi, H.; Bourgougnon, N. Antiviral activity of the extracts of Rhodophyceae from Morocco. Afr. J. Biotechnol. 2010, 9, 7968-7975.
61. Wang, W.; Wang, S. X.; Guan, H. S. The antiviral activities and mechanisms of marine polysaccharides: An overview. Mar. Drugs 2012, 10, 2795-2816.
62. Manilal, A.; Selvin, J.; George, S. In vivo therapeutic potentiality of red seaweed, Asparagopsis (Bonnemaisoniales, Rhodophyta) in the treatment of vibriosis in Penaeus monodon, Fabricius. Saudi J. Biol. Sci. 2012, 19, 165-175.
63. Freile-Pelegrín, Y.; Morales, J. L. Antibacterial activity in marine algae from the coast of Yucatan, Mexico. Bot. Mar. 2004, 47, 140-146.
64. Trigui, M.; Gasmi, L.; Zouari, I.; Tounsi, S. Seasonal variation in phenolic composition, antibacterial and antioxidant activities of Ulva rigida (Chlorophyta) and assessment of antiacetylcholinesterase potential. J. Appl. Phycol. 2013, 25, 319-328.
65. Stabili, L.; Acquaviva, M. I.; Biandolino, F.; Cavallo, R. A.; De Pascali, S. A.; Fanizzi, F. C.; Narracci, M.; Cecere, E.; Petrocelli, A. Biotechnological potential of the seaweed Cladophora rupestris (Chlorophyta, Cladophorales) lipidic extract. New Biotechnol. 2014, 31, 436-444.
66. Stirk, W. A.; Reinecke, D. L.; van Staden, J. Seasonal variation in antifungal, antibacterial and acetylcholinesterase activity in seven South African seaweeds. J. Appl. Phycol. 2007, 19, 271-276.
67. Choi, J. S.; Ha, Y. M.; Lee, B. B.; Moon, H. E.; Cho, K. K.; Choi, I. S. Seasonal variation of antibacterial activities in the green alga Ulva pertusa Kjellman. J. Environ. Biol. 2014, 35, 341-344. [PubMed]
68. Krish, S.; Das, A. In-vitro bioactivity of marine seaweed, Cladophora rupestris. Int. J. Pharm. Biol. Sci. 2014, 5, 898-908.
69. Padmakumar, K.; Ayyakkannu, K. Seasonal variation of antibacterial and antifungal activities of the extracts of marine algae from southern coasts of India. Bot. Mar. 1997, 40, 507-515.
70. Tanniou, A.; Vandanjon, L.; Incera, M.; Serrano Leon, E.; Husa, V.; Le Grand, J.; Nicolas, J. L.; Poupart, N.; Kervarec, N.; Engelen, A.; et al. Assessment of the spatial variability of phenolic contents and associated bioactivities in the invasive alga Sargassum muticum sampled along its European range from Norway to Portugal. J. Appl. Phycol. 2014, 26, 1215-1230.
71. El Amraoui, B.; El Amraoui, M.; Cohen, N.; Fassouane, A. Anti-Candida and anti-Cryptococcus antifungal produced by marine microorganisms. J. Mycol. Med. 2014, 24, 149-153.
72. Villarreal-Gómez, L. J.; Soria-Mercado, I. E.; Guerra-Rivas, G.; Ayala-Sánchez, N. E. Antibacterial and anticancer activity of seaweeds and bacteria associated with their surface. Rev. Biol. Mar. Oceanogr. 2010, 45, 267-275.
73. Horta, A.; Pinteus, S.; Alves, C.; Fino, N.; Silva, J.; Fernandez, S.; Rodrigues, A.; Pedrosa, R. Antioxidant and antimicrobial potential of the Bifurcaria bifurcata epiphytic bacteria. Mar. Drugs 2014, 12, 1676-1689.
74. Mendes, M.; Pereira, R.; Sousa Pinto, I.; Carvalho, A. P.; Gomes, A. M. Antimicrobial activity and lipid profile of seaweed extracts from the North Portuguese Coast. Int. Food Res. J. 2013, 20, 3337-3345.
