Selective striatal neuron loss and alterations in behavior correlate with impaired striatal function in Huntington's disease transgenic rats

Neurobiology of Disease

Volumn 22, Issue 3, 2006, Pages 538-547

  Kántor, Orsolya ^a,b   Temel, Yasin ^b,c,f   Holzmann, Carsten ^d   Raber, Kerstin ^e   Nguyen, Huu Phuc ^e   Cao, Chunyan ^b,c   Türkoglu, Hatice Özen ^b,c   Rutten, Bart P F ^b,c   Visser Vandewalle, Veerle ^b,c,f   Steinbusch, Harry W M ^b,c   Blokland, Arjan ^b,c   Korr, Hubert ^a,b,c   Riess, Olaf ^g   von Hörsten, Stephan ^e   Schmitz, Christoph ^b,c  

^a RWTH AACHEN UNIVERSITY   (Germany)

^b European Graduate School of Neuroscience   (Netherlands)

^c MAASTRICHT UNIVERSITY   (Netherlands)

^d UNIVERSITY OF ROSTOCK   (Germany)

^e HANNOVER MEDICAL SCHOOL   (Germany)

^f MAASTRICHT UNIVERSITY MEDICAL CENTER   (Netherlands)

^g UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

Cortex; Huntington's disease; Neuron loss; Rat; Reaction time performance; Stereology; Striatum; Transgenic

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BEHAVIOR DISORDER; BRAIN ATROPHY; BRAIN FUNCTION; BRAIN NERVE CELL; BRAIN VENTRICLE DILATATION; CELL COUNT; CELL STRUCTURE; CONTROLLED STUDY; CORPUS STRIATUM; CORRELATION ANALYSIS; EXPERIMENTAL MODEL; FEMALE; FRONTAL CORTEX; HUNTINGTON CHOREA; NERVE CELL NECROSIS; NONHUMAN; PRIORITY JOURNAL; PYRAMIDAL NERVE CELL; RAT; RESPONSE TIME; TASK PERFORMANCE; TRANSGENIC ANIMAL; WILD TYPE;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; BEHAVIOR, ANIMAL; CELL COUNT; CORPUS STRIATUM; DISEASE MODELS, ANIMAL; HUNTINGTON DISEASE; IMMUNOHISTOCHEMISTRY; NEURONS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 33744781583     PISSN: 09699961     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nbd.2005.12.014     Document Type: Article

References (44)

