Cytochrome P450 2E1 in the substantia nigra: Relevance for dopaminergic neurotransmission and free radical production

Synapse

Volumn 62, Issue 5, 2008, Pages 379-388

  Shahabi, H Niazi ^a,b   Andersson, D R ^a   Nissbrandt, H ^a  

^a UNIVERSITY OF GOTHENBURG   (Sweden)

^b Box 431 ^*  (Sweden)

Author keywords

Cytochrome P450 2E1; DA; Microdialysis; Phenylethyl isothiocyanate; Substantia nigra

Indexed keywords

4 HYDROXYBENZOIC ACID; ANESTHETIC AGENT; CYTOCHROME P450 2E1; DOPAMINE; FREE RADICAL; GAMMA BUTYROLACTONE; ISOTHIOCYANIC ACID DERIVATIVE; PROTOCATECHUIC ACID; REACTIVE OXYGEN METABOLITE; RESERPINE; TETRODOTOXIN; VANOXERINE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN PERFUSION; BRAIN REGION; CONTROLLED STUDY; DOPAMINE RELEASE; DOPAMINE UPTAKE; DOPAMINERGIC NERVE CELL; DOPAMINERGIC TRANSMISSION; ENDOPLASMIC RETICULUM; ENZYME ACTIVITY; ENZYME INHIBITION; MALE; MICRODIALYSIS; NEUROTRANSMISSION; NONHUMAN; PRIORITY JOURNAL; RAT; SUBSTANTIA NIGRA;

4-BUTYROLACTONE; ADRENERGIC ALPHA-AGONISTS; ANESTHETICS, DISSOCIATIVE; ANESTHETICS, INHALATION; ANIMALS; CYTOCHROME P-450 CYP2E1; DOPAMINE; DOPAMINE ANTAGONISTS; DOPAMINE UPTAKE INHIBITORS; ENZYME INHIBITORS; EXTRACELLULAR SPACE; FREE RADICALS; GABA MODULATORS; HYDROXYBENZOIC ACIDS; ISOFLURANE; KETAMINE; MALE; MICRODIALYSIS; PARABENS; PIPERAZINES; RATS; RATS, SPRAGUE-DAWLEY; RESERPINE; SUBSTANTIA NIGRA; SYNAPTIC TRANSMISSION; TETRODOTOXIN; XYLAZINE;

EID: 41349117373     PISSN: 08874476     EISSN: 10982396     Source Type: Journal    
DOI: 10.1002/syn.20505     Document Type: Article

References (76)