75. Chambers, L. D.; Hellio, C.; Stokes, K. R.; Dennington, S. P.; Goodes, L. R.; Wood, R. J. K.; Walsh, F. C. Investigation of Chondrus crispus as a potential source of new antifouling agents. Int. Biodeterior. Biodegrad. 2011, 65, 939-946.
76. Cox, S.; Abu-Ghannam, N.; Gupta, S. Effect of processing conditions on phytochemical constituents of edible Irish seaweed Himanthalia elongate. J. Food Proc. Preserv. 2012, 36, 348-363.
77. Eom, S. H.; Lee, D. S.; Kang, Y. M.; Son, K. T.; Jeon, Y. J.; Kim, Y. M. Application of yeast Candida utilis to ferment Eisenia.bicyclis for enhanced antibacterial effect. Appl. Biochem. Biotechnol. 2013, 171, 569-582.
78. Rosaline, S. D.; Sakthivelkumar, S.; Rajendran, K.; Janarthanan, S. Screening of selected marine algae from the coastal Tamil Nadu, South India for antibacterial activity. Asian Pac. J. Trop. Biomed. 2012, 2, S140-S146.
79. Saritha, K.; Mani, A. E.; Priyalaxmi, M.; Patterson, J. Antibacterial activity and biochemical constituents of seaweed Ulva lactuca. Glob. J. Pharmacol. 2013, 7, 276-282.
80. Karthikeyan, K.; Shweta, K.; Jayanthi, G.; Prabhu, K.; Thirumaran, G. Antimicrobial and antioxidant potential of selected seaweeds from Kodinar, Southern Coast of Saurashtra, Gujarat, India. J. Appl. Pharm. Sci. 2015, 5, 35-40.
81. Jaswir, I.; Tope, A. H. T.; Raus, R. A.; Monsur, H. A.; Ramli, N. Study on anti-bacterial potentials of some Malaysian brown seaweeds. Food Hydrocoll. 2014, 42, 275-279.
82. Osman, M. E. H.; Abushady, A. M.; Elshobary, M. E. In vitro screening of antimicrobial activity of extracts of some macroalgae collected from Abu-Qir bay Alexandria, Egypt. Afr. J. Biotechnol. 2010, 9, 7203-7208.
83. Kavita, K.; Singh, V. K.; Jha, B. 24-branched delta 5 sterols from Laurencia papillosa red seaweed with antibacterial activity against human pathogenic bacteria. Microbiol. Res. 2014, 169, 301-306.
84. Al Hazzani, A. A.; Shehata, A. I.; Moubayed, N. M. S.; Al Houri, H. J. Antimicrobial and biochemical properties of selected edible brown and red marine macroalgae. J. Pure Appl. Microbiol. 2014, 8, 1275-1282.
85. Horincar, V. B.; Parfene, G.; Tyagi, A. K.; Gottardi, D.; Dinica, R.; Guerzoni, M. E.; Bahrim, G. Extraction and characterization of volatile compounds and fatty acids from red and green macroalgae from the Romanian Black Sea in order to obtain valuable bioadditives and biopreservatives. J. Appl. Phycol. 2014, 26, 551-559.
86. Muñoz-Ochoa, M.; Murillo-Álvarez, J. I.; Zermeño-Cervantes, L. A.; Martínez-Díaz, S.; Rodríguez-Riosmena, R. Screening of extracts of algae from Baja California Sur, Mexico as reversers of the antibiotic resistance of some pathogenic bacteria. Eur. Rev. Med. Pharmacol. Sci. 2010, 14, 739-747. [PubMed]
87. Salta, M.; Wharton, J. A.; Dennington, S. P.; Stoodley, P.; Stokes, K. R. Anti-biofilm performance of three natural products against initial bacterial attachment. Int. J. Mol. Sci. 2013, 14, 21757-21780.
88. Manilal, A.; Sujith, S.; Selvin, J.; Kiran, G. S.; Shakir, C.; Lipton, A. P. Antimicrobial potential of marine organisms collected from the southwest coast of India against multiresistant human and shrimp pathogens. Sci. Mar. 2010, 74, 287-296.
