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Volumn 1362, Issue 1, 2015, Pages 176-187

B cells in the aging immune system: Time to consider B-1 cells

Author keywords

Aging; B cells; B 1 cells; Senescence

Indexed keywords

IMMUNOGLOBULIN M; SECRETORY IGM;

EID: 84959521201     PISSN: 00778923     EISSN: 17496632     Source Type: Journal    
DOI: 10.1111/nyas.12825     Document Type: Article
Times cited : (34)

References (92)
  • 1
    • 84881545211 scopus 로고    scopus 로고
    • Accessed July 7 2015
    • Centers for Disease Control and Prevention 2013. The State of Aging and Health in America 2013. http://www.cdc.gov/aging/pdf/state-aging-health-in-america-2013.pdf. Accessed July 7, 2015.
    • (2013) The State of Aging and Health in America 2013
  • 2
    • 0031552194 scopus 로고    scopus 로고
    • Prevention of pneumococcal disease: recommendations of the Advisory Committee on Immunization Practices (ACIP)
    • Centers for Disease Control and Prevention 1997. Prevention of pneumococcal disease: recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Recomm. Rep. 46: 1-24.
    • (1997) MMWR Recomm. Rep. , vol.46 , pp. 1-24
  • 4
    • 84917671469 scopus 로고    scopus 로고
    • Age-related immune response to pneumococcal polysaccharide vaccination: lessons for the clinic
    • Iyer, A.S. et al. 2015. Age-related immune response to pneumococcal polysaccharide vaccination: lessons for the clinic. Exp. Rev. Vac. 14: 85-97.
    • (2015) Exp. Rev. Vac. , vol.14 , pp. 85-97
    • Iyer, A.S.1
  • 5
    • 84907888400 scopus 로고    scopus 로고
    • The top 10 causes of death
    • Accessed July 7, 2015.
    • WHO 2014. The top 10 causes of death. http://www.who.int/mediacentre/factsheets/fs310/en/index4.html. Accessed July 7, 2015.
    • (2014)
  • 6
    • 0034648768 scopus 로고    scopus 로고
    • Atherosclerosis
    • Lusis, A.J. 2000. Atherosclerosis. Nature 407: 233-241.
    • (2000) Nature , vol.407 , pp. 233-241
    • Lusis, A.J.1
  • 7
    • 16344379409 scopus 로고    scopus 로고
    • Natural antibodies and the autoimmunity of atherosclerosis
    • Binder, C.J. & G.J. Silverman. 2005. Natural antibodies and the autoimmunity of atherosclerosis. Springer Semin. Immunopathol. 26: 385-404.
    • (2005) Springer Semin. Immunopathol. , vol.26 , pp. 385-404
    • Binder, C.J.1    Silverman, G.J.2
  • 8
    • 80053574700 scopus 로고    scopus 로고
    • B1a B lymphocytes are atheroprotective by secreting natural IgM that increases IgM deposits and reduces necrotic cores in atherosclerotic lesions
    • Kyaw, T. et al. 2011. B1a B lymphocytes are atheroprotective by secreting natural IgM that increases IgM deposits and reduces necrotic cores in atherosclerotic lesions. Circ. Res. 109: 830-840.
    • (2011) Circ. Res. , vol.109 , pp. 830-840
    • Kyaw, T.1
  • 9
    • 42349090206 scopus 로고    scopus 로고
    • The role of B lymphocytes as antigen-presenting cells
    • Chen, X. & P.E. Jensen. 2008. The role of B lymphocytes as antigen-presenting cells. Arch. Immunol. Ther. Exp. 56: 77-83.
    • (2008) Arch. Immunol. Ther. Exp. , vol.56 , pp. 77-83
    • Chen, X.1    Jensen, P.E.2
  • 10
    • 84884136543 scopus 로고    scopus 로고
    • A comparative review of aging and B cell function in mice and humans
    • Scholz, J.L. et al. 2013. A comparative review of aging and B cell function in mice and humans. Curr. Opin. Immunol. 25: 504-510.
    • (2013) Curr. Opin. Immunol. , vol.25 , pp. 504-510
    • Scholz, J.L.1
  • 11
    • 0026051781 scopus 로고
    • Mouse hematopoietic stem cells
    • Spangrude, G.J. et al. 1991. Mouse hematopoietic stem cells. Blood 78: 1395-1402.
    • (1991) Blood , vol.78 , pp. 1395-1402
    • Spangrude, G.J.1
  • 12
    • 0342711256 scopus 로고    scopus 로고
    • In vivo ablation of surface immunoglobulin on mature B cells by inducible gene targeting results in rapid cell death
    • Lam, K.P. et al. 1997. In vivo ablation of surface immunoglobulin on mature B cells by inducible gene targeting results in rapid cell death. Cell 90: 1073-1083.
