Tff3 is expressed in neurons and microglial cells

Cellular Physiology and Biochemistry

Volumn 34, Issue 6, 2014, Pages 1912-1919

  Fu, Ting ^a   Stellmacher, Anne ^a,b   Znalesniak, Eva B ^a   Dieterich, Daniela C ^a,b,c   Kalbacher, Hubert ^d   Hoffmann, Werner ^a  

^a OTTO VON GUERICKE UNIVERSITY   (Germany)

^b LEIBNIZ INSTITUTE FOR NEUROBIOLOGY   (Germany)

^c Center for Behavioral Brain Sciences (CBBS)   (Germany)

^d UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

Brain; Microglial cell; Neuron; TFF peptide; TFF3; Trefoil factor

Indexed keywords

CALCIUM BINDING PROTEIN; IBA 1 CALCIUM BINDING PROTEIN; MICROTUBULE ASSOCIATED PROTEIN 2; TREFOIL 3 PEPTIDE; TREFOIL PEPTIDE; UNCLASSIFIED DRUG; NEUROPEPTIDE; TFF3 PROTEIN, RAT;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN CELL; BRAIN REGION; CELL ACTIVATION; CELL FUNCTION; CELLULAR DISTRIBUTION; EMBRYO; FEMALE; IMMUNOCYTOCHEMISTRY; IMMUNOFLUORESCENCE; IN VITRO STUDY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; ANIMAL; BIOSYNTHESIS; BRAIN CORTEX; GENE EXPRESSION REGULATION; HIPPOCAMPUS; METABOLISM; MICROGLIA; NERVE CELL;

LOTUS; RATTUS;

ANIMALS; CEREBRAL CORTEX; GENE EXPRESSION REGULATION; HIPPOCAMPUS; MICROGLIA; NEURONS; NEUROPEPTIDES; RATS;

EID: 84917733712     PISSN: 10158987     EISSN: 14219778     Source Type: Journal    
DOI: 10.1159/000366389     Document Type: Article

References (34)