89. Jiang, Z. B.; Chen, Y. C.; Yao, F.; Chen, W. Z.; Zhong, S. P.; Zheng, F. C.; Shi, G. G. Antioxidant, antibacterial and antischistosomal activities of extracts from Grateloupia livida (Harv). Yamada. PLoS. ONE 2013, 8, 1-10.
90. Amorim, R. D. D.; Rodrigues, J. A. G.; Holanda, M. L.; Quindere, A. L. G.; de Paula, R. C. M.; Melo, V. M. M.; Benevides, N. M. B. Antimicrobial effect of a crude sulfated polysaccharide from the red seaweed Gracilaria ornata. Braz. Arch. Biol. Technol. 2012, 55, 171-181.
91. Stabili, L.; Acquaviva, M. I.; Biandolino, F.; Cavallo, R. A.; De Pascali, S. A.; Fanizzi, F. P.; Narracini, M.; Petrocelli, A.; Cecere, E. The lipidic extract of the seaweed Gracilariopsis longissima (Rhodophyta, Gracilariales): A potential resource for biotechnological purposes? New Biotechnol. 2012, 29, 443-450.
92. Taskin, E.; Caki, Z.; Ozturk, M.; Taskin, E. Assessment of in vitro antitumoral and antimicrobial activities of marine algae harvested from the eastern Mediterranean sea. Afr. J. Biotechnol. 2010, 9, 4272-4277.
93. Kandhasamy, M.; Arunachalam, K. D. Evaluation of in vitro antibacterial property of seaweeds of southeast coast of India. Afr. J. Biotechnol. 2008, 7, 1958-1961.
94. Bianco, E. M.; de Oliveira, S. Q.; Rigotto, C.; Tonini, M. L.; Guimaraes, T. D.; Bittencourt, F.; Gouvea, L. P.; Aresi, C.; de Almeida, M. T. R.; Moritz, M. I. G.; et al. Anti-Infective potential of marine invertebrates and seaweeds from the Brazilian coast. Molecules 2013, 18, 5761-5778.
95. Tan, S. P.; McLoughlin, P.; O'Sullivan, L.; Prieto, M. L.; Gardiner, G. E.; Lawlor, P. G.; Hughes, H. Development of a novel antimicrobial seaweed extract-based hydrogel wound dressing. Int. J. Pharm. 2013, 456, 10-20.
96. Rodrigues, D.; Alves, C.; Horta, A.; Pinteus, S.; Silva, J.; Culioli, G.; Thomas, O. P.; Pedrosa, R. Antitumor and antimicrobial potential of bromoditerpenes Isolated from the red alga, Sphaerococcus coronopifolius. Mar. Drugs 2015, 13, 713-726.
97. Nagappan, T.; Vairappan, C. S. Nutritional and bioactive properties of three edible species of green algae, genus Caulerpa (Caulerpaceae). J. Appl. Phycol. 2014, 26, 1019-1027.
98. Pierre, G.; Sopena, V.; Juin, C.; Mastouri, A.; Graber, M.; Maugard, T. Antibacterial activity of a sulfated galactan extracted from the marine alga Chaetomorpha aerea against Staphylococcus aureus. Biotechnol. Bioprocess Eng. 2011, 16, 937-945.
99. Yuvaraj, N.; Kanmani, P.; Satishkumar, R.; Paari, K. A.; Pattukumar, V.; Arul, V. Extraction, purification and partial characterization of Cladophora glomerata against multidrug resistant human pathogen Acinetobacter baumannii and fish pathogens. World J. Fish Mar. Sci. 2011, 3, 51-57.
100. Ha, Y. M.; Choi, J. S.; Lee, B. B.; Moon, H. E.; Cho, K. K.; Choi, I. S. Inhibitory effects of seaweed extracts on the growth of the vaginal bacterium Gardnerella vaginalis. J. Environ. Biol. 2014, 35, 537-542. [PubMed]
101. Kosanic, M.; Rankovic, B.; Stanojkovic, T. Biological activities of two macroalgae from Adriatic coast of Montenegro. Saudi J. Biol. Sci. 2015, 22, 390-397.