    • (1997) Cell , vol.90 , pp. 1073-1083
    • Lam, K.P.1
  • 13
    • 0027275497 scopus 로고
    • The regulated expression of B lineage associated genes during B cell differentiation in bone marrow and fetal liver
    • Li, Y.S. et al. 1993. The regulated expression of B lineage associated genes during B cell differentiation in bone marrow and fetal liver. J. Exp. Med. 178: 951-960.
    • (1993) J. Exp. Med. , vol.178 , pp. 951-960
    • Li, Y.S.1
  • 14
    • 0030483542 scopus 로고    scopus 로고
    • Identification of the earliest B lineage stage in mouse bone marrow
    • Li, Y.S. et al. 1996. Identification of the earliest B lineage stage in mouse bone marrow. Immunity 5: 527-535.
    • (1996) Immunity , vol.5 , pp. 527-535
    • Li, Y.S.1
  • 15
    • 0021216208 scopus 로고
    • Insertion of N regions into heavy-chain genes is correlated with expression of terminal deoxytransferase in B cells
    • Desiderio, S.V. et al. 1984. Insertion of N regions into heavy-chain genes is correlated with expression of terminal deoxytransferase in B cells. Nature 311: 752-755.
    • (1984) Nature , vol.311 , pp. 752-755
    • Desiderio, S.V.1
  • 16
    • 0027247802 scopus 로고
    • B lymphopoiesis in the mouse
    • Rolink, A. & F. Melchers. 1993. B lymphopoiesis in the mouse. Adv. Immunol. 53: 123-156.
    • (1993) Adv. Immunol. , vol.53 , pp. 123-156
    • Rolink, A.1    Melchers, F.2
  • 17
    • 78650600361 scopus 로고    scopus 로고
    • The double life of a B-1 cell: self-reactivity selects for protective effector functions
    • Baumgarth, N. 2011. The double life of a B-1 cell: self-reactivity selects for protective effector functions. Nat. Rev. Immunol. 11: 34-46.
    • (2011) Nat. Rev. Immunol. , vol.11 , pp. 34-46
    • Baumgarth, N.1
  • 18
    • 33645908488 scopus 로고    scopus 로고
    • Identification of a B-1 B cell-specified progenitor
    • Montecino-Rodriguez, E. et al. 2006. Identification of a B-1 B cell-specified progenitor. Nat. Immunol. 7: 293-301.
    • (2006) Nat. Immunol. , vol.7 , pp. 293-301
    • Montecino-Rodriguez, E.1
  • 19
    • 84876909069 scopus 로고    scopus 로고
    • The ageing haematopoietic stem cell compartment
    • Geiger, H. et al. 2013. The ageing haematopoietic stem cell compartment. Nat. Rev. Immunol. 13: 376-389.
    • (2013) Nat. Rev. Immunol. , vol.13 , pp. 376-389
    • Geiger, H.1
  • 20
    • 1142275269 scopus 로고    scopus 로고
    • Age-related changes in lymphocyte development and function
    • Linton, P.J. & K. Dorshkind. 2004. Age-related changes in lymphocyte development and function. Nat. Immunol. 5: 133-139.
    • (2004) Nat. Immunol. , vol.5 , pp. 133-139
    • Linton, P.J.1    Dorshkind, K.2
  • 21
    • 0029813378 scopus 로고    scopus 로고
    • The aging of hematopoietic stem cells
    • Morrison, S.J. et al. 1996. The aging of hematopoietic stem cells. Nat. Med. 2: 1011-1016.
    • (1996) Nat. Med. , vol.2 , pp. 1011-1016
    • Morrison, S.J.1
  • 22
    • 0034613690 scopus 로고    scopus 로고
    • Age-associated characteristics of murine hematopoietic stem cells
    • Sudo, K. et al. 2000. Age-associated characteristics of murine hematopoietic stem cells. J. Exp. Med. 192: 1273-1280.
    • (2000) J. Exp. Med. , vol.192 , pp. 1273-1280
    • Sudo, K.1
  • 23
    • 23044484028 scopus 로고    scopus 로고
    • Linking age-related defects in B lymphopoiesis to the aging of hematopoietic stem cells
    • Miller, J.P. & Allman, D. 2005. Linking age-related defects in B lymphopoiesis to the aging of hematopoietic stem cells. Semin. Immunol. 17: 321-329.
    • (2005) Semin. Immunol. , vol.17 , pp. 321-329
    • Miller, J.P.1    Allman, D.2
  • 24
    • 84861496084 scopus 로고    scopus 로고
    • CD86 is expressed on murine hematopoietic stem cells and denotes lymphopoietic potential
    • Shimazu, T. et al. 2012. CD86 is expressed on murine hematopoietic stem cells and denotes lymphopoietic potential. Blood 119: 4889-4897.
    • (2012) Blood , vol.119 , pp. 4889-4897
    • Shimazu, T.1
  • 25
    • 38549147656 scopus 로고    scopus 로고
    • Evolving views on the genealogy of B cells
    • Welner, R.S. et al. 2008. Evolving views on the genealogy of B cells. Nat. Rev. Immunol. 8: 95-106.
