Dissecting the signaling pathways that mediate cancer in PTEN and LKB1 double-knockout mice

Science Signaling

Volumn 8, Issue 392, 2015, Pages

  Chen, Jiezhong ^a,b   Zhang, Xu Dong ^a   Proud, Christopher ^c  

^a UNIVERSITY OF NEWCASTLE   (Australia)

^b UNIVERSITY OF QUEENSLAND   (Australia)

^c SOUTH AUSTRALIAN HEALTH AND MEDICAL RESEARCH INSTITUTE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN D1; GLYCOGEN SYNTHASE KINASE 3; INSULIN; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE PHOSPHODIESTERASE; PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE 1; PROGRAMMED DEATH 1 LIGAND 1; PROTEIN BAD; PROTEIN BCL 2; PROTEIN BCL XL; PROTEIN KINASE B; PROTEIN KINASE LKB1; PROTEIN TYROSINE PHOSPHATASE SHP 2; SOMATOMEDIN C; TUBERIN; MECHANISTIC TARGET OF RAPAMYCIN COMPLEX 1; MULTIPROTEIN COMPLEX; PROTEIN SERINE THREONINE KINASE; PTEN PROTEIN, MOUSE; STK11 PROTEIN, MOUSE; TARGET OF RAPAMYCIN KINASE;

CARCINOGENESIS; CELL GROWTH; CELL PROLIFERATION; CELL SPECIFICITY; CELL SURVIVAL; CYTOTOXIC T LYMPHOCYTE; ENZYME ACTIVATION; IMMUNOSURVEILLANCE; KNOCKOUT MOUSE; NEGATIVE FEEDBACK; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; REVIEW; SIGNAL TRANSDUCTION; TUMOR GROWTH; ANIMAL; GENETICS; METABOLISM; MOUSE; NEOPLASM; TUMOR ESCAPE;

ANIMALS; CELL PROLIFERATION; CELL SURVIVAL; MICE; MICE, KNOCKOUT; MULTIPROTEIN COMPLEXES; NEOPLASMS; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS C-AKT; PTEN PHOSPHOHYDROLASE; SIGNAL TRANSDUCTION; TOR SERINE-THREONINE KINASES; TUMOR ESCAPE;

EID: 84941117248     PISSN: 19450877     EISSN: 19379145     Source Type: Journal    
DOI: 10.1126/scisignal.aac8321     Document Type: Review

References (17)