102. Park, N. H.; Choi, J. S.; Hwang, S. Y.; Kim, Y. C.; Hong, Y. K.; Cho, K. K.; Choi, I. S. Antimicrobial activities of stearidonic and gamma-linolenic acids from the green seaweed Enteromorpha linza against several oral pathogenic bacteria. Bot. Stud. 2013, 54, 39-47.
103. Patra, J. K.; Das, G.; Baek, K. H. Antibacterial mechanism of the action of Enteromorpha linza L.essential oil against Escherichia coli and Salmonella typhimurium. Bot. Stud. 2015, 56, 13-21.
104. Lee, J. H.; Eom, S. H.; Lee, E. H.; Jung, Y. J.; Kim, H. J.; Jo, M. R.; Son, K. T.; Lee, H. J.; Kim, J. H.; Lee, M. S.; et al. In vitro antibacterial and synergistic effect of phlorotannins isolated from edible Brown seaweed Eisenia bicyclis against acne-related bacteria. Algae 2014, 29, 47-55.
105. Amiguet, V. T.; Jewell, L. E.; Mao, H.; Sharma, M.; Hudson, J. B.; Durst, T.; Allard, M.; Rochefort, G.; Arnason, J. T. Antibacterial properties of a glycolipid-rich extract and active principle from Nunavik collections of the macroalgae Fucus evanescens C. Agardh (Fucaceae). Can. J. Microbiol. 2011, 57, 745-749.
106. Plaza, M.; Santoyo, S.; Jaime, L.; Reina, G. G. B.; Herrero, M.; Señoráns, F. J.; Ibáñez, E. Screening for bioactive compounds from algae. J. Pharm. Biomed. Anal. 2010, 51, 450-455.
107. Rajauria, G.; Jaiswal, A. K.; Abu-Gannam, N.; Gupta, S. Antimicrobial, antioxidant and free radicalscavenging capacity of brown seaweed Himanthalia.elongata from western coast of Ireland. J. Food Biochem. 2013, 37, 322-335.
108. Patra, J. K.; Das, G.; Baek, K. H. Chemical composition and antioxidant and antibacterial activities of an essential oil extracted from an edible seaweed, Laminaria japonica L. Molecules 2015, 20, 12093-12113.
109. Manilal, J. S.; Thajuddin, N.; Sujith, S.; Panikkar, M. V. N.; Idhayadhulla, A.; Kumar, R. S. Biopotentials of marine alga, Lobophora variegata collected from the shouth indian littoral. Thalassas 2012, 28, 47-54.
110. Nogueira, L. F.; Morais, E. C.; Brito, M. A.; Santos, B. S.; Vale, D. L.; Lucena, B. F.; Figueredo, F. G.; Guedes, G. M.; Tintino, S. R.; Souza, C. E.; et al. Evaluation of antibacterial, antifungal and modulatory activity of methanol and ethanol extracts of Padina sanctae-crucis. Afr. Health Sci. 2014, 14, 372-376.
111. Meillisa, A.; Siahaan, E. A.; Park, J. N.; Woo, H. C.; Chun, B. S. Effect of subcritical water hydrolysate in the brown seaweed Saccharina japonica as a potential antibacterial agent on food-borne pathogens. J. Appl. Phycol. 2013, 25, 763-769.
112. Sivagnanam, S. P.; Yin, S.; Choi, J. H.; Park, Y. B.; Woo, H. C.; Chun, B. S. Biological properties of fucoxanthin in oil recovered from two brown seaweeds using supercritical CO2 extraction. Mar. Drugs 2015, 13, 3422-3442.
113. Adaikalaraj, G.; Patric, R. D.; Johnson, M.; Janakiraman, N.; Babu, A. Antibacterial potential of selected red seaweeds from Manapad coastal areas, Thoothukudi, Tamil Nadu, India. Asian Pac. J. Trop. Biomed. 2012, 2, 1077-1080.
