Changes in protein expression and distribution of spinal CCR2 in a rat model of bone cancer pain

Brain Research

Volumn 1509, Issue , 2013, Pages 1-7

  Hu, Ji Hua ^a   Wu, Meng Yao ^a   Tao, Min ^a   Yang, Jian Ping ^a  

^a THE FIRST AFFILIATED HOSPITAL OF SOOCHOW UNIVERSITY   (China)

Author keywords

Bone cancer pain; CCR2; Chemokine; Microglia; Spinal cord

Indexed keywords

CHEMOKINE RECEPTOR CCR2; FLUORESCENT DYE;

ALLODYNIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE CANCER; BONE CANCER PAIN; CANCER PAIN; CELLULAR DISTRIBUTION; CONTROLLED STUDY; FEMALE; GLIA CELL; IMMUNOHISTOCHEMISTRY; INOCULATION; LABORATORY; MICROGLIA; NEUROPATHIC PAIN; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RAT; SPINAL CORD NERVE CELL; WESTERN BLOTTING;

ANIMALS; BONE NEOPLASMS; DISEASE MODELS, ANIMAL; FEMALE; HYPERALGESIA; MICROGLIA; NEURALGIA; NEURONS; PAIN MEASUREMENT; PAIN THRESHOLD; PHYSICAL STIMULATION; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, CCR2; SPINAL CORD;

RATTUS;

EID: 84876408649     PISSN: 00068993     EISSN: 18726240     Source Type: Journal    
DOI: 10.1016/j.brainres.2013.03.002     Document Type: Article

References (36)