1. H. Cheng, P. Liu, F. Zhang, E. Xu, L. Symonds, C. E. Ohlson, R. T. Bronson, S. M. Maira, E. Di Tomaso, J. Li, A. P. Myers, L. C. Cantley, G. B. Mills, J. J. Zhao, A genetic mouse model of invasive endometrial cancer driven by concurrent loss of Pten and Lkb1 Is highly responsive to mTOR inhibition. Cancer Res. 74, 15-23 (2014).
2. J. M. García-Martínez, S. Wullschleger, G. Preston, S. Guichard, S. Fleming, D. R. Alessi, S. L. Duce, Effect of PI3K- and mTOR-specifi c inhibitors on spontaneous B-cell follicular lymphomas in PTEN/LKB1-defi cient mice. Br. J. Cancer 104, 1116-1125 (2011).
3. S. R. Datta, H. Dudek, X. Tao, S. Masters, H. Fu, Y. Gotoh, M. E. Greenberg, Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell 91, 231-241 (1997).
4. J. A. Diehl, M. Cheng, M. F. Roussel, C. J. Sherr, Glycogen synthase kinase-3â regulates cyclin D1 proteolysis and subcellular localization. Genes Dev. 12, 3499-3511 (1998).
5. A. Hemminki, D. Markie, I. Tomlinson, E. Avizienyte, S. Roth, A. Loukola, G. Bignell, W. Warren, M. Aminoff, P. Höglund, H. Järvinen, P. Kristo, K. Pelin, M. Ridanpää, R. Salovaara, T. Toro, W. Bodmer, S. Olschwang, A. S. Olsen, M. R. Stratton, A. de la Chapelle, L. A. Aaltonen, A serine/threonine kinase gene defective in Peutz-Jeghers syndrome. Nature 391, 184-187 (1998).
6. S. A. Hawley, J. Boudeau, J. L. Reid, K. J. Mustard, L. Udd, T. P. Mäkelä, D. R. Alessi, D. G. Hardie, Complexes between the LKB1 tumor suppressor, STRAD á/â and MO25 á/â are upstream kinases in the AMP-activated protein kinase cascade. J. Biol. 2, 28 (2003).
7. K. Inoki, T. Zhu, K. L. Guan, TSC2 mediates cellular energy response to control cell growth and survival. Cell 115, 577-590 (2003).
8. F. Dupuy, T. Griss, J. Blagih, G. Bridon, D. Avizonis, C. Ling, Z. Dong, D. R. Siwak, M. G. Annis, G. B. Mills, W. J. Muller, P. M. Siegel, R. G. Jones, LKB1 is a central regulator of tumor initiation and pro-growth metabolism in ErbB2-mediated breast cancer. Cancer Metab. 1, 18 (2013).
9. M. Laplante, D. M. Sabatini, mTOR signaling at a glance. J. Cell Sci. 122, 3589-3594 (2009).
10. J. R. Mills, Y. Hippo, F. Robert, S. M. Chen, A. Malina, C. J. Lin, U. Trojahn, H. G. Wendel, A. Charest, R. T. Bronson, S. C. Kogan, R. Nadon, D. E. Housman, S. W. Lowe, J. Pelletier, mTORC1 promotes survival through translational control of Mcl-1. Proc. Natl. Acad. Sci. U.S.A. 105, 10853-10858 (2008).
11. S. Y. Sun, L. M. Rosenberg, X. Wang, Z. Zhou, P. Yue, H. Fu, F. R. Khuri, Activation of Akt and eIF4E survival pathways by rapamycin-mediated mammalian target of rapamycin inhibition. Cancer Res. 65, 7052-7058 (2005).
12. I. S. Okon, K. A. Coughlan, M. H. Zou, Liver kinase B1 expression promotes phosphatase activity and abrogation of receptor tyrosine kinase phosphorylation in human cancer cells. J. Biol. Chem. 289, 1639-1648 (2014).
13. G. P. Dunn, A. T. Bruce, H. Ikeda, L. J. Old, R. D. Schreiber, Cancer immunoediting: From immunosurveillance to tumor escape. Nat. Immunol. 3, 991-998 (2002).
14. A. T. Parsa, J. S. Waldron, A. Panner, C. A. Crane, I. F. Parney, J. J. Barry, K. E. Cachola, J. C. Murray, T. Tihan, M. C. Jensen, P. S. Mischel, D. Stokoe, R. O. Pieper, Loss of tumor suppressor PTEN function increases B7-H1 expression and immunoresistance in glioma. Nat. Med. 13, 84-88 (2007).
15. D. M. Pardoll, The blockade of immune checkpoints in cancer immunotherapy. Nat. Rev. Cancer 12, 252-264 (2012).
16. T. Yokosuka, M. Takamatsu, W. Kobayashi-Imanishi, A. Hashimoto-Tane, M. Azuma, T. Saito, Programmed cell death 1 forms negative costimulatory microclusters that directly inhibit T cell receptor signaling by recruiting phosphatase SHP2. J. Exp. Med. 209, 1201-1217 (2012).
17. E. H. Kim, J. A. Sullivan, E. H. Plisch, M. M. Tejera, A. Jatzek, K. Y. Choi, M. Suresh, Signal integration by Akt regulates CD8 T cell effector and memory differentiation. J. Immunol. 188, 4305-4314 (2012).