114. Jassbi, A. R.; Mohabati, M.; Eslami, S.; Sohrabipour, J.; Miri, R. Biological activity and chemical constituents of red and brown algae from the Persian Gulf. Iran. J. Pharm. Res. 2013, 12, 339-348. [PubMed]
115. De Jesus Raposo, M. F.; de Morais, A. M. B.; de Morais, R. M. S. C. Marine polysaccharides from algae with potential biomedical applications. Mar. Drugs 2015, 13, 2967-3028.
116. Varahalarao, V.; Chandrasekhar, N. K. In vitro antimicrobial potentiality of some marine algae against selected phytopathogens. Biomed. Pharmacol. J. 2009, 2, 277-280.
117. Gupta, S.; Cox, S.; Rajauria, G.; Jaiswal, A. K.; Abu-Ghannam, N. Growth inhibition of common food spoilage and pathogenic microorganisms in the presence of brown seaweed extracts. Food Bioprocess Technol. 2012, 5, 1907-1916.
118. Salem, W. M.; Galal, H.; Nasr El-deen, F. Screening for antibacterial activities in some marine algae from the red sea (Hurghada, Egypt). Afr. J. Microbiol. Res. 2011, 5, 2160-2167.
119. Shanmugam, J.; Devi Raman, K.; Viswanathan, S.; Nallamuthu, T. Antibacterial and antioxidant activity of red seaweeds from Kilakarai, Rameswaram, Tamilnadu, India. J. Pharm. Biomed. Sci. 2013, 32, 1386-1395.
120. Patra, J. K.; Kim, S. H.; Baek, K. H. Antioxidant and free radical-scavenging potential of essential oil from Enteromorpha.linza L. prepared by microwave-assisted hydrodistillation. J. Food Biochem. 2015, 39, 80-90.
121. Kadam, S. U.; O'Donnell, C. P.; Rai, D. K.; Hossain, M. B.; Burgess, C. M.; Walsh, D.; Tiwari, B. K. Laminarin from Irish brown seaweeds Ascophyllum nodosum and Laminaria hyperborea: Ultrasound Assisted Extraction, characterization and bioactivity. Mar. Drugs 2015, 13, 4270-4280.
122. Michalak, I.; Chojnacka, K. Algae as production systems of bioactive compounds. Eng. Life Sci. 2015, 15, 160-176.
123. Kim, J.-Y.; Lee, J.-A.; Kim, K.-N.; Yoon, W.-J.; Lee, W. J.; Park, S.-Y. Antioxidative and Antimicrobial activities of Sargassum muticum extracts. J. Korean Soc. Food Sci. Nutr. 2007, 36, 663-669.
124. De Felício, R.; de Albuquerque, S.; Young, M. C. M.; Yokoya, N. S.; Debonsi, H. M. Trypanocidal, leishmanicidal and antifungal potential from marine red alga Bostrychia tenella J. Agardh (Rhodomelaceae, Ceramiales). J. Pharm. Biomed. Anal. 2010, 52, 763-769.
125. Ismail, A.; Salah, K. B. H.; Ahmed, M.; Mastouri, M.; Bouraoui, A.; Aouni, M. Antibacterial and antifungal activities of brown alga Zonaria tournefortii (JV Lamouroux). Allelopathy J. 2014, 34, 143-153.
126. Barreto, M.; Meyer, J. J. M. Isolation and antimicrobial activity of a lanosol derivative from Osmundaria serrata (Rhodophyta) and a visual exploration of its biofilm covering. S. Afr. J. Bot. 2006, 72, 521-528.
127. Vairappan, C. S.; Suzuki, M.; Ishii, T.; Okino, T.; Abe, T.; Masuda, M. Antibacterial activity of halogenated sesquiterpenes from Malaysian Laurencia spp. Phytochemistry 2008, 69, 2490-2494.
128. Ben Redjem, Y.; Ktari, L.; Medhioub, A.; Romdhane, M. S.; Langar, H.; El Bour, M. Antibacterial and algicidal properties of some brown seaweeds from Northern coasts of Tunisia. Life Environ. 2013, 63, 127-133.