1. Amalric M., Moukhles H., Nieoullon A., and Daszuta A. Complex deficits on reaction time performance following bilateral intrastriatal 6-OHDA infusion in the rat. Eur. J. Neurosci. 7 (1995) 972-980
2. Arrasate M., Mitra S., Schweitzer E.S., Segal M.R., and Finkbeiner S. Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death. Nature 431 (2004) 805-810
3. Aron A.R., Watkins L., Sahakian B.J., Monsell S., Barker R.A., and Robbins T.W. Task-set switching deficits in early-stage Huntington's disease: implications for basal ganglia function. J. Cogn. Neurosci. 15 (2003) 629-642
4. Beal M.F., and Ferrante R.J. Experimental therapeutics in transgenic mouse models of Huntington's disease. Nat. Rev., Neurosci. 5 (2004) 373-384
5. Blokland A. Reaction time responding in rats. Neurosci. Biobehav. Rev. 22 (1998) 847-864
6. Brouillet E., Conde F., Beal M.F., and Hantraye P. Replicating Huntington's disease phenotype in experimental animals. Prog. Neurobiol. 59 (1999) 427-468
7. Butterfield D.A., Howard B.J., and LaFontaine M.A. Brain oxidative stress in animal models of accelerated aging and the age-related neurodegenerative disorders, Alzheimer's disease and Huntington's disease. Curr. Med. Chem. 8 (2001) 815-828
8. Cavalieri, B., Geometria Indivisibilibus Continuorum. (reprinted 1966 as Geometria Degli Indivisibilii) Bononiae: Typis Clementis Ferronij. Unione Tipografico-Editrice Torinese, Torino.
9. Davies S.W., Turmaine M., Cozens B.A., DiFiglia M., Sharp A.H., Ross C.A., Scherzinger E., Wanker E.E., Mangiarini L., and Bates G.P. Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation. Cell 90 (1997) 537-548
10. DiFiglia M., Sapp E., Chase K.O., Davies S.W., Bates G.P., Vonsattel J.P., and Aronin N. Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain. Science 277 (1997) 1990-1993
11. Desbonnet L., Temel Y., Visser-Vandewalle V., Blokland A., Hornikx V., and Steinbusch H.W.M. Premature responding following bilateral stimulation of the rat subthalamic nucleus is amplitude and frequency dependent. Brain Res. 22 (2004) 198-204
12. Farrer L.A., and Conneally P.M. Predictability of phenotype in Huntington's disease. Arch. Neurol. 44 (1987) 109-113
13. Friedlander R.M. Apoptosis and caspases in neurodegenerative diseases. N. Engl. J. Med. 348 (2003) 1365-1375
14. Hedreen J.C., Peyser C.E., Folstein S.E., and Ross C.A. Neuronal loss in layers V and VI of cerebral cortex in Huntington's disease. Neurosci. Lett. 133 (1991) 257-261
15. Heinsen H., Strik M., Bauer M., Luther K., Ulmar G., Gangnus D., Jungkunz G., Eisenmenger W., and Gotz M. Cortical and striatal neurone number in Huntington's disease. Acta Neuropathol. 88 (1994) 320-333
16. Ho A.K., Manly T., Nestor P.J., Sahakian B.J., Bak T.H., Robbins T.W., Rosser A.E., and Barker R.A. A case of unilateral neglect in Huntington's disease. Neurocase 9 (2003) 261-273
17. Honavar M., and Lantos P.L. Ultrastructural changes in the frontal cortex and hippocampus in the ageing marmoset. Mech. Ageing Dev. 41 (1987) 161-175
18. Karnath H.O., Himmelbach M., and Rorden C. The subcortical anatomy of human spatial neglect: putamen, caudate nucleus and pulvinar. Brain 125 (2002) 350-360
19. Keene C.D., Rodrigues C.M., Eich T., Chhabra M.S., Steer C.J., and Low W.C. Tauroursodeoxycholic acid, a bile acid, is neuroprotective in a transgenic animal model of Huntington's disease. Proc. Natl. Acad. Sci. U. S. A. 99 (2002) 10671-10676
20. Kim M., Lee H.S., LaForet G., McIntyre C., Martin E.J., Chang P., Kim T.W., Williams M., Reddy P.H., Tagle D., Boyce F.M., Won L., Heller A., Aronin N., and DiFiglia M. Mutant huntingtin expression in clonal striatal cells: dissociation of inclusion formation and neuronal survival by caspase inhibition. J. Neurosci. 19 (1999) 964-973
21. Klement I.A., Skinner P.J., Kaytor M.D., Yi H., Hersch S.M., Clark H.B., Zoghbi H.Y., and Orr H.T. Ataxin-1 nuclear localization and aggregation: role in polyglutamine-induced disease in SCA1 transgenic mice. Cell 95 (1998) 41-53
22. Korr H., Rohde H.T., Benders J., Dafotakis M., Grolms N., and Schmitz C. Neuron loss during early adulthood following prenatal low-dose X-irradiation in the mouse brain. Int. J. Radiat. Biol. 77 (2001) 567-580
