Inhibition of airway liquid secretion and its effect on the physical properties of airway mucus

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 274, Issue 2 18-2, 1998, Pages

  Trout, Laura ^a   King, Malcolm ^b   Feng, Wei ^b   Inglis, Sarah K ^a   Ballard, Stephen T ^a,c  

^a UNIVERSITY OF SOUTH ALABAMA COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF ALBERTA   (Canada)

^c UNIVERSITY OF SOUTH ALABAMA   (United States)

Author keywords

Bicarbonate secretion; Chloride secretion; Cystic fibrosis; Distal bronchi; Mucus rheology

Indexed keywords

4,4' DIISOTHIOCYANATOSTILBENE 2,2' DISULFONIC ACID; 5 (N,N DIMETHYL)AMILORIDE; ACETAZOLAMIDE; BICARBONATE; BUMETANIDE; CHLORIDE ION; DIMETHYL SULFOXIDE;

AIRWAY; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYSTIC FIBROSIS; FEMALE; FLOW KINETICS; LIQUID; MALE; MUCUS; NONHUMAN; PRIORITY JOURNAL; SECRETION; SWINE;

EID: 0031913234     PISSN: 10400605     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajplung.1998.274.2.l258     Document Type: Article

References (16)

1. Andersen, M. P., D. P. Rieh, R. J. Gregory, A. E. Smith, and M. J. Welsh. Generation of cAMP-activated chloride currents by expression of CFTR. Science 251: 679-682, 1991.
2. Anderson, M. P., D. N. Sheppard, H. A. Berger, and M. J. Welsh. Chloride channels in the apical membrane of normal and cystic fibrosis airway and intestinal epithelia. Am. J. Physiol. 263 (Lung Cell. Mol. Physiol. 7): L1-L14, 1992.
3. Ballard, S. T., J. D. Fountain, S. K. Inglis, M. R. Corboz, and A. E. Taylor. Chloride secretion across distal airway epithelium: relationship to submucosal gland distribution. Am. J. Physiol. 268 (Lung Cell. Mol. Physiol. 12): L526-L531, 1995.
4. Ballard, S. T., L. Trout, S. K. Inglis, and M. R. Corboz. Role of chloride and bicarbonate in acetylcholine-induced liquid secretion from porcine bronchi (Abstract). Pediatr. Pulmonol. Suppl. 14: 232, 1997.
5. Barasch, J., B. Kiss, A. Prince, L. Saiman, D. Gruenert, and Q. Al-Aquati. Defective acidification of intracellular organelles in cystic fibrosis. Nature 352: 70-73, 1991.
6. Blake, J. On the movement of mucus in the lung. J. Biomech. 8: 179-190, 1975.
7. Boat, T. F., and L. W. Matthews. Chemical composition of human tracheobronchial secretions. In: Sputum: Fundamentals and Clinical Pathology, edited by M. J. Dulfano. Springfield, IL: Thomas, 1973, p. 243-274.
8. Boucher, R. C. Human airway ion transport. Am. J. Respir. Crit. CareMed. 150: 581-593, 1994.
9. Colten, H. R. Cystic fibrosis. In: Harrison's Principles of Internal Medicine (12th ed.), edited by J. D. Wilson, E. Braunwald, K J. Isselbacker, R. G. Petersdorf, J. B. Martin, A. S. Fauci, and R. K. Root. New York: McGraw-Hill, 1991, p. 1072-1074.
10. Dasgupta, B., and M. King. Molecular basis for mucolytic therapy. Can. Respir. J. 2: 223-230, 1995.
11. Engelhardt, J. F., J. R. Yankaskas, S. T. Ernst, Y. Yang, C. R. Marino, R. C. Boucher, J. A. Cohn, and J. M. Wilson. Submucosal glands are the predominant site of CFTR expression in the human bronchus. Nat. Genet. 2: 240-248, 1992.
12. Galabert, C., J. Jacquot, J. M. Zahn, and E. Puchelle. Relationship between the lipid content and the rheological properties of airway secretions in cystic fibrosis. Clin. Chim. Acta 164: 139-149, 1987.
13. Girod, S., C. Galabert, A. Lecuire, J. M. Zahm, and E. Puchelle. Phospholipid composition and surface-active properties of tracheobronchial secretions from patients with cystic fibrosis and chronic obstructive pulmonary disease. Pediatr. Pulmonol. 13: 22-27, 1992.
14. - secretion. Am. J. Physiol. 272 (Gastroinest. Liver Physiol. 35): G872-G878, 1997.
15. - transport blockers on submucosal gland duct mucin content in acetylcholine-treated bronchi (Abstract). Pediatr. Pulmonol. Suppl. 14: 232, 1997.
16. Inglis, S. K., M. R. Corboz, A. E. Taylor, and S. T. Ballard. Regulation of ion transport across porcine distal bronchi. Am. J. Physiol. 270 (Lung Cell. Mol. Physiol. 14): L289-L297, 1996.