Characterization of novel cytochrome P450 2E1 knockout rat model generated by CRISPR/Cas9

Biochemical Pharmacology

Volumn 105, Issue , 2016, Pages 80-90

  Wang, Xin ^a   Tang, Yu ^a   Lu, Jian ^a   Shao, Yanjiao ^a   Qin, Xuan ^a   Li, Yongmei ^a   Wang, Liren ^a   Li, Dali ^a   Liu, Mingyao ^a,b  

^a EAST CHINA NORMAL UNIVERSITY   (China)

^b TEXAS A AND M HEALTH SCIENCE CENTER   (United States)

Author keywords

CRISPR Cas9; CYP2E1; Drug metabolism; Knockout; Rat

Indexed keywords

6 HYDROXYCHLORZOXAZONE; ALANINE AMINOTRANSFERASE; ALBUMIN; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; BILIRUBIN; CHLORZOXAZONE; CYTOCHROME P450 2E1; GLOBULIN; GLUCOSE; GUIDE RNA; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; METACETAMOL; TRIACYLGLYCEROL;

ANIMAL EXPERIMENT; ANIMAL MODEL; AREA UNDER THE CURVE; ARTICLE; BLOOD SAMPLING; CARCINOGENICITY; CONTROLLED STUDY; CRISPR CAS SYSTEM; DRUG METABOLISM; ELIMINATION HALF-LIFE; FEMALE; GENE INACTIVATION; GENOTYPE; IN VITRO STUDY; IN VIVO STUDY; INTRINSIC CLEARANCE; KNOCKOUT RAT; LIVER MICROSOME; MALE; MAXIMUM PLASMA CONCENTRATION; MEAN RESIDENCE TIME; NONHUMAN; PLASMA CLEARANCE; PRIORITY JOURNAL; RAT; STREPTOCOCCUS PYOGENES; TIME TO MAXIMUM PLASMA CONCENTRATION; XENOBIOTIC METABOLISM; ANIMAL; BIOSYNTHESIS; DEFICIENCY; GENE SILENCING; GENETICS; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; PHYSIOLOGY; PROCEDURES; SPRAGUE DAWLEY RAT;

ANIMALS; BASE SEQUENCE; CRISPR-CAS SYSTEMS; CYTOCHROME P-450 CYP2E1; FEMALE; GENE KNOCKDOWN TECHNIQUES; MALE; MODELS, ANIMAL; MOLECULAR SEQUENCE DATA; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84960331669     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2016.03.001     Document Type: Article

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