1. Hoffmann W: TFF Peptides; in Kastin AJ (ed): Handbook of Biologically Active Peptides (2nd edition). San Diego, Elsevier, 2013, pp. 1338-1345
2. Hoffmann W, Jagla W: Cell type specific expression of secretory TFF peptides: colocalization with mucins and synthesis in the brain. Int Rev Cytol 2002;213:147-181
3. Mashimo H, Wu DC, Podolsky DK, Fishman MC: Impaired defense of intestinal mucosa in mice lacking intestinal trefoil factor. Science 1996;274:262-265
4. Chwieralski CE, Schnurra I, Thim L, Hoffmann W: Epidermal growth factor and trefoil factor family 2 synergistically trigger chemotaxis on BEAS-2B cells via different signaling cascades. Am J Respir Cell Mol Biol 2004;31:528-537
5. Rösler S, Haase T, Claassen H, Schulze U, Schicht M, Riemann D, Brandt J, Wohlrab D, Müller-Hilke B, Goldring MB, Sel S, Varoga D, Garreis F, Paulsen FP: Trefoil factor 3 is induced during degenerative and inflammatory joint disease, activates matrix metalloproteinases, and enhances apoptosis of articular cartilage chondrocytes. Arthritis Rheum 2010;62:815-825
6. Taupin DR, Kinoshita K, Podolsky DK: Intestinal trefoil factor confers colonic epithelial resistance to apoptosis. Proc Natl Acad Sci USA 2000;97:799-804
7. Hoffmann W: Trefoil factor family (TFF) peptides and chemokine receptors: a promising relationship. J Med Chem 2009;52:6505-6510
8. Hauser F, Poulsom R, Chinery R, Rogers LA, Hanby AM, Wright NA, Hoffmann W: hP1.B, a human P-domain peptide homologous with rat intestinal trefoil factor, is expressed also in the ulcer-Associated cell lineage and the uterus. Proc Natl Acad Sci USA 1993;90:6961-6965
9. Albert TK, Laubinger W, Müller S, Hanisch FG, Kalinski T, Meyer F, Hoffmann W: Human intestinal TFF3 forms disulfide-linked heteromers with the mucus-Associated FCGBP protein and is released by hydrogen sulfide. J Proteome Res 2010;9:3108-3117
10. Hoffmann W, Jagla W, Wiede A: Molecular medicine of TFF-peptides: from gut to brain. Histol Histopathol 2001;16:319-334
11. Hinz M, Schwegler H, Chwieralski CE, Laube G, Linke R, Pohle W, Hoffmann W: Trefoil factor family (TFF) expression in the mouse brain and pituitary: changes in the developing cerebellum. Peptides 2004;25:827-832
12. Probst JC, Skutella T, Müller-Schmid A, Jirikowski GF, Hoffmann W: Molecular and cellular analysis of rP1.B in the rat hypothalamus: In situ hybridization and immunohistochemistry of a new P-domain neuropeptide. Brain Res Mol Brain Res 1995;33:269-276.
13. Schwarzberg H, Kalbacher H, Hoffmann W: Differential behavioral effects of TFF peptides: injections of synthetic TFF3 into the rat amygdala. Pharmacol Biochem Behav 1999;62:173-178
14. Jagla W, Wiede A, Dietzmann K, Rutkowski K, Hoffmann W: Co-localization of TFF3 peptide and oxytocin in the human hypothalamus. FASEB J 2000;14:1126-1131
15. Schwarz H, Jagla W, Wiede A, Hoffmann W: Ultrastructural co-localization of TFF3-peptide and oxytocin in the neural lobe of the porcine pituitary. Cell Tissue Res 2001;305:411-416
16. Vestergaard EM, Poulsen SS, Gronbaek H, Larsen R, Nielsen AM, Ejskjaer K, Clausen JT, Thim L, Nexo E: Development and evaluation of an ELISA for human trefoil factor 3. Clin Chem 2002;48:1689-1695
17. Poulsen SS, Thulesen J, Hartmann B, Kissow HL, Nexo E, Thim L: Injected TFF1 and TFF3 bind to TFF2-immunoreactive cells in the gastrointestinal tract in rats. Regul Peptides 2003;115:91-99
18. Goslin K, Asmussen H: Rat hippocompal neurons in low-density culture; in Banker G and Goslin K (eds): Culturing nerve cells (2nd edition). Cambridge (MA), London, The MIT Press, 1998, pp. 339-370
19. Guizzetti M, Costa LG: Inhibition of muscarinic receptor-stimulated glial cell proliferation by ethanol. J Neurochem 1996;67:2236-2245
20. Fu T, Kalbacher H, Hoffmann W: TFF1 is differentially expressed in stationary and migratory rat gastric epithelial cells (RGM-1) after in vitro wounding: influence of TFF1 RNA interference on cell migration. Cell Physiol Biochem 2013;32:997-1010
21. Znalesniak EB, Hoffmann W: Modulation of cell-cell contacts during intestinal restitution in vitro and effects of epidermal growth factor (EGF). Cell Physiol Biochem 2010;25:533-542
22. Kouznetsova I, Laubinger W, Kalbacher H, Kalinski T, Meyer F, Roessner A, Hoffmann W: Biosynthesis of gastrokine-2 in the human gastric mucosa: restricted spatial expression along the antral gland axis and differential interaction with TFF1, TFF2 and mucins. Cell Physiol Biochem 2007;20:899-908
23. Ito D, Imai Y, Ohsawa K, Nakajima K, Fukuuchi Y, Kohsaka S: Microglia-specific localisation of a novel calcium binding protein, Iba1. Mol Brain Res 1998;57:1-9
24. Shi HS, Yin X, Song L, Guo QJ, Luo XH: Neuropeptide trefoil factor 3 improves learning and retention of novel object recognition memory in mice. Behav Brain Res 2012;227:265-269
25. Shi HS, Zhu WL, Liu JF, Luo YX, Si JJ, Wang SJ, Xue YX, Ding ZB, Shi J, Lu L: PI3K/Akt signaling pathway in the basolateral amygdala mediates the rapid antidepressant-like effects of trefoil factor 3. Neuropsychopharmacol 2012;37:2671-2683
26. Blaschke K: Vergleichende neurobiologische Untersuchungen von TFF3-defizienten Mäusen und Wildtyptieren (MD Thesis), Medical Faculty, Otto-von-Guericke-Universität Magdeburg, 2010
27. Cook GA, Familari M, Thim L, Giraud AS: The trefoil peptides TFF2 and TFF3 are expressed in rat lymphoid tissues and participate in the immune response. FEBS Lett 1999;456:155-159
28. Kreutzberg GW: Microglia: a sensor for pathological events in the CNS. Trends Neurosci 1996;19:312-318
29. Kettenmann H, Hanisch UK, Noda M, Verkhratsky A: Physiology of microglia. Physiol Rev 2011;91:461-553
30. Kettenmann H, Kirchhoff F, Verkhratsky A: Microglia: new roles for the synaptic stripper. Neuron 2013;77:10-18
31. Furuta GT, Turner JR, Taylor CT, Hershberg RM, Comerford K, Narravula S, Podolsky DK, Colgan SP: Hypoxia-inducible factor 1-dependent induction of intestinal trefoil factor protects barrier function During hypoxia. J Exp Med 2001;193:1027-1034
32. Ito D, Tanaka K, Suzuki S, Dembo T, Fukuuchi Y: Enhanced expression of Iba1, ionized calcium-binding adapter molecule 1, after transient focal cerebral ischemia in rat brain. Stroke 2001;32:1208-1215
33. Podolsky DK, Gerken G, Eyking A, Cario E: Colitis-Associated variant of TLR2 causes impaired mucosal repair because of TFF3 deficiency. Gastroenterology 2009;137:209-220
34. Zeidan-Chulia F, Salmina AB, Malinovskaya NA, Noda M, Verkhratsky A, Moreira JC: The glial perspective of autism spectrum disorders. Neurosci Biobehav Rev 2014;38:160-172