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Volumn 23, Issue 3, 2016, Pages 283-295

AAV 1/2-mediated BDNF gene therapy in a transgenic rat model of Huntington's disease

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; BRAIN DERIVED NEUROTROPHIC FACTOR RECEPTOR; NEURON SPECIFIC NUCLEAR PROTEIN; PARVOVIRUS VECTOR; PROTEIN; PROTEIN DARRP32; UNCLASSIFIED DRUG;

EID: 84960082333     PISSN: 09697128     EISSN: 14765462     Source Type: Journal    
DOI: 10.1038/gt.2015.113     Document Type: Article
Times cited : (30)

References (49)
  • 1
    • 78650031174 scopus 로고    scopus 로고
    • Huntingtons disease: From molecular pathogenesis to clinical treatment
    • Ross CA, Tabrizi SJ. Huntingtons disease: from molecular pathogenesis to clinical treatment. Lancet Neurol. 2011; 10: 83-98.
    • (2011) Lancet Neurol , vol.10 , pp. 83-98
    • Ross, C.A.1    Tabrizi, S.J.2
  • 2
    • 33846225133 scopus 로고    scopus 로고
    • Huntington's disease
    • Walker FO. Huntington's disease. Lancet. 2007; 369: 218-228.
    • (2007) Lancet , vol.369 , pp. 218-228
    • Walker, F.O.1
  • 3
    • 0027480960 scopus 로고
    • A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntingtons disease chromosomes
    • The Huntington's Disease Collaborative Research Grou.p.
    • The Huntington's Disease Collaborative Research Group. A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntingtons disease chromosomes. Cell. 1993; 72: 971-983.
    • (1993) Cell , vol.72 , pp. 971-983
  • 4
    • 77955643169 scopus 로고    scopus 로고
    • Molecular mechanisms and potential therapeutical targets in Huntington's disease
    • Zuccato C, Valenza M, Cattaneo E. Molecular mechanisms and potential therapeutical targets in Huntington's disease. Physiol Rev. 2010; 90: 905-981.
    • (2010) Physiol Rev , vol.90 , pp. 905-981
    • Zuccato, C.1    Valenza, M.2    Cattaneo, E.3
  • 6
    • 1842334441 scopus 로고    scopus 로고
    • Anterograde transport of brain-derived neurotrophic factor and its role in the brain
    • Altar CA. Anterograde transport of brain-derived neurotrophic factor and its role in the brain. Nature. 1997; 389: 856-860.
    • (1997) Nature , vol.389 , pp. 856-860
    • Altar, C.A.1
  • 7
    • 2442506955 scopus 로고    scopus 로고
    • Early striatal dendrite deficits followed by neuron loss with advanced age in the absence of anterograde cortical brain-derived neurotrophic factor
    • Baquet ZC, Gorski JA, Jones KR. Early striatal dendrite deficits followed by neuron loss with advanced age in the absence of anterograde cortical brain-derived neurotrophic factor. J Neurosci. 2004; 24: 4250-4258.
    • (2004) J Neurosci , vol.24 , pp. 4250-4258
    • Baquet, Z.C.1    Gorski, J.A.2    Jones, K.R.3
  • 8
    • 0034595722 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor in Huntington disease
    • Ferrer I, Goutan E, Marin C, Rey MJ, Ribalta T. Brain-derived neurotrophic factor in Huntington disease. Brain Res. 2000; 866: 257-261.
    • (2000) Brain Res , vol.866 , pp. 257-261
    • Ferrer, I.1    Goutan, E.2    Marin, C.3    Rey, M.J.4    Ribalta, T.5
  • 9
    • 41149120252 scopus 로고    scopus 로고
    • Systematic assessment of BDNF and its receptor levels in human cortices affected by Huntington's disease
    • Zuccato C. Systematic assessment of BDNF and its receptor levels in human cortices affected by Huntington's disease. Brain Pathol. 2008; 18: 225-238.