1. C. Abbadie, J.A. Lindia, A.M. Cumiskey, L.B. Peterson, J.S. Mudgett, E.K. Bayne, J.A. DeMartino, D.E. MacIntyre, and M.J. Forrest Impaired neuropathic pain responses in mice lacking the chemokine receptor CCR2 Proc. Natl. Acad. Sci. USA 100 2003 7947 7952
2. C. Abbadie, S. Bhangoo, Y. De Koninck, M. Malcangio, S. Melik-Parsadaniantz, and F.A. White Chemokines and pain mechanisms Brain Res. Rev. 60 2009 125 134
3. S. Bhangoo, D. Ren, R.J. Miller, K.J. Henry, J. Lineswala, C. Hamdouchi, B. Li, P.E. Monahan, D.M. Chan, M.S. Ripsch, and F.A. White Delayed functional expression of neuronal chemokine receptors following focal nerve demyelination in the rat: a mechanism for the development of chronic sensitization of peripheral nociceptors Mol. Pain 3 2007 38
4. H. Cao, and Y.Q. Zhang Spinal glial activation contributes to pathological pain states Neurosci. Biobehav. Rev. 32 2008 972 983
5. S.R. Chaplan, F.W. Bach, J.W. Pogrel, J.M. Chung, and T.L. Yaksh Quantitative assessment of tactile allodynia in the rat paw J. Neurosci. Methods 53 1994 55 63
6. R.E. Coleman Clinical features of metastatic bone disease and risk of skeletal morbidity Clin. Cancer Res. 12 2006 6243s 6249s
7. M.A. Dansereau, R.D. Gosselin, M. Pohl, B. Pommier, P. Mechighel, A. Mauborgne, W. Rostene, P. Kitabgi, N. Beaudet, P. Sarret, and S. Melik-Parsadaniantz Spinal CCL2 pronociceptive action is no longer effective in CCR2 receptor antagonist-treated rats J. Neurochem. 106 2008 757 769
8. Y.J. Gao, L. Zhang, O.A. Samad, M.R. Suter, K. Yasuhiko, Z.Z. Xu, J.Y. Park, A.L. Lind, Q. Ma, and R.R. Ji JNK-induced MCP-1 production in spinal cord astrocytes contributes to central sensitization and neuropathic pain J. Neurosci. 29 2009 4096 4108
9. Y.J. Gao, L. Zhang, and R.R. Ji Spinal injection of TNF-alpha-activated astrocytes produces persistent pain symptom mechanical allodynia by releasing monocyte chemoattractant protein-1 Glia 58 2010 1871 1880
10. R.D. Gosselin, C. Varela, G. Banisadr, P. Mechighel, W. Rostene, P. Kitabgi, and S. Melik-Parsadaniantz Constitutive expression of CCR2 chemokine receptor and inhibition by MCP-1/CCL2 of GABA-induced currents in spinal cord neurones J. Neurochem. 95 2005 1023 1034
11. R.D. Gosselin, M.A. Dansereau, M. Pohl, P. Kitabgi, N. Beaudet, P. Sarret, and S. Melik Parsadaniantz Chemokine network in the nervous system: a new target for pain relief Curr. Med. Chem. 15 2008 2866 2875
12. P. Honore, S.D. Rogers, M.J. Schwei, J.L. Salak-Johnson, N.M. Luger, M.C. Sabino, D.R. Clohisy, and P.W. Mantyh Murine models of inflammatory, neuropathic and cancer pain each generates a unique set of neurochemical changes in the spinal cord and sensory neurons Neuroscience 98 2000 585 598
13. Hu, J.H., Yang, J.P., Liu, L., Li, C.F., Wang, L.N., Ji, F.H., Cheng, H., 2012a. Involvement of CX3CR1 in bone cancer pain through the activation of microglia p38 MAPK pathway in the spinal cord. Brain Res. 1465, 2012,1-9
14. J.H. Hu, X.Y. Zheng, J.P. Yang, L.N. Wang, and F.H. Ji Involvement of spinal monocyte chemoattractant protein-1 (MCP-1) in cancer-induced bone pain in rats Neurosci. Lett. 517 2012 60 63
15. J.M. Jimenez-Andrade, W.G. Mantyh, A.P. Bloom, A.S. Ferng, C.P. Geffre, and P.W. Mantyh Bone cancer pain Ann. NY Acad. Sci. 1198 2010 173 181
16. F. Knerlich-Lukoschus, M. Juraschek, U. Blomer, R. Lucius, H.M. Mehdorn, and J. Held-Feindt Force-dependent development of neuropathic central pain and time-related CCL2/CCR2 expression after graded spinal cord contusion injuries of the rat J. Neurotrauma. 25 2008 427 448
17. L.S. Lan, Y.J. Ping, W.L. Na, J. Miao, Q.Q. Cheng, M.Z. Ni, L. Lei, L.C. Fang, R.C. Guang, Z. Jin, and L. Wei Down-regulation of Toll-like receptor 4 gene expression by short interfering RNA attenuates bone cancer pain in a rat model Mol. Pain 6 2010 2
18. P.W. Mantyh Cancer pain and its impact on diagnosis, survival and quality of life Nat. Rev. Neurosci. 7 2006 797 809