1. Anandatheerthavarada HK, Shankar SK, Bhamre S, Boyd MR, Song BJ, Ravindranath V. 1993. Induction of brain cytochrome P-450IIE1 by chronic ethanol treatment. Brain Res 601:279-285.
2. Andersen PH. 1989. The dopamine inhibitor GBR 12909: Selectivity and molecular mechanism of action. Eur J Pharmacol 166:493-504.
3. Baumane L, Dzintare M, Zvejniece L, Meirena D, Lauberte L, Sile V, Kalvinsh I, Sjakste N. 2002. Increased synthesis of nitric oxide in rat brain cortex due to halogenated volatile anesthetics confirmed by EPR spectroscopy. Acta Anaesthesiol Scand 46:378-383.
4. Bergquist F, Nissbrandt H. 2005. Dopamine release in substantia nigra. Release mechanisms and physiological function in motor control. In: Ludwig M, editor. Dendritic transmitter release. New York: Springer Science. p 85-99.
5. Chen R, Stenken JA. 2002. An in vitro hydroxyl radical generation assay for microdialysis sampling calibration. Anal Biochem 306:40-49.
6. Eckenhoff RG, Fagan D. 1994. Inhalation anaesthetic competition at high-affinity cocaine binding sites in rat brain synaptosomes. Br J Anaesth 73:820-825.
7. Eckenhoff RG, Johansson JS, Wei H, Carnini A, Kang B, Wei W, Pidikiti R, Keller JM, Eckenhoff MF. 2004. Inhaled anesthetic enhancement of amyloid-β oligomerization and cytotoxicity. Anesthesiology 101:703-709.
8. Ekstrom G, Ingelman-Sundberg M. 1989. Rat liver microsomal NADPH-supported oxidase activity and lipid peroxidation dependent on ethanol-inducible cytochrome P-450 (P-450IIE1). Biochem Pharmacol 38:1313-1319.
9. el-Maghrabi EA, Eckenhoff RG. 1993. Inhibition of dopamine transport in rat brain synaptosomes by volatile anesthetics. Anesthesiology 78:750-756.
10. Elverfors A, Pileblad E, Lagerkvist S, Bergquist F, Jonason J, Nissbrandt H. 1997. 3-Methoxytyramine formation following monoamine oxidase inhibition is a poor index of dendritic dopamine release in the substantia nigra. J Neurochem 69:1684-1692.
11. Engberg G, Elverfors A, Jonason J, Nissbrandt H. 1997. Inhibition of dopamine re-uptake: Significance for nigral dopamine neuron activity. Synapse 25:215-226.
12. Everse J, Coates PW. 2005. Role of peroxidases in Parkinson disease: A hypothesis. Free Radic Biol Med 38:1296-1310.
13. Farin FM, Omiecinski CJ. 1993. Regiospecific expression of cytochrome P-450s and microsomal epoxide hydrolase in human brain tissue. J Toxicol Environ Health 40:317-335.
14. Gonzalez FJ. 2005. Role of cytochromes P450 in Chem toxicity and oxidative stress: Studies with CYP2E1. Mutat Res 569:101-110.
15. Gonzalez J, Izenwasser S, Hurley MJ, Gorokhovskaya D, Gerdes R, Basile M, Jenner P, Edwards RJ, Mash DC. 1999.Time course for the induction of CYP2E1 in the nigrostriatal pathway, Abstr 29the Annual Meeting of Society for Neuroscience, p 1600.
16. Groves PM, Linder JC. 1983. Dendro-dendritic synapses in substantia nigra: Descriptions based on analysis of serial sections. Exp Brain Res 49:209-217.
17. Hansson T, Tindberg N, Ingelman-Sundberg M, Kohler C. 1990. Regional distribution of ethanol-inducible cytochrome P450 IIE1 in the rat central nervous system. Neuroscience 34:451-463.
18. Hattori T, McGeer PL, McGeer EG. 1979. Dendro axonic neurotransmission. II. Morphological sites for the synthesis, binding and release of neurotransmitters in dopaminergic dendrites in the substantia nigra and cholinergic dendrites in the neostriatum. Brain Res 170:71-83.
19. Heeringa MJ, Abercrombie ED. 1995. Biochemistry of somatodendritic dopamine release in substantia nigra: an in vivo comparison with striatal dopamine release. J Neurochem 65:192-200.
20. Hijazi Y, Boulieu R. 2002. Contribution of CYP3A4, CYP2B6, and CYP2C9 isoforms to N-demethylation of ketamine in human liver microsomes. Drug Metab Dispos 30:853-858.