    • (2008) Nat. Rev. Immunol. , vol.8 , pp. 95-106
    • Welner, R.S.1
  • 26
    • 77958544786 scopus 로고    scopus 로고
    • E proteins and the regulation of early lymphocyte development
    • de Pooter, R.F. & B.L. Kee. 2010. E proteins and the regulation of early lymphocyte development. Immunol. Rev. 238: 93-109.
    • (2010) Immunol. Rev. , vol.238 , pp. 93-109
    • de Pooter, R.F.1    Kee, B.L.2
  • 27
    • 77956685007 scopus 로고    scopus 로고
    • Reduced EBF expression underlies loss of B-cell potential of hematopoietic progenitors with age
    • Lescale, C. et al. 2010. Reduced EBF expression underlies loss of B-cell potential of hematopoietic progenitors with age. Aging Cell 9: 410-419.
    • (2010) Aging Cell , vol.9 , pp. 410-419
    • Lescale, C.1
  • 28
    • 0042931219 scopus 로고    scopus 로고
    • The decline in B lymphopoiesis in aged mice reflects loss of very early B-lineage precursors
    • Miller, J.P. & Allman, D. 2003. The decline in B lymphopoiesis in aged mice reflects loss of very early B-lineage precursors. J. Immunol. 171: 2326-2330.
    • (2003) J. Immunol. , vol.171 , pp. 2326-2330
    • Miller, J.P.1    Allman, D.2
  • 29
    • 0025762004 scopus 로고
    • B cell precursors are decreased in senescent BALB/c mice, but retain normal mitotic activity in vivo and in vitro
    • Riley, R.L. et al. 1991. B cell precursors are decreased in senescent BALB/c mice, but retain normal mitotic activity in vivo and in vitro. Clin. Immunol. Immunopathol. 59: 301-313.
    • (1991) Clin. Immunol. Immunopathol. , vol.59 , pp. 301-313
    • Riley, R.L.1
  • 30
    • 49149127677 scopus 로고    scopus 로고
    • Mechanisms for decreased function of B cells in aged mice and humans
    • Frasca, D. et al. 2008. Mechanisms for decreased function of B cells in aged mice and humans. J. Immunol. 180: 2741-2746.
    • (2008) J. Immunol. , vol.180 , pp. 2741-2746
    • Frasca, D.1
  • 31
    • 0034283065 scopus 로고    scopus 로고
    • The reduced expression of surrogate light chains in B cell precursors from senescent BALB/c mice is associated with decreased E2A proteins
    • Sherwood, E.M. et al. 2000. The reduced expression of surrogate light chains in B cell precursors from senescent BALB/c mice is associated with decreased E2A proteins. Mech. Ageing Dev. 118: 45-59.
    • (2000) Mech. Ageing Dev. , vol.118 , pp. 45-59
    • Sherwood, E.M.1
  • 32
    • 55249106981 scopus 로고    scopus 로고
    • FLT3 ligand and not TSLP is the key regulator of IL-7-independent B-1 and B-2 B lymphopoiesis
    • Jensen, C.T. et al. 2008. FLT3 ligand and not TSLP is the key regulator of IL-7-independent B-1 and B-2 B lymphopoiesis. Blood 112: 2297-2304.
    • (2008) Blood , vol.112 , pp. 2297-2304
    • Jensen, C.T.1
  • 33
    • 0029045161 scopus 로고
    • Failure of B-cell differentiation in mice lacking the transcription factor EBF
    • Lin, H. & R. Grosschedl. 1995. Failure of B-cell differentiation in mice lacking the transcription factor EBF. Nature 376: 263-267.
    • (1995) Nature , vol.376 , pp. 263-267
    • Lin, H.1    Grosschedl, R.2
  • 34
    • 0031568406 scopus 로고    scopus 로고
    • Development of B cells in aged mice: decline in the ability of pro-B cells to respond to IL-7 but not to other growth factors
    • Stephan, R.P. et al. 1997. Development of B cells in aged mice: decline in the ability of pro-B cells to respond to IL-7 but not to other growth factors. J. Immunol. 158: 1598-1609.
    • (1997) J. Immunol. , vol.158 , pp. 1598-1609
    • Stephan, R.P.1
  • 35
    • 4344599559 scopus 로고    scopus 로고
    • Bone marrow microenvironmental changes underlie reduced RAG-mediated recombination and B cell generation in aged mice
    • Labrie, J.E., 3rd et al. 2004. Bone marrow microenvironmental changes underlie reduced RAG-mediated recombination and B cell generation in aged mice. J. Exp. Med. 200: 411-423.
    • (2004) J. Exp. Med. , vol.200 , pp. 411-423
    • Labrie, J.E.1
  • 36
    • 84858649330 scopus 로고    scopus 로고
    • Rantes/Ccl5 influences hematopoietic stem cell subtypes and causes myeloid skewing
    • Ergen, A.V. et al. 2012. Rantes/Ccl5 influences hematopoietic stem cell subtypes and causes myeloid skewing. Blood 119: 2500-2509.