    • (2008) Brain Pathol , vol.18 , pp. 225-238
    • Zuccato, C.1
  • 10
    • 34047130812 scopus 로고    scopus 로고
    • Role of brain-derived neurotrophic factor in Huntington's disease
    • Zuccato C, Cattaneo E. Role of brain-derived neurotrophic factor in Huntington's disease. Prog Neurobiol. 2007; 81: 294-330.
    • (2007) Prog Neurobiol , vol.81 , pp. 294-330
    • Zuccato, C.1    Cattaneo, E.2
  • 11
    • 0035919701 scopus 로고    scopus 로고
    • Loss of huntingtin-mediated BDNF gene transcription in Huntington's disease
    • Zuccato C. Loss of huntingtin-mediated BDNF gene transcription in Huntington's disease. Science. 2001; 293: 493-498.
    • (2001) Science , vol.293 , pp. 493-498
    • Zuccato, C.1
  • 12
    • 0041353535 scopus 로고    scopus 로고
    • Huntingtin interacts with REST/NRSF to modulate the transcription of NRSE-controlled neuronal genes
    • Zuccato C. Huntingtin interacts with REST/NRSF to modulate the transcription of NRSE-controlled neuronal genes. Nat Genet. 2003; 35: 76-83.
    • (2003) Nat Genet , vol.35 , pp. 76-83
    • Zuccato, C.1
  • 13
    • 20444456571 scopus 로고    scopus 로고
    • Progressive loss of BDNF in a mouse model of Huntington's disease and rescue by BDNF delivery
    • Zuccato C, Liber D, Ramos C, Tarditi A, Rigamonti D, Tartari M, et al. Progressive loss of BDNF in a mouse model of Huntington's disease and rescue by BDNF delivery. Pharmacol Res. 2005; 52: 133-139.
    • (2005) Pharmacol Res , vol.52 , pp. 133-139
    • Zuccato, C.1    Liber, D.2    Ramos, C.3    Tarditi, A.4    Rigamonti, D.5    Tartari, M.6
  • 14
    • 3142636768 scopus 로고    scopus 로고
    • Huntingtin controls neurotrophic support and survival of neurons by enhancing BDNF vesicular transport along microtubules
    • Gauthier LR. Huntingtin controls neurotrophic support and survival of neurons by enhancing BDNF vesicular transport along microtubules. Cell. 2004; 118: 127-138.
    • (2004) Cell , vol.118 , pp. 127-138
    • Gauthier, L.R.1
  • 15
    • 49149112606 scopus 로고    scopus 로고
    • Huntingtin phosphorylation acts as a molecular switch for anterograde/ retrograde transport in neurons
    • Colin E. Huntingtin phosphorylation acts as a molecular switch for anterograde/ retrograde transport in neurons. EMBO J. 2008; 27: 2124-2134.
    • (2008) EMBO J , vol.27 , pp. 2124-2134
    • Colin, E.1
  • 16
    • 57049184027 scopus 로고    scopus 로고
    • Phosphorylation of mutant huntingtin at S421 restores anterograde and retrograde transport in neurons
    • Zala D. Phosphorylation of mutant huntingtin at S421 restores anterograde and retrograde transport in neurons. Hum Mol Genet. 2008; 17: 3837-3846.
    • (2008) Hum Mol Genet , vol.17 , pp. 3837-3846
    • Zala, D.1
  • 17
    • 58149385090 scopus 로고    scopus 로고
    • Enhanced sensitivity of striatal neurons to axonal transport defects induced by mutant huntingtin
    • Her LS, Goldstein LS. Enhanced sensitivity of striatal neurons to axonal transport defects induced by mutant huntingtin. J Neurosci. 2008; 28: 13662-13672.