19. J. Menetski, S. Mistry, M. Lu, J.S. Mudgett, R.M. Ransohoff, J.A. Demartino, D.E. Macintyre, and C. Abbadie Mice overexpressing chemokine ligand 2 (CCL2) in astrocytes display enhanced nociceptive responses Neuroscience. 149 2007 706 714
20. J.P. O'Callaghan, and D.B. Miller Spinal glia and chronic pain Metabolism 59 Suppl. 1 2010 S21 S26
21. E.A. Old, and M. Malcangio Chemokine mediated neuron-glia communication and aberrant signalling in neuropathic pain states Curr. Opin. Pharmacol. 12 2012 67 73
22. A. Serrano, M. Pare, F. McIntosh, S.J. Elmes, G. Martino, C. Jomphe, E. Lessard, P.M. Lembo, F. Vaillancourt, M.N. Perkins, and C.Q. Cao Blocking spinal CCR2 with AZ889 reversed hyperalgesia in a model of neuropathic pain Mol. Pain 6 2010 90
23. M.A. Thacker, A.K. Clark, T. Bishop, J. Grist, P.K. Yip, L.D. Moon, S.W. Thompson, F. Marchand, and S.B. McMahon CCL2 is a key mediator of microglia activation in neuropathic pain states Eur. J. Pain 13 2009 263 272
24. J. Van Steenwinckel, A. Reaux-Le Goazigo, B. Pommier, A. Mauborgne, M.A. Dansereau, P. Kitabgi, P. Sarret, M. Pohl, and S. Melik Parsadaniantz CCL2 released from neuronal synaptic vesicles in the spinal cord is a major mediator of local inflammation and pain after peripheral nerve injury J. Neurosci. 31 2011 5865 5875
25. J.P. Vit, P.T. Ohara, D.A. Tien, J.R. Fike, L. Eikmeier, A. Beitz, G.L. Wilcox, and L. Jasmin The analgesic effect of low dose focal irradiation in a mouse model of bone cancer is associated with spinal changes in neuro-mediators of nociception Pain 120 2006 188 201
26. Wang, L.N., Yang, J.P., Zhan, Y., Ji, F.H., Wang, X.Y., Zuo, J.L., Xu, Q.N., 2011a. Minocycline-induced reduction of brain-derived neurotrophic factor expression in relation to cancer-induced bone pain in rats. J. Neurosci. Res.
27. L.N. Wang, M. Yao, J.P. Yang, J. Peng, Y. Peng, C.F. Li, Y.B. Zhang, F.H. Ji, H. Cheng, Q.N. Xu, X.Y. Wang, and J.L. Zuo Cancer-induced bone pain sequentially activates the ERK/MAPK pathway in different cell types in the rat spinal cord Mol. Pain 7 2011 48
28. L.R. Watkins, J. Wieseler-Frank, E.D. Milligan, I. Johnston, and S.F. Maier Chapter 22 Contribution of glia to pain processing in health and disease Handb. Clin. Neurol. 81 2006 309 323
29. F.A. White, J. Sun, S.M. Waters, C. Ma, D. Ren, M. Ripsch, J. Steflik, D.N. Cortright, R.H. Lamotte, and R.J. Miller Excitatory monocyte chemoattractant protein-1 signaling is up-regulated in sensory neurons after chronic compression of the dorsal root ganglion Proc. Natl. Acad. Sci USA 102 2005 14092 14097
30. F.A. White, and N.M. Wilson Chemokines as pain mediators and modulators Curr. Opin. Anaesthesiol. 21 2008 580 585
31. F.A. White, and R.J. Miller Insights into the regulation of chemokine receptors by molecular signaling pathways: functional roles in neuropathic pain Brain Behav. Immun. 24 2010 859 865
32. M. Yao, J.P. Yang, L.N. Wang, H. Cheng, Y.B. Zhang, Q.N. Xu, and Y.W. Wu Feasibility of establishment of rat model of bone cancer pain by using Walker 256 cells cultured in vitro or in vivo Zhonghua Yi Xue Za Zhi. 88 2008 880 884
33. J. Zhang, and Y. De Koninck Spatial and temporal relationship between monocyte chemoattractant protein-1 expression and spinal glial activation following peripheral nerve injury J. Neurochem. 97 2006 772 783
34. J. Zhang, X.Q. Shi, S. Echeverry, J.S. Mogil, Y. De Koninck, and S. Rivest Expression of CCR2 in both resident and bone marrow-derived microglia plays a critical role in neuropathic pain J. Neurosci. 27 2007 12396 12406
35. Z.Y. Zhuang, P. Gerner, C.J. Woolf, and R.R. Ji ERK is sequentially activated in neurons, microglia, and astrocytes by spinal nerve ligation and contributes to mechanical allodynia in this neuropathic pain model Pain 114 2005 149 159
36. M. Zimmermann Ethical guidelines for investigations of experimental pain in conscious animals Pain 16 1983 109 110