21. Imperato A, Di Chiara G. 1984. Trans-striatal dialysis coupled to reverse phase high performance liquid chromatography with electrochemical detection: A new method for the study of the in vivo release of endogenous dopamine and metabolites. J Neurosci 4:966-977.
22. Ishizaki H, Brady JF, Ning SM, Yang CS. 1990. Effect of phenethyl isothiocyanate on microsomal N-nitrosodimethylamine metabolism and other monooxygenase activities. Xenobiotica 20:255-264.
23. Jenner P. 1998. Oxidative mechanisms in nigral cell death in Parkinson's disease. Mov Disord 13 (Suppl 1):24-34.
24. Jenner P. 2003. Oxidative stress in Parkinson's disease. Ann Neurol 53(Suppl 3):S26-S36; discussion S36-S28.
25. Jiao D, Conaway CC, Wang MH, Yang CS, Koehl W, Chung FL. 1996. Inhibition of N-nitrosodimethylamine demethylase in rat and human liver microsomes by isothiocyanates and their glutathione. L-cysteine, and N-acetyl-L-cysteine conjugates. Chem Res Toxicol 9:932-938.
26. Joshi M, Tyndale RF. 2006. Regional and cellular distribution of CYP2E1 in monkey brain and its induction by chronic nicotine. Neuropharmacology 50:568-575.
27. Karuzina II, Archakov AI. 1994. The oxidative inactivation of cytochrome P450 in monooxygenase reactions. Free Radic Biol Med 16:73-97.
28. Kharasch ED, Thummel KE. 1993. Identification of cytochrome P450 2E1 as the predominant enzyme catalyzing human liver microsomal defluorination of sevoflurane, isoflurane, and methoxyflurane. Anesthesiology 79:795-807.
29. Kharasch ED, Hankins DC, Cox K. 1999. Clinical isoflurane metabolism by cytochrome P450 2E1. Anesthesiology 90:766-771.
30. Koivusalo M, Lindros KO. 1997. Phenethyl isothiocyanate as an inhibitor of aldehyde dehydrogenases. Adv Exp Med Biol 414:225-232.
31. Koutsilieri E, Scheller C, Grunblatt E, Nara K, Li J, Riederer P. 2002. Free radicals in Parkinson's disease. J Neurol 249 (Suppl 2):II1-II5.
32. Lagerkvist S. 1991. Sample splitting provides a fast and selective method for determining brain dialysate dopamine and its metabolites. In: Rollema H, Westerink BH, Drijhout WJ, editors. Monitoring molecules in neuroscience. Groningen, The Netherlands. Proceedings of the 5th Int. Conf. on in vivo methods, Noordwijkerout. p 136.
33. Lindros KO, Badger T, Ronis M, Ingelman-Sundberg M, Koivusalo M. 1995. Phenethyl isothiocyanate, a new dietary liver aldehyde dehydrogenase inhibitor. J Pharmacol Exp Ther 275:79-83.
34. Liu M, Liu S, Peterson SL, Miyake M, Liu KJ. 2002. On the application of 4-hydroxybenzoic acid as a trapping agent to study hydroxyl radical generation during cerebral ischemia and reperfusion. Mol Cell Biochem 234/235:379-385.
35. Loeper J, Descatoire V, Maurice M, Beaune P, Belghiti J, Houssin D, Ballet F, Feldmann G, Guengerich FP, Pessayre D. 1993. Cytochromes P-450 in human hepatocyte plasma membrane: Recognition by several autoantibodies. Gastroenterology 104:203-216.
36. Marklund N, Clausen F, Lewander T, Hillered L. 2001. Monitoring of reactive oxygen species production after traumatic brain injury in rats with microdialysis and the 4-hydroxybenzoic acid trapping method. J Neurotrauma 18:1217-1227.
37. McFayden MC, Melvin WT, Murray GI. 1998. Regional distribution of individual forms of cytochrome P450 mRNA in normal adult human brain. Biochem Pharmacol 55:825-830.
38. Mercer L, del Fiacco M, Cuello AC. 1979. The smooth endoplasmic reticulum as a possible storage site for dendritic dopamine in substantia nigra neurones. Experientia 35:101-103.
39. Miksys SL, Tyndale RF. 2002. Drug-metabolizing cytochrome P450s in the brain. J Psychiatry Neurosci 27:406-415.
40. Moghaddam B, Bunney BS. 1989. Ionic composition of microdialysis perfusing solution alters the pharmacological responsiveness and basal outflow of striatal dopamine. J Neurochem 53:652-654.