129. Mathan, S.; Subramanian, V.; Nagamony, S.; Ganapathy, K. Isolation of endophytic fungiform marine algae and its bioactivity. Int. J. Res. Pharm. Sci. 2013, 4, 45-49.
130. Cortés, Y.; Hormazábal, E.; Leal, H.; Urzúa, A.; Mutis, A.; Parra, L.; Quiroz, A. Novel antimicrobial activity of a dichloromethane extract obtained from red seaweed Ceramium rubrum (Hudson) (Rhodophyta: Florideophyceae) against Yersinia ruckeri and Saprolegnia.parasitica, agents that cause diseases in salmonids. Electron. J. Biotechnol. 2014, 17, 126-131.
131. Thanigaivel, S.; Chandrasekaran, N.; Mukherjee, A.; Thomas, J. Investigation of seaweed extracts as a source of treatment against bacterial fish pathogen. Aquaculture 2015, 448, 82-86.
132. Oliveira, S. T. L.; Veneroni-Gouveia, G.; Santos, A. C.; Sousa, S. M. N.; Veiga, M. L.; Krewer, C. C.; Costa, M. M. Ascophyllum nodosum in the diet of tilapia (Oreochromis niloticus) and its effect after inoculation of Aeromonas hydrophila. Pesqui. Vet. Bras. 2014, 34, 403-408.
133. Dhanya, K. I.; Swati, V. I.; Vanka, K. S.; Osborne, W. J. Antimicrobial activity of Ulva reticulata and its endophytes. J. Ocean Univ. China, 2016, 15, 363-369.
134. Kim, I. H.; Lee, D. G.; Lee, S. H.; Ha, J. M.; Ha, B. J.; Kim, S. K.; Lee, J. H. Antibacterial activity of Ulva lactuca against methicillin-resistant Staphylococcus aureus (MRSA). Biotechnol. Bioprocess Eng. 2007, 12, 579-582.
135. Oh, K.; Lee, J. H.; Chung, S. C.; Shin, J.; Shin, H. J.; Kimd, H. K.; Lee, H. S. Antimicrobial activities of the bromophenols from the red alga Odonthalia corymbifera and some synthetic derivatives. Bioorg. Med. Chem. Lett. 2008, 18, 104-108.
136. Genovese, G.; Leitner, S.; Minicante, S. A.; Lass-Florl, C. The Mediterranean red alga Asparagopsis taxiformis has antifungal activity against Aspergillus species. Mycoses 2013, 56, 516-519.
137. Mohandass, C.; Vijayaraj, A. S.; Rajasabapathy, R.; Satheeshbabu, S.; Rao, S. V.; Shiva, C.; De-Mello, L. Biosynthesis of silver nanoparticles from marine seaweed Sargassum cinereum and their antibacterial activity. Indian J. Pharm. Sci. 2013, 75, 606-610. [PubMed]
138. Osman, M. E. H.; Aboshady, A. M.; Elshobary, M. E. Production and characterization of antimicrobial active substance from some macroalgae collected from AbuQir bay (Alexandria) Egypt. Afr. J. Biotechnol. 2013, 12, 6847-6858.
139. Gerasimenko, N. I.; Martyyas, E. A.; Busarova, N. G. Composition of lipids and biological activity of lipids and photosynthetic pigments from algae of the families Laminariaceae and Alariaceae. Chem. Nat. Compd. 2012, 48, 737-741.
140. El Wahidi, M.; El Amraoui, B.; El Amraoui, M.; Bamhaoud, T. Screening of antimicrobial activity of macroalgae extracts from the Moroccan Atlantic coast. Ann. Pharm. Fr. 2015, 73, 190-196.
141. Lopes, G.; Andrade, P. B.; Valentão, P. Screening of a marine algal extract for antifungal activities. Methods Mol. Biol. 2015, 1308, 411-420. [PubMed]
142. Wei, Y. X.; Liu, Q.; Yu, J.; Feng, Q.; Zhao, L.; Song, H. P.; Wang, W. X. Antibacterial mode of action of 1, 8-dihydroxy-anthraquinone from Porphyra haitanensis against Staphylococcus aureus. Nat. Prod. Res. 2015, 29, 976-979.
