Uncoupling Catalytic and Binding Functions in the Cyclic AMP-Dependent Protein Kinase A

Structure

Volumn 24, Issue 3, 2016, Pages 353-363

  Kim, Jonggul ^a,b   Li, Geoffrey ^a   Walters, Michael A ^c   Taylor, Susan S ^d   Veglia, Gianluigi ^a,b  

^a University of Minnesota   (United States)

^b UNIVERSITY OF MINNESOTA   (United States)

^c UNIVERSITY OF MINNESOTA   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

canonical and non canonical function; cooperativity; phospholamban; protein kinase A; pseudo kinases

Indexed keywords

ADENOSINE TRIPHOSPHATE DERIVATIVE; BALANOL; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP DEPENDENT PROTEIN KINASE A; N [2 (4 BROMOCINNAMYLAMINO)ETHYL] 5 ISOQUINOLINESULFONAMIDE; NUCLEOTIDE; PROTEIN KINASE C; UNCLASSIFIED DRUG; ADENOSINE TRIPHOSPHATE; AZEPINE DERIVATIVE; CYCLIC AMP DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT; HYDROXYBENZOIC ACID DERIVATIVE; ISOQUINOLINE DERIVATIVE; N-(2-(4-BROMOCINNAMYLAMINO)ETHYL)-5-ISOQUINOLINESULFONAMIDE; PROTEIN BINDING; SULFONAMIDE;

ALLOSTERISM; ARTICLE; BINDING AFFINITY; BINDING SITE; CALORIMETRY; CATALYSIS; CHEMICAL BOND; CHEMICAL MODIFICATION; CONFORMATIONAL TRANSITION; ENZYME ACTIVITY; ENZYME BINDING; ENZYME REGULATION; ENZYME STRUCTURE; ENZYME SUBSTRATE; ENZYME SUBUNIT; LIGAND BINDING; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; THERMOCALORIMETRY; ANIMAL; CHEMISTRY; ENZYME ACTIVE SITE; HUMAN; METABOLISM; MOLECULAR MODEL; NUCLEAR MAGNETIC RESONANCE IMAGING; PROTEIN CONFORMATION;

ADENOSINE TRIPHOSPHATE; ANIMALS; AZEPINES; CALORIMETRY; CATALYTIC DOMAIN; CYCLIC AMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNITS; HUMANS; HYDROXYBENZOATES; ISOQUINOLINES; MAGNETIC RESONANCE IMAGING; MODELS, MOLECULAR; NUCLEOTIDES; PROTEIN BINDING; PROTEIN CONFORMATION; SULFONAMIDES;

EID: 84959337006     PISSN: 09692126     EISSN: 18784186     Source Type: Journal    
DOI: 10.1016/j.str.2015.11.016     Document Type: Article

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