Role of cell death in the progression of heart failure

Heart Failure Reviews

Volumn 21, Issue 2, 2016, Pages 157-167

  Moe, Gordon W ^a   Marín García, José ^b  

^a ST MICHAEL'S HOSPITAL   (Canada)

^b The Molecular Cardiology and Neuromuscular Institute   (United States)

Author keywords

Apoptosis; Autophagy; Cell death; Extrinsic apoptotic pathways; Intrinsic apoptotic pathways; Mitophagy; Necrosis

Indexed keywords

CASPASE; CASPASE INHIBITOR; DEATH RECEPTOR; DEATH RECEPTOR 4; DEATH RECEPTOR 5; FAS ANTIGEN; GRANULOCYTE COLONY STIMULATING FACTOR; TUMOR NECROSIS FACTOR RECEPTOR 1;

APOPTOSIS; ARTICLE; AUTOPHAGY; CARDIOMYOPATHY; CELL DEATH; CYTOPLASM; DISEASE COURSE; DRUG EFFECT; HEART FAILURE; HEART MITOCHONDRION; HEART MUSCLE CELL; HUMAN; LYSOSOME; MITOPHAGY; NECROPTOSIS; NONHUMAN; PATHOGENESIS; CARDIAC MUSCLE CELL; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; SIGNAL TRANSDUCTION;

CELL DEATH; DISEASE PROGRESSION; HEART FAILURE; HUMANS; MITOCHONDRIA, HEART; MYOCYTES, CARDIAC; SIGNAL TRANSDUCTION;

EID: 84959344937     PISSN: 13824147     EISSN: 15737322     Source Type: Journal    
DOI: 10.1007/s10741-016-9532-0     Document Type: Article

References (67)