143. Lee, B. B.; Choi, J. S.; Moon, H. E.; Ha, Y. M.; Kim, M. S.; Cho, K. K.; Choi, I. S. Inhibition of growth and urease of Helicobacter pylori by Korean edible seaweed extracts. Bot. Sci. 2013, 91, 515-522.
144. Vedhagiri, K.; Manilal, A.; Valliyammai, T.; Shanmughapriya, S.; Sujith, S.; Selvin, J.; Natarajaseeniva, K. Antimicrobial potential of a marine seaweed Asparagopsis taxiformis against Leptospira javanica isolates of rodent reservoirs. Ann. Microbiol. 2009, 59, 431-437.
145. Choi, J. S.; Ha, Y. M.; Joo, C. U.; Cho, K. K.; Kim, S. J.; Choi, I. S. Inhibition of oral pathogens and collagenase activity by seaweed extracts. J. Environ. Biol. 2012, 33, 115-121. [PubMed]
146. Kim, Y. H.; Kim, J. H.; Jin, H. J.; Lee, S. Y. Antimicrobial activity of ethanol extracts of Laminaria japonica against oral microorganisms. Anaerobe 2013, 21, 34-38.
147. Naqvi, A. Z.; Buettner, C.; Phillips, R. S.; Davis, R. B.; Mukamal, K. J. n-3 fatty acids and periodontitis in US adults. J. Am. Diet. Assoc. 2010, 110, 1669-1675.
148. Lee, K. Y.; Jeong, M. R.; Choi, S. M.; Na, S. S.; Cha, J. D. Synergistic effect of fucoidan with antibiotics against oral pathogenic bacteria. Arch. Oral Biol. 2013, 58, 482-492.
149. Harden, E. A.; Falshaw, R.; Carnachan, S. M.; Kern, E. R.; Prichard, M. N. Virucidal activity of polysaccharide extracts from four algal species against herpes simplex virus. Antivir. Res. 2009, 83, 282-289.
150. De Souza, L. M.; Sassaki, G. L.; Romanos, M. T. V.; Barreto-Bergter, E. Structural characterization and anti-HSV-1 and HSV-2 activity of glycolipids from the marine algae Osmundaria obtusiloba isolated from Southeastern Brazilian coast. Mar. Drugs 2012, 10, 918-931.
151. Koishi, A. C.; Zanello, P. R.; Bianco, E. M.; Bordignon, J.; dos Santos, C. N. D. Screening of dengue virus antiviral activity of marine seaweeds by an in situ enzyme-linked immunosorbent assay. PLoS ONE 2012, 7, 1-11.
152. Abrantes, J. L.; Barbosa, J.; Cavalcanti, D.; Pereira, R. C.; Fontes, C. F. L.; Teixeira, V. L.; Souza, T. M. L.; Paixão, I. C. P. The effects of the diterpenes Isolated from the Brazilian brown algae Dictyota pfaffii and Dictyota menstrualis against the Herpes Simplex Type-1 Replicative Cycle. Planta Med. 2010, 76, 339-344.
153. Mendes, G.; Soares, A. R.; Sigiliano, L.; Machado, F.; Kaiser, C.; Romeiro, N.; Gestinari, L.; Santos, N.; Romanos, M. T. V. In vitro anti-HMPV activity of meroditerpenoids from marine alga Stypopodium zonale (Dictyotales). Molecules 2011, 16, 8437-8450.
154. Kim, S. K.; Karadeniz, F. Anti-HIV activity of extracts and compounds from marine algae. Adv. Food Nutr. Res. 2011, 64, 255-265. [PubMed]
155. Morya, V. K.; Kim, J.; Kim, E.-K. Algal fucoidan: Structural and size-dependent bioactivities and their perspectives. Appl. Microb. Biotechnol. 2012, 93, 71-82.
