Astrocyte-derived CCL2 is associated with m1 activation and recruitment of cultured microglial cells

Cellular Physiology and Biochemistry

Volumn 38, Issue 3, 2016, Pages 859-870

  He, Mingfeng ^a   Dong, Hongquan ^a   Huang, Yahui ^a   Lu, Shunmei ^a   Zhang, Shu ^a   Qian, Yanning ^a   Jin, Wenjie ^a  

^a NANJING MEDICAL UNIVERSITY   (China)

Author keywords

Astrocyte; CCL2

Indexed keywords

MONOCYTE CHEMOTACTIC PROTEIN 1; MONOCYTE CHEMOTACTIC PROTEIN 1 INHIBITOR; SMALL INTERFERING RNA; TUMOR NECROSIS FACTOR ALPHA; CCL2 PROTEIN, MOUSE; CULTURE MEDIUM; TUMOR NECROSIS FACTOR;

ANIMAL CELL; ARTICLE; ASTROCYTE; CELL ACTIVATION; CELL CULTURE; CELL MIGRATION; CELL POLARITY; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; IN VITRO STUDY; MICROGLIA; MOUSE; NONHUMAN; POLARIZATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING; ANIMAL; CELL MOTION; CULTURE MEDIUM; CYTOLOGY; DRUG EFFECTS; GENETICS; MACROPHAGE ACTIVATION; METABOLISM; PHARMACOLOGY;

ANIMALS; ASTROCYTES; CELL MOVEMENT; CELLS, CULTURED; CHEMOKINE CCL2; CULTURE MEDIA; MACROPHAGE ACTIVATION; MICE; MICROGLIA; RNA, SMALL INTERFERING; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84959220365     PISSN: 10158987     EISSN: 14219778     Source Type: Journal    
DOI: 10.1159/000443040     Document Type: Article

References (31)