    • (2012) Blood , vol.119 , pp. 2500-2509
    • Ergen, A.V.1
  • 37
    • 33646181086 scopus 로고    scopus 로고
    • Mechanism and control of V(D)J recombination at the immunoglobulin heavy chain locus
    • Jung, D. et al. 2006. Mechanism and control of V(D)J recombination at the immunoglobulin heavy chain locus. Annu. Rev. Immunol. 24: 541-570.
    • (2006) Annu. Rev. Immunol. , vol.24 , pp. 541-570
    • Jung, D.1
  • 38
    • 3142721218 scopus 로고    scopus 로고
    • Decreased E47 in senescent B cell precursors is stage specific and regulated posttranslationally by protein turnover
    • Van der Put, E. et al. 2004. Decreased E47 in senescent B cell precursors is stage specific and regulated posttranslationally by protein turnover. J. Immunol. 173: 818-827.
    • (2004) J. Immunol. , vol.173 , pp. 818-827
    • Van der Put, E.1
  • 39
    • 0037025198 scopus 로고    scopus 로고
    • Reversion of B cell commitment upon loss of Pax5 expression
    • Mikkola, I. et al. 2002. Reversion of B cell commitment upon loss of Pax5 expression. Science 297: 110-113.
    • (2002) Science , vol.297 , pp. 110-113
    • Mikkola, I.1
  • 40
    • 0030790713 scopus 로고    scopus 로고
    • EBF and E47 collaborate to induce expression of the endogenous immunoglobulin surrogate light chain genes
    • Sigvardsson, M. et al. 1997. EBF and E47 collaborate to induce expression of the endogenous immunoglobulin surrogate light chain genes. Immunity 7: 25-36.
    • (1997) Immunity , vol.7 , pp. 25-36
    • Sigvardsson, M.1
  • 41
    • 84891496727 scopus 로고    scopus 로고
    • Impaired B lymphopoiesis in old age: a role for inflammatory B cells?
    • Riley, R.L. 2013. Impaired B lymphopoiesis in old age: a role for inflammatory B cells? Immunol. Res. 57: 361-369.
    • (2013) Immunol. Res. , vol.57 , pp. 361-369
    • Riley, R.L.1
  • 42
    • 4444320808 scopus 로고    scopus 로고
    • Ageing, autoimmunity and arthritis: senescence of the B cell compartment-implications for humoral immunity
    • Johnson, S.A. & J.C. Cambier. 2004. Ageing, autoimmunity and arthritis: senescence of the B cell compartment-implications for humoral immunity. Arthritis Res. Ther. 6: 131-139.
    • (2004) Arthritis Res. Ther. , vol.6 , pp. 131-139
    • Johnson, S.A.1    Cambier, J.C.2
  • 43
    • 0033559509 scopus 로고    scopus 로고
    • B cell maintenance in aged mice reflects both increased B cell longevity and decreased B cell generation
    • Kline, G.H. et al. 1999. B cell maintenance in aged mice reflects both increased B cell longevity and decreased B cell generation. J. Immunol. 162: 3342-3349.
    • (1999) J. Immunol. , vol.162 , pp. 3342-3349
    • Kline, G.H.1
  • 44
    • 79953097625 scopus 로고    scopus 로고
    • B-cell depletion reactivates B lymphopoiesis in the BM and rejuvenates the B lineage in aging
    • Keren, Z. et al. 2011. B-cell depletion reactivates B lymphopoiesis in the BM and rejuvenates the B lineage in aging. Blood 117: 3104-3112.
    • (2011) Blood , vol.117 , pp. 3104-3112
    • Keren, Z.1
  • 45
    • 84869798045 scopus 로고    scopus 로고
    • Aging and neoteny in the B lineage
    • Melamed, D. & D.W. Scott. 2012. Aging and neoteny in the B lineage. Blood 120: 4143-4149.
    • (2012) Blood , vol.120 , pp. 4143-4149
    • Melamed, D.1    Scott, D.W.2
  • 46
    • 0031448877 scopus 로고    scopus 로고
    • The B-cell biology of aging
    • Klinman, N.R. & G.H. Kline. 1997. The B-cell biology of aging. Immunol. Rev. 160: 103-114.
    • (1997) Immunol. Rev. , vol.160 , pp. 103-114
    • Klinman, N.R.1    Kline, G.H.2
  • 47
    • 0033962638 scopus 로고    scopus 로고
    • Changes in the B-cell repertoire with age
    • Weksler, M.E. 2000. Changes in the B-cell repertoire with age. Vaccine 18: 1624-1628.
    • (2000) Vaccine , vol.18 , pp. 1624-1628
    • Weksler, M.E.1
  • 48
    • 0037094083 scopus 로고    scopus 로고
    • Aging-dependent exclusion of antigen-inexperienced cells from the peripheral B cell repertoire
    • Johnson, S.A. et al. 2002. Aging-dependent exclusion of antigen-inexperienced cells from the peripheral B cell repertoire. J. Immunol. 168: 5014-5023.
