Real-time monitoring of oxygen uptake in hepatic bioreactor shows CYP450-independent mitochondrial toxicity of acetaminophen and amiodarone

Archives of Toxicology

Volumn 90, Issue 5, 2016, Pages 1181-1191

  Prill, Sebastian ^a   Bavli, Danny ^b   Levy, Gahl ^b   Ezra, Elishai ^b   Schmälzlin, Elmar ^c   Jaeger, Magnus S ^a   Schwarz, Michael ^d   Duschl, Claus ^a   Cohen, Merav ^b   Nahmias, Yaakov ^b  

^a FRAUNHOFER INSTITUTE FOR CELL THERAPY AND IMMUNOLOGY   (Germany)

^b HEBREW UNIVERSITY OF JERUSALEM   (Israel)

^c Colibri Photonics GmbH ^*  (Germany)

^d UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

Acetaminophen; Amiodarone; Bioreactor; Liver on chip; Mitochondria; Oxygen uptake

Indexed keywords

AMIODARONE; ASCORBIC ACID; CYTOCHROME P450 2E1; CYTOCHROME P450 3A4; FLUORESCENT DYE; OXYGEN; PARACETAMOL; ANALGESIC AGENT; ANTIARRHYTHMIC AGENT; BIOLOGICAL MARKER;

ARTICLE; BIOREACTOR; CONTROLLED STUDY; DRUG MECHANISM; HELA CELL LINE; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LIPIDOSIS; LIVER MITOCHONDRION; LONG TERM EXPOSURE; MITOCHONDRIAL RESPIRATION; MITOCHONDRIAL TOXICITY; OXYGEN CONSUMPTION; PRIORITY JOURNAL; REACTOR MONITORING; STEATOSIS; TC50; CHEMICAL AND DRUG INDUCED LIVER INJURY; COCULTURE; DOSE RESPONSE; DRUG EFFECTS; ENZYMOLOGY; EQUIPMENT DESIGN; HEP-G2 CELL LINE; LAB ON A CHIP; LIVER CELL; METABOLIC ACTIVATION; METABOLISM; MULTICELLULAR SPHEROID; PATHOLOGY; TIME FACTOR; TUMOR MICROENVIRONMENT;

ACETAMINOPHEN; ACTIVATION, METABOLIC; AMIODARONE; ANALGESICS, NON-NARCOTIC; ANTI-ARRHYTHMIA AGENTS; BIOMARKERS; BIOREACTORS; CELLULAR MICROENVIRONMENT; CHEMICAL AND DRUG INDUCED LIVER INJURY; COCULTURE TECHNIQUES; CYTOCHROME P-450 CYP2E1; DOSE-RESPONSE RELATIONSHIP, DRUG; EQUIPMENT DESIGN; HEP G2 CELLS; HEPATOCYTES; HUMANS; LAB-ON-A-CHIP DEVICES; MITOCHONDRIA, LIVER; OXYGEN CONSUMPTION; SPHEROIDS, CELLULAR; TIME FACTORS;

EID: 84930370310     PISSN: 03405761     EISSN: 14320738     Source Type: Journal    
DOI: 10.1007/s00204-015-1537-2     Document Type: Article

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