    • (2008) J Neurosci , vol.28 , pp. 13662-13672
    • Her, L.S.1    Goldstein, L.S.2
  • 18
    • 33644956205 scopus 로고    scopus 로고
    • Reduced expression of the TrkB receptor in Huntington's disease mouse models and in human brain
    • Gines S, Bosch M, Marco S, Gavalda N, Diaz-Hernandez M, Lucas JJ, et al. Reduced expression of the TrkB receptor in Huntington's disease mouse models and in human brain. Eur J Neurosci. 2006; 23: 649-658.
    • (2006) Eur J Neurosci , vol.23 , pp. 649-658
    • Gines, S.1    Bosch, M.2    Marco, S.3    Gavalda, N.4    Diaz-Hernandez, M.5    Lucas, J.J.6
  • 19
    • 84875509193 scopus 로고    scopus 로고
    • Mutant Huntingtin alters retrograde transport of TrkB receptors in striatal dendrites
    • Liot G, Zala D, Pla P, Mottet G, Piel M, Saudou F. Mutant Huntingtin alters retrograde transport of TrkB receptors in striatal dendrites. J Neurosci. 2013; 33: 6298-6309.
    • (2013) J Neurosci , vol.33 , pp. 6298-6309
    • Liot, G.1    Zala, D.2    Pla, P.3    Mottet, G.4    Piel, M.5    Saudou, F.6
  • 20
    • 84903627709 scopus 로고    scopus 로고
    • Impaired TrkB receptor signaling underlies corticostriatal dysfunction in Huntington's disease
    • Plotkin JL, Day M, Peterson JD, Xie Z, Kress GJ, Rafalovich I, et al. Impaired TrkB receptor signaling underlies corticostriatal dysfunction in Huntington's disease. Neuron. 2014; 83: 178-188.
    • (2014) Neuron , vol.83 , pp. 178-188
    • Plotkin, J.L.1    Day, M.2    Peterson, J.D.3    Xie, Z.4    Kress, G.J.5    Rafalovich, I.6
  • 21
    • 68849083063 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor in neurodegenerative diseases
    • Zuccato C, Cattaneo E. Brain-derived neurotrophic factor in neurodegenerative diseases. Nat Rev Neurol. 2009; 5: 311-322.
    • (2009) Nat Rev Neurol , vol.5 , pp. 311-322
    • Zuccato, C.1    Cattaneo, E.2
  • 22
    • 35548937443 scopus 로고    scopus 로고
    • Expression profiling of Huntington's disease models suggests that brain-derived neurotrophic factor depletion plays a major role in striatal degeneration
    • Strand AD. Expression profiling of Huntington's disease models suggests that brain-derived neurotrophic factor depletion plays a major role in striatal degeneration. J Neurosci. 2007; 27: 11758-11768.
    • (2007) J Neurosci , vol.27 , pp. 11758-11768
    • Strand, A.D.1
  • 23
    • 4444350918 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor regulates the onset and severity of motor dysfunction associated with encephalinergic neuronal degeneration in Huntington's disease
    • Canals JM. Brain-derived neurotrophic factor regulates the onset and severity of motor dysfunction associated with encephalinergic neuronal degeneration in Huntington's disease. J Neurosci. 2004; 24: 7727-7739.
    • (2004) J Neurosci , vol.24 , pp. 7727-7739
    • Canals, J.M.1
  • 24
    • 20144379127 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor modulates dopaminergic deficits in a transgenic mouse model of Huntington's disease
    • Pineda JR, Canals JM, Bosch M, Adell A, Mengod G, Artigas F, et al. Brain-derived neurotrophic factor modulates dopaminergic deficits in a transgenic mouse model of Huntington's disease. J Neurochem. 2005; 93: 1057-1068.