41. Montgomery J, Ste-Marie L, Boismenu D, Vachon L. 1995. Hydroxylation of aromatic compounds as indices of hydroxyl radical production: a cautionary note revisited. Free Radic Biol Med 19:927-933.
42. Montoliu C, Valles S, Renau-Piqueras J, Guerri C. 1994. Ethanol-induced oxygen radical formation and lipid peroxidation in rat brain: Effect of chronic alcohol consumption. J Neurochem 63:1855-1862.
43. Montoliu C, Sancho-Tello M, Azorin I, Burgal M, Valles S, Renau-Piqueras J, Guerri C. 1995. Ethanol increases cytochrome P4502E1 and induces oxidative stress in astrocytes. J Neurochem 65:2561-2570.
44. Nappi AJ, Vass E, Prota G, Memoli S. 1995. The effects of hydroxyl radical attack on dopa, dopamine, 6-hydroxydopa, and 6-hydroxyDA. Pigment Cell Res 8:283-293.
45. Negrusz A, Adamowicz P, Saini BK, Webster DE, Juhascik MP, Moore CM, Schlemmer RF. 2005. Detection of ketamine and norketamine in urine of nonhuman primates after a single dose of ketamine using microplate enzyme-linked immunosorbent assay (ELISA) and NCI-GC-MS. J Anal Toxicol 29:163-168.
46. Neve EP, Ingelman-Sundberg M. 2000. Molecular basis for the transport of cytochrome P450 2E1 to the plasma membrane. J Biol Chem 275:17130-17135.
47. Neve EP, Eliasson E, Pronzato MA, Albano E, Marinari U, Ingelman-Sundberg M. 1996. Enzyme-specific transport of rat liver cytochrome P450 to the Golgi apparatus. Arch Biochem Biophys 333:459-465.
48. Niazi Shahabi H, Bergquist F, Nissbrandt H. 2003. An investigation of dopaminergic metabolites in the striatum and in the substantia nigra in vivo utilising radiolabelled L-DOPA and high performance liquid chromatography: A new approach in the search for transmitter metabolites. Neuroscience 120:425-433.
49. Nirenberg MJ, Chan J, Liu Y, Edwards RH, Pickel VM. 1996. Ultrastructural localization of the vesicular monoamine transporter-2 in midbrain dopaminergic neurons: potential sites for somatodendritic storage and release of dopamine. J Neurosci 16:4135-4145.
50. Nissbrandt H, Engberg G, Pileblad E. 1991. The effects of GBR 12909, a dopamine re-uptake inhibitor, on monoaminergic neurotransmission in rat striatum, limbic forebrain, cortical hemispheres and substantia nigra. Naunyn Schmiedebergs Arch Pharmacol 344:16-28.
51. Nissbrandt H, Bergquist F, Jonason J, Engberg G. 2001. Inhibition of cytochrome P450 2E1 induces an increase in extracellular dopamine in rat substantia nigra: A new metabolic pathway? Synapse 40:294-301.
52. Opacka-Juffry J, Ahier RG, Cremer JE. 1991. Nomifensine-induced increase in extracellular striatal dopamine is enhanced by isoflurane anaesthesia. Synapse 7:169-171.
53. Paxinos S, Watson C. 1986. The rat brain in stereotaxic co-ordinates. Sydney: Academic Press.
54. Pickel VM, Joh TH, Reis DJ. 1977. Regional and ultrastructural localization of tyrosine hydroxylase by immunocytochemistry in dopaminergic neurons of the mesolimbic and nigroneostriatal systems. Adv Biochem Psychopharmacol 16:321-329.
55. Reinke LA, Moore DR, McCay PB. 1997. Free radical formation in livers of rats treated acutely and chronically with alcohol. Alcohol Clin Exp Res 21:642-646.
56. Riedl AG, Watts PM, Edwards RJ, Boobis AR, Jenner P, Marsden CD. 1996. Selective localization of P450 enzymes and NADPH-P450 oxidoreductase in rat basal ganglia using anti-peptide antisera. Brain Res 743:324-328.
57. Robertson GS, Damsma G, Fibiger HC. 1991. Characterization of dopamine release in the substantia nigra by in vivo microdialysis in freely moving rats. J Neurosci 11:2209-2216.
58. Ronis MJJ, Lindros KO, Ingelman-Sundberg M. 1996. The CYP2E subfamily. In: Ioannides C, editor. Cytochromes P450: Metabolic and toxicological aspects. Boca Raton: CRC Press. p 211-239.