    • (2002) J. Immunol. , vol.168 , pp. 5014-5023
    • Johnson, S.A.1
  • 49
    • 20344374383 scopus 로고    scopus 로고
    • B cells and aging: gauging the interplay of generative, selective, and homeostatic events
    • Cancro, M.P. 2005. B cells and aging: gauging the interplay of generative, selective, and homeostatic events. Immunol. Rev. 205: 48-59.
    • (2005) Immunol. Rev. , vol.205 , pp. 48-59
    • Cancro, M.P.1
  • 50
    • 79953225865 scopus 로고    scopus 로고
    • Alterations in marginal zone macrophages and marginal zone B cells in old mice
    • Birjandi, S.Z. et al. 2011. Alterations in marginal zone macrophages and marginal zone B cells in old mice. J. Immunol. 186: 3441-3451.
    • (2011) J. Immunol. , vol.186 , pp. 3441-3451
    • Birjandi, S.Z.1
  • 51
    • 73949104748 scopus 로고    scopus 로고
    • Migration of immature and mature B cells in the aged microenvironment
    • Wols, H.A. et al. 2010. Migration of immature and mature B cells in the aged microenvironment. Immunology 129: 278-290.
    • (2010) Immunology , vol.129 , pp. 278-290
    • Wols, H.A.1
  • 52
    • 80051569441 scopus 로고    scopus 로고
    • A B-cell subset uniquely responsive to innate stimuli accumulates in aged mice
    • Hao, Y. et al. 2011. A B-cell subset uniquely responsive to innate stimuli accumulates in aged mice. Blood 118: 1294-1304.
    • (2011) Blood , vol.118 , pp. 1294-1304
    • Hao, Y.1
  • 53
    • 84878945504 scopus 로고    scopus 로고
    • In senescence, age-associated B cells secrete TNFalpha and inhibit survival of B-cell precursors
    • Ratliff, M. et al. 2013. In senescence, age-associated B cells secrete TNFalpha and inhibit survival of B-cell precursors. Aging Cell 12: 303-311.
    • (2013) Aging Cell , vol.12 , pp. 303-311
    • Ratliff, M.1
  • 54
    • 0031464890 scopus 로고    scopus 로고
    • Immunosenescence and germinal center reaction
    • Zheng, B. et al. 1997. Immunosenescence and germinal center reaction. Immunol. Rev. 160: 63-77.
    • (1997) Immunol. Rev. , vol.160 , pp. 63-77
    • Zheng, B.1
  • 55
    • 0031436582 scopus 로고    scopus 로고
    • Effect of age on humoral immunity, selection of the B-cell repertoire and B-cell development
    • LeMaoult, J. et al. 1997. Effect of age on humoral immunity, selection of the B-cell repertoire and B-cell development. Immunol. Rev. 160: 115-126.
    • (1997) Immunol. Rev. , vol.160 , pp. 115-126
    • LeMaoult, J.1
  • 56
    • 77952300034 scopus 로고    scopus 로고
    • The effect of age on the response to the pneumococcal polysaccharide vaccine
    • Lee, H. et al. 2010. The effect of age on the response to the pneumococcal polysaccharide vaccine. BMC Infect. Dis. 10: 60.
    • (2010) BMC Infect. Dis. , vol.10 , pp. 60
    • Lee, H.1
  • 57
    • 0026059308 scopus 로고
    • Repertoire diversity of antibody response to bacterial antigens in aged mice. II. Phosphorylcholine-antibody in young and aged mice differ in both VH/VL gene repertoire and in specificity
    • Nicoletti, C. et al. 1991. Repertoire diversity of antibody response to bacterial antigens in aged mice. II. Phosphorylcholine-antibody in young and aged mice differ in both VH/VL gene repertoire and in specificity. J. Immunol. 147: 2750-2755.
    • (1991) J. Immunol. , vol.147 , pp. 2750-2755
    • Nicoletti, C.1
  • 58
    • 0028355045 scopus 로고
    • Repertoire diversity of antibody response to bacterial antigens in aged mice. IV. Study of VH and VL gene utilization in splenic antibody foci by in situ hybridization
    • Yang, X. et al. 1994. Repertoire diversity of antibody response to bacterial antigens in aged mice. IV. Study of VH and VL gene utilization in splenic antibody foci by in situ hybridization. J. Immunol. 152: 2214-2221.
    • (1994) J. Immunol. , vol.152 , pp. 2214-2221
    • Yang, X.1
  • 59
    • 22544470027 scopus 로고    scopus 로고
    • B-1a and B-1b cells exhibit distinct developmental requirements and have unique functional roles in innate and adaptive immunity to S. pneumoniae
    • Haas, K.M. et al. 2005. B-1a and B-1b cells exhibit distinct developmental requirements and have unique functional roles in innate and adaptive immunity to S. pneumoniae. Immunity 23: 7-18.