1. Wencker D, Chandra M, Nguyen K, Miao W, Garantziotis S et al (2003) A mechanistic role for cardiac myocyte apoptosis in heart failure. J Clin Investig 111:1497–1504
2. Hein S, Arnon E, Kostin S, Schonburg M, Elsasser A et al (2003) Progression from compensated hypertrophy to failure in the pressure-overloaded human heart: structural deterioration and compensatory mechanisms. Circulation 107:984–991
3. Danial NN, Korsmeyer SJ (2004) Cell death: critical control points. Cell 116:205–219
4. Fuchs Y, Steller H (2011) Programmed cell death in animal development and disease. Cell 147:742–758
5. Micheau O, Tschopp J (2003) Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes. Cell 114:181–190
6. Peter ME, Krammer PH (2003) The CD95(APO-1/Fas) DISC and beyond. Cell Death Differ 10:26–35
7. Kischkel FC, Hellbardt S, Behrmann I, Germer M, Pawlita M et al (1995) Cytotoxicity-dependent APO-1 (Fas/CD95)-associated proteins form a death-inducing signaling complex (DISC) with the receptor. The EMBO journal 14:5579–5588
8. Pop C, Salvesen GS (2009) Human caspases: activation, specificity, and regulation. J Biol Chem 284:21777–21781
9. Bao Q, Shi Y (2007) Apoptosome: a platform for the activation of initiator caspases. Cell Death Differ 14:56–65
10. Boatright KM, Renatus M, Scott FL, Sperandio S, Shin H et al (2003) A unified model for apical caspase activation. Mol Cell 11:529–541
11. Li H, Zhu H, Xu CJ, Yuan J (1998) Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis. Cell 94:491–501
12. Bertrand MJ, Milutinovic S, Dickson KM, Ho WC, Boudreault A et al (2008) cIAP1 and cIAP2 facilitate cancer cell survival by functioning as E3 ligases that promote RIP1 ubiquitination. Mol Cell 30:689–700
13. Ea CK, Deng L, Xia ZP, Pineda G, Chen ZJ (2006) Activation of IKK by TNFalpha requires site-specific ubiquitination of RIP1 and polyubiquitin binding by NEMO. Mol Cell 22:245–257
14. Hitomi J, Christofferson DE, Ng A, Yao J, Degterev A et al (2008) Identification of a molecular signaling network that regulates a cellular necrotic cell death pathway. Cell 135:1311–1323
15. Wang L, Du F, Wang X (2008) TNF-alpha induces two distinct caspase-8 activation pathways. Cell 133:693–703
16. Lin Y, Devin A, Rodriguez Y, Liu ZG (1999) Cleavage of the death domain kinase RIP by caspase-8 prompts TNF-induced apoptosis. Genes Dev 13:2514–2526
17. Holler N, Zaru R, Micheau O, Thome M, Attinger A et al (2000) Fas triggers an alternative, caspase-8-independent cell death pathway using the kinase RIP as effector molecule. Nat Immunol 1:489–495
18. Vercammen D, Beyaert R, Denecker G, Goossens V, Van Loo G et al (1998) Inhibition of caspases increases the sensitivity of L929 cells to necrosis mediated by tumor necrosis factor. J Exp Med 187:1477–1485
19. Konstantinidis K, Whelan RS, Kitsis RN (2012) Mechanisms of cell death in heart disease. Arterioscler Thromb Vasc Biol 32:1552–1562
20. Sun L, Wang H, Wang Z, He S, Chen S et al (2012) Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase. Cell 148:213–227
21. Wilkins JM, McConnell C, Tipton PA, Hannink M (2014) A conserved motif mediates both multimer formation and allosteric activation of phosphoglycerate mutase 5. J Biol Chem 289:25137–25148
22. Perrone GG, Tan SX, Dawes IW (2008) Reactive oxygen species and yeast apoptosis. Biochim Biophys Acta 1783:1354–1368
23. Vandenabeele P, Melino G (2012) The flick of a switch: which death program to choose? Cell Death Differ 19:1093–1095
24. Yang Y, Fang S, Jensen JP, Weissman AM, Ashwell JD (2000) Ubiquitin protein ligase activity of IAPs and their degradation in proteasomes in response to apoptotic stimuli. Science 288:874–877
25. Suzuki Y, Nakabayashi Y, Takahashi R (2001) Ubiquitin-protein ligase activity of X-linked inhibitor of apoptosis protein promotes proteasomal degradation of caspase-3 and enhances its anti-apoptotic effect in Fas-induced cell death. Proc Natl Acad Sci USA 98:8662–8667
26. Ngo JK, Pomatto LC, Davies KJ (2013) Upregulation of the mitochondrial Lon Protease allows adaptation to acute oxidative stress but dysregulation is associated with chronic stress, disease, and aging. Redox Biol 1:258–264
27. Tatsuta T, Langer T (2009) AAA proteases in mitochondria: diverse functions of membrane-bound proteolytic machines. Res Microbiol 160:711–717
28. Guerra S, Leri A, Wang X, Finato N, Di Loreto C et al (1999) Myocyte death in the failing human heart is gender dependent. Circ Res 85:856–866
29. Saraste A, Pulkki K, Kallajoki M, Heikkila P, Laine P et al (1999) Cardiomyocyte apoptosis and progression of heart failure to transplantation. Eur J Clin Invest 29:380–386
30. Hayakawa Y, Chandra M, Miao W, Shirani J, Brown JH et al (2003) Inhibition of cardiac myocyte apoptosis improves cardiac function and abolishes mortality in the peripartum cardiomyopathy of Galpha(q) transgenic mice. Circulation 108:3036–3041
31. Diwan A, Krenz M, Syed FM, Wansapura J, Ren X et al (2007) Inhibition of ischemic cardiomyocyte apoptosis through targeted ablation of Bnip3 restrains postinfarction remodeling in mice. J Clin Investig 117:2825–2833
32. Honda O, Kuroda M, Joja I, Asaumi J, Takeda Y et al (2000) Assessment of secondary necrosis of Jurkat cells using a new microscopic system and double staining method with annexin V and propidium iodide. Int J Oncol 16:283–288
33. Malhi H, Gores GJ, Lemasters JJ (2006) Apoptosis and necrosis in the liver: a tale of two deaths? Hepatology 43:S31–S44