156. Naesens, L.; Stephens, C. E.; Andrei, G.; Loregian, A.; De Bolle, L.; Snoeck, R.; Sowell, J. W.; De Clercq, E. Antiviral properties of new arylsulfone derivatives with activity against human betaherpesviruses. Antivir. Res. 2006, 72, 60-67.
157. Bandyopadhyay, S. S.; Navid, M. H.; Ghosh, T.; Schnitzler, P.; Ray, B. Structural features and in vitro antiviral activities of sulfated polysaccharides from Sphacelaria indica. Phytochemistry 2011, 72, 276-283.
158. Elizondo-González, R.; Cruz-Suárez, L. E.; Ricque-Marie, D.; Mendoza-Gamboa, E.; Rodríguez-Padilla, C.; Trejo-Ávila, L. M. In vitro characterization of the antiviral activity of fucoidan from Cladosiphon okamuranus against Newcastle Disease Virus. Virol. J. 2012, 9, 1-9.
159. Nagorskaia, V. P.; Reunov, A. V.; Lapshina, L. A.; Ermak, I. M.; Barabanova, A. O. Influence of kappa/beta-carrageenan from red alga Tichocarpus crinitus on development of local infection induced by tobacco mosaic virus in Xanthinc tobacco leaves. Izv. Akad. Nauk. Ser. Biol. 2008, 3, 360-364. [PubMed]
160. De S.f-Tischer, P. C.; Talarico, L. B.; Noseda, M. D.; Guimarães, S. M.; Damonte, E. B.; Duarte, M. E. R. Chemical structure and antiviral activity of carrageenans from Meristiella gelidium against herpes simplex and dengue virus. Carbohydr. Polym. 2006, 63, 459-465.
161. Vijayavel, K.; Martínez, J. A. In vitro antioxidant and antimicrobial activities of two Hawaiian marine Limu: Ulva fasciata (Chlorophyta) and Gracilaria salicornia (Rhodophyta). J. Med. Food. 2010, 13, 1494-1499.
162. Devi, K. P.; Suganthy, N.; Kesika, P.; Karutha Pandian, S. Bioprotective properties of seaweeds: In vitro evaluation of antioxidant activity and antimicrobial activity against food-borne bacteria in relation to polyphenolic content. BMC Complement. Altern. Med. 2008, 8, 1-22.
163. Beaulieu, L.; Bondu, S.; Doiron, K.; Rioux, L. E.; Turgeon, S. L. Characterization of antibacterial activity from protein hydrolysates of the macroalga Saccharina longicruris and identification of peptides implied in bioactivity. J. Funct. Foods 2015, 17, 685-697.
164. Moroney, N. C.; O'Grady, M. N.; O'Doherty, J. V.; Kerry, J. P. Effect of a brown seaweed (Laminaria digitata) extract containing laminarin and fucoidan on the quality and shelf-life of fresh and cooked minced pork patties. Meat Sci. 2013, 94, 304-311.
165. Siahaan, E. A.; Pendleton, P.; Woo, H. C.; Chun, B. S. Brown seaweed (Saccharina japonica) as an edible natural delivery matrix for allyl isothiocyanate inhibiting food-borne bacteria. Food Chem. 2014, 152, 11-17.
166. Jiménez, E.; Dorta, F.; Medina, C.; Ramírez, A.; Ramírez, I.; Peña-Cortés, H. Anti-phytopathogenic activities of macro-algae extracts. Mar. Drugs 2011, 9, 739-756.
167. Hierholtzer, A.; Chatellard, L.; Kierans, M.; Akunna, J. C.; Collier, P. J. The impact and mode of action of phenolic compounds extracted from brown seaweed on mixed anaerobic microbial cultures. J. Appl. Microbiol. 2013, 114, 964-973.
168. O'Sullivan, L.; Murphy, B.; McLoughlin, P.; Duggan, P.; Lawlor, P. G.; Hughes, H.; Gardiner, G. E. Review prebiotics from marine macroalgae for human and animal health applications. Mar. Drugs 2010, 8, 2038-2064.