    • (2005) J Neurochem , vol.93 , pp. 1057-1068
    • Pineda, J.R.1    Canals, J.M.2    Bosch, M.3    Adell, A.4    Mengod, G.5    Artigas, F.6
  • 25
    • 2442702838 scopus 로고    scopus 로고
    • AAV-mediated gene delivery of BDNF or GDNF is neuroprotective in a model of Huntington's disease
    • Kells AP, Fong DM, Dragunow M, During MJ, Young D, Connor B. AAV-mediated gene delivery of BDNF or GDNF is neuroprotective in a model of Huntington's disease. Mol Ther. 2004; 9: 682-687.
    • (2004) Mol Ther , vol.9 , pp. 682-687
    • Kells, A.P.1    Fong, D.M.2    Dragunow, M.3    During, M.J.4    Young, D.5    Connor, B.6
  • 26
    • 45749153812 scopus 로고    scopus 로고
    • AAV-BDNF mediated attenuation of quinolinic acidinduced neuropathology and motor function impairment
    • Kells AP, Henry RA, Connor B. AAV-BDNF mediated attenuation of quinolinic acidinduced neuropathology and motor function impairment. Gene Therapy. 2008; 15: 966-977.
    • (2008) Gene Therapy , vol.15 , pp. 966-977
    • Kells, A.P.1    Henry, R.A.2    Connor, B.3
  • 29
    • 33750210519 scopus 로고    scopus 로고
    • Behavioral abnormalities precede neuropathological markers in rats transgenic for Huntington's disease
    • Nguyen HP, Kobbe P, Rahne H, Worpel T, Jager B, Stephan M, et al. Behavioral abnormalities precede neuropathological markers in rats transgenic for Huntington's disease. Hum Mol Genet. 2006; 15: 3177-3194.
    • (2006) Hum Mol Genet , vol.15 , pp. 3177-3194
    • Nguyen, H.P.1    Kobbe, P.2    Rahne, H.3    Worpel, T.4    Jager, B.5    Stephan, M.6
  • 31
    • 0035181853 scopus 로고    scopus 로고
    • Factors influencing behavior of group-housed male rats in the social interaction test: Focus on cohort removal
    • Kask A, Nguyen HP, Pabst R, von Horsten S. Factors influencing behavior of group-housed male rats in the social interaction test: focus on cohort removal. Physiol Behav. 2001; 74: 277-282.
    • (2001) Physiol Behav , vol.74 , pp. 277-282
    • Kask, A.1    Nguyen, H.P.2    Pabst, R.3    Von Horsten, S.4
  • 32
    • 59249109467 scopus 로고    scopus 로고
    • Calibration of rotational acceleration for the rotarod test of rodent motor coordination
    • Bohlen M, Cameron A, Metten P, Crabbe JC, Wahlsten D. Calibration of rotational acceleration for the rotarod test of rodent motor coordination. J Neurosci Methods. 2009; 178: 10-14.
    • (2009) J Neurosci Methods , vol.178 , pp. 10-14
    • Bohlen, M.1    Cameron, A.2    Metten, P.3    Crabbe, J.C.4    Wahlsten, D.5
  • 33
    • 34250630141 scopus 로고    scopus 로고
    • Appetitive position discrimination in the T-maze
    • Deacon RM. Appetitive position discrimination in the T-maze. Nat Protoc. 2006; 1: 13-15.
    • (2006) Nat Protoc , vol.1 , pp. 13-15
    • Deacon, R.M.1
  • 35
    • 49649121318 scopus 로고    scopus 로고
    • Sex differences in a transgenic rat model of Huntington's disease: Decreased 17β-estradiol levels correlate with reduced numbers of DARPP32+ neurons in males
    • Bode FJ, Stephan M, Suhling H, Pabst R, Straub RH, Raber KA, et al. Sex differences in a transgenic rat model of Huntington's disease: decreased 17β-estradiol levels correlate with reduced numbers of DARPP32+ neurons in males. Hum Mol Genet. 2008; 17: 2595-2609.
