Dysfunctional conformational dynamics of protein kinase a induced by a lethal mutant of phospholamban hinder phosphorylation

Proceedings of the National Academy of Sciences of the United States of America

Volumn 112, Issue 12, 2015, Pages 3716-3721

  Kim, Jonggul ^a   Masterson, Larry R ^b   Cembran, Alessandro ^a,b,e   Verardi, Raffaello ^b   Shi, Lei ^a   Gao, Jiali ^a,c   Taylor, Susan S ^d   Veglia, Gianluigi ^a,b  

^a University of Minnesota   (United States)

^b UNIVERSITY OF MINNESOTA   (United States)

^c JILIN UNIVERSITY   (China)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e UNIVERSITY OF MINNESOTA DULUTH   (United States)

Author keywords

Calcium regulation; Conformational dynamics; NMR; Phospholamban; Phosphorylation

Indexed keywords

ARGININE; CYCLIC AMP DEPENDENT PROTEIN KINASE; PHOSPHOLAMBAN; ADENOSINE TRIPHOSPHATASE (CALCIUM); CALCIUM; CALCIUM BINDING PROTEIN; LIGAND; PROTEIN BINDING;

ARTICLE; BINDING AFFINITY; CATALYSIS; COMPLEX FORMATION; CONTROLLED STUDY; ENZYME ACTIVE SITE; ENZYME CONFORMATION; ENZYME SUBSTRATE; GENE DELETION; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; AMINO ACID SEQUENCE; BINDING SITE; CARDIAC MUSCLE; CHEMISTRY; CONGESTIVE CARDIOMYOPATHY; DISEASE COURSE; ENZYMOLOGY; GENETICS; HUMAN; MOLECULAR DYNAMICS; MOLECULAR GENETICS; MUTATION; PHOSPHORYLATION; PROTEIN CONFORMATION; SEQUENCE HOMOLOGY; THERMODYNAMICS;

ALLOSTERIC SITE; AMINO ACID SEQUENCE; CALCIUM; CALCIUM-BINDING PROTEINS; CALCIUM-TRANSPORTING ATPASES; CARDIOMYOPATHY, DILATED; CATALYTIC DOMAIN; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DISEASE PROGRESSION; GENE DELETION; HUMANS; LIGANDS; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR DYNAMICS SIMULATION; MOLECULAR SEQUENCE DATA; MUTATION; MYOCARDIUM; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN CONFORMATION; SEQUENCE HOMOLOGY, AMINO ACID; THERMODYNAMICS;

EID: 84925432611     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1502299112     Document Type: Article

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