34. Kim JS, He L, Lemasters JJ (2003) Mitochondrial permeability transition: a common pathway to necrosis and apoptosis. Biochemical and biophysical research communications 304:463–470
35. Lemasters JJ, Nieminen AL, Qian T, Trost LC, Elmore SP et al (1998) The mitochondrial permeability transition in cell death: a common mechanism in necrosis, apoptosis and autophagy. Biochim Biophys Acta 1366:177–196
36. Zamzami N, Hirsch T, Dallaporta B, Petit PX, Kroemer G (1997) Mitochondrial implication in accidental and programmed cell death: apoptosis and necrosis. J Bioenerg Biomembr 29:185–193
37. Nakayama H, Chen X, Baines CP, Klevitsky R, Zhang X et al (2007) Ca2 + - and mitochondrial-dependent cardiomyocyte necrosis as a primary mediator of heart failure. J Clin Investig 117:2431–2444
38. Ucar A, Gupta SK, Fiedler J, Erikci E, Kardasinski M et al (2012) The miRNA-212/132 family regulates both cardiac hypertrophy and cardiomyocyte autophagy. Nature communications 3:1078
39. Kostin S, Pool L, Elsasser A, Hein S, Drexler HC et al (2003) Myocytes die by multiple mechanisms in failing human hearts. Circ Res 92:715–724
40. Nishida K, Otsu K (2008) Cell death in heart failure. Circ J 72(Suppl A):A17–A21
41. Nakai A, Yamaguchi O, Takeda T, Higuchi Y, Hikoso S et al (2007) The role of autophagy in cardiomyocytes in the basal state and in response to hemodynamic stress. Nat Med 13:619–624
42. Cuervo AM, Dice JF (2000) Age-related decline in chaperone-mediated autophagy. J Biol Chem 275:31505–31513
43. Cuervo AM (2004) Autophagy: many paths to the same end. Mol Cell Biochem 263:55–72
44. Levine B, Klionsky DJ (2004) Development by self-digestion: molecular mechanisms and biological functions of autophagy. Dev Cell 6:463–477
45. Ohsumi Y, Mizushima N (2004) Two ubiquitin-like conjugation systems essential for autophagy. Semin Cell Dev Biol 15:231–236
46. Lemasters JJ (2005) Selective mitochondrial autophagy, or mitophagy, as a targeted defense against oxidative stress, mitochondrial dysfunction, and aging. Rejuvenation research 8:3–5
47. Zhu H, Tannous P, Johnstone JL, Kong Y, Shelton JM et al (2007) Cardiac autophagy is a maladaptive response to hemodynamic stress. J Clin Investig 117:1782–1793
48. Takemura G, Miyata S, Kawase Y, Okada H, Maruyama R et al (2006) Autophagic degeneration and death of cardiomyocytes in heart failure. Autophagy 2:212–214
49. Terman A, Brunk UT (1998) On the degradability and exocytosis of ceroid/lipofuscin in cultured rat cardiac myocytes. Mech Ageing Dev 100:145–156
50. Grune T, Merker K, Jung T, Sitte N, Davies KJ (2005) Protein oxidation and degradation during postmitotic senescence. Free Radic Biol Med 39:1208–1215
51. Rooyackers OE, Adey DB, Ades PA, Nair KS (1996) Effect of age on in vivo rates of mitochondrial protein synthesis in human skeletal muscle. Proc Natl Acad Sci USA 93:15364–15369
52. Brunk UT, Terman A (2002) The mitochondrial-lysosomal axis theory of aging: accumulation of damaged mitochondria as a result of imperfect autophagocytosis. European journal of biochemistry/FEBS 269:1996–2002
53. Terman A, Brunk UT (2005) Autophagy in cardiac myocyte homeostasis, aging, and pathology. Cardiovasc Res 68:355–365
54. Kurz T, Eaton JW, Brunk UT (2011) The role of lysosomes in iron metabolism and recycling. The international journal of biochemistry & cell biology 43:1686–1697
55. Brunk UT, Neuzil J, Eaton JW (2001) Lysosomal involvement in apoptosis. Redox report: communications in free radical research 6:91–97
56. Terman A, Gustafsson B, Brunk UT (2006) The lysosomal-mitochondrial axis theory of postmitotic aging and cell death. Chem Biol Interact 163:29–37
57. Yan L, Sadoshima J, Vatner DE, Vatner SF (2006) Autophagy: a novel protective mechanism in chronic ischemia. Cell Cycle 5:1175–1177
58. Kunapuli S, Rosanio S, Schwarz ER (2006) “How do cardiomyocytes die?” apoptosis and autophagic cell death in cardiac myocytes. J Cardiac Fail 12:381–391
59. Iglewski M, Hill JA, Lavandero S, Rothermel BA (2010) Mitochondrial fission and autophagy in the normal and diseased heart. Curr Hypertens Rep 12:418–425
60. Taneike M, Yamaguchi O, Nakai A, Hikoso S, Takeda T et al (2010) Inhibition of autophagy in the heart induces age-related cardiomyopathy. Autophagy 6:600–606
61. Moe GW, Naik G, Konig A, Lu X, Feng Q (2002) Early and persistent activation of myocardial apoptosis, bax and caspases: insights into mechanisms of progression of heart failure. Pathophysiology 8:183–192
62. Hamacher-Brady A, Brady NR, Gottlieb RA, Gustafsson AB (2006) Autophagy as a protective response to Bnip3-mediated apoptotic signaling in the heart. Autophagy 2:307–309
63. Matsui Y, Takagi H, Qu X, Abdellatif M, Sakoda H et al (2007) Distinct roles of autophagy in the heart during ischemia and reperfusion: roles of AMP-activated protein kinase and Beclin 1 in mediating autophagy. Circ Res 100:914–922
64. Gottlieb RA, Gustafsson AB (2011) Mitochondrial turnover in the heart. Biochim Biophys Acta 1813:1295–1301
65. Kuzmicic J, Del Campo A, Lopez-Crisosto C, Morales PE, Pennanen C et al (2011) Mitochondrial dynamics: a potential new therapeutic target for heart failure. Rev Esp Cardiol 64:916–923
66. Liu Y, Levine B (2015) Autosis and autophagic cell death: the dark side of autophagy. Cell Death Differ 22:367–376
67. Ng AC (2010) Integrative systems biology and networks in autophagy. Seminars in immunopathology 32:355–361