    • (2008) Hum Mol Genet , vol.17 , pp. 2595-2609
    • Bode, F.J.1    Stephan, M.2    Suhling, H.3    Pabst, R.4    Straub, R.H.5    Raber, K.A.6
  • 36
    • 84906544487 scopus 로고    scopus 로고
    • Neurotrophins and the regulation of energy balance and body weight
    • Rios M. Neurotrophins and the regulation of energy balance and body weight. Handb Exp Pharmacol. 2014; 220: 283-307.
    • (2014) Handb Exp Pharmacol , vol.220 , pp. 283-307
    • Rios, M.1
  • 37
    • 84898775542 scopus 로고    scopus 로고
    • Effects of energy status and diet on Bdnf expression in the ventromedial hypothalamus of male and female rats
    • Liu X, Zhu Z, Kalyani M, Janik JM, Shi H. Effects of energy status and diet on Bdnf expression in the ventromedial hypothalamus of male and female rats. Physiol Behav. 2014; 130: 99-107.
    • (2014) Physiol Behav , vol.130 , pp. 99-107
    • Liu, X.1    Zhu, Z.2    Kalyani, M.3    Janik, J.M.4    Shi, H.5
  • 38
    • 33744781583 scopus 로고    scopus 로고
    • Selective striatal neuron loss and alterations in behavior correlate with impaired striatal function in Huntington's disease transgenic rats
    • Kántor O, Temel Y, Holzmann C, Raber K, Nguyen H-P, Cao C, et al. Selective striatal neuron loss and alterations in behavior correlate with impaired striatal function in Huntington's disease transgenic rats. Neurobiol Dis. 2006; 22: 538-547.
    • (2006) Neurobiol Dis , vol.22 , pp. 538-547
    • Kántor, O.1    Temel, Y.2    Holzmann, C.3    Raber, K.4    Nguyen, H.-P.5    Cao, C.6
  • 39
    • 84863100006 scopus 로고    scopus 로고
    • Influence of species differences on the neuropathology of transgenic Huntington's disease animal models
    • Li XJ, Li S. Influence of species differences on the neuropathology of transgenic Huntington's disease animal models. J Genet Genomics. 2012; 39: 239-245.
    • (2012) J Genet Genomics , vol.39 , pp. 239-245
    • Li, X.J.1    Li, S.2
  • 40
    • 84879800629 scopus 로고    scopus 로고
    • Axonopathy in Huntington's disease
    • Li J-Y, Conforti L. Axonopathy in Huntington's disease. Exp Neurol. 2013; 246: 62-71.
    • (2013) Exp Neurol , vol.246 , pp. 62-71
    • Li, J.-Y.1    Conforti, L.2
  • 41
    • 81255149512 scopus 로고    scopus 로고
    • Pathophysiology of Huntington's disease: Time-dependent alterations in synaptic and receptor function
    • Raymond LA, André VM, Cepeda C, Gladding CM, Milnerwood AJ, Levine MS. Pathophysiology of Huntington's disease: time-dependent alterations in synaptic and receptor function. Neuroscience. 2011; 198: 252-273.
    • (2011) Neuroscience , vol.198 , pp. 252-273
    • Raymond, L.A.1    André, V.M.2    Cepeda, C.3    Gladding, C.M.4    Milnerwood, A.J.5    Levine, M.S.6
  • 42
    • 74549181538 scopus 로고    scopus 로고
    • Early increase in extrasynaptic NMDA receptor signaling and expression contributes to phenotype onset in Huntington's disease mice
    • Milnerwood AJ, Gladding CM, Pouladi MA, Kaufman AM, Hines RM, Boyd JD, et al. Early increase in extrasynaptic NMDA receptor signaling and expression contributes to phenotype onset in Huntington's disease mice. Neuron. 2010; 65: 178-190.