59. Roth RH, Walters JR, Aghajanian GK. 1973. Effect of impulse flow on the release and synthesis of dopamine in the rat striatum, Frontiers in Catecholamine Research. New york: Pergamon Press. p 567-574.
60. Santiago M, Westerink BH. 1991. The regulation of dopamine release from nigrostriatal neurons in conscious rats: The role of somatodendritic autoreceptors. Eur J Pharmacol 204:79-85.
61. Sayre LM, Moreira PI, Smith MA, Perry G. 2005. Metal ions and oxidative protein modification in neurological disease. Ann Ist Super Sanita 41:143-164.
62. Sohda T, Shimizu M, Kamimura S, Okumura M. 1993. Immunohistochemical demonstration of ethanol-inducible P450 2E1 in rat brain. Alcohol Alcohol Suppl B 1:69-75.
63. Staudt H, Lichtenberger F, Ullrich V. 1974. The role of NADH in uncoupled microsomal monoxygenations. Eur J Biochem 46:99-106.
64. Ste-Marie L, Boismenu D, Vachon L, Montgomery J. 1996. Evaluation of sodium 4-hydroxybenzoate as an hydroxyl radical trap using gas chromatography-mass spectrometry and high-performance liquid chromatography with electrochemical detection. Anal Biochem 241:67-74.
65. Ste-Marie L, Vachon L, Bemeur C, Lambert J, Montgomery J. 1999. Local striatal infusion of MPP+ does not result in increased hydroxylation after systemic administration of 4-hydroxybenzoate. Free Radic Biol Med 27:997-1007.
66. Tateishi T, Watanabe M, Nakura H, Tanaka M, Kumai T, Aoki T, Kobayashi S. 1998. A comparison of the inhibitory effects of four volatile anaesthetics on the metabolism of chlorzoxazone, a substrate for CYP2E1, in rabbits. Acta Anaesthesiol Scand 42:1028-1032.
67. Tindberg N, Ingelman-Sundberg M. 1989. Cytochrome P-450 and oxygen toxicity. Oxygen-dependent induction of ethanol-inducible cytochrome P-450 (IIE1) in rat liver and lung. Biochemistry 28:4499-4504.
68. Tsukada H, Nishiyama S, Kakiuchi T, Ohba H, Sato K, Harada N, Nakanishi S. 1999. Isoflurane anesthesia enhances the inhibitory effects of cocaine and GBR12909 on DA transporter: Positronemissiontomography (PET) studies in combination with microdialysis in the monkey brain. Brain Res 849:85-96.
69. Upadhya SC, Tirumalai PS, Boyd MR, Mori T, Ravindranath V. 2000. Cytochrome P4502E (CYP2E) in brain: Constitutive expression, induction by ethanol and localization by fluorescence in situ hybridization. Arch Biochem Biophys 373:23-34.
70. Vaglini F, Pardini C, Viaggi C, Bartoli C, Dinucci D, Corsini GU. 2004. Involvement of cytochrome P450 2E1 in the 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine-induced mouse model of Parkinson's disease. J Neurochem 91:285-298.
71. Watts PM, Riedl AG, Douek DC, Edwards RJ, Boobis AR, Jenner P, Marsden CD. 1998. Co-localization of P450 enzymes in the rat substantia nigra with tyrosine hydroxylase. Neuroscience 86:511-519.
72. Westerink BH, de Boer P, Santiago M, De Vries JB. 1994. Do nerve terminals and cell bodies of nigrostriatal dopaminergic neurons of the rat contain similar receptors? Neurosci Lett 167:109-112.
73. Wilson CJ, Groves PM, Fifkova E. 1977. Monoaminergic synapses, including dendro-dendritic synapses in the rat substantia nigra. Exp Brain Res 30:161-174.
74. Votaw J, Byas-Smith M, Hua J, Voll R, Martarello L, Levey AI, Bowman FD, Goodman M. 2003. Interaction of isoflurane with the dopamine transporter. Anesthesiology 98:404-411.
75. Xie Z, Dong Y, Maeda U, Alfille P, Culley DJ, Crosby G, Tanzi RE. 2006. The common inhalation anesthetic isoflurane induces apoptosis and increases amyloid beta protein levels. Anesthesiology 104:988-994.
76. Xie Z, Dong Y, Maeda U, Moir RD, Xia W, Culley DJ, Crosby G, Tanzi RE. 2007. The inhalation anesthetic isoflurane induces a vicious cycle of apoptosis and amyloid β-protein accumulation. J Neurosci 27:1247-1254.