    • (2005) Immunity , vol.23 , pp. 7-18
    • Haas, K.M.1
  • 61
    • 78049313303 scopus 로고    scopus 로고
    • The importance of natural IgM: scavenger, protector and regulator
    • Ehrenstein, M.R. & C.A. Notley. 2010. The importance of natural IgM: scavenger, protector and regulator. Nat. Rev. Immunol. 10: 778-786.
    • (2010) Nat. Rev. Immunol. , vol.10 , pp. 778-786
    • Ehrenstein, M.R.1    Notley, C.A.2
  • 62
    • 0036217975 scopus 로고    scopus 로고
    • Origins and functions of B-1 cells with notes on the role of CD5
    • Berland, R. & H.H. Wortis. 2002. Origins and functions of B-1 cells with notes on the role of CD5. Annu. Rev. Immunol. 20: 253-300.
    • (2002) Annu. Rev. Immunol. , vol.20 , pp. 253-300
    • Berland, R.1    Wortis, H.H.2
  • 63
    • 0019972628 scopus 로고
    • Anti-phosphorylcholine antibodies of the T15 idiotype are optimally protective against Streptococcus pneumoniae
    • Briles, D.E. et al. 1982. Anti-phosphorylcholine antibodies of the T15 idiotype are optimally protective against Streptococcus pneumoniae. J. Exp. Med. 156: 1177-1185.
    • (1982) J. Exp. Med. , vol.156 , pp. 1177-1185
    • Briles, D.E.1
  • 64
    • 0033920225 scopus 로고    scopus 로고
    • Terminal deoxynucleotidyl transferase and repertoire development
    • Benedict, C.L. et al. 2000. Terminal deoxynucleotidyl transferase and repertoire development. Immunol. Rev. 175: 150-157.
    • (2000) Immunol. Rev. , vol.175 , pp. 150-157
    • Benedict, C.L.1
  • 65
    • 0033136298 scopus 로고    scopus 로고
    • Increased junctional diversity in fetal B cells results in a loss of protective anti-phosphorylcholine antibodies in adult mice
    • Benedict, C.L. & J.F. Kearney. 1999. Increased junctional diversity in fetal B cells results in a loss of protective anti-phosphorylcholine antibodies in adult mice. Immunity 10: 607-617.
    • (1999) Immunity , vol.10 , pp. 607-617
    • Benedict, C.L.1    Kearney, J.F.2
  • 66
    • 6944247877 scopus 로고    scopus 로고
    • Anti-beta 2 glycoprotein I antibodies in centenarians
    • Meroni, P.L. et al. 2004. Anti-beta 2 glycoprotein I antibodies in centenarians. Exp. Gerontol. 39: 1459-1465.
    • (2004) Exp. Gerontol. , vol.39 , pp. 1459-1465
    • Meroni, P.L.1
  • 67
    • 0342939538 scopus 로고    scopus 로고
    • Natural antibodies with the T15 idiotype may act in atherosclerosis, apoptotic clearance, and protective immunity
    • Shaw, P.X. et al. 2000. Natural antibodies with the T15 idiotype may act in atherosclerosis, apoptotic clearance, and protective immunity. J. Clin. Invest. 105: 1731-1740.
    • (2000) J. Clin. Invest. , vol.105 , pp. 1731-1740
    • Shaw, P.X.1
  • 68
    • 0038375997 scopus 로고    scopus 로고
    • Pneumococcal vaccination decreases atherosclerotic lesion formation: Molecular mimicry between Streptococcus pneumoniae and oxidized LDL
    • Binder, C.J. et al. 2003. Pneumococcal vaccination decreases atherosclerotic lesion formation: Molecular mimicry between Streptococcus pneumoniae and oxidized LDL. Nat. Med. 9: 736-743.
    • (2003) Nat. Med. , vol.9 , pp. 736-743
    • Binder, C.J.1
  • 69
    • 68249086404 scopus 로고    scopus 로고
    • Immunoglobulin M is required for protection against atherosclerosis in low-density lipoprotein receptor-deficient mice
    • Lewis, M.J. et al. 2009. Immunoglobulin M is required for protection against atherosclerosis in low-density lipoprotein receptor-deficient mice. Circulation 120: 417-426.
    • (2009) Circulation , vol.120 , pp. 417-426
    • Lewis, M.J.1
  • 71
    • 0023026836 scopus 로고
    • Immunoglobulin-bearing B cells reconstitute and maintain the murine Ly-1 B cell lineage
    • Hayakawa, K. et al. 1986. Immunoglobulin-bearing B cells reconstitute and maintain the murine Ly-1 B cell lineage. Eur. J. Immunol. 16: 1313-1316.
    • (1986) Eur. J. Immunol. , vol.16 , pp. 1313-1316
    • Hayakawa, K.1
  • 72
    • 0024598647 scopus 로고
    • Feedback regulation of murine Ly-1 B cell development
    • Lalor, P.A. et al. 1989. Feedback regulation of murine Ly-1 B cell development. Eur. J. Immunol. 19: 507-513.