    • (2010) Neuron , vol.65 , pp. 178-190
    • Milnerwood, A.J.1    Gladding, C.M.2    Pouladi, M.A.3    Kaufman, A.M.4    Hines, R.M.5    Boyd, J.D.6
  • 43
    • 84884292211 scopus 로고    scopus 로고
    • Dysregulation of synaptic proteins, dendritic spine abnormalities and pathological plasticity of synapses as experience-dependent mediators of cognitive and psychiatric symptoms in Huntington's disease
    • Nithianantharajah J, Hannan AJ. Dysregulation of synaptic proteins, dendritic spine abnormalities and pathological plasticity of synapses as experience-dependent mediators of cognitive and psychiatric symptoms in Huntington's disease. Neuroscience. 2013; 251: 66-74.
    • (2013) Neuroscience , vol.251 , pp. 66-74
    • Nithianantharajah, J.1    Hannan, A.J.2
  • 44
    • 0035816627 scopus 로고    scopus 로고
    • Polyglutamine-expanded huntingtin promotes sensitization of N-methyl-D-Aspartate receptors via post-synaptic density 95
    • Sun Y, Savanenin A, Reddy PH, Liu YF. Polyglutamine-expanded huntingtin promotes sensitization of N-methyl-D-Aspartate receptors via post-synaptic density 95. J Biol Chem. 2001; 276: 24713-24718.
    • (2001) J Biol Chem , vol.276 , pp. 24713-24718
    • Sun, Y.1    Savanenin, A.2    Reddy, P.H.3    Liu, Y.F.4
  • 45
    • 84898678139 scopus 로고    scopus 로고
    • Extrasynaptic NMDA receptor involvement in central nervous system disorders
    • Parsons MP, Raymond LA. Extrasynaptic NMDA receptor involvement in central nervous system disorders. Neuron. 2014; 82: 279-293.
    • (2014) Neuron , vol.82 , pp. 279-293
    • Parsons, M.P.1    Raymond, L.A.2
  • 46
    • 34347215864 scopus 로고    scopus 로고
    • Influence of endogenous and exogenous sex hormones on plasma brain-derived neurotrophic factor
    • Begliuomini S, Casarosa E, Pluchino N, Lenzi E, Centofanti M, Freschi L, et al. Influence of endogenous and exogenous sex hormones on plasma brain-derived neurotrophic factor. Hum Reprod. 2007; 22: 995-1002.
    • (2007) Hum Reprod , vol.22 , pp. 995-1002
    • Begliuomini, S.1    Casarosa, E.2    Pluchino, N.3    Lenzi, E.4    Centofanti, M.5    Freschi, L.6
  • 47
    • 84902509362 scopus 로고    scopus 로고
    • Estrogenic mediation of serotonergic and neurotrophic systems: Implications for female mood disorders
    • Borrow AP, Cameron NM. Estrogenic mediation of serotonergic and neurotrophic systems: implications for female mood disorders. Prog Neuropsychopharmacol Biol Psychiatry. 2014; 54: 13-25.
    • (2014) Prog Neuropsychopharmacol Biol Psychiatry , vol.54 , pp. 13-25
    • Borrow, A.P.1    Cameron, N.M.2
  • 48
    • 84876072089 scopus 로고    scopus 로고
    • Interactions between estradiol, BDNF and dendritic spines in promoting memory
    • Luine V, Frankfurt M. Interactions between estradiol, BDNF and dendritic spines in promoting memory. Neuroscience. 2013; 239: 34-45.
    • (2013) Neuroscience , vol.239 , pp. 34-45
    • Luine, V.1    Frankfurt, M.2
  • 49
    • 43049113543 scopus 로고    scopus 로고
    • AAV-mediated expression of Bcl-xL or XIAP fails to induce neuronal resistance against quinolinic acid-induced striatal lesioning
    • Kells AP, Connor B. AAV-mediated expression of Bcl-xL or XIAP fails to induce neuronal resistance against quinolinic acid-induced striatal lesioning. Neurosci Lett. 2008; 436: 326-330.
    • (2008) Neurosci Lett , vol.436 , pp. 326-330
    • Kells, A.P.1    Connor, B.2


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