23. Kuemmerle S., Gutekunst C.A., Klein A.M., Li X.J., Li S.H., Beal M.F., Hersch S.M., and Ferrante R.J. Huntington aggregates may not predict neuronal death in Huntington's disease. Ann. Neurol. 46 (1999) 842-849
24. Macdonald V., and Halliday G. Pyramidal cell loss in motor cortices in Huntington's disease. Neurobiol. Dis. 10 (2002) 378-386
25. Mangiarini L., Sathasivam K., Seller M., Cozens B., Harper A., Hetherington C., Lawton M., Trottier Y., Lehrach H., Davies S.W., and Bates G.P. Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice. Cell 87 (1996) 493-506
26. Maslinska D., Boellaard J.W., and Schlote W. Acid phosphatase activity in human neuronal and glial lipofuscin. Acta Neuropathol. 64 (1984) 222-228
27. Osmand A., Berthelier V., and Wetzel R. Identification of aggregation foci, intracellular neuronal structures in the neocortex in Huntington's disease capable of recruiting polyglutamine. Abstr.-Soc. Neurosci. 293 (2002) 6
28. Paxinos G., and Watson C. The Rat Brain in Stereotaxic Coordinates (1982), Academic Press, San Diego
29. Petersen A., Mani K., and Brundin P. Recent advances on the pathogenesis of Huntington's disease. Exp. Neurol. 157 (1999) 1-18
30. Saudou F., Finkbeiner S., Devys D., and Greenberg M.E. Huntingtin acts in the nucleus to induce apoptosis but death does not correlate with the formation of intranuclear inclusions. Cell 95 (1998) 55-66
31. Schmitz C. Variation of fractionator estimates and its prediction. Anat. Embryol. 198 (1998) 371-397
32. Schmitz C., and Hof P.R. Recommendations for straightforward and rigorous methods of counting neurons based on a computer simulation approach. J. Chem. Neuroanat. 20 (2000) 93-114
33. Schmitz C., and Hof P.R. Design-based stereology in neuroscience. Neuroscience 130 (2005) 813-831
34. Schmitz C., Bultmann E., Gube M., and Korr H. Neuron loss in the mouse hippocampus following prenatal injection of tritiated thymidine or saline. Int. J. Dev. Neurosci. 17 (1999) 185-190
35. Schnell S.A., Staines W.A., and Wessendorf M.W. Reduction of lipofuscin-like autofluorescence in fluorescently labeled tissue. J. Histochem. Cytochem. 47 (1999) 719-730
36. Slow E.J., van Raamsdonk J., Rogers D., Coleman S.H., Graham R.K., Deng Y., Oh R., Bissada N., Hossain S.M., Yang Y.Z., Li X.J., Simpson E.M., Gutekunst C.A., Leavitt B.R., and Hayden M.R. Selective striatal neuronal loss in a YAC128 mouse model of Huntington disease. Hum. Mol. Genet. 12 (2003) 1555-1567
37. Sturrock R.R. A morphological study of the neostriatum of aged mice with particular reference to neuroglia. J. Hirnforsch. 28 (1987) 505-515
38. Tellez-Nagel I., Johnson A.B., and Terry R.D. Studies on brain biopsies of patients with Huntington's chorea. J. Neuropathol. Exp. Neurol. 33 (1974) 308-332
39. Temel Y., Visser-Vandewalle V., Aendekerk B., Rutten B., Tan S., Scholtissen B., Schmitz C., Blokland A., and Steinbusch H.W.M. Acute and separate modulation of motor and cognitive performance in parkinsonian rats by bilateral stimulation of the subthalamic nucleus. Exp. Neurol. 193 (2005) 43-52
40. The Huntington's Disease Collaborative Research Group. A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes. Cell 72 (1993) 971-983
41. van de Berg W.D., Blokland A., Cuello A.C., Schmitz C., Vreuls W., Steinbusch H.W., and Blanco C.E. Perinatal asphyxia results in changes in presynaptic bouton number in striatum and cerebral cortex-A stereological and behavioral analysis. J. Chem. Neuroanat. 20 (2000) 71-82
42. von Hörsten S., Schmitt I., Nguyen H.P., Holzmann C., Schmidt T., Walther T., Bader M., Pabst R., Kobbe P., Krotova J., Stiller D., Kask A., Vaarmann A., Rathke-Hartlieb S., Schulz J.B., Grasshoff U., Bauer I., Vieira-Saecker A.M., Paul M., Jones L., Lindenberg K.S., Landwehrmeyer B., Bauer A., Li X.J., and Riess O. Transgenic rat model of Huntington's disease. Hum. Mol. Genet. 12 (2003) 617-624
43. Vonsattel J.P., Myers R.H., Stevens T.J., Ferrante R.J., Bird E.D., and RichardsonJr E.P. Neuropathological classification of Huntington's disease. J. Neuropathol. Exp. Neurol. 44 (1985) 559-577
44. West M.J., Slomianka L., and Gundersen H.J. Unbiased stereological estimation of the total number of neurons in the subdivisions of the rat hippocampus using the optical fractionator. Anat. Rec. 231 (1991) 482-497