    • (1989) Eur. J. Immunol. , vol.19 , pp. 507-513
    • Lalor, P.A.1
  • 73
    • 0029981199 scopus 로고    scopus 로고
    • V-gene usage and N-region insertions in B-1a, B-1b and conventional B cells
    • Kantor, A.B. 1996. V-gene usage and N-region insertions in B-1a, B-1b and conventional B cells. Semin. Immunol. 8: 29-35.
    • (1996) Semin. Immunol. , vol.8 , pp. 29-35
    • Kantor, A.B.1
  • 74
    • 70349257845 scopus 로고    scopus 로고
    • + B1 cells containing abundant N-region additions
    • + B1 cells containing abundant N-region additions. Eur. J. Immunol. 39: 2383-2394.
    • (2009) Eur. J. Immunol. , vol.39 , pp. 2383-2394
    • Holodick, N.E.1
  • 75
    • 73949113499 scopus 로고    scopus 로고
    • Induction of B-cell development in adult mice reveals the ability of bone marrow to produce B-1a cells
    • Duber, S. et al. 2009. Induction of B-cell development in adult mice reveals the ability of bone marrow to produce B-1a cells. Blood 114: 4960-4967.
    • (2009) Blood , vol.114 , pp. 4960-4967
    • Duber, S.1
  • 76
    • 65249099024 scopus 로고    scopus 로고
    • A differentiation pathway for B1 cells in adult bone marrow
    • Esplin, B.L. et al. 2009. A differentiation pathway for B1 cells in adult bone marrow. Proc. Natl. Acad. Sci. U.S.A. 106: 5773-5778.
    • (2009) Proc. Natl. Acad. Sci. U.S.A. , vol.106 , pp. 5773-5778
    • Esplin, B.L.1
  • 77
    • 0018290959 scopus 로고
    • Ontogeny of terminal deoxynucleotidyl transferase-positive cells in lymphohemopoietic tissues of rat and mouse
    • Gregoire, K.E. et al. 1979. Ontogeny of terminal deoxynucleotidyl transferase-positive cells in lymphohemopoietic tissues of rat and mouse. J. Immunol. 123: 1347-1352.
    • (1979) J. Immunol. , vol.123 , pp. 1347-1352
    • Gregoire, K.E.1
  • 78
    • 84896533320 scopus 로고    scopus 로고
    • B-1a cell diversity: nontemplated addition in B-1a cell Ig is determined by progenitor population and developmental location
    • Holodick, N.E. et al. 2014. B-1a cell diversity: nontemplated addition in B-1a cell Ig is determined by progenitor population and developmental location. J. Immunol. 192: 2432-2441.
    • (2014) J. Immunol. , vol.192 , pp. 2432-2441
    • Holodick, N.E.1
  • 79
    • 84859466232 scopus 로고    scopus 로고
    • Distinct B-cell lineage commitment distinguishes adult bone marrow hematopoietic stem cells
    • Ghosn, E.E. et al. 2012. Distinct B-cell lineage commitment distinguishes adult bone marrow hematopoietic stem cells. Proc. Natl. Acad. Sci. U.S.A. 109: 5394-5398.
    • (2012) Proc. Natl. Acad. Sci. U.S.A. , vol.109 , pp. 5394-5398
    • Ghosn, E.E.1
  • 80
    • 80051986296 scopus 로고    scopus 로고
    • Reduced production of B-1-specified common lymphoid progenitors results in diminished potential of adult marrow to generate B-1 cells
    • Barber, C.L. et al. 2011. Reduced production of B-1-specified common lymphoid progenitors results in diminished potential of adult marrow to generate B-1 cells. Proc. Natl. Acad. Sci. U.S.A. 108: 13700-13704.
    • (2011) Proc. Natl. Acad. Sci. U.S.A. , vol.108 , pp. 13700-13704
    • Barber, C.L.1
  • 81
    • 84856254706 scopus 로고    scopus 로고
    • B-1 B cell development in the fetus and adult
    • Montecino-Rodriguez, E. & K. Dorshkind. 2012. B-1 B cell development in the fetus and adult. Immunity 36: 13-21.
    • (2012) Immunity , vol.36 , pp. 13-21
    • Montecino-Rodriguez, E.1    Dorshkind, K.2
  • 82
    • 0345590220 scopus 로고
    • Ly-1 B-cell clones similar to human chronic lymphocytic leukemias routinely develop in older normal mice and young autoimmune (New Zealand Black-related) animals
    • Stall, A.M. et al. 1988. Ly-1 B-cell clones similar to human chronic lymphocytic leukemias routinely develop in older normal mice and young autoimmune (New Zealand Black-related) animals. Proc. Natl. Acad. Sci. U.S.A. 85: 7312-7316.