1. Frank-Cannon TC, Alto LT, McAlpine FE, Tansey MG: Does neuroinflammation fan the flame in neurodegenerative diseases? Mol Neurodegener 2009;4:47.
2. Landreth GE: Microglia in central nervous system diseases. J Neuroimmune Pharmacol 2009;4:369-370.
3. Benveniste EN, Nguyen VT, O'Keefe GM: Immunological aspects of microglia: relevance to Alzheimer's disease. Neurochem Int 2001;39:381-391.
4. Orr CF, Rowe DB, Halliday GM: An inflammatory review of Parkinson's disease. Prog Neurobiol 2002;68:325-340.
5. Appel SH, Zhao W, Beers DR, Henkel JS: The microglial-motoneuron dialogue in ALS. Acta Myol 2011;30:4-6
6. Allan SM, Rothwell NJ: Cytokines and acute neurodegeneration. Nat Rev Neurosci 2001;2:734-744.
7. McGeerPL, McGeerE: Immunotherapy for Alzheimers disease. Sci Aging Knowledge Environ 2004;2004:e29.
8. Chhor V, Le Charpentier T, Lebon S, Ore MV, Celador IL, Josserand J, Degos V, Jacotot E, Hagberg H, Savman K, Mallard C, Gressens P, Fleiss B: Characterization of phenotype markers and neuronotoxic potential of polarised primary microglia in vitro. Brain Behav Immun 2013;32:70-85.
9. Liao B, Zhao W, Beers DR, Henkel JS, Appel SH: Transformation from a neuroprotective to a neurotoxic microglial phenotype in a mouse model of ALS. Exp Neurol 2012;237:147-152.
10. David S, Kroner A: Repertoire of microglial and macrophage responses after spinal cord injury. Nat Rev Neurosci 2011;12:388-399.
11. Rhodes JK, Sharkey J, Andrews PJ: The temporal expression, cellular localization, and inhibition of the chemokines MIP-2 and MCP-1 after traumatic brain injury in the rat. J Neurotrauma 2009;26:507-525.
12. Galasso JM, Miller MJ, Cowell RM, Harrison JK, Warren JS, Silverstein FS: Acute excitotoxic injury induces expression of monocyte chemoattractant protein-1 and its receptor, CCR2, in neonatal rat brain. Exp Neurol 2000;165:295-305.
13. Van Der Voorn P, Tekstra J, Beelen RH, Tensen CP, Van Der Valk P, De Groot CJ: Expression of MCP-1 by reactive astrocytes in demyelinating multiple sclerosis lesions. Am J Pathol 1999;154:45-51.
14. Che X, Ye W, Panga L, Wu DC, Yang GY: Monocyte chemoattractant protein-1 expressed in neurons and astrocytes during focal ischemia in mice. Brain Res 2001;902:171-177.
15. Berman JW, Guida MP, Warren J, AmatJ, Brosnan CF: Localization of monocyte chemoattractant peptide-1 expression in the central nervous system in experimental autoimmune encephalomyelitis and trauma in the rat. J Immunol 1996;156:3017-3023.
16. Umehara F, Izumo S, Takeya M, Takahashi K, Sato E, Osame M: Expression of adhesion molecules and monocyte chemoattractant protein-1 (MCP-1) in the spinal cord lesions in HTLV-I-Associated myelopathy Acta Neuropathol 1996;91:343-350.
17. Zhang J, ShiXQ, Echeverry S, Mogil JS, De KoninckY, RivestS: Expression of CCR2 in both resident and bone marrow-Derived microglia plays a critical role in neuropathic pain. J Neurosci 2007;27:12396-12406.
18. Mayo L, Trauger SA, Blain M, Nadeau M, Patel B, Alvarez JI, Mascanfroni ID, Yeste A, Kivisakk P, Kallas K, Ellezam B, Bakshi R, Prat A, Antel JP, Weiner HL, Quintana FJ: Regulation of astrocyte activation by glycolipids drives chronic CNS inflammation. Nat Med 2014;20:1147-1156.
19. Kim RY, Hoffman AS, Itoh N, Ao Y, Spence R, Sofroniew MV, Voskuhl RR: Astrocyte CCL2 sustains immune cell infiltration in chronic experimental autoimmune encephalomyelitis. J Neuroimmunol 2014;274:53-61.
20. Dong H, Zhang X, Dai X, Lu S, Gui B, Jin W, Zhang S, Zhang S, Qian Y: Lithium ameliorates lipopolysaccharide-induced microglial activation via inhibition of toll-like receptor 4 expression by activating the PI3K/Akt/Fox01 pathway. J Neuroinflammation 2014;11:140.
21. Liu S, Zhang L, Wu Q, Wu Q, Wang T: Chemokine CCL2 induces apoptosis in cortex following traumatic brain injury. J Mol Neurosci 2013;51:1021-1029.
22. Zhang X, Dong H, Zhang S, Lu S, Sun J, Qian Y: Enhancement of LPS-induced microglial inflammation response via TLR4 under high glucose conditions. Cell Physiol Biochem 2015;35:1571-1581.
23. Zhang Y, Yan J, Hu R, Sun Y, Ma Y, Chen Z, Jiang H: Microglia are involved in pruritus induced by DNFB via the CX3CRl/p38 MAPK pathway. Cell Physiol Biochem 2015;35:1023-1033.
24. Fu T, Stellmacher A, Znalesniak EB, Dieterich DC, Kalbacher H, Hoffmann W: Tff3 isexpressed in neuronsandmicroglialcells. Cell Physiol Biochem 2014;34:1912-1919.
25. Zhu J, Qu C, Lu X, Zhang S: Activation of microglia by histamine and substance P. Cell Physiol Biochem 2014;34:768-780.
26. Rock RB, Gekker G, Hu S, Sheng WS, Cheeran M, Lokensgard JR Peterson PK: Role of microglia in central nervous system infections. Clin Microbiol Rev 2004;17:942-964.
27. Han Q, Liu S, Li Z, Hu F, Zhang Q, Zhou M, Chen J, Lei T, Zhang H: DCPIB, a potent volume-regulated anion channel antagonist, attenuates microglia-mediated inflammatory response and neuronal injury following focal cerebral ischemia. Brain Res 2014;1542:176-185.
28. Zhang J, De Koninck Y: Spatial and temporal relationship between monocyte chemoattractant protein-1 expression and spinal glial activation following peripheral nerve injury. J Neurochem 2006;97:772-783.
29. Hu JH, Zheng XY, Yang JP, Wang LN, Ji FH: Involvement of spinal monocyte chemoattractant protein-1 (MCP-1) in cancer-induced bone pain in rats. Neurosci Lett 2012;517:60-63.
30. Thacker MA, Clark AK, Bishop T, Grist J, Yip PK, Moon LD, Thompson SW, Marchand F, McMahon SB: CCL2 is a key mediator of microglia activation in neuropathic pain states. Eur J Pain 2009;13:263-272.
31. Hu JH, Wu MY, Tao M, Yang JP: Changes in protein expression and distribution of spinal CCR2 in a rat model of bone cancer pain. Brain Res 2013;1509:1-7.