    • (1988) Proc. Natl. Acad. Sci. U.S.A. , vol.85 , pp. 7312-7316
    • Stall, A.M.1
  • 83
    • 0033762333 scopus 로고    scopus 로고
    • B-1 cell origins and VH repertoire determination
    • Herzenberg, L.A. et al. 2000. B-1 cell origins and VH repertoire determination. Curr. Top. Microbiol. Immunol. 252: 3-13.
    • (2000) Curr. Top. Microbiol. Immunol. , vol.252 , pp. 3-13
    • Herzenberg, L.A.1
  • 84
    • 0025335392 scopus 로고
    • Sequence homologies, N sequence insertion and JH gene utilization in VHDJH joining: implications for the joining mechanism and the ontogenetic timing of Ly1 B cell and B-CLL progenitor generation
    • Gu, H. et al. 1990. Sequence homologies, N sequence insertion and JH gene utilization in VHDJH joining: implications for the joining mechanism and the ontogenetic timing of Ly1 B cell and B-CLL progenitor generation. EMBO J. 9: 2133-2140.
    • (1990) EMBO J. , vol.9 , pp. 2133-2140
    • Gu, H.1
  • 85
    • 67349143418 scopus 로고    scopus 로고
    • Old mice retain bone marrow B1 progenitors, but lose B2 precursors, and exhibit altered immature B cell phenotype and light chain usage
    • Alter-Wolf, S. et al. 2009. Old mice retain bone marrow B1 progenitors, but lose B2 precursors, and exhibit altered immature B cell phenotype and light chain usage. Mech. Ageing Dev. 130: 401-408.
    • (2009) Mech. Ageing Dev. , vol.130 , pp. 401-408
    • Alter-Wolf, S.1
  • 86
    • 84878182870 scopus 로고    scopus 로고
    • Human B-1 cells take the stage
    • Rothstein, T.L. et al. 2013. Human B-1 cells take the stage. Ann. N.Y. Acad. Sci. 1285: 97-114.
    • (2013) Ann. N.Y. Acad. Sci. , vol.1285 , pp. 97-114
    • Rothstein, T.L.1
  • 87
    • 78651486505 scopus 로고    scopus 로고
    • Immunoglobulin secretion by B1 cells: Differential intensity and IRF4-dependence of spontaneous IgM secretion by peritoneal and splenic B1 cells
    • Holodick, N.E. et al. 2010. Immunoglobulin secretion by B1 cells: Differential intensity and IRF4-dependence of spontaneous IgM secretion by peritoneal and splenic B1 cells. Eur. J. Immunol. 40: 3007-3016.
    • (2010) Eur. J. Immunol. , vol.40 , pp. 3007-3016
    • Holodick, N.E.1
  • 88
    • 34248338797 scopus 로고    scopus 로고
    • Division and differentiation of natural antibody-producing cells in mouse spleen
    • Yang, Y. et al. 2007. Division and differentiation of natural antibody-producing cells in mouse spleen. Proc. Natl. Acad. Sci. U.S.A. 104: 4542-4546.
    • (2007) Proc. Natl. Acad. Sci. U.S.A. , vol.104 , pp. 4542-4546
    • Yang, Y.1
  • 89
    • 84897945573 scopus 로고    scopus 로고
    • Splenic B-1a cells expressing CD138 spontaneously secrete large amounts of immunoglobulin in naive mice
    • Holodick, N.E. et al. 2014. Splenic B-1a cells expressing CD138 spontaneously secrete large amounts of immunoglobulin in naive mice. Front. Immunol. 5: 129.
    • (2014) Front. Immunol. , vol.5 , pp. 129
    • Holodick, N.E.1
  • 90
    • 0030983708 scopus 로고    scopus 로고
    • Mortality by cause for eight regions of the world: Global Burden of Disease Study
    • Murray, C.J. & A.D. Lopez. 1997. Mortality by cause for eight regions of the world: Global Burden of Disease Study. Lancet 349: 1269-1276.
    • (1997) Lancet , vol.349 , pp. 1269-1276
    • Murray, C.J.1    Lopez, A.D.2
  • 91
    • 67649402294 scopus 로고    scopus 로고
    • Immune therapy for age-related diseases
    • Weksler, M.E. et al. 2009. Immune therapy for age-related diseases. Trends Immunol. 30: 344-350.
    • (2009) Trends Immunol. , vol.30 , pp. 344-350
    • Weksler, M.E.1
  • 92
    • 79952140062 scopus 로고    scopus 로고
    • Embryonic day 9 yolk sac and intra-embryonic hemogenic endothelium independently generate a B-1 and marginal zone progenitor lacking B-2 potential
    • Yoshimoto, M. et al. 2011. Embryonic day 9 yolk sac and intra-embryonic hemogenic endothelium independently generate a B-1 and marginal zone progenitor lacking B-2 potential. Proc. Natl. Acad. Sci. U.S.A. 108: 1468-1473.
    • (2011) Proc. Natl. Acad. Sci. U.S.A. , vol.108 , pp. 1468-1473
    • Yoshimoto, M.1


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